TLC—Densitometric Determination of Guaifenesin, Pseudoephedrine Hydrochloride and Guaifenesin Related Substance (Guaiacol)
Summary This research article describes a simple and sensitive thin-layer chromatographic (TLC)-densitometric method for simultaneous determination of guaifenesin (GUF) and pseudoephedrine HCl (PSH) in their binary mixtures and in the presence of guaifenesin impurity and related substance, guaiacol....
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Abdelwahab, Nada S. [verfasserIn] Abdelaleem, Eglal A. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of planar chromatography, modern TLC - Budapest : Akadémiai Kiadó, 2001, 26(2013), 1 vom: 01. Feb., Seite 73-77 |
|---|---|
| Übergeordnetes Werk: |
volume:26 ; year:2013 ; number:1 ; day:01 ; month:02 ; pages:73-77 |
| Links: |
|---|
| DOI / URN: |
10.1556/JPC.26.2013.1.11 |
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SPR039219755 |
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| 520 | |a Summary This research article describes a simple and sensitive thin-layer chromatographic (TLC)-densitometric method for simultaneous determination of guaifenesin (GUF) and pseudoephedrine HCl (PSH) in their binary mixtures and in the presence of guaifenesin impurity and related substance, guaiacol. The proposed chromatographic method has been developed using silica gel plates 60 $ F_{254} $ as a stationary phase with hexane-acetone-ethyl acetate-triethylamine-water (3:4:3:0.1:0.3, by volume) as a developing system followed by densitometric measurements at 208 (for pseudoephedrine HCl and guaifenesin) and 278 nm (for guaiacol). Experimental conditions have been optimized to get the desired separation and sensitivity. Calibration curves for the three studied components were constructed using polynomial equation which was superior to linear equation with respect to correlation coefficients and quantified ranges (14–25, 2–12, and 0.1–1.1 µg $ band^{−1} $) for pseudoephedrine HCl, guaifenesin and guaiacol, respectively. The developed method has been successfully applied for determination of pseudoephedrine HCl and guaifenesin in Triaminic® Chest Congestion syrup where no interference from syrup additives has been found. The data obtained from method validation confirm the specificity, sensitivity and accuracy of the method. Statistical comparison of the results obtained by the proposed chromatographic method and of those obtained by the reported chemometric technique showed no significant difference at 95% confidence limit. | ||
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10.1556/JPC.26.2013.1.11 doi (DE-627)SPR039219755 (SPR)JPC.26.2013.1.11-e DE-627 ger DE-627 rakwb eng 540 530 ASE Abdelwahab, Nada S. verfasserin aut TLC—Densitometric Determination of Guaifenesin, Pseudoephedrine Hydrochloride and Guaifenesin Related Substance (Guaiacol) 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary This research article describes a simple and sensitive thin-layer chromatographic (TLC)-densitometric method for simultaneous determination of guaifenesin (GUF) and pseudoephedrine HCl (PSH) in their binary mixtures and in the presence of guaifenesin impurity and related substance, guaiacol. The proposed chromatographic method has been developed using silica gel plates 60 $ F_{254} $ as a stationary phase with hexane-acetone-ethyl acetate-triethylamine-water (3:4:3:0.1:0.3, by volume) as a developing system followed by densitometric measurements at 208 (for pseudoephedrine HCl and guaifenesin) and 278 nm (for guaiacol). Experimental conditions have been optimized to get the desired separation and sensitivity. Calibration curves for the three studied components were constructed using polynomial equation which was superior to linear equation with respect to correlation coefficients and quantified ranges (14–25, 2–12, and 0.1–1.1 µg $ band^{−1} $) for pseudoephedrine HCl, guaifenesin and guaiacol, respectively. The developed method has been successfully applied for determination of pseudoephedrine HCl and guaifenesin in Triaminic® Chest Congestion syrup where no interference from syrup additives has been found. The data obtained from method validation confirm the specificity, sensitivity and accuracy of the method. Statistical comparison of the results obtained by the proposed chromatographic method and of those obtained by the reported chemometric technique showed no significant difference at 95% confidence limit. Abdelaleem, Eglal A. verfasserin aut Enthalten in Journal of planar chromatography, modern TLC Budapest : Akadémiai Kiadó, 2001 26(2013), 1 vom: 01. Feb., Seite 73-77 (DE-627)529764563 (DE-600)2304198-5 1789-0993 nnns volume:26 year:2013 number:1 day:01 month:02 pages:73-77 https://dx.doi.org/10.1556/JPC.26.2013.1.11 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_22 GBV_ILN_31 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2129 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4305 AR 26 2013 1 01 02 73-77 |
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10.1556/JPC.26.2013.1.11 doi (DE-627)SPR039219755 (SPR)JPC.26.2013.1.11-e DE-627 ger DE-627 rakwb eng 540 530 ASE Abdelwahab, Nada S. verfasserin aut TLC—Densitometric Determination of Guaifenesin, Pseudoephedrine Hydrochloride and Guaifenesin Related Substance (Guaiacol) 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary This research article describes a simple and sensitive thin-layer chromatographic (TLC)-densitometric method for simultaneous determination of guaifenesin (GUF) and pseudoephedrine HCl (PSH) in their binary mixtures and in the presence of guaifenesin impurity and related substance, guaiacol. The proposed chromatographic method has been developed using silica gel plates 60 $ F_{254} $ as a stationary phase with hexane-acetone-ethyl acetate-triethylamine-water (3:4:3:0.1:0.3, by volume) as a developing system followed by densitometric measurements at 208 (for pseudoephedrine HCl and guaifenesin) and 278 nm (for guaiacol). Experimental conditions have been optimized to get the desired separation and sensitivity. Calibration curves for the three studied components were constructed using polynomial equation which was superior to linear equation with respect to correlation coefficients and quantified ranges (14–25, 2–12, and 0.1–1.1 µg $ band^{−1} $) for pseudoephedrine HCl, guaifenesin and guaiacol, respectively. The developed method has been successfully applied for determination of pseudoephedrine HCl and guaifenesin in Triaminic® Chest Congestion syrup where no interference from syrup additives has been found. The data obtained from method validation confirm the specificity, sensitivity and accuracy of the method. Statistical comparison of the results obtained by the proposed chromatographic method and of those obtained by the reported chemometric technique showed no significant difference at 95% confidence limit. Abdelaleem, Eglal A. verfasserin aut Enthalten in Journal of planar chromatography, modern TLC Budapest : Akadémiai Kiadó, 2001 26(2013), 1 vom: 01. Feb., Seite 73-77 (DE-627)529764563 (DE-600)2304198-5 1789-0993 nnns volume:26 year:2013 number:1 day:01 month:02 pages:73-77 https://dx.doi.org/10.1556/JPC.26.2013.1.11 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_22 GBV_ILN_31 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2129 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4305 AR 26 2013 1 01 02 73-77 |
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10.1556/JPC.26.2013.1.11 doi (DE-627)SPR039219755 (SPR)JPC.26.2013.1.11-e DE-627 ger DE-627 rakwb eng 540 530 ASE Abdelwahab, Nada S. verfasserin aut TLC—Densitometric Determination of Guaifenesin, Pseudoephedrine Hydrochloride and Guaifenesin Related Substance (Guaiacol) 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary This research article describes a simple and sensitive thin-layer chromatographic (TLC)-densitometric method for simultaneous determination of guaifenesin (GUF) and pseudoephedrine HCl (PSH) in their binary mixtures and in the presence of guaifenesin impurity and related substance, guaiacol. The proposed chromatographic method has been developed using silica gel plates 60 $ F_{254} $ as a stationary phase with hexane-acetone-ethyl acetate-triethylamine-water (3:4:3:0.1:0.3, by volume) as a developing system followed by densitometric measurements at 208 (for pseudoephedrine HCl and guaifenesin) and 278 nm (for guaiacol). Experimental conditions have been optimized to get the desired separation and sensitivity. Calibration curves for the three studied components were constructed using polynomial equation which was superior to linear equation with respect to correlation coefficients and quantified ranges (14–25, 2–12, and 0.1–1.1 µg $ band^{−1} $) for pseudoephedrine HCl, guaifenesin and guaiacol, respectively. The developed method has been successfully applied for determination of pseudoephedrine HCl and guaifenesin in Triaminic® Chest Congestion syrup where no interference from syrup additives has been found. The data obtained from method validation confirm the specificity, sensitivity and accuracy of the method. Statistical comparison of the results obtained by the proposed chromatographic method and of those obtained by the reported chemometric technique showed no significant difference at 95% confidence limit. Abdelaleem, Eglal A. verfasserin aut Enthalten in Journal of planar chromatography, modern TLC Budapest : Akadémiai Kiadó, 2001 26(2013), 1 vom: 01. Feb., Seite 73-77 (DE-627)529764563 (DE-600)2304198-5 1789-0993 nnns volume:26 year:2013 number:1 day:01 month:02 pages:73-77 https://dx.doi.org/10.1556/JPC.26.2013.1.11 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_22 GBV_ILN_31 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2129 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4305 AR 26 2013 1 01 02 73-77 |
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10.1556/JPC.26.2013.1.11 doi (DE-627)SPR039219755 (SPR)JPC.26.2013.1.11-e DE-627 ger DE-627 rakwb eng 540 530 ASE Abdelwahab, Nada S. verfasserin aut TLC—Densitometric Determination of Guaifenesin, Pseudoephedrine Hydrochloride and Guaifenesin Related Substance (Guaiacol) 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary This research article describes a simple and sensitive thin-layer chromatographic (TLC)-densitometric method for simultaneous determination of guaifenesin (GUF) and pseudoephedrine HCl (PSH) in their binary mixtures and in the presence of guaifenesin impurity and related substance, guaiacol. The proposed chromatographic method has been developed using silica gel plates 60 $ F_{254} $ as a stationary phase with hexane-acetone-ethyl acetate-triethylamine-water (3:4:3:0.1:0.3, by volume) as a developing system followed by densitometric measurements at 208 (for pseudoephedrine HCl and guaifenesin) and 278 nm (for guaiacol). Experimental conditions have been optimized to get the desired separation and sensitivity. Calibration curves for the three studied components were constructed using polynomial equation which was superior to linear equation with respect to correlation coefficients and quantified ranges (14–25, 2–12, and 0.1–1.1 µg $ band^{−1} $) for pseudoephedrine HCl, guaifenesin and guaiacol, respectively. The developed method has been successfully applied for determination of pseudoephedrine HCl and guaifenesin in Triaminic® Chest Congestion syrup where no interference from syrup additives has been found. The data obtained from method validation confirm the specificity, sensitivity and accuracy of the method. Statistical comparison of the results obtained by the proposed chromatographic method and of those obtained by the reported chemometric technique showed no significant difference at 95% confidence limit. Abdelaleem, Eglal A. verfasserin aut Enthalten in Journal of planar chromatography, modern TLC Budapest : Akadémiai Kiadó, 2001 26(2013), 1 vom: 01. Feb., Seite 73-77 (DE-627)529764563 (DE-600)2304198-5 1789-0993 nnns volume:26 year:2013 number:1 day:01 month:02 pages:73-77 https://dx.doi.org/10.1556/JPC.26.2013.1.11 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_22 GBV_ILN_31 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2129 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4305 AR 26 2013 1 01 02 73-77 |
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10.1556/JPC.26.2013.1.11 doi (DE-627)SPR039219755 (SPR)JPC.26.2013.1.11-e DE-627 ger DE-627 rakwb eng 540 530 ASE Abdelwahab, Nada S. verfasserin aut TLC—Densitometric Determination of Guaifenesin, Pseudoephedrine Hydrochloride and Guaifenesin Related Substance (Guaiacol) 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary This research article describes a simple and sensitive thin-layer chromatographic (TLC)-densitometric method for simultaneous determination of guaifenesin (GUF) and pseudoephedrine HCl (PSH) in their binary mixtures and in the presence of guaifenesin impurity and related substance, guaiacol. The proposed chromatographic method has been developed using silica gel plates 60 $ F_{254} $ as a stationary phase with hexane-acetone-ethyl acetate-triethylamine-water (3:4:3:0.1:0.3, by volume) as a developing system followed by densitometric measurements at 208 (for pseudoephedrine HCl and guaifenesin) and 278 nm (for guaiacol). Experimental conditions have been optimized to get the desired separation and sensitivity. Calibration curves for the three studied components were constructed using polynomial equation which was superior to linear equation with respect to correlation coefficients and quantified ranges (14–25, 2–12, and 0.1–1.1 µg $ band^{−1} $) for pseudoephedrine HCl, guaifenesin and guaiacol, respectively. The developed method has been successfully applied for determination of pseudoephedrine HCl and guaifenesin in Triaminic® Chest Congestion syrup where no interference from syrup additives has been found. The data obtained from method validation confirm the specificity, sensitivity and accuracy of the method. Statistical comparison of the results obtained by the proposed chromatographic method and of those obtained by the reported chemometric technique showed no significant difference at 95% confidence limit. Abdelaleem, Eglal A. verfasserin aut Enthalten in Journal of planar chromatography, modern TLC Budapest : Akadémiai Kiadó, 2001 26(2013), 1 vom: 01. Feb., Seite 73-77 (DE-627)529764563 (DE-600)2304198-5 1789-0993 nnns volume:26 year:2013 number:1 day:01 month:02 pages:73-77 https://dx.doi.org/10.1556/JPC.26.2013.1.11 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_22 GBV_ILN_31 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2129 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4305 AR 26 2013 1 01 02 73-77 |
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TLC—Densitometric Determination of Guaifenesin, Pseudoephedrine Hydrochloride and Guaifenesin Related Substance (Guaiacol) |
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TLC—Densitometric Determination of Guaifenesin, Pseudoephedrine Hydrochloride and Guaifenesin Related Substance (Guaiacol) |
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Abdelwahab, Nada S. |
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Journal of planar chromatography, modern TLC |
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Journal of planar chromatography, modern TLC |
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73 |
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Abdelwahab, Nada S. Abdelaleem, Eglal A. |
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Abdelwahab, Nada S. |
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10.1556/JPC.26.2013.1.11 |
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tlc—densitometric determination of guaifenesin, pseudoephedrine hydrochloride and guaifenesin related substance (guaiacol) |
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TLC—Densitometric Determination of Guaifenesin, Pseudoephedrine Hydrochloride and Guaifenesin Related Substance (Guaiacol) |
| abstract |
Summary This research article describes a simple and sensitive thin-layer chromatographic (TLC)-densitometric method for simultaneous determination of guaifenesin (GUF) and pseudoephedrine HCl (PSH) in their binary mixtures and in the presence of guaifenesin impurity and related substance, guaiacol. The proposed chromatographic method has been developed using silica gel plates 60 $ F_{254} $ as a stationary phase with hexane-acetone-ethyl acetate-triethylamine-water (3:4:3:0.1:0.3, by volume) as a developing system followed by densitometric measurements at 208 (for pseudoephedrine HCl and guaifenesin) and 278 nm (for guaiacol). Experimental conditions have been optimized to get the desired separation and sensitivity. Calibration curves for the three studied components were constructed using polynomial equation which was superior to linear equation with respect to correlation coefficients and quantified ranges (14–25, 2–12, and 0.1–1.1 µg $ band^{−1} $) for pseudoephedrine HCl, guaifenesin and guaiacol, respectively. The developed method has been successfully applied for determination of pseudoephedrine HCl and guaifenesin in Triaminic® Chest Congestion syrup where no interference from syrup additives has been found. The data obtained from method validation confirm the specificity, sensitivity and accuracy of the method. Statistical comparison of the results obtained by the proposed chromatographic method and of those obtained by the reported chemometric technique showed no significant difference at 95% confidence limit. |
| abstractGer |
Summary This research article describes a simple and sensitive thin-layer chromatographic (TLC)-densitometric method for simultaneous determination of guaifenesin (GUF) and pseudoephedrine HCl (PSH) in their binary mixtures and in the presence of guaifenesin impurity and related substance, guaiacol. The proposed chromatographic method has been developed using silica gel plates 60 $ F_{254} $ as a stationary phase with hexane-acetone-ethyl acetate-triethylamine-water (3:4:3:0.1:0.3, by volume) as a developing system followed by densitometric measurements at 208 (for pseudoephedrine HCl and guaifenesin) and 278 nm (for guaiacol). Experimental conditions have been optimized to get the desired separation and sensitivity. Calibration curves for the three studied components were constructed using polynomial equation which was superior to linear equation with respect to correlation coefficients and quantified ranges (14–25, 2–12, and 0.1–1.1 µg $ band^{−1} $) for pseudoephedrine HCl, guaifenesin and guaiacol, respectively. The developed method has been successfully applied for determination of pseudoephedrine HCl and guaifenesin in Triaminic® Chest Congestion syrup where no interference from syrup additives has been found. The data obtained from method validation confirm the specificity, sensitivity and accuracy of the method. Statistical comparison of the results obtained by the proposed chromatographic method and of those obtained by the reported chemometric technique showed no significant difference at 95% confidence limit. |
| abstract_unstemmed |
Summary This research article describes a simple and sensitive thin-layer chromatographic (TLC)-densitometric method for simultaneous determination of guaifenesin (GUF) and pseudoephedrine HCl (PSH) in their binary mixtures and in the presence of guaifenesin impurity and related substance, guaiacol. The proposed chromatographic method has been developed using silica gel plates 60 $ F_{254} $ as a stationary phase with hexane-acetone-ethyl acetate-triethylamine-water (3:4:3:0.1:0.3, by volume) as a developing system followed by densitometric measurements at 208 (for pseudoephedrine HCl and guaifenesin) and 278 nm (for guaiacol). Experimental conditions have been optimized to get the desired separation and sensitivity. Calibration curves for the three studied components were constructed using polynomial equation which was superior to linear equation with respect to correlation coefficients and quantified ranges (14–25, 2–12, and 0.1–1.1 µg $ band^{−1} $) for pseudoephedrine HCl, guaifenesin and guaiacol, respectively. The developed method has been successfully applied for determination of pseudoephedrine HCl and guaifenesin in Triaminic® Chest Congestion syrup where no interference from syrup additives has been found. The data obtained from method validation confirm the specificity, sensitivity and accuracy of the method. Statistical comparison of the results obtained by the proposed chromatographic method and of those obtained by the reported chemometric technique showed no significant difference at 95% confidence limit. |
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| title_short |
TLC—Densitometric Determination of Guaifenesin, Pseudoephedrine Hydrochloride and Guaifenesin Related Substance (Guaiacol) |
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https://dx.doi.org/10.1556/JPC.26.2013.1.11 |
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