Principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases

Objectives Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The possible underlying mechanism for this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis facto...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yarizadeh, Habib [verfasserIn] Setayesh, Leila [verfasserIn] Askarpoor, Moein [verfasserIn] Pooyan, Sara [verfasserIn] Sajjadi, Seyedeh Forough [verfasserIn] Badrooj, Negin [verfasserIn] Roberts, Caroline [verfasserIn] Mirzaei, Khadijeh [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Adipocytokines Cardiovascular diseases Obesity

Übergeordnetes Werk:	Enthalten in: BMC Research Notes - London, 2008, 13(2020), 1 vom: 14. Apr.
Übergeordnetes Werk:	volume:13 ; year:2020 ; number:1 ; day:14 ; month:04

Links:	Volltext

DOI / URN:	10.1186/s13104-020-04976-9

Katalog-ID:	SPR039397726

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520			\|a Objectives Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The possible underlying mechanism for this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, and interleukin-1-beta). This study aimed to investigate the linkage between adipocytokines and insulin with the cardiovascular disease risk, with particular reference to the adipokines galectin-3, plasminogen activator inhibitor-1, and interleukin-1-beta, C-reactive protein, and monocyte chemoattractant protein. Result Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and interleukin-1-beta and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern was strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (p < 0.05 for all). This is a retrospective study. Ethics approval (IR.TUMS.VCR.REC.1395.1597).
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allfields	10.1186/s13104-020-04976-9 doi (DE-627)SPR039397726 (SPR)s13104-020-04976-9-e DE-627 ger DE-627 rakwb eng 610 570 ASE Yarizadeh, Habib verfasserin aut Principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The possible underlying mechanism for this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, and interleukin-1-beta). This study aimed to investigate the linkage between adipocytokines and insulin with the cardiovascular disease risk, with particular reference to the adipokines galectin-3, plasminogen activator inhibitor-1, and interleukin-1-beta, C-reactive protein, and monocyte chemoattractant protein. Result Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and interleukin-1-beta and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern was strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (p < 0.05 for all). This is a retrospective study. Ethics approval (IR.TUMS.VCR.REC.1395.1597). Adipocytokines (dpeaa)DE-He213 Cardiovascular diseases (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Setayesh, Leila verfasserin aut Askarpoor, Moein verfasserin aut Pooyan, Sara verfasserin aut Sajjadi, Seyedeh Forough verfasserin aut Badrooj, Negin verfasserin aut Roberts, Caroline verfasserin aut Mirzaei, Khadijeh verfasserin aut Enthalten in BMC Research Notes London, 2008 13(2020), 1 vom: 14. Apr. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:13 year:2020 number:1 day:14 month:04 https://dx.doi.org/10.1186/s13104-020-04976-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2020 1 14 04
spelling	10.1186/s13104-020-04976-9 doi (DE-627)SPR039397726 (SPR)s13104-020-04976-9-e DE-627 ger DE-627 rakwb eng 610 570 ASE Yarizadeh, Habib verfasserin aut Principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The possible underlying mechanism for this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, and interleukin-1-beta). This study aimed to investigate the linkage between adipocytokines and insulin with the cardiovascular disease risk, with particular reference to the adipokines galectin-3, plasminogen activator inhibitor-1, and interleukin-1-beta, C-reactive protein, and monocyte chemoattractant protein. Result Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and interleukin-1-beta and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern was strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (p < 0.05 for all). This is a retrospective study. Ethics approval (IR.TUMS.VCR.REC.1395.1597). Adipocytokines (dpeaa)DE-He213 Cardiovascular diseases (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Setayesh, Leila verfasserin aut Askarpoor, Moein verfasserin aut Pooyan, Sara verfasserin aut Sajjadi, Seyedeh Forough verfasserin aut Badrooj, Negin verfasserin aut Roberts, Caroline verfasserin aut Mirzaei, Khadijeh verfasserin aut Enthalten in BMC Research Notes London, 2008 13(2020), 1 vom: 14. Apr. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:13 year:2020 number:1 day:14 month:04 https://dx.doi.org/10.1186/s13104-020-04976-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2020 1 14 04
allfields_unstemmed	10.1186/s13104-020-04976-9 doi (DE-627)SPR039397726 (SPR)s13104-020-04976-9-e DE-627 ger DE-627 rakwb eng 610 570 ASE Yarizadeh, Habib verfasserin aut Principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The possible underlying mechanism for this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, and interleukin-1-beta). This study aimed to investigate the linkage between adipocytokines and insulin with the cardiovascular disease risk, with particular reference to the adipokines galectin-3, plasminogen activator inhibitor-1, and interleukin-1-beta, C-reactive protein, and monocyte chemoattractant protein. Result Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and interleukin-1-beta and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern was strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (p < 0.05 for all). This is a retrospective study. Ethics approval (IR.TUMS.VCR.REC.1395.1597). Adipocytokines (dpeaa)DE-He213 Cardiovascular diseases (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Setayesh, Leila verfasserin aut Askarpoor, Moein verfasserin aut Pooyan, Sara verfasserin aut Sajjadi, Seyedeh Forough verfasserin aut Badrooj, Negin verfasserin aut Roberts, Caroline verfasserin aut Mirzaei, Khadijeh verfasserin aut Enthalten in BMC Research Notes London, 2008 13(2020), 1 vom: 14. Apr. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:13 year:2020 number:1 day:14 month:04 https://dx.doi.org/10.1186/s13104-020-04976-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2020 1 14 04
allfieldsGer	10.1186/s13104-020-04976-9 doi (DE-627)SPR039397726 (SPR)s13104-020-04976-9-e DE-627 ger DE-627 rakwb eng 610 570 ASE Yarizadeh, Habib verfasserin aut Principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The possible underlying mechanism for this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, and interleukin-1-beta). This study aimed to investigate the linkage between adipocytokines and insulin with the cardiovascular disease risk, with particular reference to the adipokines galectin-3, plasminogen activator inhibitor-1, and interleukin-1-beta, C-reactive protein, and monocyte chemoattractant protein. Result Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and interleukin-1-beta and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern was strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (p < 0.05 for all). This is a retrospective study. Ethics approval (IR.TUMS.VCR.REC.1395.1597). Adipocytokines (dpeaa)DE-He213 Cardiovascular diseases (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Setayesh, Leila verfasserin aut Askarpoor, Moein verfasserin aut Pooyan, Sara verfasserin aut Sajjadi, Seyedeh Forough verfasserin aut Badrooj, Negin verfasserin aut Roberts, Caroline verfasserin aut Mirzaei, Khadijeh verfasserin aut Enthalten in BMC Research Notes London, 2008 13(2020), 1 vom: 14. Apr. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:13 year:2020 number:1 day:14 month:04 https://dx.doi.org/10.1186/s13104-020-04976-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2020 1 14 04
allfieldsSound	10.1186/s13104-020-04976-9 doi (DE-627)SPR039397726 (SPR)s13104-020-04976-9-e DE-627 ger DE-627 rakwb eng 610 570 ASE Yarizadeh, Habib verfasserin aut Principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The possible underlying mechanism for this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, and interleukin-1-beta). This study aimed to investigate the linkage between adipocytokines and insulin with the cardiovascular disease risk, with particular reference to the adipokines galectin-3, plasminogen activator inhibitor-1, and interleukin-1-beta, C-reactive protein, and monocyte chemoattractant protein. Result Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and interleukin-1-beta and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern was strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (p < 0.05 for all). This is a retrospective study. Ethics approval (IR.TUMS.VCR.REC.1395.1597). Adipocytokines (dpeaa)DE-He213 Cardiovascular diseases (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Setayesh, Leila verfasserin aut Askarpoor, Moein verfasserin aut Pooyan, Sara verfasserin aut Sajjadi, Seyedeh Forough verfasserin aut Badrooj, Negin verfasserin aut Roberts, Caroline verfasserin aut Mirzaei, Khadijeh verfasserin aut Enthalten in BMC Research Notes London, 2008 13(2020), 1 vom: 14. Apr. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:13 year:2020 number:1 day:14 month:04 https://dx.doi.org/10.1186/s13104-020-04976-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2020 1 14 04
language	English
source	Enthalten in BMC Research Notes 13(2020), 1 vom: 14. Apr. volume:13 year:2020 number:1 day:14 month:04
sourceStr	Enthalten in BMC Research Notes 13(2020), 1 vom: 14. Apr. volume:13 year:2020 number:1 day:14 month:04
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institution	findex.gbv.de
topic_facet	Adipocytokines Cardiovascular diseases Obesity
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authorswithroles_txt_mv	Yarizadeh, Habib @@aut@@ Setayesh, Leila @@aut@@ Askarpoor, Moein @@aut@@ Pooyan, Sara @@aut@@ Sajjadi, Seyedeh Forough @@aut@@ Badrooj, Negin @@aut@@ Roberts, Caroline @@aut@@ Mirzaei, Khadijeh @@aut@@
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The possible underlying mechanism for this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, and interleukin-1-beta). This study aimed to investigate the linkage between adipocytokines and insulin with the cardiovascular disease risk, with particular reference to the adipokines galectin-3, plasminogen activator inhibitor-1, and interleukin-1-beta, C-reactive protein, and monocyte chemoattractant protein. Result Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and interleukin-1-beta and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern was strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (p < 0.05 for all). This is a retrospective study. 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author	Yarizadeh, Habib
spellingShingle	Yarizadeh, Habib ddc 610 misc Adipocytokines misc Cardiovascular diseases misc Obesity Principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases
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topic_title	610 570 ASE Principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases Adipocytokines (dpeaa)DE-He213 Cardiovascular diseases (dpeaa)DE-He213 Obesity (dpeaa)DE-He213
topic	ddc 610 misc Adipocytokines misc Cardiovascular diseases misc Obesity
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title	Principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases
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title_full	Principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases
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title_sort	principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases
title_auth	Principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases
abstract	Objectives Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The possible underlying mechanism for this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, and interleukin-1-beta). This study aimed to investigate the linkage between adipocytokines and insulin with the cardiovascular disease risk, with particular reference to the adipokines galectin-3, plasminogen activator inhibitor-1, and interleukin-1-beta, C-reactive protein, and monocyte chemoattractant protein. Result Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and interleukin-1-beta and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern was strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (p < 0.05 for all). This is a retrospective study. Ethics approval (IR.TUMS.VCR.REC.1395.1597).
abstractGer	Objectives Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The possible underlying mechanism for this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, and interleukin-1-beta). This study aimed to investigate the linkage between adipocytokines and insulin with the cardiovascular disease risk, with particular reference to the adipokines galectin-3, plasminogen activator inhibitor-1, and interleukin-1-beta, C-reactive protein, and monocyte chemoattractant protein. Result Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and interleukin-1-beta and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern was strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (p < 0.05 for all). This is a retrospective study. Ethics approval (IR.TUMS.VCR.REC.1395.1597).
abstract_unstemmed	Objectives Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The possible underlying mechanism for this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, and interleukin-1-beta). This study aimed to investigate the linkage between adipocytokines and insulin with the cardiovascular disease risk, with particular reference to the adipokines galectin-3, plasminogen activator inhibitor-1, and interleukin-1-beta, C-reactive protein, and monocyte chemoattractant protein. Result Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and interleukin-1-beta and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern was strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (p < 0.05 for all). This is a retrospective study. Ethics approval (IR.TUMS.VCR.REC.1395.1597).
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title_short	Principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases
url	https://dx.doi.org/10.1186/s13104-020-04976-9
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author2	Setayesh, Leila Askarpoor, Moein Pooyan, Sara Sajjadi, Seyedeh Forough Badrooj, Negin Roberts, Caroline Mirzaei, Khadijeh
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up_date	2024-07-03T23:44:08.528Z
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The second pattern was strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (p < 0.05 for all). This is a retrospective study. 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Principal component analysis of adipocytokines and insulin associate with risk factors of cardiovascular diseases

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