Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway
Background Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities. This study aimed to investigate the effect of Circaea mollis Siebold & Zucc on postmenopausal osteoporosis. Methods For in vitro study, MCF7 b...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Park, Ji Hye [verfasserIn] Son, Yang Ju [verfasserIn] Lee, Chang Ho [verfasserIn] Nho, Chu Won [verfasserIn] Yoo, Gyhye [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: BMC complementary and alternative medicine - London : BioMed Central, 2001, 20(2020), 1 vom: 22. Apr. |
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| Übergeordnetes Werk: |
volume:20 ; year:2020 ; number:1 ; day:22 ; month:04 |
| Links: |
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| DOI / URN: |
10.1186/s12906-020-02914-7 |
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SPR039489531 |
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| 520 | |a Background Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities. This study aimed to investigate the effect of Circaea mollis Siebold & Zucc on postmenopausal osteoporosis. Methods For in vitro study, MCF7 breast cancer cells and MC3T3-E1 pre-osteoblast cells were utilized to estimate estrogenic and osteogenic activity. Osteoblastic markers were measured by western blot and real-time PCR. For in vivo study, female mature C57BL/6 mice were ovariectomized and oral administrated with 10 mg/kg and 40 mg/kg of EECM respectively. Results EtOH extract of Circaea mollis Siebold & Zucc. (EECM) increased alkaline phosphatase activity and osteoblast marker levels at day 7 during differentiation of mouse preosteoblasts. EECM reduced osteoclast differentiation and bone resorption in an osteoblast-osteoclast primary co-culture system. In ovariectomized mice, EECM prevented the decrease in bone mineral density and recovered OSX and Runx2 via BMP2/4, Smad1/5/9 and p38. Conclusions The results suggest that EECM may be effective in preventing bone loss, offering a promising alternative for the nutritional management of postmenopausal osteoporosis. | ||
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10.1186/s12906-020-02914-7 doi (DE-627)SPR039489531 (SPR)s12906-020-02914-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Park, Ji Hye verfasserin aut Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities. This study aimed to investigate the effect of Circaea mollis Siebold & Zucc on postmenopausal osteoporosis. Methods For in vitro study, MCF7 breast cancer cells and MC3T3-E1 pre-osteoblast cells were utilized to estimate estrogenic and osteogenic activity. Osteoblastic markers were measured by western blot and real-time PCR. For in vivo study, female mature C57BL/6 mice were ovariectomized and oral administrated with 10 mg/kg and 40 mg/kg of EECM respectively. Results EtOH extract of Circaea mollis Siebold & Zucc. (EECM) increased alkaline phosphatase activity and osteoblast marker levels at day 7 during differentiation of mouse preosteoblasts. EECM reduced osteoclast differentiation and bone resorption in an osteoblast-osteoclast primary co-culture system. In ovariectomized mice, EECM prevented the decrease in bone mineral density and recovered OSX and Runx2 via BMP2/4, Smad1/5/9 and p38. Conclusions The results suggest that EECM may be effective in preventing bone loss, offering a promising alternative for the nutritional management of postmenopausal osteoporosis. Siebold & Zucc (dpeaa)DE-He213 Postmenopausal osteoporosis (dpeaa)DE-He213 Osteoblast differentiation (dpeaa)DE-He213 Runt-related transcription factor 2 (dpeaa)DE-He213 Bone morphogenetic protein 2/4 (dpeaa)DE-He213 Son, Yang Ju verfasserin aut Lee, Chang Ho verfasserin aut Nho, Chu Won verfasserin aut Yoo, Gyhye verfasserin aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 20(2020), 1 vom: 22. Apr. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:20 year:2020 number:1 day:22 month:04 https://dx.doi.org/10.1186/s12906-020-02914-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA 44.00 ASE AR 20 2020 1 22 04 |
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10.1186/s12906-020-02914-7 doi (DE-627)SPR039489531 (SPR)s12906-020-02914-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Park, Ji Hye verfasserin aut Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities. This study aimed to investigate the effect of Circaea mollis Siebold & Zucc on postmenopausal osteoporosis. Methods For in vitro study, MCF7 breast cancer cells and MC3T3-E1 pre-osteoblast cells were utilized to estimate estrogenic and osteogenic activity. Osteoblastic markers were measured by western blot and real-time PCR. For in vivo study, female mature C57BL/6 mice were ovariectomized and oral administrated with 10 mg/kg and 40 mg/kg of EECM respectively. Results EtOH extract of Circaea mollis Siebold & Zucc. (EECM) increased alkaline phosphatase activity and osteoblast marker levels at day 7 during differentiation of mouse preosteoblasts. EECM reduced osteoclast differentiation and bone resorption in an osteoblast-osteoclast primary co-culture system. In ovariectomized mice, EECM prevented the decrease in bone mineral density and recovered OSX and Runx2 via BMP2/4, Smad1/5/9 and p38. Conclusions The results suggest that EECM may be effective in preventing bone loss, offering a promising alternative for the nutritional management of postmenopausal osteoporosis. Siebold & Zucc (dpeaa)DE-He213 Postmenopausal osteoporosis (dpeaa)DE-He213 Osteoblast differentiation (dpeaa)DE-He213 Runt-related transcription factor 2 (dpeaa)DE-He213 Bone morphogenetic protein 2/4 (dpeaa)DE-He213 Son, Yang Ju verfasserin aut Lee, Chang Ho verfasserin aut Nho, Chu Won verfasserin aut Yoo, Gyhye verfasserin aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 20(2020), 1 vom: 22. Apr. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:20 year:2020 number:1 day:22 month:04 https://dx.doi.org/10.1186/s12906-020-02914-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA 44.00 ASE AR 20 2020 1 22 04 |
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10.1186/s12906-020-02914-7 doi (DE-627)SPR039489531 (SPR)s12906-020-02914-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Park, Ji Hye verfasserin aut Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities. This study aimed to investigate the effect of Circaea mollis Siebold & Zucc on postmenopausal osteoporosis. Methods For in vitro study, MCF7 breast cancer cells and MC3T3-E1 pre-osteoblast cells were utilized to estimate estrogenic and osteogenic activity. Osteoblastic markers were measured by western blot and real-time PCR. For in vivo study, female mature C57BL/6 mice were ovariectomized and oral administrated with 10 mg/kg and 40 mg/kg of EECM respectively. Results EtOH extract of Circaea mollis Siebold & Zucc. (EECM) increased alkaline phosphatase activity and osteoblast marker levels at day 7 during differentiation of mouse preosteoblasts. EECM reduced osteoclast differentiation and bone resorption in an osteoblast-osteoclast primary co-culture system. In ovariectomized mice, EECM prevented the decrease in bone mineral density and recovered OSX and Runx2 via BMP2/4, Smad1/5/9 and p38. Conclusions The results suggest that EECM may be effective in preventing bone loss, offering a promising alternative for the nutritional management of postmenopausal osteoporosis. Siebold & Zucc (dpeaa)DE-He213 Postmenopausal osteoporosis (dpeaa)DE-He213 Osteoblast differentiation (dpeaa)DE-He213 Runt-related transcription factor 2 (dpeaa)DE-He213 Bone morphogenetic protein 2/4 (dpeaa)DE-He213 Son, Yang Ju verfasserin aut Lee, Chang Ho verfasserin aut Nho, Chu Won verfasserin aut Yoo, Gyhye verfasserin aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 20(2020), 1 vom: 22. Apr. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:20 year:2020 number:1 day:22 month:04 https://dx.doi.org/10.1186/s12906-020-02914-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA 44.00 ASE AR 20 2020 1 22 04 |
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10.1186/s12906-020-02914-7 doi (DE-627)SPR039489531 (SPR)s12906-020-02914-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Park, Ji Hye verfasserin aut Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities. This study aimed to investigate the effect of Circaea mollis Siebold & Zucc on postmenopausal osteoporosis. Methods For in vitro study, MCF7 breast cancer cells and MC3T3-E1 pre-osteoblast cells were utilized to estimate estrogenic and osteogenic activity. Osteoblastic markers were measured by western blot and real-time PCR. For in vivo study, female mature C57BL/6 mice were ovariectomized and oral administrated with 10 mg/kg and 40 mg/kg of EECM respectively. Results EtOH extract of Circaea mollis Siebold & Zucc. (EECM) increased alkaline phosphatase activity and osteoblast marker levels at day 7 during differentiation of mouse preosteoblasts. EECM reduced osteoclast differentiation and bone resorption in an osteoblast-osteoclast primary co-culture system. In ovariectomized mice, EECM prevented the decrease in bone mineral density and recovered OSX and Runx2 via BMP2/4, Smad1/5/9 and p38. Conclusions The results suggest that EECM may be effective in preventing bone loss, offering a promising alternative for the nutritional management of postmenopausal osteoporosis. Siebold & Zucc (dpeaa)DE-He213 Postmenopausal osteoporosis (dpeaa)DE-He213 Osteoblast differentiation (dpeaa)DE-He213 Runt-related transcription factor 2 (dpeaa)DE-He213 Bone morphogenetic protein 2/4 (dpeaa)DE-He213 Son, Yang Ju verfasserin aut Lee, Chang Ho verfasserin aut Nho, Chu Won verfasserin aut Yoo, Gyhye verfasserin aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 20(2020), 1 vom: 22. Apr. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:20 year:2020 number:1 day:22 month:04 https://dx.doi.org/10.1186/s12906-020-02914-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA 44.00 ASE AR 20 2020 1 22 04 |
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10.1186/s12906-020-02914-7 doi (DE-627)SPR039489531 (SPR)s12906-020-02914-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Park, Ji Hye verfasserin aut Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities. This study aimed to investigate the effect of Circaea mollis Siebold & Zucc on postmenopausal osteoporosis. Methods For in vitro study, MCF7 breast cancer cells and MC3T3-E1 pre-osteoblast cells were utilized to estimate estrogenic and osteogenic activity. Osteoblastic markers were measured by western blot and real-time PCR. For in vivo study, female mature C57BL/6 mice were ovariectomized and oral administrated with 10 mg/kg and 40 mg/kg of EECM respectively. Results EtOH extract of Circaea mollis Siebold & Zucc. (EECM) increased alkaline phosphatase activity and osteoblast marker levels at day 7 during differentiation of mouse preosteoblasts. EECM reduced osteoclast differentiation and bone resorption in an osteoblast-osteoclast primary co-culture system. In ovariectomized mice, EECM prevented the decrease in bone mineral density and recovered OSX and Runx2 via BMP2/4, Smad1/5/9 and p38. Conclusions The results suggest that EECM may be effective in preventing bone loss, offering a promising alternative for the nutritional management of postmenopausal osteoporosis. Siebold & Zucc (dpeaa)DE-He213 Postmenopausal osteoporosis (dpeaa)DE-He213 Osteoblast differentiation (dpeaa)DE-He213 Runt-related transcription factor 2 (dpeaa)DE-He213 Bone morphogenetic protein 2/4 (dpeaa)DE-He213 Son, Yang Ju verfasserin aut Lee, Chang Ho verfasserin aut Nho, Chu Won verfasserin aut Yoo, Gyhye verfasserin aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 20(2020), 1 vom: 22. Apr. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:20 year:2020 number:1 day:22 month:04 https://dx.doi.org/10.1186/s12906-020-02914-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA 44.00 ASE AR 20 2020 1 22 04 |
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Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway |
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Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway |
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Park, Ji Hye |
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Park, Ji Hye Son, Yang Ju Lee, Chang Ho Nho, Chu Won Yoo, Gyhye |
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circaea mollis siebold & zucc. alleviates postmenopausal osteoporosis in a mouse model via the bmp-2/4/runx2 pathway |
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Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway |
| abstract |
Background Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities. This study aimed to investigate the effect of Circaea mollis Siebold & Zucc on postmenopausal osteoporosis. Methods For in vitro study, MCF7 breast cancer cells and MC3T3-E1 pre-osteoblast cells were utilized to estimate estrogenic and osteogenic activity. Osteoblastic markers were measured by western blot and real-time PCR. For in vivo study, female mature C57BL/6 mice were ovariectomized and oral administrated with 10 mg/kg and 40 mg/kg of EECM respectively. Results EtOH extract of Circaea mollis Siebold & Zucc. (EECM) increased alkaline phosphatase activity and osteoblast marker levels at day 7 during differentiation of mouse preosteoblasts. EECM reduced osteoclast differentiation and bone resorption in an osteoblast-osteoclast primary co-culture system. In ovariectomized mice, EECM prevented the decrease in bone mineral density and recovered OSX and Runx2 via BMP2/4, Smad1/5/9 and p38. Conclusions The results suggest that EECM may be effective in preventing bone loss, offering a promising alternative for the nutritional management of postmenopausal osteoporosis. |
| abstractGer |
Background Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities. This study aimed to investigate the effect of Circaea mollis Siebold & Zucc on postmenopausal osteoporosis. Methods For in vitro study, MCF7 breast cancer cells and MC3T3-E1 pre-osteoblast cells were utilized to estimate estrogenic and osteogenic activity. Osteoblastic markers were measured by western blot and real-time PCR. For in vivo study, female mature C57BL/6 mice were ovariectomized and oral administrated with 10 mg/kg and 40 mg/kg of EECM respectively. Results EtOH extract of Circaea mollis Siebold & Zucc. (EECM) increased alkaline phosphatase activity and osteoblast marker levels at day 7 during differentiation of mouse preosteoblasts. EECM reduced osteoclast differentiation and bone resorption in an osteoblast-osteoclast primary co-culture system. In ovariectomized mice, EECM prevented the decrease in bone mineral density and recovered OSX and Runx2 via BMP2/4, Smad1/5/9 and p38. Conclusions The results suggest that EECM may be effective in preventing bone loss, offering a promising alternative for the nutritional management of postmenopausal osteoporosis. |
| abstract_unstemmed |
Background Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities. This study aimed to investigate the effect of Circaea mollis Siebold & Zucc on postmenopausal osteoporosis. Methods For in vitro study, MCF7 breast cancer cells and MC3T3-E1 pre-osteoblast cells were utilized to estimate estrogenic and osteogenic activity. Osteoblastic markers were measured by western blot and real-time PCR. For in vivo study, female mature C57BL/6 mice were ovariectomized and oral administrated with 10 mg/kg and 40 mg/kg of EECM respectively. Results EtOH extract of Circaea mollis Siebold & Zucc. (EECM) increased alkaline phosphatase activity and osteoblast marker levels at day 7 during differentiation of mouse preosteoblasts. EECM reduced osteoclast differentiation and bone resorption in an osteoblast-osteoclast primary co-culture system. In ovariectomized mice, EECM prevented the decrease in bone mineral density and recovered OSX and Runx2 via BMP2/4, Smad1/5/9 and p38. Conclusions The results suggest that EECM may be effective in preventing bone loss, offering a promising alternative for the nutritional management of postmenopausal osteoporosis. |
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Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway |
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