Prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the AGO Study Group
Purpose Although thrombocytosis in patients with primary ovarian cancer has been widely investigated, there are only very few data about the role of thrombocytosis in recurrent ovarian cancer. The aim of our study was to investigate the impact of pretreatment thrombocytosis prior to chemotherapy on...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Canzler, Ulrich [verfasserIn] Lück, Hans-Joachim [verfasserIn] Neuser, Petra [verfasserIn] Sehouli, Jalid [verfasserIn] Burges, Alexander [verfasserIn] Harter, Philipp [verfasserIn] Schmalfeldt, Barbara [verfasserIn] Aminossadati, Behnaz [verfasserIn] Mahner, Sven [verfasserIn] Kommoss, Stefan [verfasserIn] Wimberger, Pauline [verfasserIn] Pfisterer, Jacobus [verfasserIn] de Gregorio, Nikolaus [verfasserIn] Hasenburg, Annette [verfasserIn] Gropp-Meier, Martina [verfasserIn] El-Balat, Ahmed [verfasserIn] Jackisch, Christian [verfasserIn] du Bois, Andreas [verfasserIn] Meier, Werner [verfasserIn] Wagner, Uwe [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Archives of gynecology and obstetrics - Berlin : Springer, 1870, 301(2020), 5 vom: 10. Apr., Seite 1267-1274 |
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| Übergeordnetes Werk: |
volume:301 ; year:2020 ; number:5 ; day:10 ; month:04 ; pages:1267-1274 |
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| DOI / URN: |
10.1007/s00404-020-05529-y |
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| Katalog-ID: |
SPR039503143 |
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| 100 | 1 | |a Canzler, Ulrich |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the AGO Study Group |
| 264 | 1 | |c 2020 | |
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| 520 | |a Purpose Although thrombocytosis in patients with primary ovarian cancer has been widely investigated, there are only very few data about the role of thrombocytosis in recurrent ovarian cancer. The aim of our study was to investigate the impact of pretreatment thrombocytosis prior to chemotherapy on clinical outcome in patients with recurrent platinum eligible ovarian cancer. Methods In our retrospective analysis we included 300 patients who were treated by AGO Study Group Centers within three prospective, randomized phase-III-trials. All patients included had been treatment-free for at least 6 months after platinum-based chemotherapy. We excluded patients who underwent secondary cytoreductive surgery before randomization to the trial. Thrombocytosis was defined as a platelet count of ≥ 400⋅$ 10^{9} $/L. Results Pretreatment thrombocytosis was present in 37 out of 300 (12.3%) patients. Patients with thrombocytosis responded statistically significantly less to chemotherapy (overall response rate 35.3% and 41.6%, P = 0.046). The median progression-free survival (PFS) for patients with thrombocytosis was 6.36 months compared to 9.00 months for patients without thrombocytosis (hazard ratio [HR] = 1.19, 95% confidence interval [CI] = 0.84–1.69, P = 0.336). Median overall survival (OS) of patients with thrombocytosis was 16.33 months compared to 23.92 months of patients with a normal platelet count (HR = 1.46, 95% CI = 1.00–2.14, P = 0.047). Conclusions The present analysis suggests that pretreatment thrombocytosis is associated with unfavorable outcome with regard to response to chemotherapy and overall survival in recurrent ovarian cancer. | ||
| 650 | 4 | |a Thrombocytosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Recurrent ovarian cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Chemotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Survival |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Lück, Hans-Joachim |e verfasserin |4 aut | |
| 700 | 1 | |a Neuser, Petra |e verfasserin |4 aut | |
| 700 | 1 | |a Sehouli, Jalid |e verfasserin |4 aut | |
| 700 | 1 | |a Burges, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Harter, Philipp |e verfasserin |4 aut | |
| 700 | 1 | |a Schmalfeldt, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Aminossadati, Behnaz |e verfasserin |4 aut | |
| 700 | 1 | |a Mahner, Sven |e verfasserin |4 aut | |
| 700 | 1 | |a Kommoss, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Wimberger, Pauline |e verfasserin |4 aut | |
| 700 | 1 | |a Pfisterer, Jacobus |e verfasserin |4 aut | |
| 700 | 1 | |a de Gregorio, Nikolaus |e verfasserin |4 aut | |
| 700 | 1 | |a Hasenburg, Annette |e verfasserin |4 aut | |
| 700 | 1 | |a Gropp-Meier, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a El-Balat, Ahmed |e verfasserin |4 aut | |
| 700 | 1 | |a Jackisch, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a du Bois, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Meier, Werner |e verfasserin |4 aut | |
| 700 | 1 | |a Wagner, Uwe |e verfasserin |4 aut | |
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10.1007/s00404-020-05529-y doi (DE-627)SPR039503143 (SPR)s00404-020-05529-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Canzler, Ulrich verfasserin aut Prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the AGO Study Group 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Although thrombocytosis in patients with primary ovarian cancer has been widely investigated, there are only very few data about the role of thrombocytosis in recurrent ovarian cancer. The aim of our study was to investigate the impact of pretreatment thrombocytosis prior to chemotherapy on clinical outcome in patients with recurrent platinum eligible ovarian cancer. Methods In our retrospective analysis we included 300 patients who were treated by AGO Study Group Centers within three prospective, randomized phase-III-trials. All patients included had been treatment-free for at least 6 months after platinum-based chemotherapy. We excluded patients who underwent secondary cytoreductive surgery before randomization to the trial. Thrombocytosis was defined as a platelet count of ≥ 400⋅$ 10^{9} $/L. Results Pretreatment thrombocytosis was present in 37 out of 300 (12.3%) patients. Patients with thrombocytosis responded statistically significantly less to chemotherapy (overall response rate 35.3% and 41.6%, P = 0.046). The median progression-free survival (PFS) for patients with thrombocytosis was 6.36 months compared to 9.00 months for patients without thrombocytosis (hazard ratio [HR] = 1.19, 95% confidence interval [CI] = 0.84–1.69, P = 0.336). Median overall survival (OS) of patients with thrombocytosis was 16.33 months compared to 23.92 months of patients with a normal platelet count (HR = 1.46, 95% CI = 1.00–2.14, P = 0.047). Conclusions The present analysis suggests that pretreatment thrombocytosis is associated with unfavorable outcome with regard to response to chemotherapy and overall survival in recurrent ovarian cancer. Thrombocytosis (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Chemotherapy (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Lück, Hans-Joachim verfasserin aut Neuser, Petra verfasserin aut Sehouli, Jalid verfasserin aut Burges, Alexander verfasserin aut Harter, Philipp verfasserin aut Schmalfeldt, Barbara verfasserin aut Aminossadati, Behnaz verfasserin aut Mahner, Sven verfasserin aut Kommoss, Stefan verfasserin aut Wimberger, Pauline verfasserin aut Pfisterer, Jacobus verfasserin aut de Gregorio, Nikolaus verfasserin aut Hasenburg, Annette verfasserin aut Gropp-Meier, Martina verfasserin aut El-Balat, Ahmed verfasserin aut Jackisch, Christian verfasserin aut du Bois, Andreas verfasserin aut Meier, Werner verfasserin aut Wagner, Uwe verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 301(2020), 5 vom: 10. Apr., Seite 1267-1274 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:301 year:2020 number:5 day:10 month:04 pages:1267-1274 https://dx.doi.org/10.1007/s00404-020-05529-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 301 2020 5 10 04 1267-1274 |
| spelling |
10.1007/s00404-020-05529-y doi (DE-627)SPR039503143 (SPR)s00404-020-05529-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Canzler, Ulrich verfasserin aut Prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the AGO Study Group 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Although thrombocytosis in patients with primary ovarian cancer has been widely investigated, there are only very few data about the role of thrombocytosis in recurrent ovarian cancer. The aim of our study was to investigate the impact of pretreatment thrombocytosis prior to chemotherapy on clinical outcome in patients with recurrent platinum eligible ovarian cancer. Methods In our retrospective analysis we included 300 patients who were treated by AGO Study Group Centers within three prospective, randomized phase-III-trials. All patients included had been treatment-free for at least 6 months after platinum-based chemotherapy. We excluded patients who underwent secondary cytoreductive surgery before randomization to the trial. Thrombocytosis was defined as a platelet count of ≥ 400⋅$ 10^{9} $/L. Results Pretreatment thrombocytosis was present in 37 out of 300 (12.3%) patients. Patients with thrombocytosis responded statistically significantly less to chemotherapy (overall response rate 35.3% and 41.6%, P = 0.046). The median progression-free survival (PFS) for patients with thrombocytosis was 6.36 months compared to 9.00 months for patients without thrombocytosis (hazard ratio [HR] = 1.19, 95% confidence interval [CI] = 0.84–1.69, P = 0.336). Median overall survival (OS) of patients with thrombocytosis was 16.33 months compared to 23.92 months of patients with a normal platelet count (HR = 1.46, 95% CI = 1.00–2.14, P = 0.047). Conclusions The present analysis suggests that pretreatment thrombocytosis is associated with unfavorable outcome with regard to response to chemotherapy and overall survival in recurrent ovarian cancer. Thrombocytosis (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Chemotherapy (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Lück, Hans-Joachim verfasserin aut Neuser, Petra verfasserin aut Sehouli, Jalid verfasserin aut Burges, Alexander verfasserin aut Harter, Philipp verfasserin aut Schmalfeldt, Barbara verfasserin aut Aminossadati, Behnaz verfasserin aut Mahner, Sven verfasserin aut Kommoss, Stefan verfasserin aut Wimberger, Pauline verfasserin aut Pfisterer, Jacobus verfasserin aut de Gregorio, Nikolaus verfasserin aut Hasenburg, Annette verfasserin aut Gropp-Meier, Martina verfasserin aut El-Balat, Ahmed verfasserin aut Jackisch, Christian verfasserin aut du Bois, Andreas verfasserin aut Meier, Werner verfasserin aut Wagner, Uwe verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 301(2020), 5 vom: 10. Apr., Seite 1267-1274 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:301 year:2020 number:5 day:10 month:04 pages:1267-1274 https://dx.doi.org/10.1007/s00404-020-05529-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 301 2020 5 10 04 1267-1274 |
| allfields_unstemmed |
10.1007/s00404-020-05529-y doi (DE-627)SPR039503143 (SPR)s00404-020-05529-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Canzler, Ulrich verfasserin aut Prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the AGO Study Group 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Although thrombocytosis in patients with primary ovarian cancer has been widely investigated, there are only very few data about the role of thrombocytosis in recurrent ovarian cancer. The aim of our study was to investigate the impact of pretreatment thrombocytosis prior to chemotherapy on clinical outcome in patients with recurrent platinum eligible ovarian cancer. Methods In our retrospective analysis we included 300 patients who were treated by AGO Study Group Centers within three prospective, randomized phase-III-trials. All patients included had been treatment-free for at least 6 months after platinum-based chemotherapy. We excluded patients who underwent secondary cytoreductive surgery before randomization to the trial. Thrombocytosis was defined as a platelet count of ≥ 400⋅$ 10^{9} $/L. Results Pretreatment thrombocytosis was present in 37 out of 300 (12.3%) patients. Patients with thrombocytosis responded statistically significantly less to chemotherapy (overall response rate 35.3% and 41.6%, P = 0.046). The median progression-free survival (PFS) for patients with thrombocytosis was 6.36 months compared to 9.00 months for patients without thrombocytosis (hazard ratio [HR] = 1.19, 95% confidence interval [CI] = 0.84–1.69, P = 0.336). Median overall survival (OS) of patients with thrombocytosis was 16.33 months compared to 23.92 months of patients with a normal platelet count (HR = 1.46, 95% CI = 1.00–2.14, P = 0.047). Conclusions The present analysis suggests that pretreatment thrombocytosis is associated with unfavorable outcome with regard to response to chemotherapy and overall survival in recurrent ovarian cancer. Thrombocytosis (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Chemotherapy (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Lück, Hans-Joachim verfasserin aut Neuser, Petra verfasserin aut Sehouli, Jalid verfasserin aut Burges, Alexander verfasserin aut Harter, Philipp verfasserin aut Schmalfeldt, Barbara verfasserin aut Aminossadati, Behnaz verfasserin aut Mahner, Sven verfasserin aut Kommoss, Stefan verfasserin aut Wimberger, Pauline verfasserin aut Pfisterer, Jacobus verfasserin aut de Gregorio, Nikolaus verfasserin aut Hasenburg, Annette verfasserin aut Gropp-Meier, Martina verfasserin aut El-Balat, Ahmed verfasserin aut Jackisch, Christian verfasserin aut du Bois, Andreas verfasserin aut Meier, Werner verfasserin aut Wagner, Uwe verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 301(2020), 5 vom: 10. Apr., Seite 1267-1274 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:301 year:2020 number:5 day:10 month:04 pages:1267-1274 https://dx.doi.org/10.1007/s00404-020-05529-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 301 2020 5 10 04 1267-1274 |
| allfieldsGer |
10.1007/s00404-020-05529-y doi (DE-627)SPR039503143 (SPR)s00404-020-05529-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Canzler, Ulrich verfasserin aut Prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the AGO Study Group 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Although thrombocytosis in patients with primary ovarian cancer has been widely investigated, there are only very few data about the role of thrombocytosis in recurrent ovarian cancer. The aim of our study was to investigate the impact of pretreatment thrombocytosis prior to chemotherapy on clinical outcome in patients with recurrent platinum eligible ovarian cancer. Methods In our retrospective analysis we included 300 patients who were treated by AGO Study Group Centers within three prospective, randomized phase-III-trials. All patients included had been treatment-free for at least 6 months after platinum-based chemotherapy. We excluded patients who underwent secondary cytoreductive surgery before randomization to the trial. Thrombocytosis was defined as a platelet count of ≥ 400⋅$ 10^{9} $/L. Results Pretreatment thrombocytosis was present in 37 out of 300 (12.3%) patients. Patients with thrombocytosis responded statistically significantly less to chemotherapy (overall response rate 35.3% and 41.6%, P = 0.046). The median progression-free survival (PFS) for patients with thrombocytosis was 6.36 months compared to 9.00 months for patients without thrombocytosis (hazard ratio [HR] = 1.19, 95% confidence interval [CI] = 0.84–1.69, P = 0.336). Median overall survival (OS) of patients with thrombocytosis was 16.33 months compared to 23.92 months of patients with a normal platelet count (HR = 1.46, 95% CI = 1.00–2.14, P = 0.047). Conclusions The present analysis suggests that pretreatment thrombocytosis is associated with unfavorable outcome with regard to response to chemotherapy and overall survival in recurrent ovarian cancer. Thrombocytosis (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Chemotherapy (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Lück, Hans-Joachim verfasserin aut Neuser, Petra verfasserin aut Sehouli, Jalid verfasserin aut Burges, Alexander verfasserin aut Harter, Philipp verfasserin aut Schmalfeldt, Barbara verfasserin aut Aminossadati, Behnaz verfasserin aut Mahner, Sven verfasserin aut Kommoss, Stefan verfasserin aut Wimberger, Pauline verfasserin aut Pfisterer, Jacobus verfasserin aut de Gregorio, Nikolaus verfasserin aut Hasenburg, Annette verfasserin aut Gropp-Meier, Martina verfasserin aut El-Balat, Ahmed verfasserin aut Jackisch, Christian verfasserin aut du Bois, Andreas verfasserin aut Meier, Werner verfasserin aut Wagner, Uwe verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 301(2020), 5 vom: 10. Apr., Seite 1267-1274 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:301 year:2020 number:5 day:10 month:04 pages:1267-1274 https://dx.doi.org/10.1007/s00404-020-05529-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 301 2020 5 10 04 1267-1274 |
| allfieldsSound |
10.1007/s00404-020-05529-y doi (DE-627)SPR039503143 (SPR)s00404-020-05529-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Canzler, Ulrich verfasserin aut Prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the AGO Study Group 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Although thrombocytosis in patients with primary ovarian cancer has been widely investigated, there are only very few data about the role of thrombocytosis in recurrent ovarian cancer. The aim of our study was to investigate the impact of pretreatment thrombocytosis prior to chemotherapy on clinical outcome in patients with recurrent platinum eligible ovarian cancer. Methods In our retrospective analysis we included 300 patients who were treated by AGO Study Group Centers within three prospective, randomized phase-III-trials. All patients included had been treatment-free for at least 6 months after platinum-based chemotherapy. We excluded patients who underwent secondary cytoreductive surgery before randomization to the trial. Thrombocytosis was defined as a platelet count of ≥ 400⋅$ 10^{9} $/L. Results Pretreatment thrombocytosis was present in 37 out of 300 (12.3%) patients. Patients with thrombocytosis responded statistically significantly less to chemotherapy (overall response rate 35.3% and 41.6%, P = 0.046). The median progression-free survival (PFS) for patients with thrombocytosis was 6.36 months compared to 9.00 months for patients without thrombocytosis (hazard ratio [HR] = 1.19, 95% confidence interval [CI] = 0.84–1.69, P = 0.336). Median overall survival (OS) of patients with thrombocytosis was 16.33 months compared to 23.92 months of patients with a normal platelet count (HR = 1.46, 95% CI = 1.00–2.14, P = 0.047). Conclusions The present analysis suggests that pretreatment thrombocytosis is associated with unfavorable outcome with regard to response to chemotherapy and overall survival in recurrent ovarian cancer. Thrombocytosis (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Chemotherapy (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Lück, Hans-Joachim verfasserin aut Neuser, Petra verfasserin aut Sehouli, Jalid verfasserin aut Burges, Alexander verfasserin aut Harter, Philipp verfasserin aut Schmalfeldt, Barbara verfasserin aut Aminossadati, Behnaz verfasserin aut Mahner, Sven verfasserin aut Kommoss, Stefan verfasserin aut Wimberger, Pauline verfasserin aut Pfisterer, Jacobus verfasserin aut de Gregorio, Nikolaus verfasserin aut Hasenburg, Annette verfasserin aut Gropp-Meier, Martina verfasserin aut El-Balat, Ahmed verfasserin aut Jackisch, Christian verfasserin aut du Bois, Andreas verfasserin aut Meier, Werner verfasserin aut Wagner, Uwe verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 301(2020), 5 vom: 10. Apr., Seite 1267-1274 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:301 year:2020 number:5 day:10 month:04 pages:1267-1274 https://dx.doi.org/10.1007/s00404-020-05529-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 301 2020 5 10 04 1267-1274 |
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Enthalten in Archives of gynecology and obstetrics 301(2020), 5 vom: 10. Apr., Seite 1267-1274 volume:301 year:2020 number:5 day:10 month:04 pages:1267-1274 |
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Enthalten in Archives of gynecology and obstetrics 301(2020), 5 vom: 10. Apr., Seite 1267-1274 volume:301 year:2020 number:5 day:10 month:04 pages:1267-1274 |
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findex.gbv.de |
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Thrombocytosis Recurrent ovarian cancer Chemotherapy Survival |
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Archives of gynecology and obstetrics |
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Canzler, Ulrich @@aut@@ Lück, Hans-Joachim @@aut@@ Neuser, Petra @@aut@@ Sehouli, Jalid @@aut@@ Burges, Alexander @@aut@@ Harter, Philipp @@aut@@ Schmalfeldt, Barbara @@aut@@ Aminossadati, Behnaz @@aut@@ Mahner, Sven @@aut@@ Kommoss, Stefan @@aut@@ Wimberger, Pauline @@aut@@ Pfisterer, Jacobus @@aut@@ de Gregorio, Nikolaus @@aut@@ Hasenburg, Annette @@aut@@ Gropp-Meier, Martina @@aut@@ El-Balat, Ahmed @@aut@@ Jackisch, Christian @@aut@@ du Bois, Andreas @@aut@@ Meier, Werner @@aut@@ Wagner, Uwe @@aut@@ |
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2020-04-10T00:00:00Z |
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253390060 |
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3610 |
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SPR039503143 |
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englisch |
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The aim of our study was to investigate the impact of pretreatment thrombocytosis prior to chemotherapy on clinical outcome in patients with recurrent platinum eligible ovarian cancer. Methods In our retrospective analysis we included 300 patients who were treated by AGO Study Group Centers within three prospective, randomized phase-III-trials. All patients included had been treatment-free for at least 6 months after platinum-based chemotherapy. We excluded patients who underwent secondary cytoreductive surgery before randomization to the trial. Thrombocytosis was defined as a platelet count of ≥ 400⋅$ 10^{9} $/L. Results Pretreatment thrombocytosis was present in 37 out of 300 (12.3%) patients. Patients with thrombocytosis responded statistically significantly less to chemotherapy (overall response rate 35.3% and 41.6%, P = 0.046). The median progression-free survival (PFS) for patients with thrombocytosis was 6.36 months compared to 9.00 months for patients without thrombocytosis (hazard ratio [HR] = 1.19, 95% confidence interval [CI] = 0.84–1.69, P = 0.336). Median overall survival (OS) of patients with thrombocytosis was 16.33 months compared to 23.92 months of patients with a normal platelet count (HR = 1.46, 95% CI = 1.00–2.14, P = 0.047). 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|
| author |
Canzler, Ulrich |
| spellingShingle |
Canzler, Ulrich ddc 610 bkl 44.92 misc Thrombocytosis misc Recurrent ovarian cancer misc Chemotherapy misc Survival Prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the AGO Study Group |
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1432-0711 |
| topic_title |
610 ASE 44.92 bkl Prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the AGO Study Group Thrombocytosis (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Chemotherapy (dpeaa)DE-He213 Survival (dpeaa)DE-He213 |
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ddc 610 bkl 44.92 misc Thrombocytosis misc Recurrent ovarian cancer misc Chemotherapy misc Survival |
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ddc 610 bkl 44.92 misc Thrombocytosis misc Recurrent ovarian cancer misc Chemotherapy misc Survival |
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ddc 610 bkl 44.92 misc Thrombocytosis misc Recurrent ovarian cancer misc Chemotherapy misc Survival |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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Archives of gynecology and obstetrics |
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610 - Medicine & health |
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Archives of gynecology and obstetrics |
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Prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the AGO Study Group |
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(DE-627)SPR039503143 (SPR)s00404-020-05529-y-e |
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Prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the AGO Study Group |
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Canzler, Ulrich |
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Archives of gynecology and obstetrics |
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Archives of gynecology and obstetrics |
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eng |
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600 - Technology |
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2020 |
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Canzler, Ulrich Lück, Hans-Joachim Neuser, Petra Sehouli, Jalid Burges, Alexander Harter, Philipp Schmalfeldt, Barbara Aminossadati, Behnaz Mahner, Sven Kommoss, Stefan Wimberger, Pauline Pfisterer, Jacobus de Gregorio, Nikolaus Hasenburg, Annette Gropp-Meier, Martina El-Balat, Ahmed Jackisch, Christian du Bois, Andreas Meier, Werner Wagner, Uwe |
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301 |
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610 ASE 44.92 bkl |
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Elektronische Aufsätze |
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Canzler, Ulrich |
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10.1007/s00404-020-05529-y |
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610 |
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verfasserin |
| title_sort |
prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the ago study group |
| title_auth |
Prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the AGO Study Group |
| abstract |
Purpose Although thrombocytosis in patients with primary ovarian cancer has been widely investigated, there are only very few data about the role of thrombocytosis in recurrent ovarian cancer. The aim of our study was to investigate the impact of pretreatment thrombocytosis prior to chemotherapy on clinical outcome in patients with recurrent platinum eligible ovarian cancer. Methods In our retrospective analysis we included 300 patients who were treated by AGO Study Group Centers within three prospective, randomized phase-III-trials. All patients included had been treatment-free for at least 6 months after platinum-based chemotherapy. We excluded patients who underwent secondary cytoreductive surgery before randomization to the trial. Thrombocytosis was defined as a platelet count of ≥ 400⋅$ 10^{9} $/L. Results Pretreatment thrombocytosis was present in 37 out of 300 (12.3%) patients. Patients with thrombocytosis responded statistically significantly less to chemotherapy (overall response rate 35.3% and 41.6%, P = 0.046). The median progression-free survival (PFS) for patients with thrombocytosis was 6.36 months compared to 9.00 months for patients without thrombocytosis (hazard ratio [HR] = 1.19, 95% confidence interval [CI] = 0.84–1.69, P = 0.336). Median overall survival (OS) of patients with thrombocytosis was 16.33 months compared to 23.92 months of patients with a normal platelet count (HR = 1.46, 95% CI = 1.00–2.14, P = 0.047). Conclusions The present analysis suggests that pretreatment thrombocytosis is associated with unfavorable outcome with regard to response to chemotherapy and overall survival in recurrent ovarian cancer. |
| abstractGer |
Purpose Although thrombocytosis in patients with primary ovarian cancer has been widely investigated, there are only very few data about the role of thrombocytosis in recurrent ovarian cancer. The aim of our study was to investigate the impact of pretreatment thrombocytosis prior to chemotherapy on clinical outcome in patients with recurrent platinum eligible ovarian cancer. Methods In our retrospective analysis we included 300 patients who were treated by AGO Study Group Centers within three prospective, randomized phase-III-trials. All patients included had been treatment-free for at least 6 months after platinum-based chemotherapy. We excluded patients who underwent secondary cytoreductive surgery before randomization to the trial. Thrombocytosis was defined as a platelet count of ≥ 400⋅$ 10^{9} $/L. Results Pretreatment thrombocytosis was present in 37 out of 300 (12.3%) patients. Patients with thrombocytosis responded statistically significantly less to chemotherapy (overall response rate 35.3% and 41.6%, P = 0.046). The median progression-free survival (PFS) for patients with thrombocytosis was 6.36 months compared to 9.00 months for patients without thrombocytosis (hazard ratio [HR] = 1.19, 95% confidence interval [CI] = 0.84–1.69, P = 0.336). Median overall survival (OS) of patients with thrombocytosis was 16.33 months compared to 23.92 months of patients with a normal platelet count (HR = 1.46, 95% CI = 1.00–2.14, P = 0.047). Conclusions The present analysis suggests that pretreatment thrombocytosis is associated with unfavorable outcome with regard to response to chemotherapy and overall survival in recurrent ovarian cancer. |
| abstract_unstemmed |
Purpose Although thrombocytosis in patients with primary ovarian cancer has been widely investigated, there are only very few data about the role of thrombocytosis in recurrent ovarian cancer. The aim of our study was to investigate the impact of pretreatment thrombocytosis prior to chemotherapy on clinical outcome in patients with recurrent platinum eligible ovarian cancer. Methods In our retrospective analysis we included 300 patients who were treated by AGO Study Group Centers within three prospective, randomized phase-III-trials. All patients included had been treatment-free for at least 6 months after platinum-based chemotherapy. We excluded patients who underwent secondary cytoreductive surgery before randomization to the trial. Thrombocytosis was defined as a platelet count of ≥ 400⋅$ 10^{9} $/L. Results Pretreatment thrombocytosis was present in 37 out of 300 (12.3%) patients. Patients with thrombocytosis responded statistically significantly less to chemotherapy (overall response rate 35.3% and 41.6%, P = 0.046). The median progression-free survival (PFS) for patients with thrombocytosis was 6.36 months compared to 9.00 months for patients without thrombocytosis (hazard ratio [HR] = 1.19, 95% confidence interval [CI] = 0.84–1.69, P = 0.336). Median overall survival (OS) of patients with thrombocytosis was 16.33 months compared to 23.92 months of patients with a normal platelet count (HR = 1.46, 95% CI = 1.00–2.14, P = 0.047). Conclusions The present analysis suggests that pretreatment thrombocytosis is associated with unfavorable outcome with regard to response to chemotherapy and overall survival in recurrent ovarian cancer. |
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| title_short |
Prognostic role of thrombocytosis in recurrent ovarian cancer: a pooled analysis of the AGO Study Group |
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https://dx.doi.org/10.1007/s00404-020-05529-y |
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Lück, Hans-Joachim Neuser, Petra Sehouli, Jalid Burges, Alexander Harter, Philipp Schmalfeldt, Barbara Aminossadati, Behnaz Mahner, Sven Kommoss, Stefan Wimberger, Pauline Pfisterer, Jacobus de Gregorio, Nikolaus Hasenburg, Annette Gropp-Meier, Martina El-Balat, Ahmed Jackisch, Christian du Bois, Andreas Meier, Werner Wagner, Uwe |
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Lück, Hans-Joachim Neuser, Petra Sehouli, Jalid Burges, Alexander Harter, Philipp Schmalfeldt, Barbara Aminossadati, Behnaz Mahner, Sven Kommoss, Stefan Wimberger, Pauline Pfisterer, Jacobus de Gregorio, Nikolaus Hasenburg, Annette Gropp-Meier, Martina El-Balat, Ahmed Jackisch, Christian du Bois, Andreas Meier, Werner Wagner, Uwe |
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10.1007/s00404-020-05529-y |
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2024-07-04T00:13:45.112Z |
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|
| score |
7.4012003 |