Behavior of metastatic breast cancer according to subtype
Purpose To explore the impact of breast cancer subtype on metastatic behavior and long-term outcome defined as breast cancer specific survival (BCSS). Methods Retrospective single centre cross-sectional study of 5972 patients with newly diagnosed, unilateral first diagnosis of breast cancer, diagnos...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Van Mechelen, Margot [verfasserIn] Van Herck, Anke [verfasserIn] Punie, Kevin [verfasserIn] Nevelsteen, Ines [verfasserIn] Smeets, Ann [verfasserIn] Neven, Patrick [verfasserIn] Weltens, Caroline [verfasserIn] Han, Sileny [verfasserIn] Vanderstichele, Adriaan [verfasserIn] Floris, Giuseppe [verfasserIn] Lobelle, Jean-Pierre [verfasserIn] Wildiers, Hans [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Breast cancer research and treatment - Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981, 181(2020), 1 vom: 19. März, Seite 115-125 |
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| Übergeordnetes Werk: |
volume:181 ; year:2020 ; number:1 ; day:19 ; month:03 ; pages:115-125 |
| Links: |
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| DOI / URN: |
10.1007/s10549-020-05597-3 |
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| Katalog-ID: |
SPR039512290 |
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| 520 | |a Purpose To explore the impact of breast cancer subtype on metastatic behavior and long-term outcome defined as breast cancer specific survival (BCSS). Methods Retrospective single centre cross-sectional study of 5972 patients with newly diagnosed, unilateral first diagnosis of breast cancer, diagnosed 2000–2010. Patients had either early breast cancer (EBC) treated primarily by surgery (SURG n = 5072), neoadjuvant systemic therapy (NEO n = 592), or upfront metastatic disease (META n = 308). Surrogate breast cancer subtypes were defined according to classical pathological criteria. Analysis was performed using Kaplan–Meier method and logistic/Cox regression. Results After median follow-up time of 103.6 months (IQR 73.4–139.2 months), 817 patients with EBC at diagnosis (14.4%) developed distant metastases of which 621 (12.2%) SURG and 196 (33.1%) NEO. Metastasis rate after EBC was: LuminalA 8.1%, LuminalB1(HER2−) 20.4%, LuminalB2(HER2+) without (neo)adjuvant trastuzumab 21.7%, LuminalB2(HER2+) with trastuzumab 9.0%, HER2Positive(ER−) without trastuzumab 30.0%, HER2Positive(ER−) with trastuzumab 19.9% and TripleNegative 25.3%. There were major differences in site of first metastases according to subtype. For single site first metastases, median BCSS assessed from time of metastases was worst for brain localization (13.9 months) and best for bone (48.4 months). Multiple sites of first metastases had worse BCSS from date of metastases than single site first metastases (median BCSS for 1 site 40.0, 2 sites 27.1, ≥ 3 sites 20.5 months). Median BCSS from date of metastases is longer in upfront metastases compared to secondary metastases after EBC (43.4 vs. 27.9 months). Conclusions Tumor subtype influences the metastatic behavior and survival after development of distant metastases. | ||
| 650 | 4 | |a Metastatic breast cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Breast cancer subtype |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Disease free survival |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Disease specific survival |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Trastuzumab |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Van Herck, Anke |e verfasserin |4 aut | |
| 700 | 1 | |a Punie, Kevin |e verfasserin |4 aut | |
| 700 | 1 | |a Nevelsteen, Ines |e verfasserin |4 aut | |
| 700 | 1 | |a Smeets, Ann |e verfasserin |4 aut | |
| 700 | 1 | |a Neven, Patrick |e verfasserin |4 aut | |
| 700 | 1 | |a Weltens, Caroline |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Sileny |e verfasserin |4 aut | |
| 700 | 1 | |a Vanderstichele, Adriaan |e verfasserin |4 aut | |
| 700 | 1 | |a Floris, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Lobelle, Jean-Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Wildiers, Hans |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:181 |g year:2020 |g number:1 |g day:19 |g month:03 |g pages:115-125 |
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10.1007/s10549-020-05597-3 doi (DE-627)SPR039512290 (DE-599)SPRs10549-020-05597-3-e (SPR)s10549-020-05597-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Van Mechelen, Margot verfasserin aut Behavior of metastatic breast cancer according to subtype 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To explore the impact of breast cancer subtype on metastatic behavior and long-term outcome defined as breast cancer specific survival (BCSS). Methods Retrospective single centre cross-sectional study of 5972 patients with newly diagnosed, unilateral first diagnosis of breast cancer, diagnosed 2000–2010. Patients had either early breast cancer (EBC) treated primarily by surgery (SURG n = 5072), neoadjuvant systemic therapy (NEO n = 592), or upfront metastatic disease (META n = 308). Surrogate breast cancer subtypes were defined according to classical pathological criteria. Analysis was performed using Kaplan–Meier method and logistic/Cox regression. Results After median follow-up time of 103.6 months (IQR 73.4–139.2 months), 817 patients with EBC at diagnosis (14.4%) developed distant metastases of which 621 (12.2%) SURG and 196 (33.1%) NEO. Metastasis rate after EBC was: LuminalA 8.1%, LuminalB1(HER2−) 20.4%, LuminalB2(HER2+) without (neo)adjuvant trastuzumab 21.7%, LuminalB2(HER2+) with trastuzumab 9.0%, HER2Positive(ER−) without trastuzumab 30.0%, HER2Positive(ER−) with trastuzumab 19.9% and TripleNegative 25.3%. There were major differences in site of first metastases according to subtype. For single site first metastases, median BCSS assessed from time of metastases was worst for brain localization (13.9 months) and best for bone (48.4 months). Multiple sites of first metastases had worse BCSS from date of metastases than single site first metastases (median BCSS for 1 site 40.0, 2 sites 27.1, ≥ 3 sites 20.5 months). Median BCSS from date of metastases is longer in upfront metastases compared to secondary metastases after EBC (43.4 vs. 27.9 months). Conclusions Tumor subtype influences the metastatic behavior and survival after development of distant metastases. Metastatic breast cancer (dpeaa)DE-He213 Breast cancer subtype (dpeaa)DE-He213 Disease free survival (dpeaa)DE-He213 Disease specific survival (dpeaa)DE-He213 Trastuzumab (dpeaa)DE-He213 Van Herck, Anke verfasserin aut Punie, Kevin verfasserin aut Nevelsteen, Ines verfasserin aut Smeets, Ann verfasserin aut Neven, Patrick verfasserin aut Weltens, Caroline verfasserin aut Han, Sileny verfasserin aut Vanderstichele, Adriaan verfasserin aut Floris, Giuseppe verfasserin aut Lobelle, Jean-Pierre verfasserin aut Wildiers, Hans verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 181(2020), 1 vom: 19. März, Seite 115-125 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:181 year:2020 number:1 day:19 month:03 pages:115-125 https://dx.doi.org/10.1007/s10549-020-05597-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 181 2020 1 19 03 115-125 |
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10.1007/s10549-020-05597-3 doi (DE-627)SPR039512290 (DE-599)SPRs10549-020-05597-3-e (SPR)s10549-020-05597-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Van Mechelen, Margot verfasserin aut Behavior of metastatic breast cancer according to subtype 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To explore the impact of breast cancer subtype on metastatic behavior and long-term outcome defined as breast cancer specific survival (BCSS). Methods Retrospective single centre cross-sectional study of 5972 patients with newly diagnosed, unilateral first diagnosis of breast cancer, diagnosed 2000–2010. Patients had either early breast cancer (EBC) treated primarily by surgery (SURG n = 5072), neoadjuvant systemic therapy (NEO n = 592), or upfront metastatic disease (META n = 308). Surrogate breast cancer subtypes were defined according to classical pathological criteria. Analysis was performed using Kaplan–Meier method and logistic/Cox regression. Results After median follow-up time of 103.6 months (IQR 73.4–139.2 months), 817 patients with EBC at diagnosis (14.4%) developed distant metastases of which 621 (12.2%) SURG and 196 (33.1%) NEO. Metastasis rate after EBC was: LuminalA 8.1%, LuminalB1(HER2−) 20.4%, LuminalB2(HER2+) without (neo)adjuvant trastuzumab 21.7%, LuminalB2(HER2+) with trastuzumab 9.0%, HER2Positive(ER−) without trastuzumab 30.0%, HER2Positive(ER−) with trastuzumab 19.9% and TripleNegative 25.3%. There were major differences in site of first metastases according to subtype. For single site first metastases, median BCSS assessed from time of metastases was worst for brain localization (13.9 months) and best for bone (48.4 months). Multiple sites of first metastases had worse BCSS from date of metastases than single site first metastases (median BCSS for 1 site 40.0, 2 sites 27.1, ≥ 3 sites 20.5 months). Median BCSS from date of metastases is longer in upfront metastases compared to secondary metastases after EBC (43.4 vs. 27.9 months). Conclusions Tumor subtype influences the metastatic behavior and survival after development of distant metastases. Metastatic breast cancer (dpeaa)DE-He213 Breast cancer subtype (dpeaa)DE-He213 Disease free survival (dpeaa)DE-He213 Disease specific survival (dpeaa)DE-He213 Trastuzumab (dpeaa)DE-He213 Van Herck, Anke verfasserin aut Punie, Kevin verfasserin aut Nevelsteen, Ines verfasserin aut Smeets, Ann verfasserin aut Neven, Patrick verfasserin aut Weltens, Caroline verfasserin aut Han, Sileny verfasserin aut Vanderstichele, Adriaan verfasserin aut Floris, Giuseppe verfasserin aut Lobelle, Jean-Pierre verfasserin aut Wildiers, Hans verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 181(2020), 1 vom: 19. März, Seite 115-125 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:181 year:2020 number:1 day:19 month:03 pages:115-125 https://dx.doi.org/10.1007/s10549-020-05597-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 181 2020 1 19 03 115-125 |
| allfields_unstemmed |
10.1007/s10549-020-05597-3 doi (DE-627)SPR039512290 (DE-599)SPRs10549-020-05597-3-e (SPR)s10549-020-05597-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Van Mechelen, Margot verfasserin aut Behavior of metastatic breast cancer according to subtype 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To explore the impact of breast cancer subtype on metastatic behavior and long-term outcome defined as breast cancer specific survival (BCSS). Methods Retrospective single centre cross-sectional study of 5972 patients with newly diagnosed, unilateral first diagnosis of breast cancer, diagnosed 2000–2010. Patients had either early breast cancer (EBC) treated primarily by surgery (SURG n = 5072), neoadjuvant systemic therapy (NEO n = 592), or upfront metastatic disease (META n = 308). Surrogate breast cancer subtypes were defined according to classical pathological criteria. Analysis was performed using Kaplan–Meier method and logistic/Cox regression. Results After median follow-up time of 103.6 months (IQR 73.4–139.2 months), 817 patients with EBC at diagnosis (14.4%) developed distant metastases of which 621 (12.2%) SURG and 196 (33.1%) NEO. Metastasis rate after EBC was: LuminalA 8.1%, LuminalB1(HER2−) 20.4%, LuminalB2(HER2+) without (neo)adjuvant trastuzumab 21.7%, LuminalB2(HER2+) with trastuzumab 9.0%, HER2Positive(ER−) without trastuzumab 30.0%, HER2Positive(ER−) with trastuzumab 19.9% and TripleNegative 25.3%. There were major differences in site of first metastases according to subtype. For single site first metastases, median BCSS assessed from time of metastases was worst for brain localization (13.9 months) and best for bone (48.4 months). Multiple sites of first metastases had worse BCSS from date of metastases than single site first metastases (median BCSS for 1 site 40.0, 2 sites 27.1, ≥ 3 sites 20.5 months). Median BCSS from date of metastases is longer in upfront metastases compared to secondary metastases after EBC (43.4 vs. 27.9 months). Conclusions Tumor subtype influences the metastatic behavior and survival after development of distant metastases. Metastatic breast cancer (dpeaa)DE-He213 Breast cancer subtype (dpeaa)DE-He213 Disease free survival (dpeaa)DE-He213 Disease specific survival (dpeaa)DE-He213 Trastuzumab (dpeaa)DE-He213 Van Herck, Anke verfasserin aut Punie, Kevin verfasserin aut Nevelsteen, Ines verfasserin aut Smeets, Ann verfasserin aut Neven, Patrick verfasserin aut Weltens, Caroline verfasserin aut Han, Sileny verfasserin aut Vanderstichele, Adriaan verfasserin aut Floris, Giuseppe verfasserin aut Lobelle, Jean-Pierre verfasserin aut Wildiers, Hans verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 181(2020), 1 vom: 19. März, Seite 115-125 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:181 year:2020 number:1 day:19 month:03 pages:115-125 https://dx.doi.org/10.1007/s10549-020-05597-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 181 2020 1 19 03 115-125 |
| allfieldsGer |
10.1007/s10549-020-05597-3 doi (DE-627)SPR039512290 (DE-599)SPRs10549-020-05597-3-e (SPR)s10549-020-05597-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Van Mechelen, Margot verfasserin aut Behavior of metastatic breast cancer according to subtype 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To explore the impact of breast cancer subtype on metastatic behavior and long-term outcome defined as breast cancer specific survival (BCSS). Methods Retrospective single centre cross-sectional study of 5972 patients with newly diagnosed, unilateral first diagnosis of breast cancer, diagnosed 2000–2010. Patients had either early breast cancer (EBC) treated primarily by surgery (SURG n = 5072), neoadjuvant systemic therapy (NEO n = 592), or upfront metastatic disease (META n = 308). Surrogate breast cancer subtypes were defined according to classical pathological criteria. Analysis was performed using Kaplan–Meier method and logistic/Cox regression. Results After median follow-up time of 103.6 months (IQR 73.4–139.2 months), 817 patients with EBC at diagnosis (14.4%) developed distant metastases of which 621 (12.2%) SURG and 196 (33.1%) NEO. Metastasis rate after EBC was: LuminalA 8.1%, LuminalB1(HER2−) 20.4%, LuminalB2(HER2+) without (neo)adjuvant trastuzumab 21.7%, LuminalB2(HER2+) with trastuzumab 9.0%, HER2Positive(ER−) without trastuzumab 30.0%, HER2Positive(ER−) with trastuzumab 19.9% and TripleNegative 25.3%. There were major differences in site of first metastases according to subtype. For single site first metastases, median BCSS assessed from time of metastases was worst for brain localization (13.9 months) and best for bone (48.4 months). Multiple sites of first metastases had worse BCSS from date of metastases than single site first metastases (median BCSS for 1 site 40.0, 2 sites 27.1, ≥ 3 sites 20.5 months). Median BCSS from date of metastases is longer in upfront metastases compared to secondary metastases after EBC (43.4 vs. 27.9 months). Conclusions Tumor subtype influences the metastatic behavior and survival after development of distant metastases. Metastatic breast cancer (dpeaa)DE-He213 Breast cancer subtype (dpeaa)DE-He213 Disease free survival (dpeaa)DE-He213 Disease specific survival (dpeaa)DE-He213 Trastuzumab (dpeaa)DE-He213 Van Herck, Anke verfasserin aut Punie, Kevin verfasserin aut Nevelsteen, Ines verfasserin aut Smeets, Ann verfasserin aut Neven, Patrick verfasserin aut Weltens, Caroline verfasserin aut Han, Sileny verfasserin aut Vanderstichele, Adriaan verfasserin aut Floris, Giuseppe verfasserin aut Lobelle, Jean-Pierre verfasserin aut Wildiers, Hans verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 181(2020), 1 vom: 19. März, Seite 115-125 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:181 year:2020 number:1 day:19 month:03 pages:115-125 https://dx.doi.org/10.1007/s10549-020-05597-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 181 2020 1 19 03 115-125 |
| allfieldsSound |
10.1007/s10549-020-05597-3 doi (DE-627)SPR039512290 (DE-599)SPRs10549-020-05597-3-e (SPR)s10549-020-05597-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Van Mechelen, Margot verfasserin aut Behavior of metastatic breast cancer according to subtype 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To explore the impact of breast cancer subtype on metastatic behavior and long-term outcome defined as breast cancer specific survival (BCSS). Methods Retrospective single centre cross-sectional study of 5972 patients with newly diagnosed, unilateral first diagnosis of breast cancer, diagnosed 2000–2010. Patients had either early breast cancer (EBC) treated primarily by surgery (SURG n = 5072), neoadjuvant systemic therapy (NEO n = 592), or upfront metastatic disease (META n = 308). Surrogate breast cancer subtypes were defined according to classical pathological criteria. Analysis was performed using Kaplan–Meier method and logistic/Cox regression. Results After median follow-up time of 103.6 months (IQR 73.4–139.2 months), 817 patients with EBC at diagnosis (14.4%) developed distant metastases of which 621 (12.2%) SURG and 196 (33.1%) NEO. Metastasis rate after EBC was: LuminalA 8.1%, LuminalB1(HER2−) 20.4%, LuminalB2(HER2+) without (neo)adjuvant trastuzumab 21.7%, LuminalB2(HER2+) with trastuzumab 9.0%, HER2Positive(ER−) without trastuzumab 30.0%, HER2Positive(ER−) with trastuzumab 19.9% and TripleNegative 25.3%. There were major differences in site of first metastases according to subtype. For single site first metastases, median BCSS assessed from time of metastases was worst for brain localization (13.9 months) and best for bone (48.4 months). Multiple sites of first metastases had worse BCSS from date of metastases than single site first metastases (median BCSS for 1 site 40.0, 2 sites 27.1, ≥ 3 sites 20.5 months). Median BCSS from date of metastases is longer in upfront metastases compared to secondary metastases after EBC (43.4 vs. 27.9 months). Conclusions Tumor subtype influences the metastatic behavior and survival after development of distant metastases. Metastatic breast cancer (dpeaa)DE-He213 Breast cancer subtype (dpeaa)DE-He213 Disease free survival (dpeaa)DE-He213 Disease specific survival (dpeaa)DE-He213 Trastuzumab (dpeaa)DE-He213 Van Herck, Anke verfasserin aut Punie, Kevin verfasserin aut Nevelsteen, Ines verfasserin aut Smeets, Ann verfasserin aut Neven, Patrick verfasserin aut Weltens, Caroline verfasserin aut Han, Sileny verfasserin aut Vanderstichele, Adriaan verfasserin aut Floris, Giuseppe verfasserin aut Lobelle, Jean-Pierre verfasserin aut Wildiers, Hans verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 181(2020), 1 vom: 19. März, Seite 115-125 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:181 year:2020 number:1 day:19 month:03 pages:115-125 https://dx.doi.org/10.1007/s10549-020-05597-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 181 2020 1 19 03 115-125 |
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Enthalten in Breast cancer research and treatment 181(2020), 1 vom: 19. März, Seite 115-125 volume:181 year:2020 number:1 day:19 month:03 pages:115-125 |
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Enthalten in Breast cancer research and treatment 181(2020), 1 vom: 19. März, Seite 115-125 volume:181 year:2020 number:1 day:19 month:03 pages:115-125 |
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Metastatic breast cancer Breast cancer subtype Disease free survival Disease specific survival Trastuzumab |
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Van Mechelen, Margot @@aut@@ Van Herck, Anke @@aut@@ Punie, Kevin @@aut@@ Nevelsteen, Ines @@aut@@ Smeets, Ann @@aut@@ Neven, Patrick @@aut@@ Weltens, Caroline @@aut@@ Han, Sileny @@aut@@ Vanderstichele, Adriaan @@aut@@ Floris, Giuseppe @@aut@@ Lobelle, Jean-Pierre @@aut@@ Wildiers, Hans @@aut@@ |
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Methods Retrospective single centre cross-sectional study of 5972 patients with newly diagnosed, unilateral first diagnosis of breast cancer, diagnosed 2000–2010. Patients had either early breast cancer (EBC) treated primarily by surgery (SURG n = 5072), neoadjuvant systemic therapy (NEO n = 592), or upfront metastatic disease (META n = 308). Surrogate breast cancer subtypes were defined according to classical pathological criteria. Analysis was performed using Kaplan–Meier method and logistic/Cox regression. Results After median follow-up time of 103.6 months (IQR 73.4–139.2 months), 817 patients with EBC at diagnosis (14.4%) developed distant metastases of which 621 (12.2%) SURG and 196 (33.1%) NEO. Metastasis rate after EBC was: LuminalA 8.1%, LuminalB1(HER2−) 20.4%, LuminalB2(HER2+) without (neo)adjuvant trastuzumab 21.7%, LuminalB2(HER2+) with trastuzumab 9.0%, HER2Positive(ER−) without trastuzumab 30.0%, HER2Positive(ER−) with trastuzumab 19.9% and TripleNegative 25.3%. There were major differences in site of first metastases according to subtype. For single site first metastases, median BCSS assessed from time of metastases was worst for brain localization (13.9 months) and best for bone (48.4 months). Multiple sites of first metastases had worse BCSS from date of metastases than single site first metastases (median BCSS for 1 site 40.0, 2 sites 27.1, ≥ 3 sites 20.5 months). Median BCSS from date of metastases is longer in upfront metastases compared to secondary metastases after EBC (43.4 vs. 27.9 months). 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Van Mechelen, Margot |
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Van Mechelen, Margot ddc 610 bkl 44.92 misc Metastatic breast cancer misc Breast cancer subtype misc Disease free survival misc Disease specific survival misc Trastuzumab Behavior of metastatic breast cancer according to subtype |
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610 ASE 44.92 bkl Behavior of metastatic breast cancer according to subtype Metastatic breast cancer (dpeaa)DE-He213 Breast cancer subtype (dpeaa)DE-He213 Disease free survival (dpeaa)DE-He213 Disease specific survival (dpeaa)DE-He213 Trastuzumab (dpeaa)DE-He213 |
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ddc 610 bkl 44.92 misc Metastatic breast cancer misc Breast cancer subtype misc Disease free survival misc Disease specific survival misc Trastuzumab |
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ddc 610 bkl 44.92 misc Metastatic breast cancer misc Breast cancer subtype misc Disease free survival misc Disease specific survival misc Trastuzumab |
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ddc 610 bkl 44.92 misc Metastatic breast cancer misc Breast cancer subtype misc Disease free survival misc Disease specific survival misc Trastuzumab |
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Behavior of metastatic breast cancer according to subtype |
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(DE-627)SPR039512290 (DE-599)SPRs10549-020-05597-3-e (SPR)s10549-020-05597-3-e |
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Behavior of metastatic breast cancer according to subtype |
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Van Mechelen, Margot |
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Breast cancer research and treatment |
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Breast cancer research and treatment |
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Van Mechelen, Margot Van Herck, Anke Punie, Kevin Nevelsteen, Ines Smeets, Ann Neven, Patrick Weltens, Caroline Han, Sileny Vanderstichele, Adriaan Floris, Giuseppe Lobelle, Jean-Pierre Wildiers, Hans |
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Van Mechelen, Margot |
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10.1007/s10549-020-05597-3 |
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610 |
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behavior of metastatic breast cancer according to subtype |
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Behavior of metastatic breast cancer according to subtype |
| abstract |
Purpose To explore the impact of breast cancer subtype on metastatic behavior and long-term outcome defined as breast cancer specific survival (BCSS). Methods Retrospective single centre cross-sectional study of 5972 patients with newly diagnosed, unilateral first diagnosis of breast cancer, diagnosed 2000–2010. Patients had either early breast cancer (EBC) treated primarily by surgery (SURG n = 5072), neoadjuvant systemic therapy (NEO n = 592), or upfront metastatic disease (META n = 308). Surrogate breast cancer subtypes were defined according to classical pathological criteria. Analysis was performed using Kaplan–Meier method and logistic/Cox regression. Results After median follow-up time of 103.6 months (IQR 73.4–139.2 months), 817 patients with EBC at diagnosis (14.4%) developed distant metastases of which 621 (12.2%) SURG and 196 (33.1%) NEO. Metastasis rate after EBC was: LuminalA 8.1%, LuminalB1(HER2−) 20.4%, LuminalB2(HER2+) without (neo)adjuvant trastuzumab 21.7%, LuminalB2(HER2+) with trastuzumab 9.0%, HER2Positive(ER−) without trastuzumab 30.0%, HER2Positive(ER−) with trastuzumab 19.9% and TripleNegative 25.3%. There were major differences in site of first metastases according to subtype. For single site first metastases, median BCSS assessed from time of metastases was worst for brain localization (13.9 months) and best for bone (48.4 months). Multiple sites of first metastases had worse BCSS from date of metastases than single site first metastases (median BCSS for 1 site 40.0, 2 sites 27.1, ≥ 3 sites 20.5 months). Median BCSS from date of metastases is longer in upfront metastases compared to secondary metastases after EBC (43.4 vs. 27.9 months). Conclusions Tumor subtype influences the metastatic behavior and survival after development of distant metastases. |
| abstractGer |
Purpose To explore the impact of breast cancer subtype on metastatic behavior and long-term outcome defined as breast cancer specific survival (BCSS). Methods Retrospective single centre cross-sectional study of 5972 patients with newly diagnosed, unilateral first diagnosis of breast cancer, diagnosed 2000–2010. Patients had either early breast cancer (EBC) treated primarily by surgery (SURG n = 5072), neoadjuvant systemic therapy (NEO n = 592), or upfront metastatic disease (META n = 308). Surrogate breast cancer subtypes were defined according to classical pathological criteria. Analysis was performed using Kaplan–Meier method and logistic/Cox regression. Results After median follow-up time of 103.6 months (IQR 73.4–139.2 months), 817 patients with EBC at diagnosis (14.4%) developed distant metastases of which 621 (12.2%) SURG and 196 (33.1%) NEO. Metastasis rate after EBC was: LuminalA 8.1%, LuminalB1(HER2−) 20.4%, LuminalB2(HER2+) without (neo)adjuvant trastuzumab 21.7%, LuminalB2(HER2+) with trastuzumab 9.0%, HER2Positive(ER−) without trastuzumab 30.0%, HER2Positive(ER−) with trastuzumab 19.9% and TripleNegative 25.3%. There were major differences in site of first metastases according to subtype. For single site first metastases, median BCSS assessed from time of metastases was worst for brain localization (13.9 months) and best for bone (48.4 months). Multiple sites of first metastases had worse BCSS from date of metastases than single site first metastases (median BCSS for 1 site 40.0, 2 sites 27.1, ≥ 3 sites 20.5 months). Median BCSS from date of metastases is longer in upfront metastases compared to secondary metastases after EBC (43.4 vs. 27.9 months). Conclusions Tumor subtype influences the metastatic behavior and survival after development of distant metastases. |
| abstract_unstemmed |
Purpose To explore the impact of breast cancer subtype on metastatic behavior and long-term outcome defined as breast cancer specific survival (BCSS). Methods Retrospective single centre cross-sectional study of 5972 patients with newly diagnosed, unilateral first diagnosis of breast cancer, diagnosed 2000–2010. Patients had either early breast cancer (EBC) treated primarily by surgery (SURG n = 5072), neoadjuvant systemic therapy (NEO n = 592), or upfront metastatic disease (META n = 308). Surrogate breast cancer subtypes were defined according to classical pathological criteria. Analysis was performed using Kaplan–Meier method and logistic/Cox regression. Results After median follow-up time of 103.6 months (IQR 73.4–139.2 months), 817 patients with EBC at diagnosis (14.4%) developed distant metastases of which 621 (12.2%) SURG and 196 (33.1%) NEO. Metastasis rate after EBC was: LuminalA 8.1%, LuminalB1(HER2−) 20.4%, LuminalB2(HER2+) without (neo)adjuvant trastuzumab 21.7%, LuminalB2(HER2+) with trastuzumab 9.0%, HER2Positive(ER−) without trastuzumab 30.0%, HER2Positive(ER−) with trastuzumab 19.9% and TripleNegative 25.3%. There were major differences in site of first metastases according to subtype. For single site first metastases, median BCSS assessed from time of metastases was worst for brain localization (13.9 months) and best for bone (48.4 months). Multiple sites of first metastases had worse BCSS from date of metastases than single site first metastases (median BCSS for 1 site 40.0, 2 sites 27.1, ≥ 3 sites 20.5 months). Median BCSS from date of metastases is longer in upfront metastases compared to secondary metastases after EBC (43.4 vs. 27.9 months). Conclusions Tumor subtype influences the metastatic behavior and survival after development of distant metastases. |
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Behavior of metastatic breast cancer according to subtype |
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Van Herck, Anke Punie, Kevin Nevelsteen, Ines Smeets, Ann Neven, Patrick Weltens, Caroline Han, Sileny Vanderstichele, Adriaan Floris, Giuseppe Lobelle, Jean-Pierre Wildiers, Hans |
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Van Herck, Anke Punie, Kevin Nevelsteen, Ines Smeets, Ann Neven, Patrick Weltens, Caroline Han, Sileny Vanderstichele, Adriaan Floris, Giuseppe Lobelle, Jean-Pierre Wildiers, Hans |
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Methods Retrospective single centre cross-sectional study of 5972 patients with newly diagnosed, unilateral first diagnosis of breast cancer, diagnosed 2000–2010. Patients had either early breast cancer (EBC) treated primarily by surgery (SURG n = 5072), neoadjuvant systemic therapy (NEO n = 592), or upfront metastatic disease (META n = 308). Surrogate breast cancer subtypes were defined according to classical pathological criteria. Analysis was performed using Kaplan–Meier method and logistic/Cox regression. Results After median follow-up time of 103.6 months (IQR 73.4–139.2 months), 817 patients with EBC at diagnosis (14.4%) developed distant metastases of which 621 (12.2%) SURG and 196 (33.1%) NEO. Metastasis rate after EBC was: LuminalA 8.1%, LuminalB1(HER2−) 20.4%, LuminalB2(HER2+) without (neo)adjuvant trastuzumab 21.7%, LuminalB2(HER2+) with trastuzumab 9.0%, HER2Positive(ER−) without trastuzumab 30.0%, HER2Positive(ER−) with trastuzumab 19.9% and TripleNegative 25.3%. There were major differences in site of first metastases according to subtype. For single site first metastases, median BCSS assessed from time of metastases was worst for brain localization (13.9 months) and best for bone (48.4 months). Multiple sites of first metastases had worse BCSS from date of metastases than single site first metastases (median BCSS for 1 site 40.0, 2 sites 27.1, ≥ 3 sites 20.5 months). Median BCSS from date of metastases is longer in upfront metastases compared to secondary metastases after EBC (43.4 vs. 27.9 months). 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