High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas
Background Immunotherapy has demonstrated encouraging clinical benefits in patients with advanced breast carcinomas and Programmed death ligand 1 (PD-L1) expression has been proposed as an immunotherapy biomarker. Challenges with current PD-L1 testing exist and tumor mutation burden (TMB) is emergin...
Ausführliche Beschreibung
Autor*in: |
Mei, Ping [verfasserIn] Freitag, C. Eric [verfasserIn] Wei, Lai [verfasserIn] Zhang, Yunxiang [verfasserIn] Parwani, Anil V. [verfasserIn] Li, Zaibo [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Übergeordnetes Werk: |
Enthalten in: Diagnostic pathology - [S.l.] : BioMed Central, 2006, 15(2020), 1 vom: 11. Mai |
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Übergeordnetes Werk: |
volume:15 ; year:2020 ; number:1 ; day:11 ; month:05 |
Links: |
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DOI / URN: |
10.1186/s13000-020-00971-7 |
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Katalog-ID: |
SPR03968332X |
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520 | |a Background Immunotherapy has demonstrated encouraging clinical benefits in patients with advanced breast carcinomas and Programmed death ligand 1 (PD-L1) expression has been proposed as an immunotherapy biomarker. Challenges with current PD-L1 testing exist and tumor mutation burden (TMB) is emerging as a biomarker to predict clinical response to immunotherapy in melanoma and non-small cell lung cancer patients. However, TMB has not been well characterized in breast carcinomas. Methods The study cohort included 62 advanced breast cancer patients (13 primary and 49 metastatic). Genetic alterations and TMB were determined by FoundationOne CDx next generation sequencing (NGS) and the association with clinicopathologic features was analyzed. Results High TMB was observed in a relatively low frequency (3/62, 4.8%). TMB levels were positively associated tumor infiltrating lymphocytes and significantly higher TMB was observed in breast carcinomas with DNA damage repair gene mutation(s). There was no significant association between TMB levels and other analyzed clinicopathologic characteristics. Conclusions Our data indicate the importance of DNA damage repair proteins in maintaining DNA integrity and immune reaction and breast carcinoma patients with DDR mutation may benefit from immunotherapy. | ||
650 | 4 | |a Breast carcinoma |7 (dpeaa)DE-He213 | |
650 | 4 | |a Genetic mutation |7 (dpeaa)DE-He213 | |
650 | 4 | |a Tumor mutation burden |7 (dpeaa)DE-He213 | |
650 | 4 | |a DNA damage repair genes |7 (dpeaa)DE-He213 | |
700 | 1 | |a Freitag, C. Eric |e verfasserin |4 aut | |
700 | 1 | |a Wei, Lai |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Yunxiang |e verfasserin |4 aut | |
700 | 1 | |a Parwani, Anil V. |e verfasserin |4 aut | |
700 | 1 | |a Li, Zaibo |e verfasserin |4 aut | |
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10.1186/s13000-020-00971-7 doi (DE-627)SPR03968332X (SPR)s13000-020-00971-7-e DE-627 ger DE-627 rakwb eng 610 ASE Mei, Ping verfasserin aut High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Immunotherapy has demonstrated encouraging clinical benefits in patients with advanced breast carcinomas and Programmed death ligand 1 (PD-L1) expression has been proposed as an immunotherapy biomarker. Challenges with current PD-L1 testing exist and tumor mutation burden (TMB) is emerging as a biomarker to predict clinical response to immunotherapy in melanoma and non-small cell lung cancer patients. However, TMB has not been well characterized in breast carcinomas. Methods The study cohort included 62 advanced breast cancer patients (13 primary and 49 metastatic). Genetic alterations and TMB were determined by FoundationOne CDx next generation sequencing (NGS) and the association with clinicopathologic features was analyzed. Results High TMB was observed in a relatively low frequency (3/62, 4.8%). TMB levels were positively associated tumor infiltrating lymphocytes and significantly higher TMB was observed in breast carcinomas with DNA damage repair gene mutation(s). There was no significant association between TMB levels and other analyzed clinicopathologic characteristics. Conclusions Our data indicate the importance of DNA damage repair proteins in maintaining DNA integrity and immune reaction and breast carcinoma patients with DDR mutation may benefit from immunotherapy. Breast carcinoma (dpeaa)DE-He213 Genetic mutation (dpeaa)DE-He213 Tumor mutation burden (dpeaa)DE-He213 DNA damage repair genes (dpeaa)DE-He213 Freitag, C. Eric verfasserin aut Wei, Lai verfasserin aut Zhang, Yunxiang verfasserin aut Parwani, Anil V. verfasserin aut Li, Zaibo verfasserin aut Enthalten in Diagnostic pathology [S.l.] : BioMed Central, 2006 15(2020), 1 vom: 11. Mai (DE-627)503328960 (DE-600)2210518-9 1746-1596 nnns volume:15 year:2020 number:1 day:11 month:05 https://dx.doi.org/10.1186/s13000-020-00971-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1 11 05 |
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10.1186/s13000-020-00971-7 doi (DE-627)SPR03968332X (SPR)s13000-020-00971-7-e DE-627 ger DE-627 rakwb eng 610 ASE Mei, Ping verfasserin aut High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Immunotherapy has demonstrated encouraging clinical benefits in patients with advanced breast carcinomas and Programmed death ligand 1 (PD-L1) expression has been proposed as an immunotherapy biomarker. Challenges with current PD-L1 testing exist and tumor mutation burden (TMB) is emerging as a biomarker to predict clinical response to immunotherapy in melanoma and non-small cell lung cancer patients. However, TMB has not been well characterized in breast carcinomas. Methods The study cohort included 62 advanced breast cancer patients (13 primary and 49 metastatic). Genetic alterations and TMB were determined by FoundationOne CDx next generation sequencing (NGS) and the association with clinicopathologic features was analyzed. Results High TMB was observed in a relatively low frequency (3/62, 4.8%). TMB levels were positively associated tumor infiltrating lymphocytes and significantly higher TMB was observed in breast carcinomas with DNA damage repair gene mutation(s). There was no significant association between TMB levels and other analyzed clinicopathologic characteristics. Conclusions Our data indicate the importance of DNA damage repair proteins in maintaining DNA integrity and immune reaction and breast carcinoma patients with DDR mutation may benefit from immunotherapy. Breast carcinoma (dpeaa)DE-He213 Genetic mutation (dpeaa)DE-He213 Tumor mutation burden (dpeaa)DE-He213 DNA damage repair genes (dpeaa)DE-He213 Freitag, C. Eric verfasserin aut Wei, Lai verfasserin aut Zhang, Yunxiang verfasserin aut Parwani, Anil V. verfasserin aut Li, Zaibo verfasserin aut Enthalten in Diagnostic pathology [S.l.] : BioMed Central, 2006 15(2020), 1 vom: 11. Mai (DE-627)503328960 (DE-600)2210518-9 1746-1596 nnns volume:15 year:2020 number:1 day:11 month:05 https://dx.doi.org/10.1186/s13000-020-00971-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1 11 05 |
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10.1186/s13000-020-00971-7 doi (DE-627)SPR03968332X (SPR)s13000-020-00971-7-e DE-627 ger DE-627 rakwb eng 610 ASE Mei, Ping verfasserin aut High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Immunotherapy has demonstrated encouraging clinical benefits in patients with advanced breast carcinomas and Programmed death ligand 1 (PD-L1) expression has been proposed as an immunotherapy biomarker. Challenges with current PD-L1 testing exist and tumor mutation burden (TMB) is emerging as a biomarker to predict clinical response to immunotherapy in melanoma and non-small cell lung cancer patients. However, TMB has not been well characterized in breast carcinomas. Methods The study cohort included 62 advanced breast cancer patients (13 primary and 49 metastatic). Genetic alterations and TMB were determined by FoundationOne CDx next generation sequencing (NGS) and the association with clinicopathologic features was analyzed. Results High TMB was observed in a relatively low frequency (3/62, 4.8%). TMB levels were positively associated tumor infiltrating lymphocytes and significantly higher TMB was observed in breast carcinomas with DNA damage repair gene mutation(s). There was no significant association between TMB levels and other analyzed clinicopathologic characteristics. Conclusions Our data indicate the importance of DNA damage repair proteins in maintaining DNA integrity and immune reaction and breast carcinoma patients with DDR mutation may benefit from immunotherapy. Breast carcinoma (dpeaa)DE-He213 Genetic mutation (dpeaa)DE-He213 Tumor mutation burden (dpeaa)DE-He213 DNA damage repair genes (dpeaa)DE-He213 Freitag, C. Eric verfasserin aut Wei, Lai verfasserin aut Zhang, Yunxiang verfasserin aut Parwani, Anil V. verfasserin aut Li, Zaibo verfasserin aut Enthalten in Diagnostic pathology [S.l.] : BioMed Central, 2006 15(2020), 1 vom: 11. Mai (DE-627)503328960 (DE-600)2210518-9 1746-1596 nnns volume:15 year:2020 number:1 day:11 month:05 https://dx.doi.org/10.1186/s13000-020-00971-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1 11 05 |
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10.1186/s13000-020-00971-7 doi (DE-627)SPR03968332X (SPR)s13000-020-00971-7-e DE-627 ger DE-627 rakwb eng 610 ASE Mei, Ping verfasserin aut High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Immunotherapy has demonstrated encouraging clinical benefits in patients with advanced breast carcinomas and Programmed death ligand 1 (PD-L1) expression has been proposed as an immunotherapy biomarker. Challenges with current PD-L1 testing exist and tumor mutation burden (TMB) is emerging as a biomarker to predict clinical response to immunotherapy in melanoma and non-small cell lung cancer patients. However, TMB has not been well characterized in breast carcinomas. Methods The study cohort included 62 advanced breast cancer patients (13 primary and 49 metastatic). Genetic alterations and TMB were determined by FoundationOne CDx next generation sequencing (NGS) and the association with clinicopathologic features was analyzed. Results High TMB was observed in a relatively low frequency (3/62, 4.8%). TMB levels were positively associated tumor infiltrating lymphocytes and significantly higher TMB was observed in breast carcinomas with DNA damage repair gene mutation(s). There was no significant association between TMB levels and other analyzed clinicopathologic characteristics. Conclusions Our data indicate the importance of DNA damage repair proteins in maintaining DNA integrity and immune reaction and breast carcinoma patients with DDR mutation may benefit from immunotherapy. Breast carcinoma (dpeaa)DE-He213 Genetic mutation (dpeaa)DE-He213 Tumor mutation burden (dpeaa)DE-He213 DNA damage repair genes (dpeaa)DE-He213 Freitag, C. Eric verfasserin aut Wei, Lai verfasserin aut Zhang, Yunxiang verfasserin aut Parwani, Anil V. verfasserin aut Li, Zaibo verfasserin aut Enthalten in Diagnostic pathology [S.l.] : BioMed Central, 2006 15(2020), 1 vom: 11. Mai (DE-627)503328960 (DE-600)2210518-9 1746-1596 nnns volume:15 year:2020 number:1 day:11 month:05 https://dx.doi.org/10.1186/s13000-020-00971-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1 11 05 |
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10.1186/s13000-020-00971-7 doi (DE-627)SPR03968332X (SPR)s13000-020-00971-7-e DE-627 ger DE-627 rakwb eng 610 ASE Mei, Ping verfasserin aut High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Immunotherapy has demonstrated encouraging clinical benefits in patients with advanced breast carcinomas and Programmed death ligand 1 (PD-L1) expression has been proposed as an immunotherapy biomarker. Challenges with current PD-L1 testing exist and tumor mutation burden (TMB) is emerging as a biomarker to predict clinical response to immunotherapy in melanoma and non-small cell lung cancer patients. However, TMB has not been well characterized in breast carcinomas. Methods The study cohort included 62 advanced breast cancer patients (13 primary and 49 metastatic). Genetic alterations and TMB were determined by FoundationOne CDx next generation sequencing (NGS) and the association with clinicopathologic features was analyzed. Results High TMB was observed in a relatively low frequency (3/62, 4.8%). TMB levels were positively associated tumor infiltrating lymphocytes and significantly higher TMB was observed in breast carcinomas with DNA damage repair gene mutation(s). There was no significant association between TMB levels and other analyzed clinicopathologic characteristics. Conclusions Our data indicate the importance of DNA damage repair proteins in maintaining DNA integrity and immune reaction and breast carcinoma patients with DDR mutation may benefit from immunotherapy. Breast carcinoma (dpeaa)DE-He213 Genetic mutation (dpeaa)DE-He213 Tumor mutation burden (dpeaa)DE-He213 DNA damage repair genes (dpeaa)DE-He213 Freitag, C. Eric verfasserin aut Wei, Lai verfasserin aut Zhang, Yunxiang verfasserin aut Parwani, Anil V. verfasserin aut Li, Zaibo verfasserin aut Enthalten in Diagnostic pathology [S.l.] : BioMed Central, 2006 15(2020), 1 vom: 11. Mai (DE-627)503328960 (DE-600)2210518-9 1746-1596 nnns volume:15 year:2020 number:1 day:11 month:05 https://dx.doi.org/10.1186/s13000-020-00971-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1 11 05 |
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Enthalten in Diagnostic pathology 15(2020), 1 vom: 11. Mai volume:15 year:2020 number:1 day:11 month:05 |
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High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas |
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high tumor mutation burden is associated with dna damage repair gene mutation in breast carcinomas |
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High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas |
abstract |
Background Immunotherapy has demonstrated encouraging clinical benefits in patients with advanced breast carcinomas and Programmed death ligand 1 (PD-L1) expression has been proposed as an immunotherapy biomarker. Challenges with current PD-L1 testing exist and tumor mutation burden (TMB) is emerging as a biomarker to predict clinical response to immunotherapy in melanoma and non-small cell lung cancer patients. However, TMB has not been well characterized in breast carcinomas. Methods The study cohort included 62 advanced breast cancer patients (13 primary and 49 metastatic). Genetic alterations and TMB were determined by FoundationOne CDx next generation sequencing (NGS) and the association with clinicopathologic features was analyzed. Results High TMB was observed in a relatively low frequency (3/62, 4.8%). TMB levels were positively associated tumor infiltrating lymphocytes and significantly higher TMB was observed in breast carcinomas with DNA damage repair gene mutation(s). There was no significant association between TMB levels and other analyzed clinicopathologic characteristics. Conclusions Our data indicate the importance of DNA damage repair proteins in maintaining DNA integrity and immune reaction and breast carcinoma patients with DDR mutation may benefit from immunotherapy. |
abstractGer |
Background Immunotherapy has demonstrated encouraging clinical benefits in patients with advanced breast carcinomas and Programmed death ligand 1 (PD-L1) expression has been proposed as an immunotherapy biomarker. Challenges with current PD-L1 testing exist and tumor mutation burden (TMB) is emerging as a biomarker to predict clinical response to immunotherapy in melanoma and non-small cell lung cancer patients. However, TMB has not been well characterized in breast carcinomas. Methods The study cohort included 62 advanced breast cancer patients (13 primary and 49 metastatic). Genetic alterations and TMB were determined by FoundationOne CDx next generation sequencing (NGS) and the association with clinicopathologic features was analyzed. Results High TMB was observed in a relatively low frequency (3/62, 4.8%). TMB levels were positively associated tumor infiltrating lymphocytes and significantly higher TMB was observed in breast carcinomas with DNA damage repair gene mutation(s). There was no significant association between TMB levels and other analyzed clinicopathologic characteristics. Conclusions Our data indicate the importance of DNA damage repair proteins in maintaining DNA integrity and immune reaction and breast carcinoma patients with DDR mutation may benefit from immunotherapy. |
abstract_unstemmed |
Background Immunotherapy has demonstrated encouraging clinical benefits in patients with advanced breast carcinomas and Programmed death ligand 1 (PD-L1) expression has been proposed as an immunotherapy biomarker. Challenges with current PD-L1 testing exist and tumor mutation burden (TMB) is emerging as a biomarker to predict clinical response to immunotherapy in melanoma and non-small cell lung cancer patients. However, TMB has not been well characterized in breast carcinomas. Methods The study cohort included 62 advanced breast cancer patients (13 primary and 49 metastatic). Genetic alterations and TMB were determined by FoundationOne CDx next generation sequencing (NGS) and the association with clinicopathologic features was analyzed. Results High TMB was observed in a relatively low frequency (3/62, 4.8%). TMB levels were positively associated tumor infiltrating lymphocytes and significantly higher TMB was observed in breast carcinomas with DNA damage repair gene mutation(s). There was no significant association between TMB levels and other analyzed clinicopathologic characteristics. Conclusions Our data indicate the importance of DNA damage repair proteins in maintaining DNA integrity and immune reaction and breast carcinoma patients with DDR mutation may benefit from immunotherapy. |
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High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas |
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score |
7.39931 |