Synchronous Tumours in Gynaecological Malignancies
Background Synchronous gynaecological tumours, being a rare entity, cause a diagnostic and management conundrum for oncologists using the current criteria for diagnosis. Objective This study was conducted to identify the clinicopathological characteristics, treatment received and survival outcomes i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Datta, Amrita [verfasserIn] Thomas, Anitha [verfasserIn] George, Rachel [verfasserIn] Sebastian, Ajit [verfasserIn] Thomas, Vinotha [verfasserIn] Thomas, Dhanya Susan [verfasserIn] Ram, Thomas Samuel [verfasserIn] Daniel, Sherin [verfasserIn] Karuppusami, Reka [verfasserIn] Peedicayil, Abraham [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Indian Journal of Gynecologic Oncology - New Delhi : Springer India, 2015, 18(2020), 2 vom: 12. Mai |
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| Übergeordnetes Werk: |
volume:18 ; year:2020 ; number:2 ; day:12 ; month:05 |
| Links: |
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| DOI / URN: |
10.1007/s40944-020-00399-3 |
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| Katalog-ID: |
SPR039687333 |
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| 520 | |a Background Synchronous gynaecological tumours, being a rare entity, cause a diagnostic and management conundrum for oncologists using the current criteria for diagnosis. Objective This study was conducted to identify the clinicopathological characteristics, treatment received and survival outcomes in women diagnosed with synchronous gynaecological cancers. Methods A retrospective analysis was performed of patients diagnosed with synchronous gynaecological malignancies between January 2011 and December 2015 of at least two of the following sites: endometrium, cervix or ovary. Data were collected from electronic medical records. Categorical data were analysed by X2 test and Fischer’s test as appropriate. Survival was plotted by Kaplan–Meier curves. Results The study identified 20 patients diagnosed with synchronous cancers during this time: 19 cases had synchronous carcinoma of endometrium and ovary and one of cervix and ovary. The mean age at diagnosis was 48.6 years. Mean BMI was 27.4 kg/$ m^{2} $. Commonest presenting symptom was lower abdominal pain in 85% of women. Commonest synchronous tumour was endometrioid tumours of both endometrium and ovary. All patients underwent surgery followed by adjuvant treatment; 14 (70%) had chemotherapy, while 5 (25%) had chemo radiation. Of the 20 patients in our study group, 11(55%) patients had complete response, 8 (40%) had recurred after complete treatment, and 7 (35%) had expired. Extra pelvic extension and tumour size were important prognostic factors in determining the outcome. Overall survival was 38.5 months. Conclusions Synchronous tumours tend to occur more frequently in young and parous women. Endometrial tumours synchronous to ovary were more common. It is important to recognise synchronous tumours as the postoperative adjuvant therapy can be tailored to achieve better survival. | ||
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| 650 | 4 | |a Treatment |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Overall survival |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Recurrence |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Free survival |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Thomas, Anitha |e verfasserin |4 aut | |
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| 700 | 1 | |a Thomas, Vinotha |e verfasserin |4 aut | |
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| 700 | 1 | |a Daniel, Sherin |e verfasserin |4 aut | |
| 700 | 1 | |a Karuppusami, Reka |e verfasserin |4 aut | |
| 700 | 1 | |a Peedicayil, Abraham |e verfasserin |4 aut | |
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10.1007/s40944-020-00399-3 doi (DE-627)SPR039687333 (SPR)s40944-020-00399-3-e DE-627 ger DE-627 rakwb eng Datta, Amrita verfasserin aut Synchronous Tumours in Gynaecological Malignancies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Synchronous gynaecological tumours, being a rare entity, cause a diagnostic and management conundrum for oncologists using the current criteria for diagnosis. Objective This study was conducted to identify the clinicopathological characteristics, treatment received and survival outcomes in women diagnosed with synchronous gynaecological cancers. Methods A retrospective analysis was performed of patients diagnosed with synchronous gynaecological malignancies between January 2011 and December 2015 of at least two of the following sites: endometrium, cervix or ovary. Data were collected from electronic medical records. Categorical data were analysed by X2 test and Fischer’s test as appropriate. Survival was plotted by Kaplan–Meier curves. Results The study identified 20 patients diagnosed with synchronous cancers during this time: 19 cases had synchronous carcinoma of endometrium and ovary and one of cervix and ovary. The mean age at diagnosis was 48.6 years. Mean BMI was 27.4 kg/$ m^{2} $. Commonest presenting symptom was lower abdominal pain in 85% of women. Commonest synchronous tumour was endometrioid tumours of both endometrium and ovary. All patients underwent surgery followed by adjuvant treatment; 14 (70%) had chemotherapy, while 5 (25%) had chemo radiation. Of the 20 patients in our study group, 11(55%) patients had complete response, 8 (40%) had recurred after complete treatment, and 7 (35%) had expired. Extra pelvic extension and tumour size were important prognostic factors in determining the outcome. Overall survival was 38.5 months. Conclusions Synchronous tumours tend to occur more frequently in young and parous women. Endometrial tumours synchronous to ovary were more common. It is important to recognise synchronous tumours as the postoperative adjuvant therapy can be tailored to achieve better survival. Synchronous gynaecological cancer (dpeaa)DE-He213 Treatment (dpeaa)DE-He213 Overall survival (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Free survival (dpeaa)DE-He213 Thomas, Anitha verfasserin aut George, Rachel verfasserin aut Sebastian, Ajit verfasserin aut Thomas, Vinotha verfasserin aut Thomas, Dhanya Susan verfasserin aut Ram, Thomas Samuel verfasserin aut Daniel, Sherin verfasserin aut Karuppusami, Reka verfasserin aut Peedicayil, Abraham verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology New Delhi : Springer India, 2015 18(2020), 2 vom: 12. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:18 year:2020 number:2 day:12 month:05 https://dx.doi.org/10.1007/s40944-020-00399-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 2 12 05 |
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10.1007/s40944-020-00399-3 doi (DE-627)SPR039687333 (SPR)s40944-020-00399-3-e DE-627 ger DE-627 rakwb eng Datta, Amrita verfasserin aut Synchronous Tumours in Gynaecological Malignancies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Synchronous gynaecological tumours, being a rare entity, cause a diagnostic and management conundrum for oncologists using the current criteria for diagnosis. Objective This study was conducted to identify the clinicopathological characteristics, treatment received and survival outcomes in women diagnosed with synchronous gynaecological cancers. Methods A retrospective analysis was performed of patients diagnosed with synchronous gynaecological malignancies between January 2011 and December 2015 of at least two of the following sites: endometrium, cervix or ovary. Data were collected from electronic medical records. Categorical data were analysed by X2 test and Fischer’s test as appropriate. Survival was plotted by Kaplan–Meier curves. Results The study identified 20 patients diagnosed with synchronous cancers during this time: 19 cases had synchronous carcinoma of endometrium and ovary and one of cervix and ovary. The mean age at diagnosis was 48.6 years. Mean BMI was 27.4 kg/$ m^{2} $. Commonest presenting symptom was lower abdominal pain in 85% of women. Commonest synchronous tumour was endometrioid tumours of both endometrium and ovary. All patients underwent surgery followed by adjuvant treatment; 14 (70%) had chemotherapy, while 5 (25%) had chemo radiation. Of the 20 patients in our study group, 11(55%) patients had complete response, 8 (40%) had recurred after complete treatment, and 7 (35%) had expired. Extra pelvic extension and tumour size were important prognostic factors in determining the outcome. Overall survival was 38.5 months. Conclusions Synchronous tumours tend to occur more frequently in young and parous women. Endometrial tumours synchronous to ovary were more common. It is important to recognise synchronous tumours as the postoperative adjuvant therapy can be tailored to achieve better survival. Synchronous gynaecological cancer (dpeaa)DE-He213 Treatment (dpeaa)DE-He213 Overall survival (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Free survival (dpeaa)DE-He213 Thomas, Anitha verfasserin aut George, Rachel verfasserin aut Sebastian, Ajit verfasserin aut Thomas, Vinotha verfasserin aut Thomas, Dhanya Susan verfasserin aut Ram, Thomas Samuel verfasserin aut Daniel, Sherin verfasserin aut Karuppusami, Reka verfasserin aut Peedicayil, Abraham verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology New Delhi : Springer India, 2015 18(2020), 2 vom: 12. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:18 year:2020 number:2 day:12 month:05 https://dx.doi.org/10.1007/s40944-020-00399-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 2 12 05 |
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10.1007/s40944-020-00399-3 doi (DE-627)SPR039687333 (SPR)s40944-020-00399-3-e DE-627 ger DE-627 rakwb eng Datta, Amrita verfasserin aut Synchronous Tumours in Gynaecological Malignancies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Synchronous gynaecological tumours, being a rare entity, cause a diagnostic and management conundrum for oncologists using the current criteria for diagnosis. Objective This study was conducted to identify the clinicopathological characteristics, treatment received and survival outcomes in women diagnosed with synchronous gynaecological cancers. Methods A retrospective analysis was performed of patients diagnosed with synchronous gynaecological malignancies between January 2011 and December 2015 of at least two of the following sites: endometrium, cervix or ovary. Data were collected from electronic medical records. Categorical data were analysed by X2 test and Fischer’s test as appropriate. Survival was plotted by Kaplan–Meier curves. Results The study identified 20 patients diagnosed with synchronous cancers during this time: 19 cases had synchronous carcinoma of endometrium and ovary and one of cervix and ovary. The mean age at diagnosis was 48.6 years. Mean BMI was 27.4 kg/$ m^{2} $. Commonest presenting symptom was lower abdominal pain in 85% of women. Commonest synchronous tumour was endometrioid tumours of both endometrium and ovary. All patients underwent surgery followed by adjuvant treatment; 14 (70%) had chemotherapy, while 5 (25%) had chemo radiation. Of the 20 patients in our study group, 11(55%) patients had complete response, 8 (40%) had recurred after complete treatment, and 7 (35%) had expired. Extra pelvic extension and tumour size were important prognostic factors in determining the outcome. Overall survival was 38.5 months. Conclusions Synchronous tumours tend to occur more frequently in young and parous women. Endometrial tumours synchronous to ovary were more common. It is important to recognise synchronous tumours as the postoperative adjuvant therapy can be tailored to achieve better survival. Synchronous gynaecological cancer (dpeaa)DE-He213 Treatment (dpeaa)DE-He213 Overall survival (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Free survival (dpeaa)DE-He213 Thomas, Anitha verfasserin aut George, Rachel verfasserin aut Sebastian, Ajit verfasserin aut Thomas, Vinotha verfasserin aut Thomas, Dhanya Susan verfasserin aut Ram, Thomas Samuel verfasserin aut Daniel, Sherin verfasserin aut Karuppusami, Reka verfasserin aut Peedicayil, Abraham verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology New Delhi : Springer India, 2015 18(2020), 2 vom: 12. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:18 year:2020 number:2 day:12 month:05 https://dx.doi.org/10.1007/s40944-020-00399-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 2 12 05 |
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10.1007/s40944-020-00399-3 doi (DE-627)SPR039687333 (SPR)s40944-020-00399-3-e DE-627 ger DE-627 rakwb eng Datta, Amrita verfasserin aut Synchronous Tumours in Gynaecological Malignancies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Synchronous gynaecological tumours, being a rare entity, cause a diagnostic and management conundrum for oncologists using the current criteria for diagnosis. Objective This study was conducted to identify the clinicopathological characteristics, treatment received and survival outcomes in women diagnosed with synchronous gynaecological cancers. Methods A retrospective analysis was performed of patients diagnosed with synchronous gynaecological malignancies between January 2011 and December 2015 of at least two of the following sites: endometrium, cervix or ovary. Data were collected from electronic medical records. Categorical data were analysed by X2 test and Fischer’s test as appropriate. Survival was plotted by Kaplan–Meier curves. Results The study identified 20 patients diagnosed with synchronous cancers during this time: 19 cases had synchronous carcinoma of endometrium and ovary and one of cervix and ovary. The mean age at diagnosis was 48.6 years. Mean BMI was 27.4 kg/$ m^{2} $. Commonest presenting symptom was lower abdominal pain in 85% of women. Commonest synchronous tumour was endometrioid tumours of both endometrium and ovary. All patients underwent surgery followed by adjuvant treatment; 14 (70%) had chemotherapy, while 5 (25%) had chemo radiation. Of the 20 patients in our study group, 11(55%) patients had complete response, 8 (40%) had recurred after complete treatment, and 7 (35%) had expired. Extra pelvic extension and tumour size were important prognostic factors in determining the outcome. Overall survival was 38.5 months. Conclusions Synchronous tumours tend to occur more frequently in young and parous women. Endometrial tumours synchronous to ovary were more common. It is important to recognise synchronous tumours as the postoperative adjuvant therapy can be tailored to achieve better survival. Synchronous gynaecological cancer (dpeaa)DE-He213 Treatment (dpeaa)DE-He213 Overall survival (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Free survival (dpeaa)DE-He213 Thomas, Anitha verfasserin aut George, Rachel verfasserin aut Sebastian, Ajit verfasserin aut Thomas, Vinotha verfasserin aut Thomas, Dhanya Susan verfasserin aut Ram, Thomas Samuel verfasserin aut Daniel, Sherin verfasserin aut Karuppusami, Reka verfasserin aut Peedicayil, Abraham verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology New Delhi : Springer India, 2015 18(2020), 2 vom: 12. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:18 year:2020 number:2 day:12 month:05 https://dx.doi.org/10.1007/s40944-020-00399-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 2 12 05 |
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10.1007/s40944-020-00399-3 doi (DE-627)SPR039687333 (SPR)s40944-020-00399-3-e DE-627 ger DE-627 rakwb eng Datta, Amrita verfasserin aut Synchronous Tumours in Gynaecological Malignancies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Synchronous gynaecological tumours, being a rare entity, cause a diagnostic and management conundrum for oncologists using the current criteria for diagnosis. Objective This study was conducted to identify the clinicopathological characteristics, treatment received and survival outcomes in women diagnosed with synchronous gynaecological cancers. Methods A retrospective analysis was performed of patients diagnosed with synchronous gynaecological malignancies between January 2011 and December 2015 of at least two of the following sites: endometrium, cervix or ovary. Data were collected from electronic medical records. Categorical data were analysed by X2 test and Fischer’s test as appropriate. Survival was plotted by Kaplan–Meier curves. Results The study identified 20 patients diagnosed with synchronous cancers during this time: 19 cases had synchronous carcinoma of endometrium and ovary and one of cervix and ovary. The mean age at diagnosis was 48.6 years. Mean BMI was 27.4 kg/$ m^{2} $. Commonest presenting symptom was lower abdominal pain in 85% of women. Commonest synchronous tumour was endometrioid tumours of both endometrium and ovary. All patients underwent surgery followed by adjuvant treatment; 14 (70%) had chemotherapy, while 5 (25%) had chemo radiation. Of the 20 patients in our study group, 11(55%) patients had complete response, 8 (40%) had recurred after complete treatment, and 7 (35%) had expired. Extra pelvic extension and tumour size were important prognostic factors in determining the outcome. Overall survival was 38.5 months. Conclusions Synchronous tumours tend to occur more frequently in young and parous women. Endometrial tumours synchronous to ovary were more common. It is important to recognise synchronous tumours as the postoperative adjuvant therapy can be tailored to achieve better survival. Synchronous gynaecological cancer (dpeaa)DE-He213 Treatment (dpeaa)DE-He213 Overall survival (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Free survival (dpeaa)DE-He213 Thomas, Anitha verfasserin aut George, Rachel verfasserin aut Sebastian, Ajit verfasserin aut Thomas, Vinotha verfasserin aut Thomas, Dhanya Susan verfasserin aut Ram, Thomas Samuel verfasserin aut Daniel, Sherin verfasserin aut Karuppusami, Reka verfasserin aut Peedicayil, Abraham verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology New Delhi : Springer India, 2015 18(2020), 2 vom: 12. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:18 year:2020 number:2 day:12 month:05 https://dx.doi.org/10.1007/s40944-020-00399-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 2 12 05 |
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Enthalten in Indian Journal of Gynecologic Oncology 18(2020), 2 vom: 12. Mai volume:18 year:2020 number:2 day:12 month:05 |
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Datta, Amrita @@aut@@ Thomas, Anitha @@aut@@ George, Rachel @@aut@@ Sebastian, Ajit @@aut@@ Thomas, Vinotha @@aut@@ Thomas, Dhanya Susan @@aut@@ Ram, Thomas Samuel @@aut@@ Daniel, Sherin @@aut@@ Karuppusami, Reka @@aut@@ Peedicayil, Abraham @@aut@@ |
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Objective This study was conducted to identify the clinicopathological characteristics, treatment received and survival outcomes in women diagnosed with synchronous gynaecological cancers. Methods A retrospective analysis was performed of patients diagnosed with synchronous gynaecological malignancies between January 2011 and December 2015 of at least two of the following sites: endometrium, cervix or ovary. Data were collected from electronic medical records. Categorical data were analysed by X2 test and Fischer’s test as appropriate. Survival was plotted by Kaplan–Meier curves. Results The study identified 20 patients diagnosed with synchronous cancers during this time: 19 cases had synchronous carcinoma of endometrium and ovary and one of cervix and ovary. The mean age at diagnosis was 48.6 years. Mean BMI was 27.4 kg/$ m^{2} $. Commonest presenting symptom was lower abdominal pain in 85% of women. Commonest synchronous tumour was endometrioid tumours of both endometrium and ovary. All patients underwent surgery followed by adjuvant treatment; 14 (70%) had chemotherapy, while 5 (25%) had chemo radiation. Of the 20 patients in our study group, 11(55%) patients had complete response, 8 (40%) had recurred after complete treatment, and 7 (35%) had expired. Extra pelvic extension and tumour size were important prognostic factors in determining the outcome. Overall survival was 38.5 months. Conclusions Synchronous tumours tend to occur more frequently in young and parous women. Endometrial tumours synchronous to ovary were more common. 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Datta, Amrita |
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Synchronous Tumours in Gynaecological Malignancies Synchronous gynaecological cancer (dpeaa)DE-He213 Treatment (dpeaa)DE-He213 Overall survival (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Free survival (dpeaa)DE-He213 |
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Synchronous Tumours in Gynaecological Malignancies |
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Indian Journal of Gynecologic Oncology |
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Datta, Amrita Thomas, Anitha George, Rachel Sebastian, Ajit Thomas, Vinotha Thomas, Dhanya Susan Ram, Thomas Samuel Daniel, Sherin Karuppusami, Reka Peedicayil, Abraham |
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synchronous tumours in gynaecological malignancies |
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Synchronous Tumours in Gynaecological Malignancies |
| abstract |
Background Synchronous gynaecological tumours, being a rare entity, cause a diagnostic and management conundrum for oncologists using the current criteria for diagnosis. Objective This study was conducted to identify the clinicopathological characteristics, treatment received and survival outcomes in women diagnosed with synchronous gynaecological cancers. Methods A retrospective analysis was performed of patients diagnosed with synchronous gynaecological malignancies between January 2011 and December 2015 of at least two of the following sites: endometrium, cervix or ovary. Data were collected from electronic medical records. Categorical data were analysed by X2 test and Fischer’s test as appropriate. Survival was plotted by Kaplan–Meier curves. Results The study identified 20 patients diagnosed with synchronous cancers during this time: 19 cases had synchronous carcinoma of endometrium and ovary and one of cervix and ovary. The mean age at diagnosis was 48.6 years. Mean BMI was 27.4 kg/$ m^{2} $. Commonest presenting symptom was lower abdominal pain in 85% of women. Commonest synchronous tumour was endometrioid tumours of both endometrium and ovary. All patients underwent surgery followed by adjuvant treatment; 14 (70%) had chemotherapy, while 5 (25%) had chemo radiation. Of the 20 patients in our study group, 11(55%) patients had complete response, 8 (40%) had recurred after complete treatment, and 7 (35%) had expired. Extra pelvic extension and tumour size were important prognostic factors in determining the outcome. Overall survival was 38.5 months. Conclusions Synchronous tumours tend to occur more frequently in young and parous women. Endometrial tumours synchronous to ovary were more common. It is important to recognise synchronous tumours as the postoperative adjuvant therapy can be tailored to achieve better survival. |
| abstractGer |
Background Synchronous gynaecological tumours, being a rare entity, cause a diagnostic and management conundrum for oncologists using the current criteria for diagnosis. Objective This study was conducted to identify the clinicopathological characteristics, treatment received and survival outcomes in women diagnosed with synchronous gynaecological cancers. Methods A retrospective analysis was performed of patients diagnosed with synchronous gynaecological malignancies between January 2011 and December 2015 of at least two of the following sites: endometrium, cervix or ovary. Data were collected from electronic medical records. Categorical data were analysed by X2 test and Fischer’s test as appropriate. Survival was plotted by Kaplan–Meier curves. Results The study identified 20 patients diagnosed with synchronous cancers during this time: 19 cases had synchronous carcinoma of endometrium and ovary and one of cervix and ovary. The mean age at diagnosis was 48.6 years. Mean BMI was 27.4 kg/$ m^{2} $. Commonest presenting symptom was lower abdominal pain in 85% of women. Commonest synchronous tumour was endometrioid tumours of both endometrium and ovary. All patients underwent surgery followed by adjuvant treatment; 14 (70%) had chemotherapy, while 5 (25%) had chemo radiation. Of the 20 patients in our study group, 11(55%) patients had complete response, 8 (40%) had recurred after complete treatment, and 7 (35%) had expired. Extra pelvic extension and tumour size were important prognostic factors in determining the outcome. Overall survival was 38.5 months. Conclusions Synchronous tumours tend to occur more frequently in young and parous women. Endometrial tumours synchronous to ovary were more common. It is important to recognise synchronous tumours as the postoperative adjuvant therapy can be tailored to achieve better survival. |
| abstract_unstemmed |
Background Synchronous gynaecological tumours, being a rare entity, cause a diagnostic and management conundrum for oncologists using the current criteria for diagnosis. Objective This study was conducted to identify the clinicopathological characteristics, treatment received and survival outcomes in women diagnosed with synchronous gynaecological cancers. Methods A retrospective analysis was performed of patients diagnosed with synchronous gynaecological malignancies between January 2011 and December 2015 of at least two of the following sites: endometrium, cervix or ovary. Data were collected from electronic medical records. Categorical data were analysed by X2 test and Fischer’s test as appropriate. Survival was plotted by Kaplan–Meier curves. Results The study identified 20 patients diagnosed with synchronous cancers during this time: 19 cases had synchronous carcinoma of endometrium and ovary and one of cervix and ovary. The mean age at diagnosis was 48.6 years. Mean BMI was 27.4 kg/$ m^{2} $. Commonest presenting symptom was lower abdominal pain in 85% of women. Commonest synchronous tumour was endometrioid tumours of both endometrium and ovary. All patients underwent surgery followed by adjuvant treatment; 14 (70%) had chemotherapy, while 5 (25%) had chemo radiation. Of the 20 patients in our study group, 11(55%) patients had complete response, 8 (40%) had recurred after complete treatment, and 7 (35%) had expired. Extra pelvic extension and tumour size were important prognostic factors in determining the outcome. Overall survival was 38.5 months. Conclusions Synchronous tumours tend to occur more frequently in young and parous women. Endometrial tumours synchronous to ovary were more common. It is important to recognise synchronous tumours as the postoperative adjuvant therapy can be tailored to achieve better survival. |
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Synchronous Tumours in Gynaecological Malignancies |
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Thomas, Anitha George, Rachel Sebastian, Ajit Thomas, Vinotha Thomas, Dhanya Susan Ram, Thomas Samuel Daniel, Sherin Karuppusami, Reka Peedicayil, Abraham |
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Thomas, Anitha George, Rachel Sebastian, Ajit Thomas, Vinotha Thomas, Dhanya Susan Ram, Thomas Samuel Daniel, Sherin Karuppusami, Reka Peedicayil, Abraham |
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10.1007/s40944-020-00399-3 |
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2024-07-04T01:06:03.808Z |
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| score |
7.3992662 |