Methylation of CpG sites in C1QTNF1 (C1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in Han population: a case–control study
Background ACS (acute coronary syndrome), a subgroup of coronary artery disease (CHD), is a leading cause of death worldwide. Reports shown the association between methylation and CHD, while the abnormal expression of C1QTNF1 (C1q and tumor necrosis factor related protein 1) in CHD patients, but the...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zhao, Xizhe [verfasserIn] Li, Yi [verfasserIn] Yan, Yan [verfasserIn] Ma, Xuelian [verfasserIn] Guo, Caixia [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Übergeordnetes Werk: |
Enthalten in: Genes & Genomics - The Genetics Society of Korea, 2010, 42(2020), 6 vom: 07. Mai, Seite 681-689 |
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| Übergeordnetes Werk: |
volume:42 ; year:2020 ; number:6 ; day:07 ; month:05 ; pages:681-689 |
| Links: |
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| DOI / URN: |
10.1007/s13258-020-00936-6 |
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SPR039771954 |
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| 245 | 1 | 0 | |a Methylation of CpG sites in C1QTNF1 (C1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in Han population: a case–control study |
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| 520 | |a Background ACS (acute coronary syndrome), a subgroup of coronary artery disease (CHD), is a leading cause of death worldwide. Reports shown the association between methylation and CHD, while the abnormal expression of C1QTNF1 (C1q and tumor necrosis factor related protein 1) in CHD patients, but the underlying mechanisms are still unclear. Objective To analyze the methylation of CpG sites of C1QTNF1 in ACS patients. Methods Peripheral blood samples were collected from healthy controls and ACS patients. The methylation of total C1QTNF1, promoter sequence and CpG sites of C1QTNF1 were measured using methylation detection kits. The outcomes were compared between patients and controls based on gender, clinical classification and clinical stages. Results The promoter sequences from 37 ACS patients and 20 controls indicate that the methylation rate of C1QTNF1 was significantly lower in male patients compared to healthy controls at + 63 CpG sites (p = 0.03). Whereas, the methylation rate of C1QTNF1 in female patients was significantly lower than female health controls at − 89, + 39 and + 167 CpG sites (p = 0.021, 0.042, 0.021). In addition, the methylation rate of C1QTNF1 was significantly higher in male patients than female patients at − 89, − 41 and + 39 CpG sites (p = 0.011, 0.043, 0.006). Moreover, the methylation rate significantly decreased at − 24 sites (p = 0.021), but it significantly increased at − 14 site (p = 0.048) in patients with UA, compared to patients with STEMI (ST-segment elevation myocardial infarction). Conclusions There were significant differences in the methylation rate + 63 CpG sites between controls and male ACS patients. The − 14 site methylation increased in patients with UA, compared to patients with STEMI. | ||
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10.1007/s13258-020-00936-6 doi (DE-627)SPR039771954 (SPR)s13258-020-00936-6-e DE-627 ger DE-627 rakwb eng Zhao, Xizhe verfasserin aut Methylation of CpG sites in C1QTNF1 (C1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in Han population: a case–control study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background ACS (acute coronary syndrome), a subgroup of coronary artery disease (CHD), is a leading cause of death worldwide. Reports shown the association between methylation and CHD, while the abnormal expression of C1QTNF1 (C1q and tumor necrosis factor related protein 1) in CHD patients, but the underlying mechanisms are still unclear. Objective To analyze the methylation of CpG sites of C1QTNF1 in ACS patients. Methods Peripheral blood samples were collected from healthy controls and ACS patients. The methylation of total C1QTNF1, promoter sequence and CpG sites of C1QTNF1 were measured using methylation detection kits. The outcomes were compared between patients and controls based on gender, clinical classification and clinical stages. Results The promoter sequences from 37 ACS patients and 20 controls indicate that the methylation rate of C1QTNF1 was significantly lower in male patients compared to healthy controls at + 63 CpG sites (p = 0.03). Whereas, the methylation rate of C1QTNF1 in female patients was significantly lower than female health controls at − 89, + 39 and + 167 CpG sites (p = 0.021, 0.042, 0.021). In addition, the methylation rate of C1QTNF1 was significantly higher in male patients than female patients at − 89, − 41 and + 39 CpG sites (p = 0.011, 0.043, 0.006). Moreover, the methylation rate significantly decreased at − 24 sites (p = 0.021), but it significantly increased at − 14 site (p = 0.048) in patients with UA, compared to patients with STEMI (ST-segment elevation myocardial infarction). Conclusions There were significant differences in the methylation rate + 63 CpG sites between controls and male ACS patients. The − 14 site methylation increased in patients with UA, compared to patients with STEMI. ACS (acute coronary syndrome) (dpeaa)DE-He213 Methylation (dpeaa)DE-He213 CpG sites (dpeaa)DE-He213 Gender (dpeaa)DE-He213 Li, Yi verfasserin aut Yan, Yan verfasserin aut Ma, Xuelian verfasserin aut Guo, Caixia verfasserin aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 42(2020), 6 vom: 07. Mai, Seite 681-689 (DE-627)SPR031096425 nnns volume:42 year:2020 number:6 day:07 month:05 pages:681-689 https://dx.doi.org/10.1007/s13258-020-00936-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 42 2020 6 07 05 681-689 |
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10.1007/s13258-020-00936-6 doi (DE-627)SPR039771954 (SPR)s13258-020-00936-6-e DE-627 ger DE-627 rakwb eng Zhao, Xizhe verfasserin aut Methylation of CpG sites in C1QTNF1 (C1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in Han population: a case–control study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background ACS (acute coronary syndrome), a subgroup of coronary artery disease (CHD), is a leading cause of death worldwide. Reports shown the association between methylation and CHD, while the abnormal expression of C1QTNF1 (C1q and tumor necrosis factor related protein 1) in CHD patients, but the underlying mechanisms are still unclear. Objective To analyze the methylation of CpG sites of C1QTNF1 in ACS patients. Methods Peripheral blood samples were collected from healthy controls and ACS patients. The methylation of total C1QTNF1, promoter sequence and CpG sites of C1QTNF1 were measured using methylation detection kits. The outcomes were compared between patients and controls based on gender, clinical classification and clinical stages. Results The promoter sequences from 37 ACS patients and 20 controls indicate that the methylation rate of C1QTNF1 was significantly lower in male patients compared to healthy controls at + 63 CpG sites (p = 0.03). Whereas, the methylation rate of C1QTNF1 in female patients was significantly lower than female health controls at − 89, + 39 and + 167 CpG sites (p = 0.021, 0.042, 0.021). In addition, the methylation rate of C1QTNF1 was significantly higher in male patients than female patients at − 89, − 41 and + 39 CpG sites (p = 0.011, 0.043, 0.006). Moreover, the methylation rate significantly decreased at − 24 sites (p = 0.021), but it significantly increased at − 14 site (p = 0.048) in patients with UA, compared to patients with STEMI (ST-segment elevation myocardial infarction). Conclusions There were significant differences in the methylation rate + 63 CpG sites between controls and male ACS patients. The − 14 site methylation increased in patients with UA, compared to patients with STEMI. ACS (acute coronary syndrome) (dpeaa)DE-He213 Methylation (dpeaa)DE-He213 CpG sites (dpeaa)DE-He213 Gender (dpeaa)DE-He213 Li, Yi verfasserin aut Yan, Yan verfasserin aut Ma, Xuelian verfasserin aut Guo, Caixia verfasserin aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 42(2020), 6 vom: 07. Mai, Seite 681-689 (DE-627)SPR031096425 nnns volume:42 year:2020 number:6 day:07 month:05 pages:681-689 https://dx.doi.org/10.1007/s13258-020-00936-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 42 2020 6 07 05 681-689 |
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10.1007/s13258-020-00936-6 doi (DE-627)SPR039771954 (SPR)s13258-020-00936-6-e DE-627 ger DE-627 rakwb eng Zhao, Xizhe verfasserin aut Methylation of CpG sites in C1QTNF1 (C1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in Han population: a case–control study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background ACS (acute coronary syndrome), a subgroup of coronary artery disease (CHD), is a leading cause of death worldwide. Reports shown the association between methylation and CHD, while the abnormal expression of C1QTNF1 (C1q and tumor necrosis factor related protein 1) in CHD patients, but the underlying mechanisms are still unclear. Objective To analyze the methylation of CpG sites of C1QTNF1 in ACS patients. Methods Peripheral blood samples were collected from healthy controls and ACS patients. The methylation of total C1QTNF1, promoter sequence and CpG sites of C1QTNF1 were measured using methylation detection kits. The outcomes were compared between patients and controls based on gender, clinical classification and clinical stages. Results The promoter sequences from 37 ACS patients and 20 controls indicate that the methylation rate of C1QTNF1 was significantly lower in male patients compared to healthy controls at + 63 CpG sites (p = 0.03). Whereas, the methylation rate of C1QTNF1 in female patients was significantly lower than female health controls at − 89, + 39 and + 167 CpG sites (p = 0.021, 0.042, 0.021). In addition, the methylation rate of C1QTNF1 was significantly higher in male patients than female patients at − 89, − 41 and + 39 CpG sites (p = 0.011, 0.043, 0.006). Moreover, the methylation rate significantly decreased at − 24 sites (p = 0.021), but it significantly increased at − 14 site (p = 0.048) in patients with UA, compared to patients with STEMI (ST-segment elevation myocardial infarction). Conclusions There were significant differences in the methylation rate + 63 CpG sites between controls and male ACS patients. The − 14 site methylation increased in patients with UA, compared to patients with STEMI. ACS (acute coronary syndrome) (dpeaa)DE-He213 Methylation (dpeaa)DE-He213 CpG sites (dpeaa)DE-He213 Gender (dpeaa)DE-He213 Li, Yi verfasserin aut Yan, Yan verfasserin aut Ma, Xuelian verfasserin aut Guo, Caixia verfasserin aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 42(2020), 6 vom: 07. Mai, Seite 681-689 (DE-627)SPR031096425 nnns volume:42 year:2020 number:6 day:07 month:05 pages:681-689 https://dx.doi.org/10.1007/s13258-020-00936-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 42 2020 6 07 05 681-689 |
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10.1007/s13258-020-00936-6 doi (DE-627)SPR039771954 (SPR)s13258-020-00936-6-e DE-627 ger DE-627 rakwb eng Zhao, Xizhe verfasserin aut Methylation of CpG sites in C1QTNF1 (C1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in Han population: a case–control study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background ACS (acute coronary syndrome), a subgroup of coronary artery disease (CHD), is a leading cause of death worldwide. Reports shown the association between methylation and CHD, while the abnormal expression of C1QTNF1 (C1q and tumor necrosis factor related protein 1) in CHD patients, but the underlying mechanisms are still unclear. Objective To analyze the methylation of CpG sites of C1QTNF1 in ACS patients. Methods Peripheral blood samples were collected from healthy controls and ACS patients. The methylation of total C1QTNF1, promoter sequence and CpG sites of C1QTNF1 were measured using methylation detection kits. The outcomes were compared between patients and controls based on gender, clinical classification and clinical stages. Results The promoter sequences from 37 ACS patients and 20 controls indicate that the methylation rate of C1QTNF1 was significantly lower in male patients compared to healthy controls at + 63 CpG sites (p = 0.03). Whereas, the methylation rate of C1QTNF1 in female patients was significantly lower than female health controls at − 89, + 39 and + 167 CpG sites (p = 0.021, 0.042, 0.021). In addition, the methylation rate of C1QTNF1 was significantly higher in male patients than female patients at − 89, − 41 and + 39 CpG sites (p = 0.011, 0.043, 0.006). Moreover, the methylation rate significantly decreased at − 24 sites (p = 0.021), but it significantly increased at − 14 site (p = 0.048) in patients with UA, compared to patients with STEMI (ST-segment elevation myocardial infarction). Conclusions There were significant differences in the methylation rate + 63 CpG sites between controls and male ACS patients. The − 14 site methylation increased in patients with UA, compared to patients with STEMI. ACS (acute coronary syndrome) (dpeaa)DE-He213 Methylation (dpeaa)DE-He213 CpG sites (dpeaa)DE-He213 Gender (dpeaa)DE-He213 Li, Yi verfasserin aut Yan, Yan verfasserin aut Ma, Xuelian verfasserin aut Guo, Caixia verfasserin aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 42(2020), 6 vom: 07. Mai, Seite 681-689 (DE-627)SPR031096425 nnns volume:42 year:2020 number:6 day:07 month:05 pages:681-689 https://dx.doi.org/10.1007/s13258-020-00936-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 42 2020 6 07 05 681-689 |
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10.1007/s13258-020-00936-6 doi (DE-627)SPR039771954 (SPR)s13258-020-00936-6-e DE-627 ger DE-627 rakwb eng Zhao, Xizhe verfasserin aut Methylation of CpG sites in C1QTNF1 (C1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in Han population: a case–control study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background ACS (acute coronary syndrome), a subgroup of coronary artery disease (CHD), is a leading cause of death worldwide. Reports shown the association between methylation and CHD, while the abnormal expression of C1QTNF1 (C1q and tumor necrosis factor related protein 1) in CHD patients, but the underlying mechanisms are still unclear. Objective To analyze the methylation of CpG sites of C1QTNF1 in ACS patients. Methods Peripheral blood samples were collected from healthy controls and ACS patients. The methylation of total C1QTNF1, promoter sequence and CpG sites of C1QTNF1 were measured using methylation detection kits. The outcomes were compared between patients and controls based on gender, clinical classification and clinical stages. Results The promoter sequences from 37 ACS patients and 20 controls indicate that the methylation rate of C1QTNF1 was significantly lower in male patients compared to healthy controls at + 63 CpG sites (p = 0.03). Whereas, the methylation rate of C1QTNF1 in female patients was significantly lower than female health controls at − 89, + 39 and + 167 CpG sites (p = 0.021, 0.042, 0.021). In addition, the methylation rate of C1QTNF1 was significantly higher in male patients than female patients at − 89, − 41 and + 39 CpG sites (p = 0.011, 0.043, 0.006). Moreover, the methylation rate significantly decreased at − 24 sites (p = 0.021), but it significantly increased at − 14 site (p = 0.048) in patients with UA, compared to patients with STEMI (ST-segment elevation myocardial infarction). Conclusions There were significant differences in the methylation rate + 63 CpG sites between controls and male ACS patients. The − 14 site methylation increased in patients with UA, compared to patients with STEMI. ACS (acute coronary syndrome) (dpeaa)DE-He213 Methylation (dpeaa)DE-He213 CpG sites (dpeaa)DE-He213 Gender (dpeaa)DE-He213 Li, Yi verfasserin aut Yan, Yan verfasserin aut Ma, Xuelian verfasserin aut Guo, Caixia verfasserin aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 42(2020), 6 vom: 07. Mai, Seite 681-689 (DE-627)SPR031096425 nnns volume:42 year:2020 number:6 day:07 month:05 pages:681-689 https://dx.doi.org/10.1007/s13258-020-00936-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 42 2020 6 07 05 681-689 |
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Reports shown the association between methylation and CHD, while the abnormal expression of C1QTNF1 (C1q and tumor necrosis factor related protein 1) in CHD patients, but the underlying mechanisms are still unclear. Objective To analyze the methylation of CpG sites of C1QTNF1 in ACS patients. Methods Peripheral blood samples were collected from healthy controls and ACS patients. The methylation of total C1QTNF1, promoter sequence and CpG sites of C1QTNF1 were measured using methylation detection kits. The outcomes were compared between patients and controls based on gender, clinical classification and clinical stages. Results The promoter sequences from 37 ACS patients and 20 controls indicate that the methylation rate of C1QTNF1 was significantly lower in male patients compared to healthy controls at + 63 CpG sites (p = 0.03). Whereas, the methylation rate of C1QTNF1 in female patients was significantly lower than female health controls at − 89, + 39 and + 167 CpG sites (p = 0.021, 0.042, 0.021). In addition, the methylation rate of C1QTNF1 was significantly higher in male patients than female patients at − 89, − 41 and + 39 CpG sites (p = 0.011, 0.043, 0.006). Moreover, the methylation rate significantly decreased at − 24 sites (p = 0.021), but it significantly increased at − 14 site (p = 0.048) in patients with UA, compared to patients with STEMI (ST-segment elevation myocardial infarction). Conclusions There were significant differences in the methylation rate + 63 CpG sites between controls and male ACS patients. 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Methylation of CpG sites in C1QTNF1 (C1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in Han population: a case–control study ACS (acute coronary syndrome) (dpeaa)DE-He213 Methylation (dpeaa)DE-He213 CpG sites (dpeaa)DE-He213 Gender (dpeaa)DE-He213 |
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Methylation of CpG sites in C1QTNF1 (C1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in Han population: a case–control study |
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Methylation of CpG sites in C1QTNF1 (C1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in Han population: a case–control study |
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Zhao, Xizhe |
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2020 |
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Zhao, Xizhe Li, Yi Yan, Yan Ma, Xuelian Guo, Caixia |
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Zhao, Xizhe |
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methylation of cpg sites in c1qtnf1 (c1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in han population: a case–control study |
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Methylation of CpG sites in C1QTNF1 (C1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in Han population: a case–control study |
| abstract |
Background ACS (acute coronary syndrome), a subgroup of coronary artery disease (CHD), is a leading cause of death worldwide. Reports shown the association between methylation and CHD, while the abnormal expression of C1QTNF1 (C1q and tumor necrosis factor related protein 1) in CHD patients, but the underlying mechanisms are still unclear. Objective To analyze the methylation of CpG sites of C1QTNF1 in ACS patients. Methods Peripheral blood samples were collected from healthy controls and ACS patients. The methylation of total C1QTNF1, promoter sequence and CpG sites of C1QTNF1 were measured using methylation detection kits. The outcomes were compared between patients and controls based on gender, clinical classification and clinical stages. Results The promoter sequences from 37 ACS patients and 20 controls indicate that the methylation rate of C1QTNF1 was significantly lower in male patients compared to healthy controls at + 63 CpG sites (p = 0.03). Whereas, the methylation rate of C1QTNF1 in female patients was significantly lower than female health controls at − 89, + 39 and + 167 CpG sites (p = 0.021, 0.042, 0.021). In addition, the methylation rate of C1QTNF1 was significantly higher in male patients than female patients at − 89, − 41 and + 39 CpG sites (p = 0.011, 0.043, 0.006). Moreover, the methylation rate significantly decreased at − 24 sites (p = 0.021), but it significantly increased at − 14 site (p = 0.048) in patients with UA, compared to patients with STEMI (ST-segment elevation myocardial infarction). Conclusions There were significant differences in the methylation rate + 63 CpG sites between controls and male ACS patients. The − 14 site methylation increased in patients with UA, compared to patients with STEMI. |
| abstractGer |
Background ACS (acute coronary syndrome), a subgroup of coronary artery disease (CHD), is a leading cause of death worldwide. Reports shown the association between methylation and CHD, while the abnormal expression of C1QTNF1 (C1q and tumor necrosis factor related protein 1) in CHD patients, but the underlying mechanisms are still unclear. Objective To analyze the methylation of CpG sites of C1QTNF1 in ACS patients. Methods Peripheral blood samples were collected from healthy controls and ACS patients. The methylation of total C1QTNF1, promoter sequence and CpG sites of C1QTNF1 were measured using methylation detection kits. The outcomes were compared between patients and controls based on gender, clinical classification and clinical stages. Results The promoter sequences from 37 ACS patients and 20 controls indicate that the methylation rate of C1QTNF1 was significantly lower in male patients compared to healthy controls at + 63 CpG sites (p = 0.03). Whereas, the methylation rate of C1QTNF1 in female patients was significantly lower than female health controls at − 89, + 39 and + 167 CpG sites (p = 0.021, 0.042, 0.021). In addition, the methylation rate of C1QTNF1 was significantly higher in male patients than female patients at − 89, − 41 and + 39 CpG sites (p = 0.011, 0.043, 0.006). Moreover, the methylation rate significantly decreased at − 24 sites (p = 0.021), but it significantly increased at − 14 site (p = 0.048) in patients with UA, compared to patients with STEMI (ST-segment elevation myocardial infarction). Conclusions There were significant differences in the methylation rate + 63 CpG sites between controls and male ACS patients. The − 14 site methylation increased in patients with UA, compared to patients with STEMI. |
| abstract_unstemmed |
Background ACS (acute coronary syndrome), a subgroup of coronary artery disease (CHD), is a leading cause of death worldwide. Reports shown the association between methylation and CHD, while the abnormal expression of C1QTNF1 (C1q and tumor necrosis factor related protein 1) in CHD patients, but the underlying mechanisms are still unclear. Objective To analyze the methylation of CpG sites of C1QTNF1 in ACS patients. Methods Peripheral blood samples were collected from healthy controls and ACS patients. The methylation of total C1QTNF1, promoter sequence and CpG sites of C1QTNF1 were measured using methylation detection kits. The outcomes were compared between patients and controls based on gender, clinical classification and clinical stages. Results The promoter sequences from 37 ACS patients and 20 controls indicate that the methylation rate of C1QTNF1 was significantly lower in male patients compared to healthy controls at + 63 CpG sites (p = 0.03). Whereas, the methylation rate of C1QTNF1 in female patients was significantly lower than female health controls at − 89, + 39 and + 167 CpG sites (p = 0.021, 0.042, 0.021). In addition, the methylation rate of C1QTNF1 was significantly higher in male patients than female patients at − 89, − 41 and + 39 CpG sites (p = 0.011, 0.043, 0.006). Moreover, the methylation rate significantly decreased at − 24 sites (p = 0.021), but it significantly increased at − 14 site (p = 0.048) in patients with UA, compared to patients with STEMI (ST-segment elevation myocardial infarction). Conclusions There were significant differences in the methylation rate + 63 CpG sites between controls and male ACS patients. The − 14 site methylation increased in patients with UA, compared to patients with STEMI. |
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Methylation of CpG sites in C1QTNF1 (C1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in Han population: a case–control study |
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https://dx.doi.org/10.1007/s13258-020-00936-6 |
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Li, Yi Yan, Yan Ma, Xuelian Guo, Caixia |
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