Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series
Abstract Clozapine is an effective antipsychotic that can lead to symptom resolution and functional recovery in patients with schizophrenia. Its available pregnancy safety data remain limited, which presents a challenge for clinicians managing women of reproductive age on clozapine. We retrospective...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Nguyen, Thinh [verfasserIn] Mordecai, Jasmine [verfasserIn] Watt, Felice [verfasserIn] Frayne, Jacqueline [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2019 |
|---|
| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
Enthalten in: Archives of Women's Mental Health - Springer-Verlag, 2002, 23(2019), 3 vom: 15. Juni, Seite 441-445 |
|---|---|
| Übergeordnetes Werk: |
volume:23 ; year:2019 ; number:3 ; day:15 ; month:06 ; pages:441-445 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00737-019-00985-1 |
|---|
| Katalog-ID: |
SPR039795292 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR039795292 | ||
| 003 | DE-627 | ||
| 005 | 20201126014019.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201007s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00737-019-00985-1 |2 doi | |
| 035 | |a (DE-627)SPR039795292 | ||
| 035 | |a (SPR)s00737-019-00985-1-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Nguyen, Thinh |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract Clozapine is an effective antipsychotic that can lead to symptom resolution and functional recovery in patients with schizophrenia. Its available pregnancy safety data remain limited, which presents a challenge for clinicians managing women of reproductive age on clozapine. We retrospectively studied a consecutive case series of nine pregnancies where there was clozapine exposure. Our case series demonstrates that pregnant women on clozapine treatment can remain stable psychiatrically, but are vulnerable obstetrically, with high rates of obesity and gestational diabetes. Their babies also have poor neonatal adjustment, often requiring neonatal resuscitation. Furthermore, we report on clozapine-related side effects, changes in clozapine levels during pregnancy as well as variation in foetal wellbeing monitoring. These findings have implications for pregnancy care for women taking clozapine and require further exploration. | ||
| 650 | 4 | |a Clozapine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pregnancy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Obstetric complication |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neonatal complication |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Mordecai, Jasmine |e verfasserin |4 aut | |
| 700 | 1 | |a Watt, Felice |e verfasserin |4 aut | |
| 700 | 1 | |a Frayne, Jacqueline |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Archives of Women's Mental Health |d Springer-Verlag, 2002 |g 23(2019), 3 vom: 15. Juni, Seite 441-445 |w (DE-627)SPR007667299 |7 nnns |
| 773 | 1 | 8 | |g volume:23 |g year:2019 |g number:3 |g day:15 |g month:06 |g pages:441-445 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s00737-019-00985-1 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 951 | |a AR | ||
| 952 | |d 23 |j 2019 |e 3 |b 15 |c 06 |h 441-445 | ||
| author_variant |
t n tn j m jm f w fw j f jf |
|---|---|
| matchkey_str |
nguyenthinhmordecaijasminewattfelicefray:2019----:bttiadentlucmsflzpnepsripennyc |
| hierarchy_sort_str |
2019 |
| publishDate |
2019 |
| allfields |
10.1007/s00737-019-00985-1 doi (DE-627)SPR039795292 (SPR)s00737-019-00985-1-e DE-627 ger DE-627 rakwb eng Nguyen, Thinh verfasserin aut Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Clozapine is an effective antipsychotic that can lead to symptom resolution and functional recovery in patients with schizophrenia. Its available pregnancy safety data remain limited, which presents a challenge for clinicians managing women of reproductive age on clozapine. We retrospectively studied a consecutive case series of nine pregnancies where there was clozapine exposure. Our case series demonstrates that pregnant women on clozapine treatment can remain stable psychiatrically, but are vulnerable obstetrically, with high rates of obesity and gestational diabetes. Their babies also have poor neonatal adjustment, often requiring neonatal resuscitation. Furthermore, we report on clozapine-related side effects, changes in clozapine levels during pregnancy as well as variation in foetal wellbeing monitoring. These findings have implications for pregnancy care for women taking clozapine and require further exploration. Clozapine (dpeaa)DE-He213 Pregnancy (dpeaa)DE-He213 Obstetric complication (dpeaa)DE-He213 Neonatal complication (dpeaa)DE-He213 Mordecai, Jasmine verfasserin aut Watt, Felice verfasserin aut Frayne, Jacqueline verfasserin aut Enthalten in Archives of Women's Mental Health Springer-Verlag, 2002 23(2019), 3 vom: 15. Juni, Seite 441-445 (DE-627)SPR007667299 nnns volume:23 year:2019 number:3 day:15 month:06 pages:441-445 https://dx.doi.org/10.1007/s00737-019-00985-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 23 2019 3 15 06 441-445 |
| spelling |
10.1007/s00737-019-00985-1 doi (DE-627)SPR039795292 (SPR)s00737-019-00985-1-e DE-627 ger DE-627 rakwb eng Nguyen, Thinh verfasserin aut Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Clozapine is an effective antipsychotic that can lead to symptom resolution and functional recovery in patients with schizophrenia. Its available pregnancy safety data remain limited, which presents a challenge for clinicians managing women of reproductive age on clozapine. We retrospectively studied a consecutive case series of nine pregnancies where there was clozapine exposure. Our case series demonstrates that pregnant women on clozapine treatment can remain stable psychiatrically, but are vulnerable obstetrically, with high rates of obesity and gestational diabetes. Their babies also have poor neonatal adjustment, often requiring neonatal resuscitation. Furthermore, we report on clozapine-related side effects, changes in clozapine levels during pregnancy as well as variation in foetal wellbeing monitoring. These findings have implications for pregnancy care for women taking clozapine and require further exploration. Clozapine (dpeaa)DE-He213 Pregnancy (dpeaa)DE-He213 Obstetric complication (dpeaa)DE-He213 Neonatal complication (dpeaa)DE-He213 Mordecai, Jasmine verfasserin aut Watt, Felice verfasserin aut Frayne, Jacqueline verfasserin aut Enthalten in Archives of Women's Mental Health Springer-Verlag, 2002 23(2019), 3 vom: 15. Juni, Seite 441-445 (DE-627)SPR007667299 nnns volume:23 year:2019 number:3 day:15 month:06 pages:441-445 https://dx.doi.org/10.1007/s00737-019-00985-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 23 2019 3 15 06 441-445 |
| allfields_unstemmed |
10.1007/s00737-019-00985-1 doi (DE-627)SPR039795292 (SPR)s00737-019-00985-1-e DE-627 ger DE-627 rakwb eng Nguyen, Thinh verfasserin aut Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Clozapine is an effective antipsychotic that can lead to symptom resolution and functional recovery in patients with schizophrenia. Its available pregnancy safety data remain limited, which presents a challenge for clinicians managing women of reproductive age on clozapine. We retrospectively studied a consecutive case series of nine pregnancies where there was clozapine exposure. Our case series demonstrates that pregnant women on clozapine treatment can remain stable psychiatrically, but are vulnerable obstetrically, with high rates of obesity and gestational diabetes. Their babies also have poor neonatal adjustment, often requiring neonatal resuscitation. Furthermore, we report on clozapine-related side effects, changes in clozapine levels during pregnancy as well as variation in foetal wellbeing monitoring. These findings have implications for pregnancy care for women taking clozapine and require further exploration. Clozapine (dpeaa)DE-He213 Pregnancy (dpeaa)DE-He213 Obstetric complication (dpeaa)DE-He213 Neonatal complication (dpeaa)DE-He213 Mordecai, Jasmine verfasserin aut Watt, Felice verfasserin aut Frayne, Jacqueline verfasserin aut Enthalten in Archives of Women's Mental Health Springer-Verlag, 2002 23(2019), 3 vom: 15. Juni, Seite 441-445 (DE-627)SPR007667299 nnns volume:23 year:2019 number:3 day:15 month:06 pages:441-445 https://dx.doi.org/10.1007/s00737-019-00985-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 23 2019 3 15 06 441-445 |
| allfieldsGer |
10.1007/s00737-019-00985-1 doi (DE-627)SPR039795292 (SPR)s00737-019-00985-1-e DE-627 ger DE-627 rakwb eng Nguyen, Thinh verfasserin aut Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Clozapine is an effective antipsychotic that can lead to symptom resolution and functional recovery in patients with schizophrenia. Its available pregnancy safety data remain limited, which presents a challenge for clinicians managing women of reproductive age on clozapine. We retrospectively studied a consecutive case series of nine pregnancies where there was clozapine exposure. Our case series demonstrates that pregnant women on clozapine treatment can remain stable psychiatrically, but are vulnerable obstetrically, with high rates of obesity and gestational diabetes. Their babies also have poor neonatal adjustment, often requiring neonatal resuscitation. Furthermore, we report on clozapine-related side effects, changes in clozapine levels during pregnancy as well as variation in foetal wellbeing monitoring. These findings have implications for pregnancy care for women taking clozapine and require further exploration. Clozapine (dpeaa)DE-He213 Pregnancy (dpeaa)DE-He213 Obstetric complication (dpeaa)DE-He213 Neonatal complication (dpeaa)DE-He213 Mordecai, Jasmine verfasserin aut Watt, Felice verfasserin aut Frayne, Jacqueline verfasserin aut Enthalten in Archives of Women's Mental Health Springer-Verlag, 2002 23(2019), 3 vom: 15. Juni, Seite 441-445 (DE-627)SPR007667299 nnns volume:23 year:2019 number:3 day:15 month:06 pages:441-445 https://dx.doi.org/10.1007/s00737-019-00985-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 23 2019 3 15 06 441-445 |
| allfieldsSound |
10.1007/s00737-019-00985-1 doi (DE-627)SPR039795292 (SPR)s00737-019-00985-1-e DE-627 ger DE-627 rakwb eng Nguyen, Thinh verfasserin aut Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Clozapine is an effective antipsychotic that can lead to symptom resolution and functional recovery in patients with schizophrenia. Its available pregnancy safety data remain limited, which presents a challenge for clinicians managing women of reproductive age on clozapine. We retrospectively studied a consecutive case series of nine pregnancies where there was clozapine exposure. Our case series demonstrates that pregnant women on clozapine treatment can remain stable psychiatrically, but are vulnerable obstetrically, with high rates of obesity and gestational diabetes. Their babies also have poor neonatal adjustment, often requiring neonatal resuscitation. Furthermore, we report on clozapine-related side effects, changes in clozapine levels during pregnancy as well as variation in foetal wellbeing monitoring. These findings have implications for pregnancy care for women taking clozapine and require further exploration. Clozapine (dpeaa)DE-He213 Pregnancy (dpeaa)DE-He213 Obstetric complication (dpeaa)DE-He213 Neonatal complication (dpeaa)DE-He213 Mordecai, Jasmine verfasserin aut Watt, Felice verfasserin aut Frayne, Jacqueline verfasserin aut Enthalten in Archives of Women's Mental Health Springer-Verlag, 2002 23(2019), 3 vom: 15. Juni, Seite 441-445 (DE-627)SPR007667299 nnns volume:23 year:2019 number:3 day:15 month:06 pages:441-445 https://dx.doi.org/10.1007/s00737-019-00985-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 23 2019 3 15 06 441-445 |
| language |
English |
| source |
Enthalten in Archives of Women's Mental Health 23(2019), 3 vom: 15. Juni, Seite 441-445 volume:23 year:2019 number:3 day:15 month:06 pages:441-445 |
| sourceStr |
Enthalten in Archives of Women's Mental Health 23(2019), 3 vom: 15. Juni, Seite 441-445 volume:23 year:2019 number:3 day:15 month:06 pages:441-445 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Clozapine Pregnancy Obstetric complication Neonatal complication |
| isfreeaccess_bool |
false |
| container_title |
Archives of Women's Mental Health |
| authorswithroles_txt_mv |
Nguyen, Thinh @@aut@@ Mordecai, Jasmine @@aut@@ Watt, Felice @@aut@@ Frayne, Jacqueline @@aut@@ |
| publishDateDaySort_date |
2019-06-15T00:00:00Z |
| hierarchy_top_id |
SPR007667299 |
| id |
SPR039795292 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR039795292</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20201126014019.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00737-019-00985-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR039795292</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00737-019-00985-1-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Nguyen, Thinh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Clozapine is an effective antipsychotic that can lead to symptom resolution and functional recovery in patients with schizophrenia. Its available pregnancy safety data remain limited, which presents a challenge for clinicians managing women of reproductive age on clozapine. We retrospectively studied a consecutive case series of nine pregnancies where there was clozapine exposure. Our case series demonstrates that pregnant women on clozapine treatment can remain stable psychiatrically, but are vulnerable obstetrically, with high rates of obesity and gestational diabetes. Their babies also have poor neonatal adjustment, often requiring neonatal resuscitation. Furthermore, we report on clozapine-related side effects, changes in clozapine levels during pregnancy as well as variation in foetal wellbeing monitoring. These findings have implications for pregnancy care for women taking clozapine and require further exploration.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Clozapine</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pregnancy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Obstetric complication</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neonatal complication</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mordecai, Jasmine</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Watt, Felice</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Frayne, Jacqueline</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Archives of Women's Mental Health</subfield><subfield code="d">Springer-Verlag, 2002</subfield><subfield code="g">23(2019), 3 vom: 15. Juni, Seite 441-445</subfield><subfield code="w">(DE-627)SPR007667299</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:23</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:3</subfield><subfield code="g">day:15</subfield><subfield code="g">month:06</subfield><subfield code="g">pages:441-445</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s00737-019-00985-1</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">23</subfield><subfield code="j">2019</subfield><subfield code="e">3</subfield><subfield code="b">15</subfield><subfield code="c">06</subfield><subfield code="h">441-445</subfield></datafield></record></collection>
|
| author |
Nguyen, Thinh |
| spellingShingle |
Nguyen, Thinh misc Clozapine misc Pregnancy misc Obstetric complication misc Neonatal complication Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series |
| authorStr |
Nguyen, Thinh |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)SPR007667299 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut |
| collection |
springer |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series Clozapine (dpeaa)DE-He213 Pregnancy (dpeaa)DE-He213 Obstetric complication (dpeaa)DE-He213 Neonatal complication (dpeaa)DE-He213 |
| topic |
misc Clozapine misc Pregnancy misc Obstetric complication misc Neonatal complication |
| topic_unstemmed |
misc Clozapine misc Pregnancy misc Obstetric complication misc Neonatal complication |
| topic_browse |
misc Clozapine misc Pregnancy misc Obstetric complication misc Neonatal complication |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Archives of Women's Mental Health |
| hierarchy_parent_id |
SPR007667299 |
| hierarchy_top_title |
Archives of Women's Mental Health |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)SPR007667299 |
| title |
Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series |
| ctrlnum |
(DE-627)SPR039795292 (SPR)s00737-019-00985-1-e |
| title_full |
Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series |
| author_sort |
Nguyen, Thinh |
| journal |
Archives of Women's Mental Health |
| journalStr |
Archives of Women's Mental Health |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
2019 |
| contenttype_str_mv |
txt |
| container_start_page |
441 |
| author_browse |
Nguyen, Thinh Mordecai, Jasmine Watt, Felice Frayne, Jacqueline |
| container_volume |
23 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Nguyen, Thinh |
| doi_str_mv |
10.1007/s00737-019-00985-1 |
| author2-role |
verfasserin |
| title_sort |
obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series |
| title_auth |
Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series |
| abstract |
Abstract Clozapine is an effective antipsychotic that can lead to symptom resolution and functional recovery in patients with schizophrenia. Its available pregnancy safety data remain limited, which presents a challenge for clinicians managing women of reproductive age on clozapine. We retrospectively studied a consecutive case series of nine pregnancies where there was clozapine exposure. Our case series demonstrates that pregnant women on clozapine treatment can remain stable psychiatrically, but are vulnerable obstetrically, with high rates of obesity and gestational diabetes. Their babies also have poor neonatal adjustment, often requiring neonatal resuscitation. Furthermore, we report on clozapine-related side effects, changes in clozapine levels during pregnancy as well as variation in foetal wellbeing monitoring. These findings have implications for pregnancy care for women taking clozapine and require further exploration. |
| abstractGer |
Abstract Clozapine is an effective antipsychotic that can lead to symptom resolution and functional recovery in patients with schizophrenia. Its available pregnancy safety data remain limited, which presents a challenge for clinicians managing women of reproductive age on clozapine. We retrospectively studied a consecutive case series of nine pregnancies where there was clozapine exposure. Our case series demonstrates that pregnant women on clozapine treatment can remain stable psychiatrically, but are vulnerable obstetrically, with high rates of obesity and gestational diabetes. Their babies also have poor neonatal adjustment, often requiring neonatal resuscitation. Furthermore, we report on clozapine-related side effects, changes in clozapine levels during pregnancy as well as variation in foetal wellbeing monitoring. These findings have implications for pregnancy care for women taking clozapine and require further exploration. |
| abstract_unstemmed |
Abstract Clozapine is an effective antipsychotic that can lead to symptom resolution and functional recovery in patients with schizophrenia. Its available pregnancy safety data remain limited, which presents a challenge for clinicians managing women of reproductive age on clozapine. We retrospectively studied a consecutive case series of nine pregnancies where there was clozapine exposure. Our case series demonstrates that pregnant women on clozapine treatment can remain stable psychiatrically, but are vulnerable obstetrically, with high rates of obesity and gestational diabetes. Their babies also have poor neonatal adjustment, often requiring neonatal resuscitation. Furthermore, we report on clozapine-related side effects, changes in clozapine levels during pregnancy as well as variation in foetal wellbeing monitoring. These findings have implications for pregnancy care for women taking clozapine and require further exploration. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER |
| container_issue |
3 |
| title_short |
Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series |
| url |
https://dx.doi.org/10.1007/s00737-019-00985-1 |
| remote_bool |
true |
| author2 |
Mordecai, Jasmine Watt, Felice Frayne, Jacqueline |
| author2Str |
Mordecai, Jasmine Watt, Felice Frayne, Jacqueline |
| ppnlink |
SPR007667299 |
| mediatype_str_mv |
c |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1007/s00737-019-00985-1 |
| up_date |
2024-07-04T01:36:18.912Z |
| _version_ |
1803610466720677888 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR039795292</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20201126014019.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00737-019-00985-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR039795292</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00737-019-00985-1-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Nguyen, Thinh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Clozapine is an effective antipsychotic that can lead to symptom resolution and functional recovery in patients with schizophrenia. Its available pregnancy safety data remain limited, which presents a challenge for clinicians managing women of reproductive age on clozapine. We retrospectively studied a consecutive case series of nine pregnancies where there was clozapine exposure. Our case series demonstrates that pregnant women on clozapine treatment can remain stable psychiatrically, but are vulnerable obstetrically, with high rates of obesity and gestational diabetes. Their babies also have poor neonatal adjustment, often requiring neonatal resuscitation. Furthermore, we report on clozapine-related side effects, changes in clozapine levels during pregnancy as well as variation in foetal wellbeing monitoring. These findings have implications for pregnancy care for women taking clozapine and require further exploration.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Clozapine</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pregnancy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Obstetric complication</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neonatal complication</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mordecai, Jasmine</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Watt, Felice</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Frayne, Jacqueline</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Archives of Women's Mental Health</subfield><subfield code="d">Springer-Verlag, 2002</subfield><subfield code="g">23(2019), 3 vom: 15. Juni, Seite 441-445</subfield><subfield code="w">(DE-627)SPR007667299</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:23</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:3</subfield><subfield code="g">day:15</subfield><subfield code="g">month:06</subfield><subfield code="g">pages:441-445</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s00737-019-00985-1</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">23</subfield><subfield code="j">2019</subfield><subfield code="e">3</subfield><subfield code="b">15</subfield><subfield code="c">06</subfield><subfield code="h">441-445</subfield></datafield></record></collection>
|
| score |
7.4013834 |