The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients
Abstract The TANDEM investigation was carried out in 17 Italian Movement Disorder centers on behalf of a joint initiative of neurologist members of the Italian Academy for Parkinson’s disease and Movement Disorders (LIMPE-DISMOV Academy) and gastroenterologist members of the Italian Society of Diges...
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| Autor*in: |
Antonini, Angelo [verfasserIn] Abbruzzese, Giovanni [verfasserIn] Berardelli, Alfredo [verfasserIn] Modugno, Nicola [verfasserIn] Stroppa, Italo [verfasserIn] Tamma, Filippo [verfasserIn] Sensi, Mariachiara [verfasserIn] Mancini, Francesca [verfasserIn] Cossu, Giovanni [verfasserIn] Stefani, Alessandro [verfasserIn] Tambasco, Nicola [verfasserIn] Tessitore, Alessandro [verfasserIn] Fabbrini, Giovanni [verfasserIn] Pontieri, Francesco E. [verfasserIn] Solla, Paolo [verfasserIn] Bentivoglio, Anna Rita [verfasserIn] Comi, Cristoforo [verfasserIn] Minafra, Brigida [verfasserIn] Riboldazzi, Giulio [verfasserIn] Melchionda, Donato [verfasserIn] Martino, Tommaso [verfasserIn] Lopiano, Leonardo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of neural transmission - Wien [u.a.] : Springer, 1950, 127(2020), 6 vom: 24. März, Seite 881-891 |
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| Übergeordnetes Werk: |
volume:127 ; year:2020 ; number:6 ; day:24 ; month:03 ; pages:881-891 |
| Links: |
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| DOI / URN: |
10.1007/s00702-020-02175-1 |
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| Katalog-ID: |
SPR039822370 |
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| 245 | 1 | 4 | |a The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients |
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| 520 | |a Abstract The TANDEM investigation was carried out in 17 Italian Movement Disorder centers on behalf of a joint initiative of neurologist members of the Italian Academy for Parkinson’s disease and Movement Disorders (LIMPE-DISMOV Academy) and gastroenterologist members of the Italian Society of Digestive Endoscopy (SIED) to evaluate the efficacy and tolerability of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced Parkinson's disease (PD) in routine medical care. Motor scores in “ON” and OFF” state (UPDRS-III), complications of therapy (UPDRS-IV), activities of daily living, sleep disorders and quality of life were evaluated at baseline and at two follow-up assessments (FUV1 and FUV2) within the initial 12-month LCIG treatment. In 159 patients (55% males) with a mean age of 69.1 ± 6.6 years and a diagnosis of PD since 13.6 ± 5.5 years, the UPDRS-III total score (in “OFF”) decreased from baseline (45.8 ± 13.2) to FUV1 (41.0 ± 17.4; p < 0.001) and FUV2 (40.5 ± 15.5; p < 0.001), the UPDRS-IV total score decreased from baseline (8.8 ± 2.9) to FUV1 (5.1 ± 3.4; p < 0.001) and FUV2 (5.5 ± 3.2; p < 0.001). The percentage of patients exhibiting freezing, dystonia, gait/walking disturbances, falls, pain and sleep disorders was significantly reduced. Twenty-eight device complications were reported and 11 (6.9%) patients prematurely terminated the study. LCIG after 12-month treatment led to sustained improvement of time spent in “OFF”, complications of therapy, PD-associated symptoms and sleep disorders. LCIG tolerability was consistent with the established safety profile of LCIG. | ||
| 650 | 4 | |a Parkinson’s disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Levodopa-carbidopa intestinal gel |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Motor symptoms |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Quality of life |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Routine patient follow-up |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Abbruzzese, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Berardelli, Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Modugno, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Stroppa, Italo |e verfasserin |4 aut | |
| 700 | 1 | |a Tamma, Filippo |e verfasserin |4 aut | |
| 700 | 1 | |a Sensi, Mariachiara |e verfasserin |4 aut | |
| 700 | 1 | |a Mancini, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Cossu, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Stefani, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Tambasco, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Tessitore, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Fabbrini, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Pontieri, Francesco E. |e verfasserin |4 aut | |
| 700 | 1 | |a Solla, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Bentivoglio, Anna Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Comi, Cristoforo |e verfasserin |4 aut | |
| 700 | 1 | |a Minafra, Brigida |e verfasserin |4 aut | |
| 700 | 1 | |a Riboldazzi, Giulio |e verfasserin |4 aut | |
| 700 | 1 | |a Melchionda, Donato |e verfasserin |4 aut | |
| 700 | 1 | |a Martino, Tommaso |e verfasserin |4 aut | |
| 700 | 1 | |a Lopiano, Leonardo |e verfasserin |4 aut | |
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10.1007/s00702-020-02175-1 doi (DE-627)SPR039822370 (SPR)s00702-020-02175-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Antonini, Angelo verfasserin aut The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The TANDEM investigation was carried out in 17 Italian Movement Disorder centers on behalf of a joint initiative of neurologist members of the Italian Academy for Parkinson’s disease and Movement Disorders (LIMPE-DISMOV Academy) and gastroenterologist members of the Italian Society of Digestive Endoscopy (SIED) to evaluate the efficacy and tolerability of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced Parkinson's disease (PD) in routine medical care. Motor scores in “ON” and OFF” state (UPDRS-III), complications of therapy (UPDRS-IV), activities of daily living, sleep disorders and quality of life were evaluated at baseline and at two follow-up assessments (FUV1 and FUV2) within the initial 12-month LCIG treatment. In 159 patients (55% males) with a mean age of 69.1 ± 6.6 years and a diagnosis of PD since 13.6 ± 5.5 years, the UPDRS-III total score (in “OFF”) decreased from baseline (45.8 ± 13.2) to FUV1 (41.0 ± 17.4; p < 0.001) and FUV2 (40.5 ± 15.5; p < 0.001), the UPDRS-IV total score decreased from baseline (8.8 ± 2.9) to FUV1 (5.1 ± 3.4; p < 0.001) and FUV2 (5.5 ± 3.2; p < 0.001). The percentage of patients exhibiting freezing, dystonia, gait/walking disturbances, falls, pain and sleep disorders was significantly reduced. Twenty-eight device complications were reported and 11 (6.9%) patients prematurely terminated the study. LCIG after 12-month treatment led to sustained improvement of time spent in “OFF”, complications of therapy, PD-associated symptoms and sleep disorders. LCIG tolerability was consistent with the established safety profile of LCIG. Parkinson’s disease (dpeaa)DE-He213 Levodopa-carbidopa intestinal gel (dpeaa)DE-He213 Motor symptoms (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Routine patient follow-up (dpeaa)DE-He213 Abbruzzese, Giovanni verfasserin aut Berardelli, Alfredo verfasserin aut Modugno, Nicola verfasserin aut Stroppa, Italo verfasserin aut Tamma, Filippo verfasserin aut Sensi, Mariachiara verfasserin aut Mancini, Francesca verfasserin aut Cossu, Giovanni verfasserin aut Stefani, Alessandro verfasserin aut Tambasco, Nicola verfasserin aut Tessitore, Alessandro verfasserin aut Fabbrini, Giovanni verfasserin aut Pontieri, Francesco E. verfasserin aut Solla, Paolo verfasserin aut Bentivoglio, Anna Rita verfasserin aut Comi, Cristoforo verfasserin aut Minafra, Brigida verfasserin aut Riboldazzi, Giulio verfasserin aut Melchionda, Donato verfasserin aut Martino, Tommaso verfasserin aut Lopiano, Leonardo verfasserin aut Enthalten in Journal of neural transmission Wien [u.a.] : Springer, 1950 127(2020), 6 vom: 24. März, Seite 881-891 (DE-627)300185901 (DE-600)1481655-6 1435-1463 nnns volume:127 year:2020 number:6 day:24 month:03 pages:881-891 https://dx.doi.org/10.1007/s00702-020-02175-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 127 2020 6 24 03 881-891 |
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10.1007/s00702-020-02175-1 doi (DE-627)SPR039822370 (SPR)s00702-020-02175-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Antonini, Angelo verfasserin aut The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The TANDEM investigation was carried out in 17 Italian Movement Disorder centers on behalf of a joint initiative of neurologist members of the Italian Academy for Parkinson’s disease and Movement Disorders (LIMPE-DISMOV Academy) and gastroenterologist members of the Italian Society of Digestive Endoscopy (SIED) to evaluate the efficacy and tolerability of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced Parkinson's disease (PD) in routine medical care. Motor scores in “ON” and OFF” state (UPDRS-III), complications of therapy (UPDRS-IV), activities of daily living, sleep disorders and quality of life were evaluated at baseline and at two follow-up assessments (FUV1 and FUV2) within the initial 12-month LCIG treatment. In 159 patients (55% males) with a mean age of 69.1 ± 6.6 years and a diagnosis of PD since 13.6 ± 5.5 years, the UPDRS-III total score (in “OFF”) decreased from baseline (45.8 ± 13.2) to FUV1 (41.0 ± 17.4; p < 0.001) and FUV2 (40.5 ± 15.5; p < 0.001), the UPDRS-IV total score decreased from baseline (8.8 ± 2.9) to FUV1 (5.1 ± 3.4; p < 0.001) and FUV2 (5.5 ± 3.2; p < 0.001). The percentage of patients exhibiting freezing, dystonia, gait/walking disturbances, falls, pain and sleep disorders was significantly reduced. Twenty-eight device complications were reported and 11 (6.9%) patients prematurely terminated the study. LCIG after 12-month treatment led to sustained improvement of time spent in “OFF”, complications of therapy, PD-associated symptoms and sleep disorders. LCIG tolerability was consistent with the established safety profile of LCIG. Parkinson’s disease (dpeaa)DE-He213 Levodopa-carbidopa intestinal gel (dpeaa)DE-He213 Motor symptoms (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Routine patient follow-up (dpeaa)DE-He213 Abbruzzese, Giovanni verfasserin aut Berardelli, Alfredo verfasserin aut Modugno, Nicola verfasserin aut Stroppa, Italo verfasserin aut Tamma, Filippo verfasserin aut Sensi, Mariachiara verfasserin aut Mancini, Francesca verfasserin aut Cossu, Giovanni verfasserin aut Stefani, Alessandro verfasserin aut Tambasco, Nicola verfasserin aut Tessitore, Alessandro verfasserin aut Fabbrini, Giovanni verfasserin aut Pontieri, Francesco E. verfasserin aut Solla, Paolo verfasserin aut Bentivoglio, Anna Rita verfasserin aut Comi, Cristoforo verfasserin aut Minafra, Brigida verfasserin aut Riboldazzi, Giulio verfasserin aut Melchionda, Donato verfasserin aut Martino, Tommaso verfasserin aut Lopiano, Leonardo verfasserin aut Enthalten in Journal of neural transmission Wien [u.a.] : Springer, 1950 127(2020), 6 vom: 24. März, Seite 881-891 (DE-627)300185901 (DE-600)1481655-6 1435-1463 nnns volume:127 year:2020 number:6 day:24 month:03 pages:881-891 https://dx.doi.org/10.1007/s00702-020-02175-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 127 2020 6 24 03 881-891 |
| allfields_unstemmed |
10.1007/s00702-020-02175-1 doi (DE-627)SPR039822370 (SPR)s00702-020-02175-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Antonini, Angelo verfasserin aut The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The TANDEM investigation was carried out in 17 Italian Movement Disorder centers on behalf of a joint initiative of neurologist members of the Italian Academy for Parkinson’s disease and Movement Disorders (LIMPE-DISMOV Academy) and gastroenterologist members of the Italian Society of Digestive Endoscopy (SIED) to evaluate the efficacy and tolerability of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced Parkinson's disease (PD) in routine medical care. Motor scores in “ON” and OFF” state (UPDRS-III), complications of therapy (UPDRS-IV), activities of daily living, sleep disorders and quality of life were evaluated at baseline and at two follow-up assessments (FUV1 and FUV2) within the initial 12-month LCIG treatment. In 159 patients (55% males) with a mean age of 69.1 ± 6.6 years and a diagnosis of PD since 13.6 ± 5.5 years, the UPDRS-III total score (in “OFF”) decreased from baseline (45.8 ± 13.2) to FUV1 (41.0 ± 17.4; p < 0.001) and FUV2 (40.5 ± 15.5; p < 0.001), the UPDRS-IV total score decreased from baseline (8.8 ± 2.9) to FUV1 (5.1 ± 3.4; p < 0.001) and FUV2 (5.5 ± 3.2; p < 0.001). The percentage of patients exhibiting freezing, dystonia, gait/walking disturbances, falls, pain and sleep disorders was significantly reduced. Twenty-eight device complications were reported and 11 (6.9%) patients prematurely terminated the study. LCIG after 12-month treatment led to sustained improvement of time spent in “OFF”, complications of therapy, PD-associated symptoms and sleep disorders. LCIG tolerability was consistent with the established safety profile of LCIG. Parkinson’s disease (dpeaa)DE-He213 Levodopa-carbidopa intestinal gel (dpeaa)DE-He213 Motor symptoms (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Routine patient follow-up (dpeaa)DE-He213 Abbruzzese, Giovanni verfasserin aut Berardelli, Alfredo verfasserin aut Modugno, Nicola verfasserin aut Stroppa, Italo verfasserin aut Tamma, Filippo verfasserin aut Sensi, Mariachiara verfasserin aut Mancini, Francesca verfasserin aut Cossu, Giovanni verfasserin aut Stefani, Alessandro verfasserin aut Tambasco, Nicola verfasserin aut Tessitore, Alessandro verfasserin aut Fabbrini, Giovanni verfasserin aut Pontieri, Francesco E. verfasserin aut Solla, Paolo verfasserin aut Bentivoglio, Anna Rita verfasserin aut Comi, Cristoforo verfasserin aut Minafra, Brigida verfasserin aut Riboldazzi, Giulio verfasserin aut Melchionda, Donato verfasserin aut Martino, Tommaso verfasserin aut Lopiano, Leonardo verfasserin aut Enthalten in Journal of neural transmission Wien [u.a.] : Springer, 1950 127(2020), 6 vom: 24. März, Seite 881-891 (DE-627)300185901 (DE-600)1481655-6 1435-1463 nnns volume:127 year:2020 number:6 day:24 month:03 pages:881-891 https://dx.doi.org/10.1007/s00702-020-02175-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 127 2020 6 24 03 881-891 |
| allfieldsGer |
10.1007/s00702-020-02175-1 doi (DE-627)SPR039822370 (SPR)s00702-020-02175-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Antonini, Angelo verfasserin aut The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The TANDEM investigation was carried out in 17 Italian Movement Disorder centers on behalf of a joint initiative of neurologist members of the Italian Academy for Parkinson’s disease and Movement Disorders (LIMPE-DISMOV Academy) and gastroenterologist members of the Italian Society of Digestive Endoscopy (SIED) to evaluate the efficacy and tolerability of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced Parkinson's disease (PD) in routine medical care. Motor scores in “ON” and OFF” state (UPDRS-III), complications of therapy (UPDRS-IV), activities of daily living, sleep disorders and quality of life were evaluated at baseline and at two follow-up assessments (FUV1 and FUV2) within the initial 12-month LCIG treatment. In 159 patients (55% males) with a mean age of 69.1 ± 6.6 years and a diagnosis of PD since 13.6 ± 5.5 years, the UPDRS-III total score (in “OFF”) decreased from baseline (45.8 ± 13.2) to FUV1 (41.0 ± 17.4; p < 0.001) and FUV2 (40.5 ± 15.5; p < 0.001), the UPDRS-IV total score decreased from baseline (8.8 ± 2.9) to FUV1 (5.1 ± 3.4; p < 0.001) and FUV2 (5.5 ± 3.2; p < 0.001). The percentage of patients exhibiting freezing, dystonia, gait/walking disturbances, falls, pain and sleep disorders was significantly reduced. Twenty-eight device complications were reported and 11 (6.9%) patients prematurely terminated the study. LCIG after 12-month treatment led to sustained improvement of time spent in “OFF”, complications of therapy, PD-associated symptoms and sleep disorders. LCIG tolerability was consistent with the established safety profile of LCIG. Parkinson’s disease (dpeaa)DE-He213 Levodopa-carbidopa intestinal gel (dpeaa)DE-He213 Motor symptoms (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Routine patient follow-up (dpeaa)DE-He213 Abbruzzese, Giovanni verfasserin aut Berardelli, Alfredo verfasserin aut Modugno, Nicola verfasserin aut Stroppa, Italo verfasserin aut Tamma, Filippo verfasserin aut Sensi, Mariachiara verfasserin aut Mancini, Francesca verfasserin aut Cossu, Giovanni verfasserin aut Stefani, Alessandro verfasserin aut Tambasco, Nicola verfasserin aut Tessitore, Alessandro verfasserin aut Fabbrini, Giovanni verfasserin aut Pontieri, Francesco E. verfasserin aut Solla, Paolo verfasserin aut Bentivoglio, Anna Rita verfasserin aut Comi, Cristoforo verfasserin aut Minafra, Brigida verfasserin aut Riboldazzi, Giulio verfasserin aut Melchionda, Donato verfasserin aut Martino, Tommaso verfasserin aut Lopiano, Leonardo verfasserin aut Enthalten in Journal of neural transmission Wien [u.a.] : Springer, 1950 127(2020), 6 vom: 24. März, Seite 881-891 (DE-627)300185901 (DE-600)1481655-6 1435-1463 nnns volume:127 year:2020 number:6 day:24 month:03 pages:881-891 https://dx.doi.org/10.1007/s00702-020-02175-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 127 2020 6 24 03 881-891 |
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10.1007/s00702-020-02175-1 doi (DE-627)SPR039822370 (SPR)s00702-020-02175-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Antonini, Angelo verfasserin aut The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The TANDEM investigation was carried out in 17 Italian Movement Disorder centers on behalf of a joint initiative of neurologist members of the Italian Academy for Parkinson’s disease and Movement Disorders (LIMPE-DISMOV Academy) and gastroenterologist members of the Italian Society of Digestive Endoscopy (SIED) to evaluate the efficacy and tolerability of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced Parkinson's disease (PD) in routine medical care. Motor scores in “ON” and OFF” state (UPDRS-III), complications of therapy (UPDRS-IV), activities of daily living, sleep disorders and quality of life were evaluated at baseline and at two follow-up assessments (FUV1 and FUV2) within the initial 12-month LCIG treatment. In 159 patients (55% males) with a mean age of 69.1 ± 6.6 years and a diagnosis of PD since 13.6 ± 5.5 years, the UPDRS-III total score (in “OFF”) decreased from baseline (45.8 ± 13.2) to FUV1 (41.0 ± 17.4; p < 0.001) and FUV2 (40.5 ± 15.5; p < 0.001), the UPDRS-IV total score decreased from baseline (8.8 ± 2.9) to FUV1 (5.1 ± 3.4; p < 0.001) and FUV2 (5.5 ± 3.2; p < 0.001). The percentage of patients exhibiting freezing, dystonia, gait/walking disturbances, falls, pain and sleep disorders was significantly reduced. Twenty-eight device complications were reported and 11 (6.9%) patients prematurely terminated the study. LCIG after 12-month treatment led to sustained improvement of time spent in “OFF”, complications of therapy, PD-associated symptoms and sleep disorders. LCIG tolerability was consistent with the established safety profile of LCIG. Parkinson’s disease (dpeaa)DE-He213 Levodopa-carbidopa intestinal gel (dpeaa)DE-He213 Motor symptoms (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Routine patient follow-up (dpeaa)DE-He213 Abbruzzese, Giovanni verfasserin aut Berardelli, Alfredo verfasserin aut Modugno, Nicola verfasserin aut Stroppa, Italo verfasserin aut Tamma, Filippo verfasserin aut Sensi, Mariachiara verfasserin aut Mancini, Francesca verfasserin aut Cossu, Giovanni verfasserin aut Stefani, Alessandro verfasserin aut Tambasco, Nicola verfasserin aut Tessitore, Alessandro verfasserin aut Fabbrini, Giovanni verfasserin aut Pontieri, Francesco E. verfasserin aut Solla, Paolo verfasserin aut Bentivoglio, Anna Rita verfasserin aut Comi, Cristoforo verfasserin aut Minafra, Brigida verfasserin aut Riboldazzi, Giulio verfasserin aut Melchionda, Donato verfasserin aut Martino, Tommaso verfasserin aut Lopiano, Leonardo verfasserin aut Enthalten in Journal of neural transmission Wien [u.a.] : Springer, 1950 127(2020), 6 vom: 24. März, Seite 881-891 (DE-627)300185901 (DE-600)1481655-6 1435-1463 nnns volume:127 year:2020 number:6 day:24 month:03 pages:881-891 https://dx.doi.org/10.1007/s00702-020-02175-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 127 2020 6 24 03 881-891 |
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Enthalten in Journal of neural transmission 127(2020), 6 vom: 24. März, Seite 881-891 volume:127 year:2020 number:6 day:24 month:03 pages:881-891 |
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Enthalten in Journal of neural transmission 127(2020), 6 vom: 24. März, Seite 881-891 volume:127 year:2020 number:6 day:24 month:03 pages:881-891 |
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Parkinson’s disease Levodopa-carbidopa intestinal gel Motor symptoms Quality of life Routine patient follow-up |
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Journal of neural transmission |
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Antonini, Angelo @@aut@@ Abbruzzese, Giovanni @@aut@@ Berardelli, Alfredo @@aut@@ Modugno, Nicola @@aut@@ Stroppa, Italo @@aut@@ Tamma, Filippo @@aut@@ Sensi, Mariachiara @@aut@@ Mancini, Francesca @@aut@@ Cossu, Giovanni @@aut@@ Stefani, Alessandro @@aut@@ Tambasco, Nicola @@aut@@ Tessitore, Alessandro @@aut@@ Fabbrini, Giovanni @@aut@@ Pontieri, Francesco E. @@aut@@ Solla, Paolo @@aut@@ Bentivoglio, Anna Rita @@aut@@ Comi, Cristoforo @@aut@@ Minafra, Brigida @@aut@@ Riboldazzi, Giulio @@aut@@ Melchionda, Donato @@aut@@ Martino, Tommaso @@aut@@ Lopiano, Leonardo @@aut@@ |
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2020-03-24T00:00:00Z |
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| author |
Antonini, Angelo |
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Antonini, Angelo ddc 610 bkl 44.90 misc Parkinson’s disease misc Levodopa-carbidopa intestinal gel misc Motor symptoms misc Quality of life misc Routine patient follow-up The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients |
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610 ASE 44.90 bkl The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients Parkinson’s disease (dpeaa)DE-He213 Levodopa-carbidopa intestinal gel (dpeaa)DE-He213 Motor symptoms (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Routine patient follow-up (dpeaa)DE-He213 |
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ddc 610 bkl 44.90 misc Parkinson’s disease misc Levodopa-carbidopa intestinal gel misc Motor symptoms misc Quality of life misc Routine patient follow-up |
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ddc 610 bkl 44.90 misc Parkinson’s disease misc Levodopa-carbidopa intestinal gel misc Motor symptoms misc Quality of life misc Routine patient follow-up |
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ddc 610 bkl 44.90 misc Parkinson’s disease misc Levodopa-carbidopa intestinal gel misc Motor symptoms misc Quality of life misc Routine patient follow-up |
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The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients |
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The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients |
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Antonini, Angelo |
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Journal of neural transmission |
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Antonini, Angelo Abbruzzese, Giovanni Berardelli, Alfredo Modugno, Nicola Stroppa, Italo Tamma, Filippo Sensi, Mariachiara Mancini, Francesca Cossu, Giovanni Stefani, Alessandro Tambasco, Nicola Tessitore, Alessandro Fabbrini, Giovanni Pontieri, Francesco E. Solla, Paolo Bentivoglio, Anna Rita Comi, Cristoforo Minafra, Brigida Riboldazzi, Giulio Melchionda, Donato Martino, Tommaso Lopiano, Leonardo |
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Antonini, Angelo |
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10.1007/s00702-020-02175-1 |
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610 |
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tandem investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (lcig) advanced parkinson’s disease patients |
| title_auth |
The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients |
| abstract |
Abstract The TANDEM investigation was carried out in 17 Italian Movement Disorder centers on behalf of a joint initiative of neurologist members of the Italian Academy for Parkinson’s disease and Movement Disorders (LIMPE-DISMOV Academy) and gastroenterologist members of the Italian Society of Digestive Endoscopy (SIED) to evaluate the efficacy and tolerability of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced Parkinson's disease (PD) in routine medical care. Motor scores in “ON” and OFF” state (UPDRS-III), complications of therapy (UPDRS-IV), activities of daily living, sleep disorders and quality of life were evaluated at baseline and at two follow-up assessments (FUV1 and FUV2) within the initial 12-month LCIG treatment. In 159 patients (55% males) with a mean age of 69.1 ± 6.6 years and a diagnosis of PD since 13.6 ± 5.5 years, the UPDRS-III total score (in “OFF”) decreased from baseline (45.8 ± 13.2) to FUV1 (41.0 ± 17.4; p < 0.001) and FUV2 (40.5 ± 15.5; p < 0.001), the UPDRS-IV total score decreased from baseline (8.8 ± 2.9) to FUV1 (5.1 ± 3.4; p < 0.001) and FUV2 (5.5 ± 3.2; p < 0.001). The percentage of patients exhibiting freezing, dystonia, gait/walking disturbances, falls, pain and sleep disorders was significantly reduced. Twenty-eight device complications were reported and 11 (6.9%) patients prematurely terminated the study. LCIG after 12-month treatment led to sustained improvement of time spent in “OFF”, complications of therapy, PD-associated symptoms and sleep disorders. LCIG tolerability was consistent with the established safety profile of LCIG. |
| abstractGer |
Abstract The TANDEM investigation was carried out in 17 Italian Movement Disorder centers on behalf of a joint initiative of neurologist members of the Italian Academy for Parkinson’s disease and Movement Disorders (LIMPE-DISMOV Academy) and gastroenterologist members of the Italian Society of Digestive Endoscopy (SIED) to evaluate the efficacy and tolerability of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced Parkinson's disease (PD) in routine medical care. Motor scores in “ON” and OFF” state (UPDRS-III), complications of therapy (UPDRS-IV), activities of daily living, sleep disorders and quality of life were evaluated at baseline and at two follow-up assessments (FUV1 and FUV2) within the initial 12-month LCIG treatment. In 159 patients (55% males) with a mean age of 69.1 ± 6.6 years and a diagnosis of PD since 13.6 ± 5.5 years, the UPDRS-III total score (in “OFF”) decreased from baseline (45.8 ± 13.2) to FUV1 (41.0 ± 17.4; p < 0.001) and FUV2 (40.5 ± 15.5; p < 0.001), the UPDRS-IV total score decreased from baseline (8.8 ± 2.9) to FUV1 (5.1 ± 3.4; p < 0.001) and FUV2 (5.5 ± 3.2; p < 0.001). The percentage of patients exhibiting freezing, dystonia, gait/walking disturbances, falls, pain and sleep disorders was significantly reduced. Twenty-eight device complications were reported and 11 (6.9%) patients prematurely terminated the study. LCIG after 12-month treatment led to sustained improvement of time spent in “OFF”, complications of therapy, PD-associated symptoms and sleep disorders. LCIG tolerability was consistent with the established safety profile of LCIG. |
| abstract_unstemmed |
Abstract The TANDEM investigation was carried out in 17 Italian Movement Disorder centers on behalf of a joint initiative of neurologist members of the Italian Academy for Parkinson’s disease and Movement Disorders (LIMPE-DISMOV Academy) and gastroenterologist members of the Italian Society of Digestive Endoscopy (SIED) to evaluate the efficacy and tolerability of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced Parkinson's disease (PD) in routine medical care. Motor scores in “ON” and OFF” state (UPDRS-III), complications of therapy (UPDRS-IV), activities of daily living, sleep disorders and quality of life were evaluated at baseline and at two follow-up assessments (FUV1 and FUV2) within the initial 12-month LCIG treatment. In 159 patients (55% males) with a mean age of 69.1 ± 6.6 years and a diagnosis of PD since 13.6 ± 5.5 years, the UPDRS-III total score (in “OFF”) decreased from baseline (45.8 ± 13.2) to FUV1 (41.0 ± 17.4; p < 0.001) and FUV2 (40.5 ± 15.5; p < 0.001), the UPDRS-IV total score decreased from baseline (8.8 ± 2.9) to FUV1 (5.1 ± 3.4; p < 0.001) and FUV2 (5.5 ± 3.2; p < 0.001). The percentage of patients exhibiting freezing, dystonia, gait/walking disturbances, falls, pain and sleep disorders was significantly reduced. Twenty-eight device complications were reported and 11 (6.9%) patients prematurely terminated the study. LCIG after 12-month treatment led to sustained improvement of time spent in “OFF”, complications of therapy, PD-associated symptoms and sleep disorders. LCIG tolerability was consistent with the established safety profile of LCIG. |
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The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients |
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Abbruzzese, Giovanni Berardelli, Alfredo Modugno, Nicola Stroppa, Italo Tamma, Filippo Sensi, Mariachiara Mancini, Francesca Cossu, Giovanni Stefani, Alessandro Tambasco, Nicola Tessitore, Alessandro Fabbrini, Giovanni Pontieri, Francesco E. Solla, Paolo Bentivoglio, Anna Rita Comi, Cristoforo Minafra, Brigida Riboldazzi, Giulio Melchionda, Donato Martino, Tommaso Lopiano, Leonardo |
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Abbruzzese, Giovanni Berardelli, Alfredo Modugno, Nicola Stroppa, Italo Tamma, Filippo Sensi, Mariachiara Mancini, Francesca Cossu, Giovanni Stefani, Alessandro Tambasco, Nicola Tessitore, Alessandro Fabbrini, Giovanni Pontieri, Francesco E. Solla, Paolo Bentivoglio, Anna Rita Comi, Cristoforo Minafra, Brigida Riboldazzi, Giulio Melchionda, Donato Martino, Tommaso Lopiano, Leonardo |
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10.1007/s00702-020-02175-1 |
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2024-07-04T01:43:35.267Z |
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| score |
7.401613 |