Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study
Purpose Although the role of classical (clinico-pathological features) and modern prognostic factors (immune biomarkers) has been described in pathogenesis of squamous cell carcinoma cervix (SCCC), the role of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels has been a subje...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jais-Sahu, Nidhi [verfasserIn] Deshmukh, Abhay V. [verfasserIn] Gangane, Nitin M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
Squamous cell carcinoma cervix |
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| Übergeordnetes Werk: |
Enthalten in: Indian Journal of Gynecologic Oncology - New Delhi : Springer India, 2015, 18(2020), 2 vom: 28. Mai |
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| Übergeordnetes Werk: |
volume:18 ; year:2020 ; number:2 ; day:28 ; month:05 |
| Links: |
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| DOI / URN: |
10.1007/s40944-020-00404-9 |
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| Katalog-ID: |
SPR039857379 |
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| 100 | 1 | |a Jais-Sahu, Nidhi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study |
| 264 | 1 | |c 2020 | |
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| 520 | |a Purpose Although the role of classical (clinico-pathological features) and modern prognostic factors (immune biomarkers) has been described in pathogenesis of squamous cell carcinoma cervix (SCCC), the role of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels has been a subject of great interest and has not been validated yet. So, the present pilot study was aimed to study the expression of VEGF and PCNA-positive cells in CD34 positive blood vessels in “cervical intraepithelial lesion-3” (CIN-3) and “invasive” areas of SCCC. It was a cross-sectional observational pilot study. Methods In this study, 100 hysterectomy specimens done for SCCC were screened. Immunohistochemical expression of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels was studied on 21 cases which showed both CIN-3 and invasive areas. Results In “invasive” areas, epithelial component had higher expression of VEGF with 61.9% and 38.1% cases showing grades 2 and 3 staining, respectively. 100% stromal component showed grade 1 in “CIN-3” areas, and 90.4% showed grade 2 in invasive cases. In case of VEGF expression in “CIN-3” compartment, epithelial compartment had grade I in 57.1% cases and grade II expression in 42.9% cases. PCNA expression was up to grade 1 in most “CIN-3” areas, whereas higher grades (2 or 3) were seen in “invasive” compartments. Conclusion VEGF expression is more in “invasive” front of the tumour. The tumour parenchyma rather than the tumour stroma is responsible for neovascularisation. The vessels at the periphery on “invasive” front of tumour proliferate more. | ||
| 650 | 4 | |a Squamous cell carcinoma cervix |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a VEGF |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a PCNA |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a CD34 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cervical intraepithelial lesion-3 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Invasive |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Deshmukh, Abhay V. |e verfasserin |4 aut | |
| 700 | 1 | |a Gangane, Nitin M. |e verfasserin |4 aut | |
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10.1007/s40944-020-00404-9 doi (DE-627)SPR039857379 (SPR)s40944-020-00404-9-e DE-627 ger DE-627 rakwb eng Jais-Sahu, Nidhi verfasserin aut Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Although the role of classical (clinico-pathological features) and modern prognostic factors (immune biomarkers) has been described in pathogenesis of squamous cell carcinoma cervix (SCCC), the role of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels has been a subject of great interest and has not been validated yet. So, the present pilot study was aimed to study the expression of VEGF and PCNA-positive cells in CD34 positive blood vessels in “cervical intraepithelial lesion-3” (CIN-3) and “invasive” areas of SCCC. It was a cross-sectional observational pilot study. Methods In this study, 100 hysterectomy specimens done for SCCC were screened. Immunohistochemical expression of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels was studied on 21 cases which showed both CIN-3 and invasive areas. Results In “invasive” areas, epithelial component had higher expression of VEGF with 61.9% and 38.1% cases showing grades 2 and 3 staining, respectively. 100% stromal component showed grade 1 in “CIN-3” areas, and 90.4% showed grade 2 in invasive cases. In case of VEGF expression in “CIN-3” compartment, epithelial compartment had grade I in 57.1% cases and grade II expression in 42.9% cases. PCNA expression was up to grade 1 in most “CIN-3” areas, whereas higher grades (2 or 3) were seen in “invasive” compartments. Conclusion VEGF expression is more in “invasive” front of the tumour. The tumour parenchyma rather than the tumour stroma is responsible for neovascularisation. The vessels at the periphery on “invasive” front of tumour proliferate more. Squamous cell carcinoma cervix (dpeaa)DE-He213 VEGF (dpeaa)DE-He213 PCNA (dpeaa)DE-He213 CD34 (dpeaa)DE-He213 Cervical intraepithelial lesion-3 (dpeaa)DE-He213 Invasive (dpeaa)DE-He213 Deshmukh, Abhay V. verfasserin aut Gangane, Nitin M. verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology New Delhi : Springer India, 2015 18(2020), 2 vom: 28. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:18 year:2020 number:2 day:28 month:05 https://dx.doi.org/10.1007/s40944-020-00404-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 2 28 05 |
| spelling |
10.1007/s40944-020-00404-9 doi (DE-627)SPR039857379 (SPR)s40944-020-00404-9-e DE-627 ger DE-627 rakwb eng Jais-Sahu, Nidhi verfasserin aut Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Although the role of classical (clinico-pathological features) and modern prognostic factors (immune biomarkers) has been described in pathogenesis of squamous cell carcinoma cervix (SCCC), the role of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels has been a subject of great interest and has not been validated yet. So, the present pilot study was aimed to study the expression of VEGF and PCNA-positive cells in CD34 positive blood vessels in “cervical intraepithelial lesion-3” (CIN-3) and “invasive” areas of SCCC. It was a cross-sectional observational pilot study. Methods In this study, 100 hysterectomy specimens done for SCCC were screened. Immunohistochemical expression of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels was studied on 21 cases which showed both CIN-3 and invasive areas. Results In “invasive” areas, epithelial component had higher expression of VEGF with 61.9% and 38.1% cases showing grades 2 and 3 staining, respectively. 100% stromal component showed grade 1 in “CIN-3” areas, and 90.4% showed grade 2 in invasive cases. In case of VEGF expression in “CIN-3” compartment, epithelial compartment had grade I in 57.1% cases and grade II expression in 42.9% cases. PCNA expression was up to grade 1 in most “CIN-3” areas, whereas higher grades (2 or 3) were seen in “invasive” compartments. Conclusion VEGF expression is more in “invasive” front of the tumour. The tumour parenchyma rather than the tumour stroma is responsible for neovascularisation. The vessels at the periphery on “invasive” front of tumour proliferate more. Squamous cell carcinoma cervix (dpeaa)DE-He213 VEGF (dpeaa)DE-He213 PCNA (dpeaa)DE-He213 CD34 (dpeaa)DE-He213 Cervical intraepithelial lesion-3 (dpeaa)DE-He213 Invasive (dpeaa)DE-He213 Deshmukh, Abhay V. verfasserin aut Gangane, Nitin M. verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology New Delhi : Springer India, 2015 18(2020), 2 vom: 28. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:18 year:2020 number:2 day:28 month:05 https://dx.doi.org/10.1007/s40944-020-00404-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 2 28 05 |
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10.1007/s40944-020-00404-9 doi (DE-627)SPR039857379 (SPR)s40944-020-00404-9-e DE-627 ger DE-627 rakwb eng Jais-Sahu, Nidhi verfasserin aut Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Although the role of classical (clinico-pathological features) and modern prognostic factors (immune biomarkers) has been described in pathogenesis of squamous cell carcinoma cervix (SCCC), the role of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels has been a subject of great interest and has not been validated yet. So, the present pilot study was aimed to study the expression of VEGF and PCNA-positive cells in CD34 positive blood vessels in “cervical intraepithelial lesion-3” (CIN-3) and “invasive” areas of SCCC. It was a cross-sectional observational pilot study. Methods In this study, 100 hysterectomy specimens done for SCCC were screened. Immunohistochemical expression of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels was studied on 21 cases which showed both CIN-3 and invasive areas. Results In “invasive” areas, epithelial component had higher expression of VEGF with 61.9% and 38.1% cases showing grades 2 and 3 staining, respectively. 100% stromal component showed grade 1 in “CIN-3” areas, and 90.4% showed grade 2 in invasive cases. In case of VEGF expression in “CIN-3” compartment, epithelial compartment had grade I in 57.1% cases and grade II expression in 42.9% cases. PCNA expression was up to grade 1 in most “CIN-3” areas, whereas higher grades (2 or 3) were seen in “invasive” compartments. Conclusion VEGF expression is more in “invasive” front of the tumour. The tumour parenchyma rather than the tumour stroma is responsible for neovascularisation. The vessels at the periphery on “invasive” front of tumour proliferate more. Squamous cell carcinoma cervix (dpeaa)DE-He213 VEGF (dpeaa)DE-He213 PCNA (dpeaa)DE-He213 CD34 (dpeaa)DE-He213 Cervical intraepithelial lesion-3 (dpeaa)DE-He213 Invasive (dpeaa)DE-He213 Deshmukh, Abhay V. verfasserin aut Gangane, Nitin M. verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology New Delhi : Springer India, 2015 18(2020), 2 vom: 28. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:18 year:2020 number:2 day:28 month:05 https://dx.doi.org/10.1007/s40944-020-00404-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 2 28 05 |
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10.1007/s40944-020-00404-9 doi (DE-627)SPR039857379 (SPR)s40944-020-00404-9-e DE-627 ger DE-627 rakwb eng Jais-Sahu, Nidhi verfasserin aut Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Although the role of classical (clinico-pathological features) and modern prognostic factors (immune biomarkers) has been described in pathogenesis of squamous cell carcinoma cervix (SCCC), the role of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels has been a subject of great interest and has not been validated yet. So, the present pilot study was aimed to study the expression of VEGF and PCNA-positive cells in CD34 positive blood vessels in “cervical intraepithelial lesion-3” (CIN-3) and “invasive” areas of SCCC. It was a cross-sectional observational pilot study. Methods In this study, 100 hysterectomy specimens done for SCCC were screened. Immunohistochemical expression of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels was studied on 21 cases which showed both CIN-3 and invasive areas. Results In “invasive” areas, epithelial component had higher expression of VEGF with 61.9% and 38.1% cases showing grades 2 and 3 staining, respectively. 100% stromal component showed grade 1 in “CIN-3” areas, and 90.4% showed grade 2 in invasive cases. In case of VEGF expression in “CIN-3” compartment, epithelial compartment had grade I in 57.1% cases and grade II expression in 42.9% cases. PCNA expression was up to grade 1 in most “CIN-3” areas, whereas higher grades (2 or 3) were seen in “invasive” compartments. Conclusion VEGF expression is more in “invasive” front of the tumour. The tumour parenchyma rather than the tumour stroma is responsible for neovascularisation. The vessels at the periphery on “invasive” front of tumour proliferate more. Squamous cell carcinoma cervix (dpeaa)DE-He213 VEGF (dpeaa)DE-He213 PCNA (dpeaa)DE-He213 CD34 (dpeaa)DE-He213 Cervical intraepithelial lesion-3 (dpeaa)DE-He213 Invasive (dpeaa)DE-He213 Deshmukh, Abhay V. verfasserin aut Gangane, Nitin M. verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology New Delhi : Springer India, 2015 18(2020), 2 vom: 28. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:18 year:2020 number:2 day:28 month:05 https://dx.doi.org/10.1007/s40944-020-00404-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 2 28 05 |
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10.1007/s40944-020-00404-9 doi (DE-627)SPR039857379 (SPR)s40944-020-00404-9-e DE-627 ger DE-627 rakwb eng Jais-Sahu, Nidhi verfasserin aut Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Although the role of classical (clinico-pathological features) and modern prognostic factors (immune biomarkers) has been described in pathogenesis of squamous cell carcinoma cervix (SCCC), the role of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels has been a subject of great interest and has not been validated yet. So, the present pilot study was aimed to study the expression of VEGF and PCNA-positive cells in CD34 positive blood vessels in “cervical intraepithelial lesion-3” (CIN-3) and “invasive” areas of SCCC. It was a cross-sectional observational pilot study. Methods In this study, 100 hysterectomy specimens done for SCCC were screened. Immunohistochemical expression of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels was studied on 21 cases which showed both CIN-3 and invasive areas. Results In “invasive” areas, epithelial component had higher expression of VEGF with 61.9% and 38.1% cases showing grades 2 and 3 staining, respectively. 100% stromal component showed grade 1 in “CIN-3” areas, and 90.4% showed grade 2 in invasive cases. In case of VEGF expression in “CIN-3” compartment, epithelial compartment had grade I in 57.1% cases and grade II expression in 42.9% cases. PCNA expression was up to grade 1 in most “CIN-3” areas, whereas higher grades (2 or 3) were seen in “invasive” compartments. Conclusion VEGF expression is more in “invasive” front of the tumour. The tumour parenchyma rather than the tumour stroma is responsible for neovascularisation. The vessels at the periphery on “invasive” front of tumour proliferate more. Squamous cell carcinoma cervix (dpeaa)DE-He213 VEGF (dpeaa)DE-He213 PCNA (dpeaa)DE-He213 CD34 (dpeaa)DE-He213 Cervical intraepithelial lesion-3 (dpeaa)DE-He213 Invasive (dpeaa)DE-He213 Deshmukh, Abhay V. verfasserin aut Gangane, Nitin M. verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology New Delhi : Springer India, 2015 18(2020), 2 vom: 28. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:18 year:2020 number:2 day:28 month:05 https://dx.doi.org/10.1007/s40944-020-00404-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 2 28 05 |
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Enthalten in Indian Journal of Gynecologic Oncology 18(2020), 2 vom: 28. Mai volume:18 year:2020 number:2 day:28 month:05 |
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Squamous cell carcinoma cervix VEGF PCNA CD34 Cervical intraepithelial lesion-3 Invasive |
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Indian Journal of Gynecologic Oncology |
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Jais-Sahu, Nidhi @@aut@@ Deshmukh, Abhay V. @@aut@@ Gangane, Nitin M. @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR039857379</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20201126020451.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2020 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s40944-020-00404-9</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR039857379</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s40944-020-00404-9-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Jais-Sahu, Nidhi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose Although the role of classical (clinico-pathological features) and modern prognostic factors (immune biomarkers) has been described in pathogenesis of squamous cell carcinoma cervix (SCCC), the role of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels has been a subject of great interest and has not been validated yet. So, the present pilot study was aimed to study the expression of VEGF and PCNA-positive cells in CD34 positive blood vessels in “cervical intraepithelial lesion-3” (CIN-3) and “invasive” areas of SCCC. It was a cross-sectional observational pilot study. Methods In this study, 100 hysterectomy specimens done for SCCC were screened. Immunohistochemical expression of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels was studied on 21 cases which showed both CIN-3 and invasive areas. Results In “invasive” areas, epithelial component had higher expression of VEGF with 61.9% and 38.1% cases showing grades 2 and 3 staining, respectively. 100% stromal component showed grade 1 in “CIN-3” areas, and 90.4% showed grade 2 in invasive cases. In case of VEGF expression in “CIN-3” compartment, epithelial compartment had grade I in 57.1% cases and grade II expression in 42.9% cases. PCNA expression was up to grade 1 in most “CIN-3” areas, whereas higher grades (2 or 3) were seen in “invasive” compartments. Conclusion VEGF expression is more in “invasive” front of the tumour. The tumour parenchyma rather than the tumour stroma is responsible for neovascularisation. 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Jais-Sahu, Nidhi |
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Jais-Sahu, Nidhi misc Squamous cell carcinoma cervix misc VEGF misc PCNA misc CD34 misc Cervical intraepithelial lesion-3 misc Invasive Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study |
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Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study Squamous cell carcinoma cervix (dpeaa)DE-He213 VEGF (dpeaa)DE-He213 PCNA (dpeaa)DE-He213 CD34 (dpeaa)DE-He213 Cervical intraepithelial lesion-3 (dpeaa)DE-He213 Invasive (dpeaa)DE-He213 |
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misc Squamous cell carcinoma cervix misc VEGF misc PCNA misc CD34 misc Cervical intraepithelial lesion-3 misc Invasive |
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misc Squamous cell carcinoma cervix misc VEGF misc PCNA misc CD34 misc Cervical intraepithelial lesion-3 misc Invasive |
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Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study |
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Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study |
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Jais-Sahu, Nidhi |
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Indian Journal of Gynecologic Oncology |
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Jais-Sahu, Nidhi Deshmukh, Abhay V. Gangane, Nitin M. |
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Jais-Sahu, Nidhi |
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expression of cd34, pcna and vegf in cin-3 and invasive squamous cell carcinoma cervix: a pilot study |
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Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study |
| abstract |
Purpose Although the role of classical (clinico-pathological features) and modern prognostic factors (immune biomarkers) has been described in pathogenesis of squamous cell carcinoma cervix (SCCC), the role of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels has been a subject of great interest and has not been validated yet. So, the present pilot study was aimed to study the expression of VEGF and PCNA-positive cells in CD34 positive blood vessels in “cervical intraepithelial lesion-3” (CIN-3) and “invasive” areas of SCCC. It was a cross-sectional observational pilot study. Methods In this study, 100 hysterectomy specimens done for SCCC were screened. Immunohistochemical expression of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels was studied on 21 cases which showed both CIN-3 and invasive areas. Results In “invasive” areas, epithelial component had higher expression of VEGF with 61.9% and 38.1% cases showing grades 2 and 3 staining, respectively. 100% stromal component showed grade 1 in “CIN-3” areas, and 90.4% showed grade 2 in invasive cases. In case of VEGF expression in “CIN-3” compartment, epithelial compartment had grade I in 57.1% cases and grade II expression in 42.9% cases. PCNA expression was up to grade 1 in most “CIN-3” areas, whereas higher grades (2 or 3) were seen in “invasive” compartments. Conclusion VEGF expression is more in “invasive” front of the tumour. The tumour parenchyma rather than the tumour stroma is responsible for neovascularisation. The vessels at the periphery on “invasive” front of tumour proliferate more. |
| abstractGer |
Purpose Although the role of classical (clinico-pathological features) and modern prognostic factors (immune biomarkers) has been described in pathogenesis of squamous cell carcinoma cervix (SCCC), the role of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels has been a subject of great interest and has not been validated yet. So, the present pilot study was aimed to study the expression of VEGF and PCNA-positive cells in CD34 positive blood vessels in “cervical intraepithelial lesion-3” (CIN-3) and “invasive” areas of SCCC. It was a cross-sectional observational pilot study. Methods In this study, 100 hysterectomy specimens done for SCCC were screened. Immunohistochemical expression of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels was studied on 21 cases which showed both CIN-3 and invasive areas. Results In “invasive” areas, epithelial component had higher expression of VEGF with 61.9% and 38.1% cases showing grades 2 and 3 staining, respectively. 100% stromal component showed grade 1 in “CIN-3” areas, and 90.4% showed grade 2 in invasive cases. In case of VEGF expression in “CIN-3” compartment, epithelial compartment had grade I in 57.1% cases and grade II expression in 42.9% cases. PCNA expression was up to grade 1 in most “CIN-3” areas, whereas higher grades (2 or 3) were seen in “invasive” compartments. Conclusion VEGF expression is more in “invasive” front of the tumour. The tumour parenchyma rather than the tumour stroma is responsible for neovascularisation. The vessels at the periphery on “invasive” front of tumour proliferate more. |
| abstract_unstemmed |
Purpose Although the role of classical (clinico-pathological features) and modern prognostic factors (immune biomarkers) has been described in pathogenesis of squamous cell carcinoma cervix (SCCC), the role of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels has been a subject of great interest and has not been validated yet. So, the present pilot study was aimed to study the expression of VEGF and PCNA-positive cells in CD34 positive blood vessels in “cervical intraepithelial lesion-3” (CIN-3) and “invasive” areas of SCCC. It was a cross-sectional observational pilot study. Methods In this study, 100 hysterectomy specimens done for SCCC were screened. Immunohistochemical expression of VEGF and PCNA-positive endothelial cells in CD34 expressing blood vessels was studied on 21 cases which showed both CIN-3 and invasive areas. Results In “invasive” areas, epithelial component had higher expression of VEGF with 61.9% and 38.1% cases showing grades 2 and 3 staining, respectively. 100% stromal component showed grade 1 in “CIN-3” areas, and 90.4% showed grade 2 in invasive cases. In case of VEGF expression in “CIN-3” compartment, epithelial compartment had grade I in 57.1% cases and grade II expression in 42.9% cases. PCNA expression was up to grade 1 in most “CIN-3” areas, whereas higher grades (2 or 3) were seen in “invasive” compartments. Conclusion VEGF expression is more in “invasive” front of the tumour. The tumour parenchyma rather than the tumour stroma is responsible for neovascularisation. The vessels at the periphery on “invasive” front of tumour proliferate more. |
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Expression of CD34, PCNA and VEGF in CIN-3 and Invasive Squamous Cell Carcinoma Cervix: A Pilot Study |
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https://dx.doi.org/10.1007/s40944-020-00404-9 |
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Deshmukh, Abhay V. Gangane, Nitin M. |
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10.1007/s40944-020-00404-9 |
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2024-07-04T01:53:03.878Z |
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| score |
7.4013157 |