Outcomes of Simultaneous Resections and Classical Strategy for Synchronous Colorectal Liver Metastases in Sweden: A Nationwide Study with Special Reference to Major Liver Resections
Background About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and surgical resection offers a chance for cure. The aim of the present study was to compare outcomes for patients that underwent simultaneous resection to those that underwent a staged procedure...
Ausführliche Beschreibung
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| Autor*in: |
Valdimarsson, Valentinus T. [verfasserIn] Syk, Ingvar [verfasserIn] Lindell, Gert [verfasserIn] Sandström, Per [verfasserIn] Isaksson, Bengt [verfasserIn] Rizell, Magnus [verfasserIn] Norén, Agneta [verfasserIn] Ardnor, Bjarne [verfasserIn] Sturesson, Christian [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Übergeordnetes Werk: |
Enthalten in: World Journal of Surgery - Springer-Verlag, 1996, 44(2020), 7 vom: 17. März, Seite 2409-2417 |
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| Übergeordnetes Werk: |
volume:44 ; year:2020 ; number:7 ; day:17 ; month:03 ; pages:2409-2417 |
| Links: |
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| DOI / URN: |
10.1007/s00268-020-05475-5 |
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SPR039904504 |
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| 520 | |a Background About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and surgical resection offers a chance for cure. The aim of the present study was to compare outcomes for patients that underwent simultaneous resection to those that underwent a staged procedure with the bowel-first (classical) strategy by using information from two national registries in Sweden. Methods In this prospectively registered cohort study, we analyzed clinical, pathological, and survival outcomes for patients operated in the period 2008–2015 and compared the two strategies. Results In total, 537 patients constituted the study cohort, where 160 were treated with the simultaneous strategy and 377 with the classical strategy. Patients managed with the simultaneous strategy had less often rectal primary tumors (22% vs. 31%, p = 0.046) and underwent to a lesser extent a major liver resection (16% vs. 41%, p < 0.001), but had a shorter total length of stay (11 vs. 15 days, p < 0.001) and more complications (52% vs. 36%, p < 0.001). No significant 5-year overall survival (p = 0.110) difference was detected. Twenty-five patients had a major liver resection in the simultaneous strategy group and 155 in the classical strategy group without difference in 5-year overall survival (p = 0.198). Conclusion Simultaneous resection of the colorectal primary cancer and liver metastases can possibly have more complications, with no difference in overall survival compared to the classical strategy. | ||
| 700 | 1 | |a Syk, Ingvar |e verfasserin |4 aut | |
| 700 | 1 | |a Lindell, Gert |e verfasserin |4 aut | |
| 700 | 1 | |a Sandström, Per |e verfasserin |4 aut | |
| 700 | 1 | |a Isaksson, Bengt |e verfasserin |4 aut | |
| 700 | 1 | |a Rizell, Magnus |e verfasserin |4 aut | |
| 700 | 1 | |a Norén, Agneta |e verfasserin |4 aut | |
| 700 | 1 | |a Ardnor, Bjarne |e verfasserin |4 aut | |
| 700 | 1 | |a Sturesson, Christian |e verfasserin |4 aut | |
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10.1007/s00268-020-05475-5 doi (DE-627)SPR039904504 (SPR)s00268-020-05475-5-e DE-627 ger DE-627 rakwb eng Valdimarsson, Valentinus T. verfasserin aut Outcomes of Simultaneous Resections and Classical Strategy for Synchronous Colorectal Liver Metastases in Sweden: A Nationwide Study with Special Reference to Major Liver Resections 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and surgical resection offers a chance for cure. The aim of the present study was to compare outcomes for patients that underwent simultaneous resection to those that underwent a staged procedure with the bowel-first (classical) strategy by using information from two national registries in Sweden. Methods In this prospectively registered cohort study, we analyzed clinical, pathological, and survival outcomes for patients operated in the period 2008–2015 and compared the two strategies. Results In total, 537 patients constituted the study cohort, where 160 were treated with the simultaneous strategy and 377 with the classical strategy. Patients managed with the simultaneous strategy had less often rectal primary tumors (22% vs. 31%, p = 0.046) and underwent to a lesser extent a major liver resection (16% vs. 41%, p < 0.001), but had a shorter total length of stay (11 vs. 15 days, p < 0.001) and more complications (52% vs. 36%, p < 0.001). No significant 5-year overall survival (p = 0.110) difference was detected. Twenty-five patients had a major liver resection in the simultaneous strategy group and 155 in the classical strategy group without difference in 5-year overall survival (p = 0.198). Conclusion Simultaneous resection of the colorectal primary cancer and liver metastases can possibly have more complications, with no difference in overall survival compared to the classical strategy. Syk, Ingvar verfasserin aut Lindell, Gert verfasserin aut Sandström, Per verfasserin aut Isaksson, Bengt verfasserin aut Rizell, Magnus verfasserin aut Norén, Agneta verfasserin aut Ardnor, Bjarne verfasserin aut Sturesson, Christian verfasserin aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 44(2020), 7 vom: 17. März, Seite 2409-2417 (DE-627)SPR003391159 nnns volume:44 year:2020 number:7 day:17 month:03 pages:2409-2417 https://dx.doi.org/10.1007/s00268-020-05475-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 44 2020 7 17 03 2409-2417 |
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10.1007/s00268-020-05475-5 doi (DE-627)SPR039904504 (SPR)s00268-020-05475-5-e DE-627 ger DE-627 rakwb eng Valdimarsson, Valentinus T. verfasserin aut Outcomes of Simultaneous Resections and Classical Strategy for Synchronous Colorectal Liver Metastases in Sweden: A Nationwide Study with Special Reference to Major Liver Resections 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and surgical resection offers a chance for cure. The aim of the present study was to compare outcomes for patients that underwent simultaneous resection to those that underwent a staged procedure with the bowel-first (classical) strategy by using information from two national registries in Sweden. Methods In this prospectively registered cohort study, we analyzed clinical, pathological, and survival outcomes for patients operated in the period 2008–2015 and compared the two strategies. Results In total, 537 patients constituted the study cohort, where 160 were treated with the simultaneous strategy and 377 with the classical strategy. Patients managed with the simultaneous strategy had less often rectal primary tumors (22% vs. 31%, p = 0.046) and underwent to a lesser extent a major liver resection (16% vs. 41%, p < 0.001), but had a shorter total length of stay (11 vs. 15 days, p < 0.001) and more complications (52% vs. 36%, p < 0.001). No significant 5-year overall survival (p = 0.110) difference was detected. Twenty-five patients had a major liver resection in the simultaneous strategy group and 155 in the classical strategy group without difference in 5-year overall survival (p = 0.198). Conclusion Simultaneous resection of the colorectal primary cancer and liver metastases can possibly have more complications, with no difference in overall survival compared to the classical strategy. Syk, Ingvar verfasserin aut Lindell, Gert verfasserin aut Sandström, Per verfasserin aut Isaksson, Bengt verfasserin aut Rizell, Magnus verfasserin aut Norén, Agneta verfasserin aut Ardnor, Bjarne verfasserin aut Sturesson, Christian verfasserin aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 44(2020), 7 vom: 17. März, Seite 2409-2417 (DE-627)SPR003391159 nnns volume:44 year:2020 number:7 day:17 month:03 pages:2409-2417 https://dx.doi.org/10.1007/s00268-020-05475-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 44 2020 7 17 03 2409-2417 |
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10.1007/s00268-020-05475-5 doi (DE-627)SPR039904504 (SPR)s00268-020-05475-5-e DE-627 ger DE-627 rakwb eng Valdimarsson, Valentinus T. verfasserin aut Outcomes of Simultaneous Resections and Classical Strategy for Synchronous Colorectal Liver Metastases in Sweden: A Nationwide Study with Special Reference to Major Liver Resections 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and surgical resection offers a chance for cure. The aim of the present study was to compare outcomes for patients that underwent simultaneous resection to those that underwent a staged procedure with the bowel-first (classical) strategy by using information from two national registries in Sweden. Methods In this prospectively registered cohort study, we analyzed clinical, pathological, and survival outcomes for patients operated in the period 2008–2015 and compared the two strategies. Results In total, 537 patients constituted the study cohort, where 160 were treated with the simultaneous strategy and 377 with the classical strategy. Patients managed with the simultaneous strategy had less often rectal primary tumors (22% vs. 31%, p = 0.046) and underwent to a lesser extent a major liver resection (16% vs. 41%, p < 0.001), but had a shorter total length of stay (11 vs. 15 days, p < 0.001) and more complications (52% vs. 36%, p < 0.001). No significant 5-year overall survival (p = 0.110) difference was detected. Twenty-five patients had a major liver resection in the simultaneous strategy group and 155 in the classical strategy group without difference in 5-year overall survival (p = 0.198). Conclusion Simultaneous resection of the colorectal primary cancer and liver metastases can possibly have more complications, with no difference in overall survival compared to the classical strategy. Syk, Ingvar verfasserin aut Lindell, Gert verfasserin aut Sandström, Per verfasserin aut Isaksson, Bengt verfasserin aut Rizell, Magnus verfasserin aut Norén, Agneta verfasserin aut Ardnor, Bjarne verfasserin aut Sturesson, Christian verfasserin aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 44(2020), 7 vom: 17. März, Seite 2409-2417 (DE-627)SPR003391159 nnns volume:44 year:2020 number:7 day:17 month:03 pages:2409-2417 https://dx.doi.org/10.1007/s00268-020-05475-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 44 2020 7 17 03 2409-2417 |
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10.1007/s00268-020-05475-5 doi (DE-627)SPR039904504 (SPR)s00268-020-05475-5-e DE-627 ger DE-627 rakwb eng Valdimarsson, Valentinus T. verfasserin aut Outcomes of Simultaneous Resections and Classical Strategy for Synchronous Colorectal Liver Metastases in Sweden: A Nationwide Study with Special Reference to Major Liver Resections 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and surgical resection offers a chance for cure. The aim of the present study was to compare outcomes for patients that underwent simultaneous resection to those that underwent a staged procedure with the bowel-first (classical) strategy by using information from two national registries in Sweden. Methods In this prospectively registered cohort study, we analyzed clinical, pathological, and survival outcomes for patients operated in the period 2008–2015 and compared the two strategies. Results In total, 537 patients constituted the study cohort, where 160 were treated with the simultaneous strategy and 377 with the classical strategy. Patients managed with the simultaneous strategy had less often rectal primary tumors (22% vs. 31%, p = 0.046) and underwent to a lesser extent a major liver resection (16% vs. 41%, p < 0.001), but had a shorter total length of stay (11 vs. 15 days, p < 0.001) and more complications (52% vs. 36%, p < 0.001). No significant 5-year overall survival (p = 0.110) difference was detected. Twenty-five patients had a major liver resection in the simultaneous strategy group and 155 in the classical strategy group without difference in 5-year overall survival (p = 0.198). Conclusion Simultaneous resection of the colorectal primary cancer and liver metastases can possibly have more complications, with no difference in overall survival compared to the classical strategy. Syk, Ingvar verfasserin aut Lindell, Gert verfasserin aut Sandström, Per verfasserin aut Isaksson, Bengt verfasserin aut Rizell, Magnus verfasserin aut Norén, Agneta verfasserin aut Ardnor, Bjarne verfasserin aut Sturesson, Christian verfasserin aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 44(2020), 7 vom: 17. März, Seite 2409-2417 (DE-627)SPR003391159 nnns volume:44 year:2020 number:7 day:17 month:03 pages:2409-2417 https://dx.doi.org/10.1007/s00268-020-05475-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 44 2020 7 17 03 2409-2417 |
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10.1007/s00268-020-05475-5 doi (DE-627)SPR039904504 (SPR)s00268-020-05475-5-e DE-627 ger DE-627 rakwb eng Valdimarsson, Valentinus T. verfasserin aut Outcomes of Simultaneous Resections and Classical Strategy for Synchronous Colorectal Liver Metastases in Sweden: A Nationwide Study with Special Reference to Major Liver Resections 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and surgical resection offers a chance for cure. The aim of the present study was to compare outcomes for patients that underwent simultaneous resection to those that underwent a staged procedure with the bowel-first (classical) strategy by using information from two national registries in Sweden. Methods In this prospectively registered cohort study, we analyzed clinical, pathological, and survival outcomes for patients operated in the period 2008–2015 and compared the two strategies. Results In total, 537 patients constituted the study cohort, where 160 were treated with the simultaneous strategy and 377 with the classical strategy. Patients managed with the simultaneous strategy had less often rectal primary tumors (22% vs. 31%, p = 0.046) and underwent to a lesser extent a major liver resection (16% vs. 41%, p < 0.001), but had a shorter total length of stay (11 vs. 15 days, p < 0.001) and more complications (52% vs. 36%, p < 0.001). No significant 5-year overall survival (p = 0.110) difference was detected. Twenty-five patients had a major liver resection in the simultaneous strategy group and 155 in the classical strategy group without difference in 5-year overall survival (p = 0.198). Conclusion Simultaneous resection of the colorectal primary cancer and liver metastases can possibly have more complications, with no difference in overall survival compared to the classical strategy. Syk, Ingvar verfasserin aut Lindell, Gert verfasserin aut Sandström, Per verfasserin aut Isaksson, Bengt verfasserin aut Rizell, Magnus verfasserin aut Norén, Agneta verfasserin aut Ardnor, Bjarne verfasserin aut Sturesson, Christian verfasserin aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 44(2020), 7 vom: 17. März, Seite 2409-2417 (DE-627)SPR003391159 nnns volume:44 year:2020 number:7 day:17 month:03 pages:2409-2417 https://dx.doi.org/10.1007/s00268-020-05475-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 44 2020 7 17 03 2409-2417 |
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outcomes of simultaneous resections and classical strategy for synchronous colorectal liver metastases in sweden: a nationwide study with special reference to major liver resections |
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Outcomes of Simultaneous Resections and Classical Strategy for Synchronous Colorectal Liver Metastases in Sweden: A Nationwide Study with Special Reference to Major Liver Resections |
| abstract |
Background About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and surgical resection offers a chance for cure. The aim of the present study was to compare outcomes for patients that underwent simultaneous resection to those that underwent a staged procedure with the bowel-first (classical) strategy by using information from two national registries in Sweden. Methods In this prospectively registered cohort study, we analyzed clinical, pathological, and survival outcomes for patients operated in the period 2008–2015 and compared the two strategies. Results In total, 537 patients constituted the study cohort, where 160 were treated with the simultaneous strategy and 377 with the classical strategy. Patients managed with the simultaneous strategy had less often rectal primary tumors (22% vs. 31%, p = 0.046) and underwent to a lesser extent a major liver resection (16% vs. 41%, p < 0.001), but had a shorter total length of stay (11 vs. 15 days, p < 0.001) and more complications (52% vs. 36%, p < 0.001). No significant 5-year overall survival (p = 0.110) difference was detected. Twenty-five patients had a major liver resection in the simultaneous strategy group and 155 in the classical strategy group without difference in 5-year overall survival (p = 0.198). Conclusion Simultaneous resection of the colorectal primary cancer and liver metastases can possibly have more complications, with no difference in overall survival compared to the classical strategy. |
| abstractGer |
Background About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and surgical resection offers a chance for cure. The aim of the present study was to compare outcomes for patients that underwent simultaneous resection to those that underwent a staged procedure with the bowel-first (classical) strategy by using information from two national registries in Sweden. Methods In this prospectively registered cohort study, we analyzed clinical, pathological, and survival outcomes for patients operated in the period 2008–2015 and compared the two strategies. Results In total, 537 patients constituted the study cohort, where 160 were treated with the simultaneous strategy and 377 with the classical strategy. Patients managed with the simultaneous strategy had less often rectal primary tumors (22% vs. 31%, p = 0.046) and underwent to a lesser extent a major liver resection (16% vs. 41%, p < 0.001), but had a shorter total length of stay (11 vs. 15 days, p < 0.001) and more complications (52% vs. 36%, p < 0.001). No significant 5-year overall survival (p = 0.110) difference was detected. Twenty-five patients had a major liver resection in the simultaneous strategy group and 155 in the classical strategy group without difference in 5-year overall survival (p = 0.198). Conclusion Simultaneous resection of the colorectal primary cancer and liver metastases can possibly have more complications, with no difference in overall survival compared to the classical strategy. |
| abstract_unstemmed |
Background About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and surgical resection offers a chance for cure. The aim of the present study was to compare outcomes for patients that underwent simultaneous resection to those that underwent a staged procedure with the bowel-first (classical) strategy by using information from two national registries in Sweden. Methods In this prospectively registered cohort study, we analyzed clinical, pathological, and survival outcomes for patients operated in the period 2008–2015 and compared the two strategies. Results In total, 537 patients constituted the study cohort, where 160 were treated with the simultaneous strategy and 377 with the classical strategy. Patients managed with the simultaneous strategy had less often rectal primary tumors (22% vs. 31%, p = 0.046) and underwent to a lesser extent a major liver resection (16% vs. 41%, p < 0.001), but had a shorter total length of stay (11 vs. 15 days, p < 0.001) and more complications (52% vs. 36%, p < 0.001). No significant 5-year overall survival (p = 0.110) difference was detected. Twenty-five patients had a major liver resection in the simultaneous strategy group and 155 in the classical strategy group without difference in 5-year overall survival (p = 0.198). Conclusion Simultaneous resection of the colorectal primary cancer and liver metastases can possibly have more complications, with no difference in overall survival compared to the classical strategy. |
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| title_short |
Outcomes of Simultaneous Resections and Classical Strategy for Synchronous Colorectal Liver Metastases in Sweden: A Nationwide Study with Special Reference to Major Liver Resections |
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https://dx.doi.org/10.1007/s00268-020-05475-5 |
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Syk, Ingvar Lindell, Gert Sandström, Per Isaksson, Bengt Rizell, Magnus Norén, Agneta Ardnor, Bjarne Sturesson, Christian |
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Syk, Ingvar Lindell, Gert Sandström, Per Isaksson, Bengt Rizell, Magnus Norén, Agneta Ardnor, Bjarne Sturesson, Christian |
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10.1007/s00268-020-05475-5 |
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2024-07-04T02:04:52.950Z |
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