Generation of viable blastocysts from discarded human cleavage embryos
Background While a relationship between embryo morphology, developmental ability, and genetic integrity exists, the selection of embryos with higher implantation potential remains a major challenge in assisted reproductive technology (ART). This study investigated blastocyst developmental competence...
Ausführliche Beschreibung
Autor*in: |
Taheri, Fatemeh [verfasserIn] Khalili, Mohammad Ali [verfasserIn] Kalantar, Seyed Mehdi [verfasserIn] Fesahat, Farzaneh [verfasserIn] Montazeri, Fatemeh [verfasserIn] Palmerini, Maria Grazia [verfasserIn] Woodward, Bryan [verfasserIn] |
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Englisch |
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2020 |
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Übergeordnetes Werk: |
Enthalten in: Middle East Fertility Society journal - [S.l.] : Elsevier, 2004, 25(2020), 1 vom: 09. Juni |
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Übergeordnetes Werk: |
volume:25 ; year:2020 ; number:1 ; day:09 ; month:06 |
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DOI / URN: |
10.1186/s43043-020-00028-1 |
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Katalog-ID: |
SPR039983382 |
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520 | |a Background While a relationship between embryo morphology, developmental ability, and genetic integrity exists, the selection of embryos with higher implantation potential remains a major challenge in assisted reproductive technology (ART). This study investigated blastocyst developmental competence and euploidy status in human embryos that had been classed as too poor quality to transfer (ET) or cryopreserve at the cleavage stage. Embryos were divided into three groups. Group 1 (n = 41) included good quality embryos from candidates of preimplantation genetic testing for aneuploidy (PGT-A). Groups II and III were the “rejected” supernumerary embryos, defined as suboptimal for ET or vitrification after morphological examination, with embryos randomly divided between the groups. Group II embryos (n = 31) were cultured up to the day 3 cleavage stage, when they were biopsied and fixed. Group III embryos (n = 27) were cultured up to the day 5 blastocyst stage, when they were evaluated for morphology and chromosomal status. Chromosomal status in all groups was assessed by multi-color fluorescence in situ hybridization (FISH) for chromosomes 13, 18, 21, X, and Y. Results Euploidy rates in groups I, II, and III were 56.1%, 38.7%, and 55.5 %, respectively. Among the blastocysts that developed from “rejected” embryos, 59.3% were classed as good quality. The most frequent chromosomal aneuploidy was related to the sex chromosome (22.2%). The mosaicism rate was not significantly different between the group II and III embryos (25.8% vs. 37.0%, p = 0.28). Conclusion In conclusion, surplus poor-quality embryos rejected from clinical utilization at the cleavage stage may develop into viable blastocysts with normal chromosomal status for at least 5 chromosomes. Recovery of euploidy during poor-quality embryo transition from cleavage stage to blastocyst could provide an alternative choice for ET. | ||
650 | 4 | |a Blastocyst |7 (dpeaa)DE-He213 | |
650 | 4 | |a Poor-quality embryo |7 (dpeaa)DE-He213 | |
650 | 4 | |a FISH |7 (dpeaa)DE-He213 | |
650 | 4 | |a Aneuploidy |7 (dpeaa)DE-He213 | |
700 | 1 | |a Khalili, Mohammad Ali |e verfasserin |4 aut | |
700 | 1 | |a Kalantar, Seyed Mehdi |e verfasserin |4 aut | |
700 | 1 | |a Fesahat, Farzaneh |e verfasserin |4 aut | |
700 | 1 | |a Montazeri, Fatemeh |e verfasserin |4 aut | |
700 | 1 | |a Palmerini, Maria Grazia |e verfasserin |4 aut | |
700 | 1 | |a Woodward, Bryan |e verfasserin |4 aut | |
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10.1186/s43043-020-00028-1 doi (DE-627)SPR039983382 (SPR)s43043-020-00028-1-e DE-627 ger DE-627 rakwb eng 610 ASE Taheri, Fatemeh verfasserin aut Generation of viable blastocysts from discarded human cleavage embryos 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background While a relationship between embryo morphology, developmental ability, and genetic integrity exists, the selection of embryos with higher implantation potential remains a major challenge in assisted reproductive technology (ART). This study investigated blastocyst developmental competence and euploidy status in human embryos that had been classed as too poor quality to transfer (ET) or cryopreserve at the cleavage stage. Embryos were divided into three groups. Group 1 (n = 41) included good quality embryos from candidates of preimplantation genetic testing for aneuploidy (PGT-A). Groups II and III were the “rejected” supernumerary embryos, defined as suboptimal for ET or vitrification after morphological examination, with embryos randomly divided between the groups. Group II embryos (n = 31) were cultured up to the day 3 cleavage stage, when they were biopsied and fixed. Group III embryos (n = 27) were cultured up to the day 5 blastocyst stage, when they were evaluated for morphology and chromosomal status. Chromosomal status in all groups was assessed by multi-color fluorescence in situ hybridization (FISH) for chromosomes 13, 18, 21, X, and Y. Results Euploidy rates in groups I, II, and III were 56.1%, 38.7%, and 55.5 %, respectively. Among the blastocysts that developed from “rejected” embryos, 59.3% were classed as good quality. The most frequent chromosomal aneuploidy was related to the sex chromosome (22.2%). The mosaicism rate was not significantly different between the group II and III embryos (25.8% vs. 37.0%, p = 0.28). Conclusion In conclusion, surplus poor-quality embryos rejected from clinical utilization at the cleavage stage may develop into viable blastocysts with normal chromosomal status for at least 5 chromosomes. Recovery of euploidy during poor-quality embryo transition from cleavage stage to blastocyst could provide an alternative choice for ET. Blastocyst (dpeaa)DE-He213 Poor-quality embryo (dpeaa)DE-He213 FISH (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Khalili, Mohammad Ali verfasserin aut Kalantar, Seyed Mehdi verfasserin aut Fesahat, Farzaneh verfasserin aut Montazeri, Fatemeh verfasserin aut Palmerini, Maria Grazia verfasserin aut Woodward, Bryan verfasserin aut Enthalten in Middle East Fertility Society journal [S.l.] : Elsevier, 2004 25(2020), 1 vom: 09. Juni (DE-627)494831642 (DE-600)2196955-3 2090-3251 nnns volume:25 year:2020 number:1 day:09 month:06 https://dx.doi.org/10.1186/s43043-020-00028-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_206 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 25 2020 1 09 06 |
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10.1186/s43043-020-00028-1 doi (DE-627)SPR039983382 (SPR)s43043-020-00028-1-e DE-627 ger DE-627 rakwb eng 610 ASE Taheri, Fatemeh verfasserin aut Generation of viable blastocysts from discarded human cleavage embryos 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background While a relationship between embryo morphology, developmental ability, and genetic integrity exists, the selection of embryos with higher implantation potential remains a major challenge in assisted reproductive technology (ART). This study investigated blastocyst developmental competence and euploidy status in human embryos that had been classed as too poor quality to transfer (ET) or cryopreserve at the cleavage stage. Embryos were divided into three groups. Group 1 (n = 41) included good quality embryos from candidates of preimplantation genetic testing for aneuploidy (PGT-A). Groups II and III were the “rejected” supernumerary embryos, defined as suboptimal for ET or vitrification after morphological examination, with embryos randomly divided between the groups. Group II embryos (n = 31) were cultured up to the day 3 cleavage stage, when they were biopsied and fixed. Group III embryos (n = 27) were cultured up to the day 5 blastocyst stage, when they were evaluated for morphology and chromosomal status. Chromosomal status in all groups was assessed by multi-color fluorescence in situ hybridization (FISH) for chromosomes 13, 18, 21, X, and Y. Results Euploidy rates in groups I, II, and III were 56.1%, 38.7%, and 55.5 %, respectively. Among the blastocysts that developed from “rejected” embryos, 59.3% were classed as good quality. The most frequent chromosomal aneuploidy was related to the sex chromosome (22.2%). The mosaicism rate was not significantly different between the group II and III embryos (25.8% vs. 37.0%, p = 0.28). Conclusion In conclusion, surplus poor-quality embryos rejected from clinical utilization at the cleavage stage may develop into viable blastocysts with normal chromosomal status for at least 5 chromosomes. Recovery of euploidy during poor-quality embryo transition from cleavage stage to blastocyst could provide an alternative choice for ET. Blastocyst (dpeaa)DE-He213 Poor-quality embryo (dpeaa)DE-He213 FISH (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Khalili, Mohammad Ali verfasserin aut Kalantar, Seyed Mehdi verfasserin aut Fesahat, Farzaneh verfasserin aut Montazeri, Fatemeh verfasserin aut Palmerini, Maria Grazia verfasserin aut Woodward, Bryan verfasserin aut Enthalten in Middle East Fertility Society journal [S.l.] : Elsevier, 2004 25(2020), 1 vom: 09. Juni (DE-627)494831642 (DE-600)2196955-3 2090-3251 nnns volume:25 year:2020 number:1 day:09 month:06 https://dx.doi.org/10.1186/s43043-020-00028-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_206 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 25 2020 1 09 06 |
allfields_unstemmed |
10.1186/s43043-020-00028-1 doi (DE-627)SPR039983382 (SPR)s43043-020-00028-1-e DE-627 ger DE-627 rakwb eng 610 ASE Taheri, Fatemeh verfasserin aut Generation of viable blastocysts from discarded human cleavage embryos 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background While a relationship between embryo morphology, developmental ability, and genetic integrity exists, the selection of embryos with higher implantation potential remains a major challenge in assisted reproductive technology (ART). This study investigated blastocyst developmental competence and euploidy status in human embryos that had been classed as too poor quality to transfer (ET) or cryopreserve at the cleavage stage. Embryos were divided into three groups. Group 1 (n = 41) included good quality embryos from candidates of preimplantation genetic testing for aneuploidy (PGT-A). Groups II and III were the “rejected” supernumerary embryos, defined as suboptimal for ET or vitrification after morphological examination, with embryos randomly divided between the groups. Group II embryos (n = 31) were cultured up to the day 3 cleavage stage, when they were biopsied and fixed. Group III embryos (n = 27) were cultured up to the day 5 blastocyst stage, when they were evaluated for morphology and chromosomal status. Chromosomal status in all groups was assessed by multi-color fluorescence in situ hybridization (FISH) for chromosomes 13, 18, 21, X, and Y. Results Euploidy rates in groups I, II, and III were 56.1%, 38.7%, and 55.5 %, respectively. Among the blastocysts that developed from “rejected” embryos, 59.3% were classed as good quality. The most frequent chromosomal aneuploidy was related to the sex chromosome (22.2%). The mosaicism rate was not significantly different between the group II and III embryos (25.8% vs. 37.0%, p = 0.28). Conclusion In conclusion, surplus poor-quality embryos rejected from clinical utilization at the cleavage stage may develop into viable blastocysts with normal chromosomal status for at least 5 chromosomes. Recovery of euploidy during poor-quality embryo transition from cleavage stage to blastocyst could provide an alternative choice for ET. Blastocyst (dpeaa)DE-He213 Poor-quality embryo (dpeaa)DE-He213 FISH (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Khalili, Mohammad Ali verfasserin aut Kalantar, Seyed Mehdi verfasserin aut Fesahat, Farzaneh verfasserin aut Montazeri, Fatemeh verfasserin aut Palmerini, Maria Grazia verfasserin aut Woodward, Bryan verfasserin aut Enthalten in Middle East Fertility Society journal [S.l.] : Elsevier, 2004 25(2020), 1 vom: 09. Juni (DE-627)494831642 (DE-600)2196955-3 2090-3251 nnns volume:25 year:2020 number:1 day:09 month:06 https://dx.doi.org/10.1186/s43043-020-00028-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_206 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 25 2020 1 09 06 |
allfieldsGer |
10.1186/s43043-020-00028-1 doi (DE-627)SPR039983382 (SPR)s43043-020-00028-1-e DE-627 ger DE-627 rakwb eng 610 ASE Taheri, Fatemeh verfasserin aut Generation of viable blastocysts from discarded human cleavage embryos 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background While a relationship between embryo morphology, developmental ability, and genetic integrity exists, the selection of embryos with higher implantation potential remains a major challenge in assisted reproductive technology (ART). This study investigated blastocyst developmental competence and euploidy status in human embryos that had been classed as too poor quality to transfer (ET) or cryopreserve at the cleavage stage. Embryos were divided into three groups. Group 1 (n = 41) included good quality embryos from candidates of preimplantation genetic testing for aneuploidy (PGT-A). Groups II and III were the “rejected” supernumerary embryos, defined as suboptimal for ET or vitrification after morphological examination, with embryos randomly divided between the groups. Group II embryos (n = 31) were cultured up to the day 3 cleavage stage, when they were biopsied and fixed. Group III embryos (n = 27) were cultured up to the day 5 blastocyst stage, when they were evaluated for morphology and chromosomal status. Chromosomal status in all groups was assessed by multi-color fluorescence in situ hybridization (FISH) for chromosomes 13, 18, 21, X, and Y. Results Euploidy rates in groups I, II, and III were 56.1%, 38.7%, and 55.5 %, respectively. Among the blastocysts that developed from “rejected” embryos, 59.3% were classed as good quality. The most frequent chromosomal aneuploidy was related to the sex chromosome (22.2%). The mosaicism rate was not significantly different between the group II and III embryos (25.8% vs. 37.0%, p = 0.28). Conclusion In conclusion, surplus poor-quality embryos rejected from clinical utilization at the cleavage stage may develop into viable blastocysts with normal chromosomal status for at least 5 chromosomes. Recovery of euploidy during poor-quality embryo transition from cleavage stage to blastocyst could provide an alternative choice for ET. Blastocyst (dpeaa)DE-He213 Poor-quality embryo (dpeaa)DE-He213 FISH (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Khalili, Mohammad Ali verfasserin aut Kalantar, Seyed Mehdi verfasserin aut Fesahat, Farzaneh verfasserin aut Montazeri, Fatemeh verfasserin aut Palmerini, Maria Grazia verfasserin aut Woodward, Bryan verfasserin aut Enthalten in Middle East Fertility Society journal [S.l.] : Elsevier, 2004 25(2020), 1 vom: 09. Juni (DE-627)494831642 (DE-600)2196955-3 2090-3251 nnns volume:25 year:2020 number:1 day:09 month:06 https://dx.doi.org/10.1186/s43043-020-00028-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_206 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 25 2020 1 09 06 |
allfieldsSound |
10.1186/s43043-020-00028-1 doi (DE-627)SPR039983382 (SPR)s43043-020-00028-1-e DE-627 ger DE-627 rakwb eng 610 ASE Taheri, Fatemeh verfasserin aut Generation of viable blastocysts from discarded human cleavage embryos 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background While a relationship between embryo morphology, developmental ability, and genetic integrity exists, the selection of embryos with higher implantation potential remains a major challenge in assisted reproductive technology (ART). This study investigated blastocyst developmental competence and euploidy status in human embryos that had been classed as too poor quality to transfer (ET) or cryopreserve at the cleavage stage. Embryos were divided into three groups. Group 1 (n = 41) included good quality embryos from candidates of preimplantation genetic testing for aneuploidy (PGT-A). Groups II and III were the “rejected” supernumerary embryos, defined as suboptimal for ET or vitrification after morphological examination, with embryos randomly divided between the groups. Group II embryos (n = 31) were cultured up to the day 3 cleavage stage, when they were biopsied and fixed. Group III embryos (n = 27) were cultured up to the day 5 blastocyst stage, when they were evaluated for morphology and chromosomal status. Chromosomal status in all groups was assessed by multi-color fluorescence in situ hybridization (FISH) for chromosomes 13, 18, 21, X, and Y. Results Euploidy rates in groups I, II, and III were 56.1%, 38.7%, and 55.5 %, respectively. Among the blastocysts that developed from “rejected” embryos, 59.3% were classed as good quality. The most frequent chromosomal aneuploidy was related to the sex chromosome (22.2%). The mosaicism rate was not significantly different between the group II and III embryos (25.8% vs. 37.0%, p = 0.28). Conclusion In conclusion, surplus poor-quality embryos rejected from clinical utilization at the cleavage stage may develop into viable blastocysts with normal chromosomal status for at least 5 chromosomes. Recovery of euploidy during poor-quality embryo transition from cleavage stage to blastocyst could provide an alternative choice for ET. Blastocyst (dpeaa)DE-He213 Poor-quality embryo (dpeaa)DE-He213 FISH (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Khalili, Mohammad Ali verfasserin aut Kalantar, Seyed Mehdi verfasserin aut Fesahat, Farzaneh verfasserin aut Montazeri, Fatemeh verfasserin aut Palmerini, Maria Grazia verfasserin aut Woodward, Bryan verfasserin aut Enthalten in Middle East Fertility Society journal [S.l.] : Elsevier, 2004 25(2020), 1 vom: 09. Juni (DE-627)494831642 (DE-600)2196955-3 2090-3251 nnns volume:25 year:2020 number:1 day:09 month:06 https://dx.doi.org/10.1186/s43043-020-00028-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_206 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 25 2020 1 09 06 |
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Enthalten in Middle East Fertility Society journal 25(2020), 1 vom: 09. Juni volume:25 year:2020 number:1 day:09 month:06 |
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Taheri, Fatemeh @@aut@@ Khalili, Mohammad Ali @@aut@@ Kalantar, Seyed Mehdi @@aut@@ Fesahat, Farzaneh @@aut@@ Montazeri, Fatemeh @@aut@@ Palmerini, Maria Grazia @@aut@@ Woodward, Bryan @@aut@@ |
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This study investigated blastocyst developmental competence and euploidy status in human embryos that had been classed as too poor quality to transfer (ET) or cryopreserve at the cleavage stage. Embryos were divided into three groups. Group 1 (n = 41) included good quality embryos from candidates of preimplantation genetic testing for aneuploidy (PGT-A). Groups II and III were the “rejected” supernumerary embryos, defined as suboptimal for ET or vitrification after morphological examination, with embryos randomly divided between the groups. Group II embryos (n = 31) were cultured up to the day 3 cleavage stage, when they were biopsied and fixed. Group III embryos (n = 27) were cultured up to the day 5 blastocyst stage, when they were evaluated for morphology and chromosomal status. Chromosomal status in all groups was assessed by multi-color fluorescence in situ hybridization (FISH) for chromosomes 13, 18, 21, X, and Y. Results Euploidy rates in groups I, II, and III were 56.1%, 38.7%, and 55.5 %, respectively. Among the blastocysts that developed from “rejected” embryos, 59.3% were classed as good quality. The most frequent chromosomal aneuploidy was related to the sex chromosome (22.2%). The mosaicism rate was not significantly different between the group II and III embryos (25.8% vs. 37.0%, p = 0.28). Conclusion In conclusion, surplus poor-quality embryos rejected from clinical utilization at the cleavage stage may develop into viable blastocysts with normal chromosomal status for at least 5 chromosomes. 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Taheri, Fatemeh ddc 610 misc Blastocyst misc Poor-quality embryo misc FISH misc Aneuploidy Generation of viable blastocysts from discarded human cleavage embryos |
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610 ASE Generation of viable blastocysts from discarded human cleavage embryos Blastocyst (dpeaa)DE-He213 Poor-quality embryo (dpeaa)DE-He213 FISH (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 |
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Generation of viable blastocysts from discarded human cleavage embryos |
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Generation of viable blastocysts from discarded human cleavage embryos |
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Taheri, Fatemeh Khalili, Mohammad Ali Kalantar, Seyed Mehdi Fesahat, Farzaneh Montazeri, Fatemeh Palmerini, Maria Grazia Woodward, Bryan |
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generation of viable blastocysts from discarded human cleavage embryos |
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Generation of viable blastocysts from discarded human cleavage embryos |
abstract |
Background While a relationship between embryo morphology, developmental ability, and genetic integrity exists, the selection of embryos with higher implantation potential remains a major challenge in assisted reproductive technology (ART). This study investigated blastocyst developmental competence and euploidy status in human embryos that had been classed as too poor quality to transfer (ET) or cryopreserve at the cleavage stage. Embryos were divided into three groups. Group 1 (n = 41) included good quality embryos from candidates of preimplantation genetic testing for aneuploidy (PGT-A). Groups II and III were the “rejected” supernumerary embryos, defined as suboptimal for ET or vitrification after morphological examination, with embryos randomly divided between the groups. Group II embryos (n = 31) were cultured up to the day 3 cleavage stage, when they were biopsied and fixed. Group III embryos (n = 27) were cultured up to the day 5 blastocyst stage, when they were evaluated for morphology and chromosomal status. Chromosomal status in all groups was assessed by multi-color fluorescence in situ hybridization (FISH) for chromosomes 13, 18, 21, X, and Y. Results Euploidy rates in groups I, II, and III were 56.1%, 38.7%, and 55.5 %, respectively. Among the blastocysts that developed from “rejected” embryos, 59.3% were classed as good quality. The most frequent chromosomal aneuploidy was related to the sex chromosome (22.2%). The mosaicism rate was not significantly different between the group II and III embryos (25.8% vs. 37.0%, p = 0.28). Conclusion In conclusion, surplus poor-quality embryos rejected from clinical utilization at the cleavage stage may develop into viable blastocysts with normal chromosomal status for at least 5 chromosomes. Recovery of euploidy during poor-quality embryo transition from cleavage stage to blastocyst could provide an alternative choice for ET. |
abstractGer |
Background While a relationship between embryo morphology, developmental ability, and genetic integrity exists, the selection of embryos with higher implantation potential remains a major challenge in assisted reproductive technology (ART). This study investigated blastocyst developmental competence and euploidy status in human embryos that had been classed as too poor quality to transfer (ET) or cryopreserve at the cleavage stage. Embryos were divided into three groups. Group 1 (n = 41) included good quality embryos from candidates of preimplantation genetic testing for aneuploidy (PGT-A). Groups II and III were the “rejected” supernumerary embryos, defined as suboptimal for ET or vitrification after morphological examination, with embryos randomly divided between the groups. Group II embryos (n = 31) were cultured up to the day 3 cleavage stage, when they were biopsied and fixed. Group III embryos (n = 27) were cultured up to the day 5 blastocyst stage, when they were evaluated for morphology and chromosomal status. Chromosomal status in all groups was assessed by multi-color fluorescence in situ hybridization (FISH) for chromosomes 13, 18, 21, X, and Y. Results Euploidy rates in groups I, II, and III were 56.1%, 38.7%, and 55.5 %, respectively. Among the blastocysts that developed from “rejected” embryos, 59.3% were classed as good quality. The most frequent chromosomal aneuploidy was related to the sex chromosome (22.2%). The mosaicism rate was not significantly different between the group II and III embryos (25.8% vs. 37.0%, p = 0.28). Conclusion In conclusion, surplus poor-quality embryos rejected from clinical utilization at the cleavage stage may develop into viable blastocysts with normal chromosomal status for at least 5 chromosomes. Recovery of euploidy during poor-quality embryo transition from cleavage stage to blastocyst could provide an alternative choice for ET. |
abstract_unstemmed |
Background While a relationship between embryo morphology, developmental ability, and genetic integrity exists, the selection of embryos with higher implantation potential remains a major challenge in assisted reproductive technology (ART). This study investigated blastocyst developmental competence and euploidy status in human embryos that had been classed as too poor quality to transfer (ET) or cryopreserve at the cleavage stage. Embryos were divided into three groups. Group 1 (n = 41) included good quality embryos from candidates of preimplantation genetic testing for aneuploidy (PGT-A). Groups II and III were the “rejected” supernumerary embryos, defined as suboptimal for ET or vitrification after morphological examination, with embryos randomly divided between the groups. Group II embryos (n = 31) were cultured up to the day 3 cleavage stage, when they were biopsied and fixed. Group III embryos (n = 27) were cultured up to the day 5 blastocyst stage, when they were evaluated for morphology and chromosomal status. Chromosomal status in all groups was assessed by multi-color fluorescence in situ hybridization (FISH) for chromosomes 13, 18, 21, X, and Y. Results Euploidy rates in groups I, II, and III were 56.1%, 38.7%, and 55.5 %, respectively. Among the blastocysts that developed from “rejected” embryos, 59.3% were classed as good quality. The most frequent chromosomal aneuploidy was related to the sex chromosome (22.2%). The mosaicism rate was not significantly different between the group II and III embryos (25.8% vs. 37.0%, p = 0.28). Conclusion In conclusion, surplus poor-quality embryos rejected from clinical utilization at the cleavage stage may develop into viable blastocysts with normal chromosomal status for at least 5 chromosomes. Recovery of euploidy during poor-quality embryo transition from cleavage stage to blastocyst could provide an alternative choice for ET. |
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Generation of viable blastocysts from discarded human cleavage embryos |
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https://dx.doi.org/10.1186/s43043-020-00028-1 |
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Khalili, Mohammad Ali Kalantar, Seyed Mehdi Fesahat, Farzaneh Montazeri, Fatemeh Palmerini, Maria Grazia Woodward, Bryan |
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