Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter”
Abstract The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Rece...
Ausführliche Beschreibung
Autor*in: |
Grillone, Katia [verfasserIn] Riillo, Caterina [verfasserIn] Scionti, Francesca [verfasserIn] Rocca, Roberta [verfasserIn] Tradigo, Giuseppe [verfasserIn] Guzzi, Pietro Hiram [verfasserIn] Alcaro, Stefano [verfasserIn] Di Martino, Maria Teresa [verfasserIn] Tagliaferri, Pierosandro [verfasserIn] Tassone, Pierfrancesco [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2020 |
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Übergeordnetes Werk: |
Enthalten in: Journal of experimental & clinical cancer research - Berlin : Springer, 2008, 39(2020), 1 vom: 20. Juni |
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Übergeordnetes Werk: |
volume:39 ; year:2020 ; number:1 ; day:20 ; month:06 |
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DOI / URN: |
10.1186/s13046-020-01622-x |
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Katalog-ID: |
SPR040102157 |
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10.1186/s13046-020-01622-x doi (DE-627)SPR040102157 (SPR)s13046-020-01622-x-e DE-627 ger DE-627 rakwb eng 610 ASE Grillone, Katia verfasserin aut Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter” 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently, profiling and sequencing of ncRNAs disclosed deep deregulation in human cancers mostly due to aberrant mechanisms of ncRNAs biogenesis, such as amplification, deletion, abnormal epigenetic or transcriptional regulation. Although dysregulated ncRNAs may promote hallmarks of cancer as oncogenes or antagonize them as tumor suppressors, the mechanisms behind these events remain to be clarified. The development of new bioinformatic tools as well as novel molecular technologies is a challenging opportunity to disclose the role of the “dark matter” of the genome. In this review, we focus on currently available platforms, computational analyses and experimental strategies to investigate ncRNAs in cancer. We highlight the differences among experimental approaches aimed to dissect miRNAs and lncRNAs, which are the most studied ncRNAs. These two classes indeed need different investigation taking into account their intrinsic characteristics, such as length, structures and also the interacting molecules. Finally, we discuss the relevance of ncRNAs in clinical practice by considering promises and challenges behind the bench to bedside translation. Cancer genetics (dpeaa)DE-He213 Non-coding RNAs (dpeaa)DE-He213 microRNAs (dpeaa)DE-He213 miRNAs (dpeaa)DE-He213 Long-non coding RNAs (dpeaa)DE-He213 lncRNAs (dpeaa)DE-He213 ncRNA functions (dpeaa)DE-He213 Riillo, Caterina verfasserin aut Scionti, Francesca verfasserin aut Rocca, Roberta verfasserin aut Tradigo, Giuseppe verfasserin aut Guzzi, Pietro Hiram verfasserin aut Alcaro, Stefano verfasserin aut Di Martino, Maria Teresa verfasserin aut Tagliaferri, Pierosandro verfasserin aut Tassone, Pierfrancesco verfasserin aut Enthalten in Journal of experimental & clinical cancer research Berlin : Springer, 2008 39(2020), 1 vom: 20. Juni (DE-627)568921380 (DE-600)2430698-8 1756-9966 nnns volume:39 year:2020 number:1 day:20 month:06 https://dx.doi.org/10.1186/s13046-020-01622-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2020 1 20 06 |
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10.1186/s13046-020-01622-x doi (DE-627)SPR040102157 (SPR)s13046-020-01622-x-e DE-627 ger DE-627 rakwb eng 610 ASE Grillone, Katia verfasserin aut Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter” 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently, profiling and sequencing of ncRNAs disclosed deep deregulation in human cancers mostly due to aberrant mechanisms of ncRNAs biogenesis, such as amplification, deletion, abnormal epigenetic or transcriptional regulation. Although dysregulated ncRNAs may promote hallmarks of cancer as oncogenes or antagonize them as tumor suppressors, the mechanisms behind these events remain to be clarified. The development of new bioinformatic tools as well as novel molecular technologies is a challenging opportunity to disclose the role of the “dark matter” of the genome. In this review, we focus on currently available platforms, computational analyses and experimental strategies to investigate ncRNAs in cancer. We highlight the differences among experimental approaches aimed to dissect miRNAs and lncRNAs, which are the most studied ncRNAs. These two classes indeed need different investigation taking into account their intrinsic characteristics, such as length, structures and also the interacting molecules. Finally, we discuss the relevance of ncRNAs in clinical practice by considering promises and challenges behind the bench to bedside translation. Cancer genetics (dpeaa)DE-He213 Non-coding RNAs (dpeaa)DE-He213 microRNAs (dpeaa)DE-He213 miRNAs (dpeaa)DE-He213 Long-non coding RNAs (dpeaa)DE-He213 lncRNAs (dpeaa)DE-He213 ncRNA functions (dpeaa)DE-He213 Riillo, Caterina verfasserin aut Scionti, Francesca verfasserin aut Rocca, Roberta verfasserin aut Tradigo, Giuseppe verfasserin aut Guzzi, Pietro Hiram verfasserin aut Alcaro, Stefano verfasserin aut Di Martino, Maria Teresa verfasserin aut Tagliaferri, Pierosandro verfasserin aut Tassone, Pierfrancesco verfasserin aut Enthalten in Journal of experimental & clinical cancer research Berlin : Springer, 2008 39(2020), 1 vom: 20. Juni (DE-627)568921380 (DE-600)2430698-8 1756-9966 nnns volume:39 year:2020 number:1 day:20 month:06 https://dx.doi.org/10.1186/s13046-020-01622-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2020 1 20 06 |
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10.1186/s13046-020-01622-x doi (DE-627)SPR040102157 (SPR)s13046-020-01622-x-e DE-627 ger DE-627 rakwb eng 610 ASE Grillone, Katia verfasserin aut Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter” 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently, profiling and sequencing of ncRNAs disclosed deep deregulation in human cancers mostly due to aberrant mechanisms of ncRNAs biogenesis, such as amplification, deletion, abnormal epigenetic or transcriptional regulation. Although dysregulated ncRNAs may promote hallmarks of cancer as oncogenes or antagonize them as tumor suppressors, the mechanisms behind these events remain to be clarified. The development of new bioinformatic tools as well as novel molecular technologies is a challenging opportunity to disclose the role of the “dark matter” of the genome. In this review, we focus on currently available platforms, computational analyses and experimental strategies to investigate ncRNAs in cancer. We highlight the differences among experimental approaches aimed to dissect miRNAs and lncRNAs, which are the most studied ncRNAs. These two classes indeed need different investigation taking into account their intrinsic characteristics, such as length, structures and also the interacting molecules. Finally, we discuss the relevance of ncRNAs in clinical practice by considering promises and challenges behind the bench to bedside translation. Cancer genetics (dpeaa)DE-He213 Non-coding RNAs (dpeaa)DE-He213 microRNAs (dpeaa)DE-He213 miRNAs (dpeaa)DE-He213 Long-non coding RNAs (dpeaa)DE-He213 lncRNAs (dpeaa)DE-He213 ncRNA functions (dpeaa)DE-He213 Riillo, Caterina verfasserin aut Scionti, Francesca verfasserin aut Rocca, Roberta verfasserin aut Tradigo, Giuseppe verfasserin aut Guzzi, Pietro Hiram verfasserin aut Alcaro, Stefano verfasserin aut Di Martino, Maria Teresa verfasserin aut Tagliaferri, Pierosandro verfasserin aut Tassone, Pierfrancesco verfasserin aut Enthalten in Journal of experimental & clinical cancer research Berlin : Springer, 2008 39(2020), 1 vom: 20. Juni (DE-627)568921380 (DE-600)2430698-8 1756-9966 nnns volume:39 year:2020 number:1 day:20 month:06 https://dx.doi.org/10.1186/s13046-020-01622-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2020 1 20 06 |
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10.1186/s13046-020-01622-x doi (DE-627)SPR040102157 (SPR)s13046-020-01622-x-e DE-627 ger DE-627 rakwb eng 610 ASE Grillone, Katia verfasserin aut Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter” 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently, profiling and sequencing of ncRNAs disclosed deep deregulation in human cancers mostly due to aberrant mechanisms of ncRNAs biogenesis, such as amplification, deletion, abnormal epigenetic or transcriptional regulation. Although dysregulated ncRNAs may promote hallmarks of cancer as oncogenes or antagonize them as tumor suppressors, the mechanisms behind these events remain to be clarified. The development of new bioinformatic tools as well as novel molecular technologies is a challenging opportunity to disclose the role of the “dark matter” of the genome. In this review, we focus on currently available platforms, computational analyses and experimental strategies to investigate ncRNAs in cancer. We highlight the differences among experimental approaches aimed to dissect miRNAs and lncRNAs, which are the most studied ncRNAs. These two classes indeed need different investigation taking into account their intrinsic characteristics, such as length, structures and also the interacting molecules. Finally, we discuss the relevance of ncRNAs in clinical practice by considering promises and challenges behind the bench to bedside translation. Cancer genetics (dpeaa)DE-He213 Non-coding RNAs (dpeaa)DE-He213 microRNAs (dpeaa)DE-He213 miRNAs (dpeaa)DE-He213 Long-non coding RNAs (dpeaa)DE-He213 lncRNAs (dpeaa)DE-He213 ncRNA functions (dpeaa)DE-He213 Riillo, Caterina verfasserin aut Scionti, Francesca verfasserin aut Rocca, Roberta verfasserin aut Tradigo, Giuseppe verfasserin aut Guzzi, Pietro Hiram verfasserin aut Alcaro, Stefano verfasserin aut Di Martino, Maria Teresa verfasserin aut Tagliaferri, Pierosandro verfasserin aut Tassone, Pierfrancesco verfasserin aut Enthalten in Journal of experimental & clinical cancer research Berlin : Springer, 2008 39(2020), 1 vom: 20. Juni (DE-627)568921380 (DE-600)2430698-8 1756-9966 nnns volume:39 year:2020 number:1 day:20 month:06 https://dx.doi.org/10.1186/s13046-020-01622-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2020 1 20 06 |
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10.1186/s13046-020-01622-x doi (DE-627)SPR040102157 (SPR)s13046-020-01622-x-e DE-627 ger DE-627 rakwb eng 610 ASE Grillone, Katia verfasserin aut Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter” 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently, profiling and sequencing of ncRNAs disclosed deep deregulation in human cancers mostly due to aberrant mechanisms of ncRNAs biogenesis, such as amplification, deletion, abnormal epigenetic or transcriptional regulation. Although dysregulated ncRNAs may promote hallmarks of cancer as oncogenes or antagonize them as tumor suppressors, the mechanisms behind these events remain to be clarified. The development of new bioinformatic tools as well as novel molecular technologies is a challenging opportunity to disclose the role of the “dark matter” of the genome. In this review, we focus on currently available platforms, computational analyses and experimental strategies to investigate ncRNAs in cancer. We highlight the differences among experimental approaches aimed to dissect miRNAs and lncRNAs, which are the most studied ncRNAs. These two classes indeed need different investigation taking into account their intrinsic characteristics, such as length, structures and also the interacting molecules. Finally, we discuss the relevance of ncRNAs in clinical practice by considering promises and challenges behind the bench to bedside translation. Cancer genetics (dpeaa)DE-He213 Non-coding RNAs (dpeaa)DE-He213 microRNAs (dpeaa)DE-He213 miRNAs (dpeaa)DE-He213 Long-non coding RNAs (dpeaa)DE-He213 lncRNAs (dpeaa)DE-He213 ncRNA functions (dpeaa)DE-He213 Riillo, Caterina verfasserin aut Scionti, Francesca verfasserin aut Rocca, Roberta verfasserin aut Tradigo, Giuseppe verfasserin aut Guzzi, Pietro Hiram verfasserin aut Alcaro, Stefano verfasserin aut Di Martino, Maria Teresa verfasserin aut Tagliaferri, Pierosandro verfasserin aut Tassone, Pierfrancesco verfasserin aut Enthalten in Journal of experimental & clinical cancer research Berlin : Springer, 2008 39(2020), 1 vom: 20. Juni (DE-627)568921380 (DE-600)2430698-8 1756-9966 nnns volume:39 year:2020 number:1 day:20 month:06 https://dx.doi.org/10.1186/s13046-020-01622-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2020 1 20 06 |
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Grillone, Katia @@aut@@ Riillo, Caterina @@aut@@ Scionti, Francesca @@aut@@ Rocca, Roberta @@aut@@ Tradigo, Giuseppe @@aut@@ Guzzi, Pietro Hiram @@aut@@ Alcaro, Stefano @@aut@@ Di Martino, Maria Teresa @@aut@@ Tagliaferri, Pierosandro @@aut@@ Tassone, Pierfrancesco @@aut@@ |
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2020-06-20T00:00:00Z |
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Grillone, Katia |
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610 ASE Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter” Cancer genetics (dpeaa)DE-He213 Non-coding RNAs (dpeaa)DE-He213 microRNAs (dpeaa)DE-He213 miRNAs (dpeaa)DE-He213 Long-non coding RNAs (dpeaa)DE-He213 lncRNAs (dpeaa)DE-He213 ncRNA functions (dpeaa)DE-He213 |
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Grillone, Katia Riillo, Caterina Scionti, Francesca Rocca, Roberta Tradigo, Giuseppe Guzzi, Pietro Hiram Alcaro, Stefano Di Martino, Maria Teresa Tagliaferri, Pierosandro Tassone, Pierfrancesco |
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non-coding rnas in cancer: platforms and strategies for investigating the genomic “dark matter” |
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Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter” |
abstract |
Abstract The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently, profiling and sequencing of ncRNAs disclosed deep deregulation in human cancers mostly due to aberrant mechanisms of ncRNAs biogenesis, such as amplification, deletion, abnormal epigenetic or transcriptional regulation. Although dysregulated ncRNAs may promote hallmarks of cancer as oncogenes or antagonize them as tumor suppressors, the mechanisms behind these events remain to be clarified. The development of new bioinformatic tools as well as novel molecular technologies is a challenging opportunity to disclose the role of the “dark matter” of the genome. In this review, we focus on currently available platforms, computational analyses and experimental strategies to investigate ncRNAs in cancer. We highlight the differences among experimental approaches aimed to dissect miRNAs and lncRNAs, which are the most studied ncRNAs. These two classes indeed need different investigation taking into account their intrinsic characteristics, such as length, structures and also the interacting molecules. Finally, we discuss the relevance of ncRNAs in clinical practice by considering promises and challenges behind the bench to bedside translation. |
abstractGer |
Abstract The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently, profiling and sequencing of ncRNAs disclosed deep deregulation in human cancers mostly due to aberrant mechanisms of ncRNAs biogenesis, such as amplification, deletion, abnormal epigenetic or transcriptional regulation. Although dysregulated ncRNAs may promote hallmarks of cancer as oncogenes or antagonize them as tumor suppressors, the mechanisms behind these events remain to be clarified. The development of new bioinformatic tools as well as novel molecular technologies is a challenging opportunity to disclose the role of the “dark matter” of the genome. In this review, we focus on currently available platforms, computational analyses and experimental strategies to investigate ncRNAs in cancer. We highlight the differences among experimental approaches aimed to dissect miRNAs and lncRNAs, which are the most studied ncRNAs. These two classes indeed need different investigation taking into account their intrinsic characteristics, such as length, structures and also the interacting molecules. Finally, we discuss the relevance of ncRNAs in clinical practice by considering promises and challenges behind the bench to bedside translation. |
abstract_unstemmed |
Abstract The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently, profiling and sequencing of ncRNAs disclosed deep deregulation in human cancers mostly due to aberrant mechanisms of ncRNAs biogenesis, such as amplification, deletion, abnormal epigenetic or transcriptional regulation. Although dysregulated ncRNAs may promote hallmarks of cancer as oncogenes or antagonize them as tumor suppressors, the mechanisms behind these events remain to be clarified. The development of new bioinformatic tools as well as novel molecular technologies is a challenging opportunity to disclose the role of the “dark matter” of the genome. In this review, we focus on currently available platforms, computational analyses and experimental strategies to investigate ncRNAs in cancer. We highlight the differences among experimental approaches aimed to dissect miRNAs and lncRNAs, which are the most studied ncRNAs. These two classes indeed need different investigation taking into account their intrinsic characteristics, such as length, structures and also the interacting molecules. Finally, we discuss the relevance of ncRNAs in clinical practice by considering promises and challenges behind the bench to bedside translation. |
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Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter” |
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Riillo, Caterina Scionti, Francesca Rocca, Roberta Tradigo, Giuseppe Guzzi, Pietro Hiram Alcaro, Stefano Di Martino, Maria Teresa Tagliaferri, Pierosandro Tassone, Pierfrancesco |
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It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently, profiling and sequencing of ncRNAs disclosed deep deregulation in human cancers mostly due to aberrant mechanisms of ncRNAs biogenesis, such as amplification, deletion, abnormal epigenetic or transcriptional regulation. Although dysregulated ncRNAs may promote hallmarks of cancer as oncogenes or antagonize them as tumor suppressors, the mechanisms behind these events remain to be clarified. The development of new bioinformatic tools as well as novel molecular technologies is a challenging opportunity to disclose the role of the “dark matter” of the genome. In this review, we focus on currently available platforms, computational analyses and experimental strategies to investigate ncRNAs in cancer. We highlight the differences among experimental approaches aimed to dissect miRNAs and lncRNAs, which are the most studied ncRNAs. These two classes indeed need different investigation taking into account their intrinsic characteristics, such as length, structures and also the interacting molecules. 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7.3976707 |