Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions
Abstract Some preceding studies show that a desmoplastic reaction (DR) at the invasive front of a primary tumor ($ DR^{primary} $) is a promising prognostic indicator, and its histologic classification is an independent prognostic factor in patients with colorectal cancer (CRC). Although DR is obser...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ao, Tadakazu [verfasserIn] Kajiwara, Yoshiki [verfasserIn] Yonemura, Keisuke [verfasserIn] Shinto, Eiji [verfasserIn] Mochizuki, Satsuki [verfasserIn] Okamoto, Koichi [verfasserIn] Kishi, Yoji [verfasserIn] Ueno, Hideki [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Virchows Archiv - Berlin : Springer, 1847, 477(2020), 1 vom: 13. Jan., Seite 47-55 |
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| Übergeordnetes Werk: |
volume:477 ; year:2020 ; number:1 ; day:13 ; month:01 ; pages:47-55 |
| Links: |
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| DOI / URN: |
10.1007/s00428-019-02742-2 |
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| Katalog-ID: |
SPR040157636 |
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| 245 | 1 | 0 | |a Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions |
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| 520 | |a Abstract Some preceding studies show that a desmoplastic reaction (DR) at the invasive front of a primary tumor ($ DR^{primary} $) is a promising prognostic indicator, and its histologic classification is an independent prognostic factor in patients with colorectal cancer (CRC). Although DR is observed in metastatic lesions, such as those in lymph nodes ($ DR^{LN} $) and the liver ($ DR^{liver} $), the association between $ DR^{primary} $ and DR of metastatic lesions is unclear. We investigated whether $ DR^{LN} $ and $ DR^{liver} $ could be categorized in the same manner as $ DR^{primary} $ and examined the features and prognostic implications of $ DR^{LN} $ and $ DR^{liver} $. In this study, we evaluated 363 patients with metastases to lymph nodes and 45 patients with synchronous liver metastases who underwent curative resection. $ DR^{LN} $ and $ DR^{liver} $ statuses were classified as mature, intermediate, or immature, based on keloid-like collagen and myxoid stroma appearances in the metastatic lesions. Overall, 109, 106, and 148 patients had mature, intermediate, and immature $ DR^{LN} $, respectively; in total, 5, 21, and 19 patients had mature, intermediate, and immature $ DR^{liver} $, respectively. $ DR^{LN} $ and $ DR^{primary} $ (spearman’s rho = 0.43, P < 0.0001) and $ DR^{liver} $ and $ DR^{primary} $ (spearman’s rho = 0.40, P = 0.0069) were each significantly correlated. The 5-year relapse-free survival (RFS) after surgery was 67.7% for mature/intermediate $ DR^{LN} $ and 52.9% for immature $ DR^{LN} $; the 5-year RFS after hepatectomy was 11.5% for mature/intermediate $ DR^{liver} $ and 5.6% for immature $ DR^{liver} $. In conclusion, $ DR^{LN} $ and $ DR^{liver} $ may be classified in the same manner as $ DR^{primary} $; morphological consistency of DR was observed between primary and metastatic lesions. | ||
| 650 | 4 | |a Desmoplastic reaction |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Colorectal cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Lymphatic metastases |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Liver metastases |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cancer-associated fibroblasts |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kajiwara, Yoshiki |e verfasserin |4 aut | |
| 700 | 1 | |a Yonemura, Keisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Shinto, Eiji |e verfasserin |4 aut | |
| 700 | 1 | |a Mochizuki, Satsuki |e verfasserin |4 aut | |
| 700 | 1 | |a Okamoto, Koichi |e verfasserin |4 aut | |
| 700 | 1 | |a Kishi, Yoji |e verfasserin |4 aut | |
| 700 | 1 | |a Ueno, Hideki |e verfasserin |4 aut | |
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10.1007/s00428-019-02742-2 doi (DE-627)SPR040157636 (SPR)s00428-019-02742-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Ao, Tadakazu verfasserin aut Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Some preceding studies show that a desmoplastic reaction (DR) at the invasive front of a primary tumor ($ DR^{primary} $) is a promising prognostic indicator, and its histologic classification is an independent prognostic factor in patients with colorectal cancer (CRC). Although DR is observed in metastatic lesions, such as those in lymph nodes ($ DR^{LN} $) and the liver ($ DR^{liver} $), the association between $ DR^{primary} $ and DR of metastatic lesions is unclear. We investigated whether $ DR^{LN} $ and $ DR^{liver} $ could be categorized in the same manner as $ DR^{primary} $ and examined the features and prognostic implications of $ DR^{LN} $ and $ DR^{liver} $. In this study, we evaluated 363 patients with metastases to lymph nodes and 45 patients with synchronous liver metastases who underwent curative resection. $ DR^{LN} $ and $ DR^{liver} $ statuses were classified as mature, intermediate, or immature, based on keloid-like collagen and myxoid stroma appearances in the metastatic lesions. Overall, 109, 106, and 148 patients had mature, intermediate, and immature $ DR^{LN} $, respectively; in total, 5, 21, and 19 patients had mature, intermediate, and immature $ DR^{liver} $, respectively. $ DR^{LN} $ and $ DR^{primary} $ (spearman’s rho = 0.43, P < 0.0001) and $ DR^{liver} $ and $ DR^{primary} $ (spearman’s rho = 0.40, P = 0.0069) were each significantly correlated. The 5-year relapse-free survival (RFS) after surgery was 67.7% for mature/intermediate $ DR^{LN} $ and 52.9% for immature $ DR^{LN} $; the 5-year RFS after hepatectomy was 11.5% for mature/intermediate $ DR^{liver} $ and 5.6% for immature $ DR^{liver} $. In conclusion, $ DR^{LN} $ and $ DR^{liver} $ may be classified in the same manner as $ DR^{primary} $; morphological consistency of DR was observed between primary and metastatic lesions. Desmoplastic reaction (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Lymphatic metastases (dpeaa)DE-He213 Liver metastases (dpeaa)DE-He213 Cancer-associated fibroblasts (dpeaa)DE-He213 Kajiwara, Yoshiki verfasserin aut Yonemura, Keisuke verfasserin aut Shinto, Eiji verfasserin aut Mochizuki, Satsuki verfasserin aut Okamoto, Koichi verfasserin aut Kishi, Yoji verfasserin aut Ueno, Hideki verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 477(2020), 1 vom: 13. Jan., Seite 47-55 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:477 year:2020 number:1 day:13 month:01 pages:47-55 https://dx.doi.org/10.1007/s00428-019-02742-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 477 2020 1 13 01 47-55 |
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10.1007/s00428-019-02742-2 doi (DE-627)SPR040157636 (SPR)s00428-019-02742-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Ao, Tadakazu verfasserin aut Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Some preceding studies show that a desmoplastic reaction (DR) at the invasive front of a primary tumor ($ DR^{primary} $) is a promising prognostic indicator, and its histologic classification is an independent prognostic factor in patients with colorectal cancer (CRC). Although DR is observed in metastatic lesions, such as those in lymph nodes ($ DR^{LN} $) and the liver ($ DR^{liver} $), the association between $ DR^{primary} $ and DR of metastatic lesions is unclear. We investigated whether $ DR^{LN} $ and $ DR^{liver} $ could be categorized in the same manner as $ DR^{primary} $ and examined the features and prognostic implications of $ DR^{LN} $ and $ DR^{liver} $. In this study, we evaluated 363 patients with metastases to lymph nodes and 45 patients with synchronous liver metastases who underwent curative resection. $ DR^{LN} $ and $ DR^{liver} $ statuses were classified as mature, intermediate, or immature, based on keloid-like collagen and myxoid stroma appearances in the metastatic lesions. Overall, 109, 106, and 148 patients had mature, intermediate, and immature $ DR^{LN} $, respectively; in total, 5, 21, and 19 patients had mature, intermediate, and immature $ DR^{liver} $, respectively. $ DR^{LN} $ and $ DR^{primary} $ (spearman’s rho = 0.43, P < 0.0001) and $ DR^{liver} $ and $ DR^{primary} $ (spearman’s rho = 0.40, P = 0.0069) were each significantly correlated. The 5-year relapse-free survival (RFS) after surgery was 67.7% for mature/intermediate $ DR^{LN} $ and 52.9% for immature $ DR^{LN} $; the 5-year RFS after hepatectomy was 11.5% for mature/intermediate $ DR^{liver} $ and 5.6% for immature $ DR^{liver} $. In conclusion, $ DR^{LN} $ and $ DR^{liver} $ may be classified in the same manner as $ DR^{primary} $; morphological consistency of DR was observed between primary and metastatic lesions. Desmoplastic reaction (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Lymphatic metastases (dpeaa)DE-He213 Liver metastases (dpeaa)DE-He213 Cancer-associated fibroblasts (dpeaa)DE-He213 Kajiwara, Yoshiki verfasserin aut Yonemura, Keisuke verfasserin aut Shinto, Eiji verfasserin aut Mochizuki, Satsuki verfasserin aut Okamoto, Koichi verfasserin aut Kishi, Yoji verfasserin aut Ueno, Hideki verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 477(2020), 1 vom: 13. Jan., Seite 47-55 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:477 year:2020 number:1 day:13 month:01 pages:47-55 https://dx.doi.org/10.1007/s00428-019-02742-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 477 2020 1 13 01 47-55 |
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10.1007/s00428-019-02742-2 doi (DE-627)SPR040157636 (SPR)s00428-019-02742-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Ao, Tadakazu verfasserin aut Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Some preceding studies show that a desmoplastic reaction (DR) at the invasive front of a primary tumor ($ DR^{primary} $) is a promising prognostic indicator, and its histologic classification is an independent prognostic factor in patients with colorectal cancer (CRC). Although DR is observed in metastatic lesions, such as those in lymph nodes ($ DR^{LN} $) and the liver ($ DR^{liver} $), the association between $ DR^{primary} $ and DR of metastatic lesions is unclear. We investigated whether $ DR^{LN} $ and $ DR^{liver} $ could be categorized in the same manner as $ DR^{primary} $ and examined the features and prognostic implications of $ DR^{LN} $ and $ DR^{liver} $. In this study, we evaluated 363 patients with metastases to lymph nodes and 45 patients with synchronous liver metastases who underwent curative resection. $ DR^{LN} $ and $ DR^{liver} $ statuses were classified as mature, intermediate, or immature, based on keloid-like collagen and myxoid stroma appearances in the metastatic lesions. Overall, 109, 106, and 148 patients had mature, intermediate, and immature $ DR^{LN} $, respectively; in total, 5, 21, and 19 patients had mature, intermediate, and immature $ DR^{liver} $, respectively. $ DR^{LN} $ and $ DR^{primary} $ (spearman’s rho = 0.43, P < 0.0001) and $ DR^{liver} $ and $ DR^{primary} $ (spearman’s rho = 0.40, P = 0.0069) were each significantly correlated. The 5-year relapse-free survival (RFS) after surgery was 67.7% for mature/intermediate $ DR^{LN} $ and 52.9% for immature $ DR^{LN} $; the 5-year RFS after hepatectomy was 11.5% for mature/intermediate $ DR^{liver} $ and 5.6% for immature $ DR^{liver} $. In conclusion, $ DR^{LN} $ and $ DR^{liver} $ may be classified in the same manner as $ DR^{primary} $; morphological consistency of DR was observed between primary and metastatic lesions. Desmoplastic reaction (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Lymphatic metastases (dpeaa)DE-He213 Liver metastases (dpeaa)DE-He213 Cancer-associated fibroblasts (dpeaa)DE-He213 Kajiwara, Yoshiki verfasserin aut Yonemura, Keisuke verfasserin aut Shinto, Eiji verfasserin aut Mochizuki, Satsuki verfasserin aut Okamoto, Koichi verfasserin aut Kishi, Yoji verfasserin aut Ueno, Hideki verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 477(2020), 1 vom: 13. Jan., Seite 47-55 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:477 year:2020 number:1 day:13 month:01 pages:47-55 https://dx.doi.org/10.1007/s00428-019-02742-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 477 2020 1 13 01 47-55 |
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10.1007/s00428-019-02742-2 doi (DE-627)SPR040157636 (SPR)s00428-019-02742-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Ao, Tadakazu verfasserin aut Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Some preceding studies show that a desmoplastic reaction (DR) at the invasive front of a primary tumor ($ DR^{primary} $) is a promising prognostic indicator, and its histologic classification is an independent prognostic factor in patients with colorectal cancer (CRC). Although DR is observed in metastatic lesions, such as those in lymph nodes ($ DR^{LN} $) and the liver ($ DR^{liver} $), the association between $ DR^{primary} $ and DR of metastatic lesions is unclear. We investigated whether $ DR^{LN} $ and $ DR^{liver} $ could be categorized in the same manner as $ DR^{primary} $ and examined the features and prognostic implications of $ DR^{LN} $ and $ DR^{liver} $. In this study, we evaluated 363 patients with metastases to lymph nodes and 45 patients with synchronous liver metastases who underwent curative resection. $ DR^{LN} $ and $ DR^{liver} $ statuses were classified as mature, intermediate, or immature, based on keloid-like collagen and myxoid stroma appearances in the metastatic lesions. Overall, 109, 106, and 148 patients had mature, intermediate, and immature $ DR^{LN} $, respectively; in total, 5, 21, and 19 patients had mature, intermediate, and immature $ DR^{liver} $, respectively. $ DR^{LN} $ and $ DR^{primary} $ (spearman’s rho = 0.43, P < 0.0001) and $ DR^{liver} $ and $ DR^{primary} $ (spearman’s rho = 0.40, P = 0.0069) were each significantly correlated. The 5-year relapse-free survival (RFS) after surgery was 67.7% for mature/intermediate $ DR^{LN} $ and 52.9% for immature $ DR^{LN} $; the 5-year RFS after hepatectomy was 11.5% for mature/intermediate $ DR^{liver} $ and 5.6% for immature $ DR^{liver} $. In conclusion, $ DR^{LN} $ and $ DR^{liver} $ may be classified in the same manner as $ DR^{primary} $; morphological consistency of DR was observed between primary and metastatic lesions. Desmoplastic reaction (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Lymphatic metastases (dpeaa)DE-He213 Liver metastases (dpeaa)DE-He213 Cancer-associated fibroblasts (dpeaa)DE-He213 Kajiwara, Yoshiki verfasserin aut Yonemura, Keisuke verfasserin aut Shinto, Eiji verfasserin aut Mochizuki, Satsuki verfasserin aut Okamoto, Koichi verfasserin aut Kishi, Yoji verfasserin aut Ueno, Hideki verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 477(2020), 1 vom: 13. Jan., Seite 47-55 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:477 year:2020 number:1 day:13 month:01 pages:47-55 https://dx.doi.org/10.1007/s00428-019-02742-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 477 2020 1 13 01 47-55 |
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10.1007/s00428-019-02742-2 doi (DE-627)SPR040157636 (SPR)s00428-019-02742-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Ao, Tadakazu verfasserin aut Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Some preceding studies show that a desmoplastic reaction (DR) at the invasive front of a primary tumor ($ DR^{primary} $) is a promising prognostic indicator, and its histologic classification is an independent prognostic factor in patients with colorectal cancer (CRC). Although DR is observed in metastatic lesions, such as those in lymph nodes ($ DR^{LN} $) and the liver ($ DR^{liver} $), the association between $ DR^{primary} $ and DR of metastatic lesions is unclear. We investigated whether $ DR^{LN} $ and $ DR^{liver} $ could be categorized in the same manner as $ DR^{primary} $ and examined the features and prognostic implications of $ DR^{LN} $ and $ DR^{liver} $. In this study, we evaluated 363 patients with metastases to lymph nodes and 45 patients with synchronous liver metastases who underwent curative resection. $ DR^{LN} $ and $ DR^{liver} $ statuses were classified as mature, intermediate, or immature, based on keloid-like collagen and myxoid stroma appearances in the metastatic lesions. Overall, 109, 106, and 148 patients had mature, intermediate, and immature $ DR^{LN} $, respectively; in total, 5, 21, and 19 patients had mature, intermediate, and immature $ DR^{liver} $, respectively. $ DR^{LN} $ and $ DR^{primary} $ (spearman’s rho = 0.43, P < 0.0001) and $ DR^{liver} $ and $ DR^{primary} $ (spearman’s rho = 0.40, P = 0.0069) were each significantly correlated. The 5-year relapse-free survival (RFS) after surgery was 67.7% for mature/intermediate $ DR^{LN} $ and 52.9% for immature $ DR^{LN} $; the 5-year RFS after hepatectomy was 11.5% for mature/intermediate $ DR^{liver} $ and 5.6% for immature $ DR^{liver} $. In conclusion, $ DR^{LN} $ and $ DR^{liver} $ may be classified in the same manner as $ DR^{primary} $; morphological consistency of DR was observed between primary and metastatic lesions. Desmoplastic reaction (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Lymphatic metastases (dpeaa)DE-He213 Liver metastases (dpeaa)DE-He213 Cancer-associated fibroblasts (dpeaa)DE-He213 Kajiwara, Yoshiki verfasserin aut Yonemura, Keisuke verfasserin aut Shinto, Eiji verfasserin aut Mochizuki, Satsuki verfasserin aut Okamoto, Koichi verfasserin aut Kishi, Yoji verfasserin aut Ueno, Hideki verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 477(2020), 1 vom: 13. Jan., Seite 47-55 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:477 year:2020 number:1 day:13 month:01 pages:47-55 https://dx.doi.org/10.1007/s00428-019-02742-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 477 2020 1 13 01 47-55 |
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English |
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Enthalten in Virchows Archiv 477(2020), 1 vom: 13. Jan., Seite 47-55 volume:477 year:2020 number:1 day:13 month:01 pages:47-55 |
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Enthalten in Virchows Archiv 477(2020), 1 vom: 13. Jan., Seite 47-55 volume:477 year:2020 number:1 day:13 month:01 pages:47-55 |
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Desmoplastic reaction Colorectal cancer Lymphatic metastases Liver metastases Cancer-associated fibroblasts |
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Ao, Tadakazu @@aut@@ Kajiwara, Yoshiki @@aut@@ Yonemura, Keisuke @@aut@@ Shinto, Eiji @@aut@@ Mochizuki, Satsuki @@aut@@ Okamoto, Koichi @@aut@@ Kishi, Yoji @@aut@@ Ueno, Hideki @@aut@@ |
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Although DR is observed in metastatic lesions, such as those in lymph nodes ($ DR^{LN} $) and the liver ($ DR^{liver} $), the association between $ DR^{primary} $ and DR of metastatic lesions is unclear. We investigated whether $ DR^{LN} $ and $ DR^{liver} $ could be categorized in the same manner as $ DR^{primary} $ and examined the features and prognostic implications of $ DR^{LN} $ and $ DR^{liver} $. In this study, we evaluated 363 patients with metastases to lymph nodes and 45 patients with synchronous liver metastases who underwent curative resection. $ DR^{LN} $ and $ DR^{liver} $ statuses were classified as mature, intermediate, or immature, based on keloid-like collagen and myxoid stroma appearances in the metastatic lesions. Overall, 109, 106, and 148 patients had mature, intermediate, and immature $ DR^{LN} $, respectively; in total, 5, 21, and 19 patients had mature, intermediate, and immature $ DR^{liver} $, respectively. $ DR^{LN} $ and $ DR^{primary} $ (spearman’s rho = 0.43, P < 0.0001) and $ DR^{liver} $ and $ DR^{primary} $ (spearman’s rho = 0.40, P = 0.0069) were each significantly correlated. The 5-year relapse-free survival (RFS) after surgery was 67.7% for mature/intermediate $ DR^{LN} $ and 52.9% for immature $ DR^{LN} $; the 5-year RFS after hepatectomy was 11.5% for mature/intermediate $ DR^{liver} $ and 5.6% for immature $ DR^{liver} $. 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Ao, Tadakazu |
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Ao, Tadakazu ddc 610 bkl 44.47 misc Desmoplastic reaction misc Colorectal cancer misc Lymphatic metastases misc Liver metastases misc Cancer-associated fibroblasts Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions |
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610 ASE 44.47 bkl Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions Desmoplastic reaction (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Lymphatic metastases (dpeaa)DE-He213 Liver metastases (dpeaa)DE-He213 Cancer-associated fibroblasts (dpeaa)DE-He213 |
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ddc 610 bkl 44.47 misc Desmoplastic reaction misc Colorectal cancer misc Lymphatic metastases misc Liver metastases misc Cancer-associated fibroblasts |
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ddc 610 bkl 44.47 misc Desmoplastic reaction misc Colorectal cancer misc Lymphatic metastases misc Liver metastases misc Cancer-associated fibroblasts |
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ddc 610 bkl 44.47 misc Desmoplastic reaction misc Colorectal cancer misc Lymphatic metastases misc Liver metastases misc Cancer-associated fibroblasts |
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Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions |
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Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions |
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morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions |
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Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions |
| abstract |
Abstract Some preceding studies show that a desmoplastic reaction (DR) at the invasive front of a primary tumor ($ DR^{primary} $) is a promising prognostic indicator, and its histologic classification is an independent prognostic factor in patients with colorectal cancer (CRC). Although DR is observed in metastatic lesions, such as those in lymph nodes ($ DR^{LN} $) and the liver ($ DR^{liver} $), the association between $ DR^{primary} $ and DR of metastatic lesions is unclear. We investigated whether $ DR^{LN} $ and $ DR^{liver} $ could be categorized in the same manner as $ DR^{primary} $ and examined the features and prognostic implications of $ DR^{LN} $ and $ DR^{liver} $. In this study, we evaluated 363 patients with metastases to lymph nodes and 45 patients with synchronous liver metastases who underwent curative resection. $ DR^{LN} $ and $ DR^{liver} $ statuses were classified as mature, intermediate, or immature, based on keloid-like collagen and myxoid stroma appearances in the metastatic lesions. Overall, 109, 106, and 148 patients had mature, intermediate, and immature $ DR^{LN} $, respectively; in total, 5, 21, and 19 patients had mature, intermediate, and immature $ DR^{liver} $, respectively. $ DR^{LN} $ and $ DR^{primary} $ (spearman’s rho = 0.43, P < 0.0001) and $ DR^{liver} $ and $ DR^{primary} $ (spearman’s rho = 0.40, P = 0.0069) were each significantly correlated. The 5-year relapse-free survival (RFS) after surgery was 67.7% for mature/intermediate $ DR^{LN} $ and 52.9% for immature $ DR^{LN} $; the 5-year RFS after hepatectomy was 11.5% for mature/intermediate $ DR^{liver} $ and 5.6% for immature $ DR^{liver} $. In conclusion, $ DR^{LN} $ and $ DR^{liver} $ may be classified in the same manner as $ DR^{primary} $; morphological consistency of DR was observed between primary and metastatic lesions. |
| abstractGer |
Abstract Some preceding studies show that a desmoplastic reaction (DR) at the invasive front of a primary tumor ($ DR^{primary} $) is a promising prognostic indicator, and its histologic classification is an independent prognostic factor in patients with colorectal cancer (CRC). Although DR is observed in metastatic lesions, such as those in lymph nodes ($ DR^{LN} $) and the liver ($ DR^{liver} $), the association between $ DR^{primary} $ and DR of metastatic lesions is unclear. We investigated whether $ DR^{LN} $ and $ DR^{liver} $ could be categorized in the same manner as $ DR^{primary} $ and examined the features and prognostic implications of $ DR^{LN} $ and $ DR^{liver} $. In this study, we evaluated 363 patients with metastases to lymph nodes and 45 patients with synchronous liver metastases who underwent curative resection. $ DR^{LN} $ and $ DR^{liver} $ statuses were classified as mature, intermediate, or immature, based on keloid-like collagen and myxoid stroma appearances in the metastatic lesions. Overall, 109, 106, and 148 patients had mature, intermediate, and immature $ DR^{LN} $, respectively; in total, 5, 21, and 19 patients had mature, intermediate, and immature $ DR^{liver} $, respectively. $ DR^{LN} $ and $ DR^{primary} $ (spearman’s rho = 0.43, P < 0.0001) and $ DR^{liver} $ and $ DR^{primary} $ (spearman’s rho = 0.40, P = 0.0069) were each significantly correlated. The 5-year relapse-free survival (RFS) after surgery was 67.7% for mature/intermediate $ DR^{LN} $ and 52.9% for immature $ DR^{LN} $; the 5-year RFS after hepatectomy was 11.5% for mature/intermediate $ DR^{liver} $ and 5.6% for immature $ DR^{liver} $. In conclusion, $ DR^{LN} $ and $ DR^{liver} $ may be classified in the same manner as $ DR^{primary} $; morphological consistency of DR was observed between primary and metastatic lesions. |
| abstract_unstemmed |
Abstract Some preceding studies show that a desmoplastic reaction (DR) at the invasive front of a primary tumor ($ DR^{primary} $) is a promising prognostic indicator, and its histologic classification is an independent prognostic factor in patients with colorectal cancer (CRC). Although DR is observed in metastatic lesions, such as those in lymph nodes ($ DR^{LN} $) and the liver ($ DR^{liver} $), the association between $ DR^{primary} $ and DR of metastatic lesions is unclear. We investigated whether $ DR^{LN} $ and $ DR^{liver} $ could be categorized in the same manner as $ DR^{primary} $ and examined the features and prognostic implications of $ DR^{LN} $ and $ DR^{liver} $. In this study, we evaluated 363 patients with metastases to lymph nodes and 45 patients with synchronous liver metastases who underwent curative resection. $ DR^{LN} $ and $ DR^{liver} $ statuses were classified as mature, intermediate, or immature, based on keloid-like collagen and myxoid stroma appearances in the metastatic lesions. Overall, 109, 106, and 148 patients had mature, intermediate, and immature $ DR^{LN} $, respectively; in total, 5, 21, and 19 patients had mature, intermediate, and immature $ DR^{liver} $, respectively. $ DR^{LN} $ and $ DR^{primary} $ (spearman’s rho = 0.43, P < 0.0001) and $ DR^{liver} $ and $ DR^{primary} $ (spearman’s rho = 0.40, P = 0.0069) were each significantly correlated. The 5-year relapse-free survival (RFS) after surgery was 67.7% for mature/intermediate $ DR^{LN} $ and 52.9% for immature $ DR^{LN} $; the 5-year RFS after hepatectomy was 11.5% for mature/intermediate $ DR^{liver} $ and 5.6% for immature $ DR^{liver} $. In conclusion, $ DR^{LN} $ and $ DR^{liver} $ may be classified in the same manner as $ DR^{primary} $; morphological consistency of DR was observed between primary and metastatic lesions. |
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| score |
7.40158 |