Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2

Abstract Two new sesquiterpenoids, artemlavanins A (1) and B (3), together with fifteen known compounds (2 and 4−17) were isolated from the EtOH extract of Artemisia lavandulaefolia. The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD...
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Autor*in:	Shen, Cheng [verfasserIn] Huang, Xiao-Yan [verfasserIn] Geng, Chang-An [verfasserIn] Li, Tian-Ze [verfasserIn] Tang, Shuang [verfasserIn] Su, Li-Hua [verfasserIn] Gao, Zhen [verfasserIn] Zhang, Xue-Mei [verfasserIn] Hu, Jing [verfasserIn] Chen, Ji-Jun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Sesquiterpenoids Artemlavanins Cytotoxicity HSC-LX2

Übergeordnetes Werk:	Enthalten in: Natural products and bioprospecting - Heidelberg : Springer, 2011, 10(2020), 4 vom: 24. Juni, Seite 243-250
Übergeordnetes Werk:	volume:10 ; year:2020 ; number:4 ; day:24 ; month:06 ; pages:243-250

Links:	Volltext

DOI / URN:	10.1007/s13659-020-00254-0

Katalog-ID:	SPR04037453X

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520			\|a Abstract Two new sesquiterpenoids, artemlavanins A (1) and B (3), together with fifteen known compounds (2 and 4−17) were isolated from the EtOH extract of Artemisia lavandulaefolia. The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound 1 was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds 2–5, 6–8, 9 and 10–12 belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds 13–17 were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds (1–3, 5–7, 10–12, 14, 15 and 17) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with $ IC_{50} $ values ranging from 35.1 to 370.3 μM. Compounds 2, 7, 10–12 and 17 exhibited the stronger cytotoxicity than silybin ($ IC_{50} $, 169.6 μM) with $ IC_{50} $ values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1 μM. Compound 7 as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with $ IC_{50} $ values of 10.7, 24.5 and 13.3 μM. Graphic Abstract
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author_variant	c s cs x y h xyh c a g cag t z l tzl s t st l h s lhs z g zg x m z xmz j h jh j j c jjc
matchkey_str	article:21922209:2020----::relvnnanbrmreiilvnuaflanteryooiiygis
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allfields	10.1007/s13659-020-00254-0 doi (DE-627)SPR04037453X (SPR)s13659-020-00254-0-e DE-627 ger DE-627 rakwb eng 500 570 610 ASE 58.30 bkl 35.50 bkl Shen, Cheng verfasserin aut Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Two new sesquiterpenoids, artemlavanins A (1) and B (3), together with fifteen known compounds (2 and 4−17) were isolated from the EtOH extract of Artemisia lavandulaefolia. The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound 1 was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds 2–5, 6–8, 9 and 10–12 belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds 13–17 were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds (1–3, 5–7, 10–12, 14, 15 and 17) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with $ IC_{50} $ values ranging from 35.1 to 370.3 μM. Compounds 2, 7, 10–12 and 17 exhibited the stronger cytotoxicity than silybin ($ IC_{50} $, 169.6 μM) with $ IC_{50} $ values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1 μM. Compound 7 as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with $ IC_{50} $ values of 10.7, 24.5 and 13.3 μM. Graphic Abstract Sesquiterpenoids (dpeaa)DE-He213 Artemlavanins (dpeaa)DE-He213 Cytotoxicity (dpeaa)DE-He213 HSC-LX2 (dpeaa)DE-He213 Huang, Xiao-Yan verfasserin aut Geng, Chang-An verfasserin aut Li, Tian-Ze verfasserin aut Tang, Shuang verfasserin aut Su, Li-Hua verfasserin aut Gao, Zhen verfasserin aut Zhang, Xue-Mei verfasserin aut Hu, Jing verfasserin aut Chen, Ji-Jun verfasserin aut Enthalten in Natural products and bioprospecting Heidelberg : Springer, 2011 10(2020), 4 vom: 24. Juni, Seite 243-250 (DE-627)671629077 (DE-600)2636293-4 2192-2209 nnns volume:10 year:2020 number:4 day:24 month:06 pages:243-250 https://dx.doi.org/10.1007/s13659-020-00254-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 58.30 ASE 35.50 ASE AR 10 2020 4 24 06 243-250
spelling	10.1007/s13659-020-00254-0 doi (DE-627)SPR04037453X (SPR)s13659-020-00254-0-e DE-627 ger DE-627 rakwb eng 500 570 610 ASE 58.30 bkl 35.50 bkl Shen, Cheng verfasserin aut Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Two new sesquiterpenoids, artemlavanins A (1) and B (3), together with fifteen known compounds (2 and 4−17) were isolated from the EtOH extract of Artemisia lavandulaefolia. The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound 1 was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds 2–5, 6–8, 9 and 10–12 belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds 13–17 were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds (1–3, 5–7, 10–12, 14, 15 and 17) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with $ IC_{50} $ values ranging from 35.1 to 370.3 μM. Compounds 2, 7, 10–12 and 17 exhibited the stronger cytotoxicity than silybin ($ IC_{50} $, 169.6 μM) with $ IC_{50} $ values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1 μM. Compound 7 as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with $ IC_{50} $ values of 10.7, 24.5 and 13.3 μM. Graphic Abstract Sesquiterpenoids (dpeaa)DE-He213 Artemlavanins (dpeaa)DE-He213 Cytotoxicity (dpeaa)DE-He213 HSC-LX2 (dpeaa)DE-He213 Huang, Xiao-Yan verfasserin aut Geng, Chang-An verfasserin aut Li, Tian-Ze verfasserin aut Tang, Shuang verfasserin aut Su, Li-Hua verfasserin aut Gao, Zhen verfasserin aut Zhang, Xue-Mei verfasserin aut Hu, Jing verfasserin aut Chen, Ji-Jun verfasserin aut Enthalten in Natural products and bioprospecting Heidelberg : Springer, 2011 10(2020), 4 vom: 24. Juni, Seite 243-250 (DE-627)671629077 (DE-600)2636293-4 2192-2209 nnns volume:10 year:2020 number:4 day:24 month:06 pages:243-250 https://dx.doi.org/10.1007/s13659-020-00254-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 58.30 ASE 35.50 ASE AR 10 2020 4 24 06 243-250
allfields_unstemmed	10.1007/s13659-020-00254-0 doi (DE-627)SPR04037453X (SPR)s13659-020-00254-0-e DE-627 ger DE-627 rakwb eng 500 570 610 ASE 58.30 bkl 35.50 bkl Shen, Cheng verfasserin aut Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Two new sesquiterpenoids, artemlavanins A (1) and B (3), together with fifteen known compounds (2 and 4−17) were isolated from the EtOH extract of Artemisia lavandulaefolia. The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound 1 was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds 2–5, 6–8, 9 and 10–12 belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds 13–17 were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds (1–3, 5–7, 10–12, 14, 15 and 17) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with $ IC_{50} $ values ranging from 35.1 to 370.3 μM. Compounds 2, 7, 10–12 and 17 exhibited the stronger cytotoxicity than silybin ($ IC_{50} $, 169.6 μM) with $ IC_{50} $ values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1 μM. Compound 7 as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with $ IC_{50} $ values of 10.7, 24.5 and 13.3 μM. Graphic Abstract Sesquiterpenoids (dpeaa)DE-He213 Artemlavanins (dpeaa)DE-He213 Cytotoxicity (dpeaa)DE-He213 HSC-LX2 (dpeaa)DE-He213 Huang, Xiao-Yan verfasserin aut Geng, Chang-An verfasserin aut Li, Tian-Ze verfasserin aut Tang, Shuang verfasserin aut Su, Li-Hua verfasserin aut Gao, Zhen verfasserin aut Zhang, Xue-Mei verfasserin aut Hu, Jing verfasserin aut Chen, Ji-Jun verfasserin aut Enthalten in Natural products and bioprospecting Heidelberg : Springer, 2011 10(2020), 4 vom: 24. Juni, Seite 243-250 (DE-627)671629077 (DE-600)2636293-4 2192-2209 nnns volume:10 year:2020 number:4 day:24 month:06 pages:243-250 https://dx.doi.org/10.1007/s13659-020-00254-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 58.30 ASE 35.50 ASE AR 10 2020 4 24 06 243-250
allfieldsGer	10.1007/s13659-020-00254-0 doi (DE-627)SPR04037453X (SPR)s13659-020-00254-0-e DE-627 ger DE-627 rakwb eng 500 570 610 ASE 58.30 bkl 35.50 bkl Shen, Cheng verfasserin aut Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Two new sesquiterpenoids, artemlavanins A (1) and B (3), together with fifteen known compounds (2 and 4−17) were isolated from the EtOH extract of Artemisia lavandulaefolia. The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound 1 was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds 2–5, 6–8, 9 and 10–12 belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds 13–17 were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds (1–3, 5–7, 10–12, 14, 15 and 17) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with $ IC_{50} $ values ranging from 35.1 to 370.3 μM. Compounds 2, 7, 10–12 and 17 exhibited the stronger cytotoxicity than silybin ($ IC_{50} $, 169.6 μM) with $ IC_{50} $ values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1 μM. Compound 7 as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with $ IC_{50} $ values of 10.7, 24.5 and 13.3 μM. Graphic Abstract Sesquiterpenoids (dpeaa)DE-He213 Artemlavanins (dpeaa)DE-He213 Cytotoxicity (dpeaa)DE-He213 HSC-LX2 (dpeaa)DE-He213 Huang, Xiao-Yan verfasserin aut Geng, Chang-An verfasserin aut Li, Tian-Ze verfasserin aut Tang, Shuang verfasserin aut Su, Li-Hua verfasserin aut Gao, Zhen verfasserin aut Zhang, Xue-Mei verfasserin aut Hu, Jing verfasserin aut Chen, Ji-Jun verfasserin aut Enthalten in Natural products and bioprospecting Heidelberg : Springer, 2011 10(2020), 4 vom: 24. Juni, Seite 243-250 (DE-627)671629077 (DE-600)2636293-4 2192-2209 nnns volume:10 year:2020 number:4 day:24 month:06 pages:243-250 https://dx.doi.org/10.1007/s13659-020-00254-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 58.30 ASE 35.50 ASE AR 10 2020 4 24 06 243-250
allfieldsSound	10.1007/s13659-020-00254-0 doi (DE-627)SPR04037453X (SPR)s13659-020-00254-0-e DE-627 ger DE-627 rakwb eng 500 570 610 ASE 58.30 bkl 35.50 bkl Shen, Cheng verfasserin aut Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Two new sesquiterpenoids, artemlavanins A (1) and B (3), together with fifteen known compounds (2 and 4−17) were isolated from the EtOH extract of Artemisia lavandulaefolia. The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound 1 was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds 2–5, 6–8, 9 and 10–12 belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds 13–17 were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds (1–3, 5–7, 10–12, 14, 15 and 17) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with $ IC_{50} $ values ranging from 35.1 to 370.3 μM. Compounds 2, 7, 10–12 and 17 exhibited the stronger cytotoxicity than silybin ($ IC_{50} $, 169.6 μM) with $ IC_{50} $ values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1 μM. Compound 7 as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with $ IC_{50} $ values of 10.7, 24.5 and 13.3 μM. Graphic Abstract Sesquiterpenoids (dpeaa)DE-He213 Artemlavanins (dpeaa)DE-He213 Cytotoxicity (dpeaa)DE-He213 HSC-LX2 (dpeaa)DE-He213 Huang, Xiao-Yan verfasserin aut Geng, Chang-An verfasserin aut Li, Tian-Ze verfasserin aut Tang, Shuang verfasserin aut Su, Li-Hua verfasserin aut Gao, Zhen verfasserin aut Zhang, Xue-Mei verfasserin aut Hu, Jing verfasserin aut Chen, Ji-Jun verfasserin aut Enthalten in Natural products and bioprospecting Heidelberg : Springer, 2011 10(2020), 4 vom: 24. Juni, Seite 243-250 (DE-627)671629077 (DE-600)2636293-4 2192-2209 nnns volume:10 year:2020 number:4 day:24 month:06 pages:243-250 https://dx.doi.org/10.1007/s13659-020-00254-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 58.30 ASE 35.50 ASE AR 10 2020 4 24 06 243-250
language	English
source	Enthalten in Natural products and bioprospecting 10(2020), 4 vom: 24. Juni, Seite 243-250 volume:10 year:2020 number:4 day:24 month:06 pages:243-250
sourceStr	Enthalten in Natural products and bioprospecting 10(2020), 4 vom: 24. Juni, Seite 243-250 volume:10 year:2020 number:4 day:24 month:06 pages:243-250
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Sesquiterpenoids Artemlavanins Cytotoxicity HSC-LX2
dewey-raw	500
isfreeaccess_bool	true
container_title	Natural products and bioprospecting
authorswithroles_txt_mv	Shen, Cheng @@aut@@ Huang, Xiao-Yan @@aut@@ Geng, Chang-An @@aut@@ Li, Tian-Ze @@aut@@ Tang, Shuang @@aut@@ Su, Li-Hua @@aut@@ Gao, Zhen @@aut@@ Zhang, Xue-Mei @@aut@@ Hu, Jing @@aut@@ Chen, Ji-Jun @@aut@@
publishDateDaySort_date	2020-06-24T00:00:00Z
hierarchy_top_id	671629077
dewey-sort	3500
id	SPR04037453X
language_de	englisch
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author	Shen, Cheng
spellingShingle	Shen, Cheng ddc 500 bkl 58.30 bkl 35.50 misc Sesquiterpenoids misc Artemlavanins misc Cytotoxicity misc HSC-LX2 Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2
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topic_title	500 570 610 ASE 58.30 bkl 35.50 bkl Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2 Sesquiterpenoids (dpeaa)DE-He213 Artemlavanins (dpeaa)DE-He213 Cytotoxicity (dpeaa)DE-He213 HSC-LX2 (dpeaa)DE-He213
topic	ddc 500 bkl 58.30 bkl 35.50 misc Sesquiterpenoids misc Artemlavanins misc Cytotoxicity misc HSC-LX2
topic_unstemmed	ddc 500 bkl 58.30 bkl 35.50 misc Sesquiterpenoids misc Artemlavanins misc Cytotoxicity misc HSC-LX2
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title	Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2
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title_full	Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2
author_sort	Shen, Cheng
journal	Natural products and bioprospecting
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author_browse	Shen, Cheng Huang, Xiao-Yan Geng, Chang-An Li, Tian-Ze Tang, Shuang Su, Li-Hua Gao, Zhen Zhang, Xue-Mei Hu, Jing Chen, Ji-Jun
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title_sort	artemlavanins a and b from artemisia lavandulaefolia and their cytotoxicity against hepatic stellate cell line lx2
title_auth	Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2
abstract	Abstract Two new sesquiterpenoids, artemlavanins A (1) and B (3), together with fifteen known compounds (2 and 4−17) were isolated from the EtOH extract of Artemisia lavandulaefolia. The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound 1 was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds 2–5, 6–8, 9 and 10–12 belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds 13–17 were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds (1–3, 5–7, 10–12, 14, 15 and 17) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with $ IC_{50} $ values ranging from 35.1 to 370.3 μM. Compounds 2, 7, 10–12 and 17 exhibited the stronger cytotoxicity than silybin ($ IC_{50} $, 169.6 μM) with $ IC_{50} $ values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1 μM. Compound 7 as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with $ IC_{50} $ values of 10.7, 24.5 and 13.3 μM. Graphic Abstract
abstractGer	Abstract Two new sesquiterpenoids, artemlavanins A (1) and B (3), together with fifteen known compounds (2 and 4−17) were isolated from the EtOH extract of Artemisia lavandulaefolia. The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound 1 was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds 2–5, 6–8, 9 and 10–12 belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds 13–17 were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds (1–3, 5–7, 10–12, 14, 15 and 17) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with $ IC_{50} $ values ranging from 35.1 to 370.3 μM. Compounds 2, 7, 10–12 and 17 exhibited the stronger cytotoxicity than silybin ($ IC_{50} $, 169.6 μM) with $ IC_{50} $ values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1 μM. Compound 7 as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with $ IC_{50} $ values of 10.7, 24.5 and 13.3 μM. Graphic Abstract
abstract_unstemmed	Abstract Two new sesquiterpenoids, artemlavanins A (1) and B (3), together with fifteen known compounds (2 and 4−17) were isolated from the EtOH extract of Artemisia lavandulaefolia. The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound 1 was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds 2–5, 6–8, 9 and 10–12 belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds 13–17 were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds (1–3, 5–7, 10–12, 14, 15 and 17) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with $ IC_{50} $ values ranging from 35.1 to 370.3 μM. Compounds 2, 7, 10–12 and 17 exhibited the stronger cytotoxicity than silybin ($ IC_{50} $, 169.6 μM) with $ IC_{50} $ values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1 μM. Compound 7 as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with $ IC_{50} $ values of 10.7, 24.5 and 13.3 μM. Graphic Abstract
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container_issue	4
title_short	Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2
url	https://dx.doi.org/10.1007/s13659-020-00254-0
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score	7.398527

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Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2

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