Expression of Pancreatic Stone Protein is Unaffected by Trauma and Subsequent Surgery in Burn Patients
Background Altered levels of pro-inflammatory markers secondary to trauma or surgery present a major problem to physicians in being prone to interfere with the clinical identification of infectious events. Methods Patients admitted to Zurich Burn Center between May 2015 and October 2018 with burns ≥...
Ausführliche Beschreibung
Autor*in: |
Klein, Holger J. [verfasserIn] Buehler, Philipp K. [verfasserIn] Niggemann, Pia [verfasserIn] Rittirsch, Daniel [verfasserIn] Schweizer, Riccardo [verfasserIn] Waldner, Matthias [verfasserIn] Giovanoli, Pietro [verfasserIn] Cinelli, Paolo [verfasserIn] Reding, Theresia [verfasserIn] Graf, Rolf [verfasserIn] Plock, Jan A. [verfasserIn] |
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Sprache: |
Englisch |
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2020 |
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Übergeordnetes Werk: |
Enthalten in: World Journal of Surgery - Springer-Verlag, 1996, 44(2020), 9 vom: 25. Mai, Seite 3000-3009 |
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Übergeordnetes Werk: |
volume:44 ; year:2020 ; number:9 ; day:25 ; month:05 ; pages:3000-3009 |
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DOI / URN: |
10.1007/s00268-020-05589-w |
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Katalog-ID: |
SPR04046993X |
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520 | |a Background Altered levels of pro-inflammatory markers secondary to trauma or surgery present a major problem to physicians in being prone to interfere with the clinical identification of infectious events. Methods Patients admitted to Zurich Burn Center between May 2015 and October 2018 with burns ≥10% total body surface area (TBSA) and without infection. Longitudinal analysis of the time course of PSP and routine inflammatory biomarkers [procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC)] over two days after (a) trauma with initial debridement and (b) subsequent burn surgeries was performed. The influence of TBSA, abbreviated burn severity index (ABSI), age and length of operation was investigated using a linear mixed effect regression model. Results Sixty-six patients (15 female) were included with a mean age of 45.5 ± 18.3 years, median TBSA of 22% (IQR 17) and mean ABSI score 6.8 ± 2.7. PSP was the only biomarker that showed no association with any of the baseline characteristics. Additionally, PSP serum levels did not change over time neither after the burn trauma (p = 0.832) nor after secondary procedures (p = 0.113), while PCT levels increased significantly after the trauma (p < 0.001). Similarly, CRP serum levels were elevated significantly after both trauma and surgery (p < 0.001), whereas WBC values demonstrated a significant decline after the trauma (p < 0.001). Conclusion Established biomarkers (WBC, CRP and PCT) demonstrate decisive alterations after tissue destruction caused by burn injuries and subsequent surgical interventions. The robustness of PSP serum levels toward these inflammatory insults is a quality criterion for an upcoming sepsis biomarker. | ||
700 | 1 | |a Buehler, Philipp K. |e verfasserin |4 aut | |
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700 | 1 | |a Rittirsch, Daniel |e verfasserin |4 aut | |
700 | 1 | |a Schweizer, Riccardo |e verfasserin |4 aut | |
700 | 1 | |a Waldner, Matthias |e verfasserin |4 aut | |
700 | 1 | |a Giovanoli, Pietro |e verfasserin |4 aut | |
700 | 1 | |a Cinelli, Paolo |e verfasserin |4 aut | |
700 | 1 | |a Reding, Theresia |e verfasserin |4 aut | |
700 | 1 | |a Graf, Rolf |e verfasserin |4 aut | |
700 | 1 | |a Plock, Jan A. |e verfasserin |4 aut | |
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10.1007/s00268-020-05589-w doi (DE-627)SPR04046993X (SPR)s00268-020-05589-w-e DE-627 ger DE-627 rakwb eng Klein, Holger J. verfasserin aut Expression of Pancreatic Stone Protein is Unaffected by Trauma and Subsequent Surgery in Burn Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Altered levels of pro-inflammatory markers secondary to trauma or surgery present a major problem to physicians in being prone to interfere with the clinical identification of infectious events. Methods Patients admitted to Zurich Burn Center between May 2015 and October 2018 with burns ≥10% total body surface area (TBSA) and without infection. Longitudinal analysis of the time course of PSP and routine inflammatory biomarkers [procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC)] over two days after (a) trauma with initial debridement and (b) subsequent burn surgeries was performed. The influence of TBSA, abbreviated burn severity index (ABSI), age and length of operation was investigated using a linear mixed effect regression model. Results Sixty-six patients (15 female) were included with a mean age of 45.5 ± 18.3 years, median TBSA of 22% (IQR 17) and mean ABSI score 6.8 ± 2.7. PSP was the only biomarker that showed no association with any of the baseline characteristics. Additionally, PSP serum levels did not change over time neither after the burn trauma (p = 0.832) nor after secondary procedures (p = 0.113), while PCT levels increased significantly after the trauma (p < 0.001). Similarly, CRP serum levels were elevated significantly after both trauma and surgery (p < 0.001), whereas WBC values demonstrated a significant decline after the trauma (p < 0.001). Conclusion Established biomarkers (WBC, CRP and PCT) demonstrate decisive alterations after tissue destruction caused by burn injuries and subsequent surgical interventions. The robustness of PSP serum levels toward these inflammatory insults is a quality criterion for an upcoming sepsis biomarker. Buehler, Philipp K. verfasserin aut Niggemann, Pia verfasserin aut Rittirsch, Daniel verfasserin aut Schweizer, Riccardo verfasserin aut Waldner, Matthias verfasserin aut Giovanoli, Pietro verfasserin aut Cinelli, Paolo verfasserin aut Reding, Theresia verfasserin aut Graf, Rolf verfasserin aut Plock, Jan A. verfasserin aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 44(2020), 9 vom: 25. Mai, Seite 3000-3009 (DE-627)SPR003391159 nnns volume:44 year:2020 number:9 day:25 month:05 pages:3000-3009 https://dx.doi.org/10.1007/s00268-020-05589-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 44 2020 9 25 05 3000-3009 |
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10.1007/s00268-020-05589-w doi (DE-627)SPR04046993X (SPR)s00268-020-05589-w-e DE-627 ger DE-627 rakwb eng Klein, Holger J. verfasserin aut Expression of Pancreatic Stone Protein is Unaffected by Trauma and Subsequent Surgery in Burn Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Altered levels of pro-inflammatory markers secondary to trauma or surgery present a major problem to physicians in being prone to interfere with the clinical identification of infectious events. Methods Patients admitted to Zurich Burn Center between May 2015 and October 2018 with burns ≥10% total body surface area (TBSA) and without infection. Longitudinal analysis of the time course of PSP and routine inflammatory biomarkers [procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC)] over two days after (a) trauma with initial debridement and (b) subsequent burn surgeries was performed. The influence of TBSA, abbreviated burn severity index (ABSI), age and length of operation was investigated using a linear mixed effect regression model. Results Sixty-six patients (15 female) were included with a mean age of 45.5 ± 18.3 years, median TBSA of 22% (IQR 17) and mean ABSI score 6.8 ± 2.7. PSP was the only biomarker that showed no association with any of the baseline characteristics. Additionally, PSP serum levels did not change over time neither after the burn trauma (p = 0.832) nor after secondary procedures (p = 0.113), while PCT levels increased significantly after the trauma (p < 0.001). Similarly, CRP serum levels were elevated significantly after both trauma and surgery (p < 0.001), whereas WBC values demonstrated a significant decline after the trauma (p < 0.001). Conclusion Established biomarkers (WBC, CRP and PCT) demonstrate decisive alterations after tissue destruction caused by burn injuries and subsequent surgical interventions. The robustness of PSP serum levels toward these inflammatory insults is a quality criterion for an upcoming sepsis biomarker. Buehler, Philipp K. verfasserin aut Niggemann, Pia verfasserin aut Rittirsch, Daniel verfasserin aut Schweizer, Riccardo verfasserin aut Waldner, Matthias verfasserin aut Giovanoli, Pietro verfasserin aut Cinelli, Paolo verfasserin aut Reding, Theresia verfasserin aut Graf, Rolf verfasserin aut Plock, Jan A. verfasserin aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 44(2020), 9 vom: 25. Mai, Seite 3000-3009 (DE-627)SPR003391159 nnns volume:44 year:2020 number:9 day:25 month:05 pages:3000-3009 https://dx.doi.org/10.1007/s00268-020-05589-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 44 2020 9 25 05 3000-3009 |
allfields_unstemmed |
10.1007/s00268-020-05589-w doi (DE-627)SPR04046993X (SPR)s00268-020-05589-w-e DE-627 ger DE-627 rakwb eng Klein, Holger J. verfasserin aut Expression of Pancreatic Stone Protein is Unaffected by Trauma and Subsequent Surgery in Burn Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Altered levels of pro-inflammatory markers secondary to trauma or surgery present a major problem to physicians in being prone to interfere with the clinical identification of infectious events. Methods Patients admitted to Zurich Burn Center between May 2015 and October 2018 with burns ≥10% total body surface area (TBSA) and without infection. Longitudinal analysis of the time course of PSP and routine inflammatory biomarkers [procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC)] over two days after (a) trauma with initial debridement and (b) subsequent burn surgeries was performed. The influence of TBSA, abbreviated burn severity index (ABSI), age and length of operation was investigated using a linear mixed effect regression model. Results Sixty-six patients (15 female) were included with a mean age of 45.5 ± 18.3 years, median TBSA of 22% (IQR 17) and mean ABSI score 6.8 ± 2.7. PSP was the only biomarker that showed no association with any of the baseline characteristics. Additionally, PSP serum levels did not change over time neither after the burn trauma (p = 0.832) nor after secondary procedures (p = 0.113), while PCT levels increased significantly after the trauma (p < 0.001). Similarly, CRP serum levels were elevated significantly after both trauma and surgery (p < 0.001), whereas WBC values demonstrated a significant decline after the trauma (p < 0.001). Conclusion Established biomarkers (WBC, CRP and PCT) demonstrate decisive alterations after tissue destruction caused by burn injuries and subsequent surgical interventions. The robustness of PSP serum levels toward these inflammatory insults is a quality criterion for an upcoming sepsis biomarker. Buehler, Philipp K. verfasserin aut Niggemann, Pia verfasserin aut Rittirsch, Daniel verfasserin aut Schweizer, Riccardo verfasserin aut Waldner, Matthias verfasserin aut Giovanoli, Pietro verfasserin aut Cinelli, Paolo verfasserin aut Reding, Theresia verfasserin aut Graf, Rolf verfasserin aut Plock, Jan A. verfasserin aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 44(2020), 9 vom: 25. Mai, Seite 3000-3009 (DE-627)SPR003391159 nnns volume:44 year:2020 number:9 day:25 month:05 pages:3000-3009 https://dx.doi.org/10.1007/s00268-020-05589-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 44 2020 9 25 05 3000-3009 |
allfieldsGer |
10.1007/s00268-020-05589-w doi (DE-627)SPR04046993X (SPR)s00268-020-05589-w-e DE-627 ger DE-627 rakwb eng Klein, Holger J. verfasserin aut Expression of Pancreatic Stone Protein is Unaffected by Trauma and Subsequent Surgery in Burn Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Altered levels of pro-inflammatory markers secondary to trauma or surgery present a major problem to physicians in being prone to interfere with the clinical identification of infectious events. Methods Patients admitted to Zurich Burn Center between May 2015 and October 2018 with burns ≥10% total body surface area (TBSA) and without infection. Longitudinal analysis of the time course of PSP and routine inflammatory biomarkers [procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC)] over two days after (a) trauma with initial debridement and (b) subsequent burn surgeries was performed. The influence of TBSA, abbreviated burn severity index (ABSI), age and length of operation was investigated using a linear mixed effect regression model. Results Sixty-six patients (15 female) were included with a mean age of 45.5 ± 18.3 years, median TBSA of 22% (IQR 17) and mean ABSI score 6.8 ± 2.7. PSP was the only biomarker that showed no association with any of the baseline characteristics. Additionally, PSP serum levels did not change over time neither after the burn trauma (p = 0.832) nor after secondary procedures (p = 0.113), while PCT levels increased significantly after the trauma (p < 0.001). Similarly, CRP serum levels were elevated significantly after both trauma and surgery (p < 0.001), whereas WBC values demonstrated a significant decline after the trauma (p < 0.001). Conclusion Established biomarkers (WBC, CRP and PCT) demonstrate decisive alterations after tissue destruction caused by burn injuries and subsequent surgical interventions. The robustness of PSP serum levels toward these inflammatory insults is a quality criterion for an upcoming sepsis biomarker. Buehler, Philipp K. verfasserin aut Niggemann, Pia verfasserin aut Rittirsch, Daniel verfasserin aut Schweizer, Riccardo verfasserin aut Waldner, Matthias verfasserin aut Giovanoli, Pietro verfasserin aut Cinelli, Paolo verfasserin aut Reding, Theresia verfasserin aut Graf, Rolf verfasserin aut Plock, Jan A. verfasserin aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 44(2020), 9 vom: 25. Mai, Seite 3000-3009 (DE-627)SPR003391159 nnns volume:44 year:2020 number:9 day:25 month:05 pages:3000-3009 https://dx.doi.org/10.1007/s00268-020-05589-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 44 2020 9 25 05 3000-3009 |
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10.1007/s00268-020-05589-w doi (DE-627)SPR04046993X (SPR)s00268-020-05589-w-e DE-627 ger DE-627 rakwb eng Klein, Holger J. verfasserin aut Expression of Pancreatic Stone Protein is Unaffected by Trauma and Subsequent Surgery in Burn Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Altered levels of pro-inflammatory markers secondary to trauma or surgery present a major problem to physicians in being prone to interfere with the clinical identification of infectious events. Methods Patients admitted to Zurich Burn Center between May 2015 and October 2018 with burns ≥10% total body surface area (TBSA) and without infection. Longitudinal analysis of the time course of PSP and routine inflammatory biomarkers [procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC)] over two days after (a) trauma with initial debridement and (b) subsequent burn surgeries was performed. The influence of TBSA, abbreviated burn severity index (ABSI), age and length of operation was investigated using a linear mixed effect regression model. Results Sixty-six patients (15 female) were included with a mean age of 45.5 ± 18.3 years, median TBSA of 22% (IQR 17) and mean ABSI score 6.8 ± 2.7. PSP was the only biomarker that showed no association with any of the baseline characteristics. Additionally, PSP serum levels did not change over time neither after the burn trauma (p = 0.832) nor after secondary procedures (p = 0.113), while PCT levels increased significantly after the trauma (p < 0.001). Similarly, CRP serum levels were elevated significantly after both trauma and surgery (p < 0.001), whereas WBC values demonstrated a significant decline after the trauma (p < 0.001). Conclusion Established biomarkers (WBC, CRP and PCT) demonstrate decisive alterations after tissue destruction caused by burn injuries and subsequent surgical interventions. The robustness of PSP serum levels toward these inflammatory insults is a quality criterion for an upcoming sepsis biomarker. Buehler, Philipp K. verfasserin aut Niggemann, Pia verfasserin aut Rittirsch, Daniel verfasserin aut Schweizer, Riccardo verfasserin aut Waldner, Matthias verfasserin aut Giovanoli, Pietro verfasserin aut Cinelli, Paolo verfasserin aut Reding, Theresia verfasserin aut Graf, Rolf verfasserin aut Plock, Jan A. verfasserin aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 44(2020), 9 vom: 25. Mai, Seite 3000-3009 (DE-627)SPR003391159 nnns volume:44 year:2020 number:9 day:25 month:05 pages:3000-3009 https://dx.doi.org/10.1007/s00268-020-05589-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 44 2020 9 25 05 3000-3009 |
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Expression of Pancreatic Stone Protein is Unaffected by Trauma and Subsequent Surgery in Burn Patients |
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Expression of Pancreatic Stone Protein is Unaffected by Trauma and Subsequent Surgery in Burn Patients |
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Klein, Holger J. |
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World Journal of Surgery |
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World Journal of Surgery |
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2020 |
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Klein, Holger J. Buehler, Philipp K. Niggemann, Pia Rittirsch, Daniel Schweizer, Riccardo Waldner, Matthias Giovanoli, Pietro Cinelli, Paolo Reding, Theresia Graf, Rolf Plock, Jan A. |
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Klein, Holger J. |
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10.1007/s00268-020-05589-w |
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expression of pancreatic stone protein is unaffected by trauma and subsequent surgery in burn patients |
title_auth |
Expression of Pancreatic Stone Protein is Unaffected by Trauma and Subsequent Surgery in Burn Patients |
abstract |
Background Altered levels of pro-inflammatory markers secondary to trauma or surgery present a major problem to physicians in being prone to interfere with the clinical identification of infectious events. Methods Patients admitted to Zurich Burn Center between May 2015 and October 2018 with burns ≥10% total body surface area (TBSA) and without infection. Longitudinal analysis of the time course of PSP and routine inflammatory biomarkers [procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC)] over two days after (a) trauma with initial debridement and (b) subsequent burn surgeries was performed. The influence of TBSA, abbreviated burn severity index (ABSI), age and length of operation was investigated using a linear mixed effect regression model. Results Sixty-six patients (15 female) were included with a mean age of 45.5 ± 18.3 years, median TBSA of 22% (IQR 17) and mean ABSI score 6.8 ± 2.7. PSP was the only biomarker that showed no association with any of the baseline characteristics. Additionally, PSP serum levels did not change over time neither after the burn trauma (p = 0.832) nor after secondary procedures (p = 0.113), while PCT levels increased significantly after the trauma (p < 0.001). Similarly, CRP serum levels were elevated significantly after both trauma and surgery (p < 0.001), whereas WBC values demonstrated a significant decline after the trauma (p < 0.001). Conclusion Established biomarkers (WBC, CRP and PCT) demonstrate decisive alterations after tissue destruction caused by burn injuries and subsequent surgical interventions. The robustness of PSP serum levels toward these inflammatory insults is a quality criterion for an upcoming sepsis biomarker. |
abstractGer |
Background Altered levels of pro-inflammatory markers secondary to trauma or surgery present a major problem to physicians in being prone to interfere with the clinical identification of infectious events. Methods Patients admitted to Zurich Burn Center between May 2015 and October 2018 with burns ≥10% total body surface area (TBSA) and without infection. Longitudinal analysis of the time course of PSP and routine inflammatory biomarkers [procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC)] over two days after (a) trauma with initial debridement and (b) subsequent burn surgeries was performed. The influence of TBSA, abbreviated burn severity index (ABSI), age and length of operation was investigated using a linear mixed effect regression model. Results Sixty-six patients (15 female) were included with a mean age of 45.5 ± 18.3 years, median TBSA of 22% (IQR 17) and mean ABSI score 6.8 ± 2.7. PSP was the only biomarker that showed no association with any of the baseline characteristics. Additionally, PSP serum levels did not change over time neither after the burn trauma (p = 0.832) nor after secondary procedures (p = 0.113), while PCT levels increased significantly after the trauma (p < 0.001). Similarly, CRP serum levels were elevated significantly after both trauma and surgery (p < 0.001), whereas WBC values demonstrated a significant decline after the trauma (p < 0.001). Conclusion Established biomarkers (WBC, CRP and PCT) demonstrate decisive alterations after tissue destruction caused by burn injuries and subsequent surgical interventions. The robustness of PSP serum levels toward these inflammatory insults is a quality criterion for an upcoming sepsis biomarker. |
abstract_unstemmed |
Background Altered levels of pro-inflammatory markers secondary to trauma or surgery present a major problem to physicians in being prone to interfere with the clinical identification of infectious events. Methods Patients admitted to Zurich Burn Center between May 2015 and October 2018 with burns ≥10% total body surface area (TBSA) and without infection. Longitudinal analysis of the time course of PSP and routine inflammatory biomarkers [procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC)] over two days after (a) trauma with initial debridement and (b) subsequent burn surgeries was performed. The influence of TBSA, abbreviated burn severity index (ABSI), age and length of operation was investigated using a linear mixed effect regression model. Results Sixty-six patients (15 female) were included with a mean age of 45.5 ± 18.3 years, median TBSA of 22% (IQR 17) and mean ABSI score 6.8 ± 2.7. PSP was the only biomarker that showed no association with any of the baseline characteristics. Additionally, PSP serum levels did not change over time neither after the burn trauma (p = 0.832) nor after secondary procedures (p = 0.113), while PCT levels increased significantly after the trauma (p < 0.001). Similarly, CRP serum levels were elevated significantly after both trauma and surgery (p < 0.001), whereas WBC values demonstrated a significant decline after the trauma (p < 0.001). Conclusion Established biomarkers (WBC, CRP and PCT) demonstrate decisive alterations after tissue destruction caused by burn injuries and subsequent surgical interventions. The robustness of PSP serum levels toward these inflammatory insults is a quality criterion for an upcoming sepsis biomarker. |
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9 |
title_short |
Expression of Pancreatic Stone Protein is Unaffected by Trauma and Subsequent Surgery in Burn Patients |
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https://dx.doi.org/10.1007/s00268-020-05589-w |
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Buehler, Philipp K. Niggemann, Pia Rittirsch, Daniel Schweizer, Riccardo Waldner, Matthias Giovanoli, Pietro Cinelli, Paolo Reding, Theresia Graf, Rolf Plock, Jan A. |
author2Str |
Buehler, Philipp K. Niggemann, Pia Rittirsch, Daniel Schweizer, Riccardo Waldner, Matthias Giovanoli, Pietro Cinelli, Paolo Reding, Theresia Graf, Rolf Plock, Jan A. |
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