An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems

Background In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters. By then combining this technique with PET, which provides valuable insight into a wide range of metabolic and molecular processes by using of a variety of radioactive tracers, the scope of medical imaging and diagnostics can be significantly increased. While the use of multimodal imaging is undoubtedly advantageous, identifying the optimal combination of these parameters to diagnose a specific dysfunction is very important and is advanced by the use of sophisticated imaging techniques in specific animal models. Methods In this pilot study, rats with intracerebral 9L gliosarcomas were used to explore a combination of sequential multinuclear MRI using a sophisticated switchable coil set in a small animal 9.4 T MRI scanner and, subsequently, a small animal PET with the tumour tracer O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET). This made it possible for in vivo multinuclear MR-PET experiments to be conducted without compromising the performance of either multinuclear MR or PET. Results High-quality in vivo images and spectra including high-resolution 1H imaging, 23Na-weighted imaging, detection of 31P metabolites and [18F]FET uptake were obtained, allowing the characterisation of tumour tissues in comparison to a healthy brain. It has been reported in the literature that these parameters are useful in the identification of the genetic profile of gliomas, particularly concerning the mutation of the isocitrate hydrogenase gene, which is highly relevant for treatment strategy. Conclusions The combination of multinuclear MR and PET in, for example, brain tumour models with specific genetic mutations will enable the physiological background of signal alterations to be explored and the identification of the optimal combination of imaging parameters for the non-invasive characterisation of the molecular profile of tumours. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Choi, Chang-Hoon [verfasserIn] Stegmayr, Carina [verfasserIn] Shymanskaya, Aliaksandra [verfasserIn] Worthoff, Wieland A. [verfasserIn] da Silva, Nuno A. [verfasserIn] Felder, Jörg [verfasserIn] Langen, Karl-Josef [verfasserIn] Shah, N. Jon [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	MR PET PET/MRI MRI FET PET Multinuclear Multimodal Small animal

Übergeordnetes Werk:	Enthalten in: EJNMMI Physics - Berlin : SpringerOpen, 2014, 7(2020), 1 vom: 29. Juli
Übergeordnetes Werk:	volume:7 ; year:2020 ; number:1 ; day:29 ; month:07

Links:	Volltext

DOI / URN:	10.1186/s40658-020-00319-6

Katalog-ID:	SPR040492885

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520			\|a Background In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters. By then combining this technique with PET, which provides valuable insight into a wide range of metabolic and molecular processes by using of a variety of radioactive tracers, the scope of medical imaging and diagnostics can be significantly increased. While the use of multimodal imaging is undoubtedly advantageous, identifying the optimal combination of these parameters to diagnose a specific dysfunction is very important and is advanced by the use of sophisticated imaging techniques in specific animal models. Methods In this pilot study, rats with intracerebral 9L gliosarcomas were used to explore a combination of sequential multinuclear MRI using a sophisticated switchable coil set in a small animal 9.4 T MRI scanner and, subsequently, a small animal PET with the tumour tracer O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET). This made it possible for in vivo multinuclear MR-PET experiments to be conducted without compromising the performance of either multinuclear MR or PET. Results High-quality in vivo images and spectra including high-resolution 1H imaging, 23Na-weighted imaging, detection of 31P metabolites and [18F]FET uptake were obtained, allowing the characterisation of tumour tissues in comparison to a healthy brain. It has been reported in the literature that these parameters are useful in the identification of the genetic profile of gliomas, particularly concerning the mutation of the isocitrate hydrogenase gene, which is highly relevant for treatment strategy. Conclusions The combination of multinuclear MR and PET in, for example, brain tumour models with specific genetic mutations will enable the physiological background of signal alterations to be explored and the identification of the optimal combination of imaging parameters for the non-invasive characterisation of the molecular profile of tumours.
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allfields	10.1186/s40658-020-00319-6 doi (DE-627)SPR040492885 (SPR)s40658-020-00319-6-e DE-627 ger DE-627 rakwb eng 530 610 ASE Choi, Chang-Hoon verfasserin aut An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters. By then combining this technique with PET, which provides valuable insight into a wide range of metabolic and molecular processes by using of a variety of radioactive tracers, the scope of medical imaging and diagnostics can be significantly increased. While the use of multimodal imaging is undoubtedly advantageous, identifying the optimal combination of these parameters to diagnose a specific dysfunction is very important and is advanced by the use of sophisticated imaging techniques in specific animal models. Methods In this pilot study, rats with intracerebral 9L gliosarcomas were used to explore a combination of sequential multinuclear MRI using a sophisticated switchable coil set in a small animal 9.4 T MRI scanner and, subsequently, a small animal PET with the tumour tracer O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET). This made it possible for in vivo multinuclear MR-PET experiments to be conducted without compromising the performance of either multinuclear MR or PET. Results High-quality in vivo images and spectra including high-resolution 1H imaging, 23Na-weighted imaging, detection of 31P metabolites and [18F]FET uptake were obtained, allowing the characterisation of tumour tissues in comparison to a healthy brain. It has been reported in the literature that these parameters are useful in the identification of the genetic profile of gliomas, particularly concerning the mutation of the isocitrate hydrogenase gene, which is highly relevant for treatment strategy. Conclusions The combination of multinuclear MR and PET in, for example, brain tumour models with specific genetic mutations will enable the physiological background of signal alterations to be explored and the identification of the optimal combination of imaging parameters for the non-invasive characterisation of the molecular profile of tumours. MR PET (dpeaa)DE-He213 PET/MRI (dpeaa)DE-He213 MRI (dpeaa)DE-He213 FET PET (dpeaa)DE-He213 Multinuclear (dpeaa)DE-He213 Multimodal (dpeaa)DE-He213 Small animal (dpeaa)DE-He213 Stegmayr, Carina verfasserin aut Shymanskaya, Aliaksandra verfasserin aut Worthoff, Wieland A. verfasserin aut da Silva, Nuno A. verfasserin aut Felder, Jörg verfasserin aut Langen, Karl-Josef verfasserin aut Shah, N. Jon verfasserin aut Enthalten in EJNMMI Physics Berlin : SpringerOpen, 2014 7(2020), 1 vom: 29. Juli (DE-627)785697993 (DE-600)2768912-8 2197-7364 nnns volume:7 year:2020 number:1 day:29 month:07 https://dx.doi.org/10.1186/s40658-020-00319-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 29 07
spelling	10.1186/s40658-020-00319-6 doi (DE-627)SPR040492885 (SPR)s40658-020-00319-6-e DE-627 ger DE-627 rakwb eng 530 610 ASE Choi, Chang-Hoon verfasserin aut An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters. By then combining this technique with PET, which provides valuable insight into a wide range of metabolic and molecular processes by using of a variety of radioactive tracers, the scope of medical imaging and diagnostics can be significantly increased. While the use of multimodal imaging is undoubtedly advantageous, identifying the optimal combination of these parameters to diagnose a specific dysfunction is very important and is advanced by the use of sophisticated imaging techniques in specific animal models. Methods In this pilot study, rats with intracerebral 9L gliosarcomas were used to explore a combination of sequential multinuclear MRI using a sophisticated switchable coil set in a small animal 9.4 T MRI scanner and, subsequently, a small animal PET with the tumour tracer O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET). This made it possible for in vivo multinuclear MR-PET experiments to be conducted without compromising the performance of either multinuclear MR or PET. Results High-quality in vivo images and spectra including high-resolution 1H imaging, 23Na-weighted imaging, detection of 31P metabolites and [18F]FET uptake were obtained, allowing the characterisation of tumour tissues in comparison to a healthy brain. It has been reported in the literature that these parameters are useful in the identification of the genetic profile of gliomas, particularly concerning the mutation of the isocitrate hydrogenase gene, which is highly relevant for treatment strategy. Conclusions The combination of multinuclear MR and PET in, for example, brain tumour models with specific genetic mutations will enable the physiological background of signal alterations to be explored and the identification of the optimal combination of imaging parameters for the non-invasive characterisation of the molecular profile of tumours. MR PET (dpeaa)DE-He213 PET/MRI (dpeaa)DE-He213 MRI (dpeaa)DE-He213 FET PET (dpeaa)DE-He213 Multinuclear (dpeaa)DE-He213 Multimodal (dpeaa)DE-He213 Small animal (dpeaa)DE-He213 Stegmayr, Carina verfasserin aut Shymanskaya, Aliaksandra verfasserin aut Worthoff, Wieland A. verfasserin aut da Silva, Nuno A. verfasserin aut Felder, Jörg verfasserin aut Langen, Karl-Josef verfasserin aut Shah, N. Jon verfasserin aut Enthalten in EJNMMI Physics Berlin : SpringerOpen, 2014 7(2020), 1 vom: 29. Juli (DE-627)785697993 (DE-600)2768912-8 2197-7364 nnns volume:7 year:2020 number:1 day:29 month:07 https://dx.doi.org/10.1186/s40658-020-00319-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 29 07
allfields_unstemmed	10.1186/s40658-020-00319-6 doi (DE-627)SPR040492885 (SPR)s40658-020-00319-6-e DE-627 ger DE-627 rakwb eng 530 610 ASE Choi, Chang-Hoon verfasserin aut An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters. By then combining this technique with PET, which provides valuable insight into a wide range of metabolic and molecular processes by using of a variety of radioactive tracers, the scope of medical imaging and diagnostics can be significantly increased. While the use of multimodal imaging is undoubtedly advantageous, identifying the optimal combination of these parameters to diagnose a specific dysfunction is very important and is advanced by the use of sophisticated imaging techniques in specific animal models. Methods In this pilot study, rats with intracerebral 9L gliosarcomas were used to explore a combination of sequential multinuclear MRI using a sophisticated switchable coil set in a small animal 9.4 T MRI scanner and, subsequently, a small animal PET with the tumour tracer O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET). This made it possible for in vivo multinuclear MR-PET experiments to be conducted without compromising the performance of either multinuclear MR or PET. Results High-quality in vivo images and spectra including high-resolution 1H imaging, 23Na-weighted imaging, detection of 31P metabolites and [18F]FET uptake were obtained, allowing the characterisation of tumour tissues in comparison to a healthy brain. It has been reported in the literature that these parameters are useful in the identification of the genetic profile of gliomas, particularly concerning the mutation of the isocitrate hydrogenase gene, which is highly relevant for treatment strategy. Conclusions The combination of multinuclear MR and PET in, for example, brain tumour models with specific genetic mutations will enable the physiological background of signal alterations to be explored and the identification of the optimal combination of imaging parameters for the non-invasive characterisation of the molecular profile of tumours. MR PET (dpeaa)DE-He213 PET/MRI (dpeaa)DE-He213 MRI (dpeaa)DE-He213 FET PET (dpeaa)DE-He213 Multinuclear (dpeaa)DE-He213 Multimodal (dpeaa)DE-He213 Small animal (dpeaa)DE-He213 Stegmayr, Carina verfasserin aut Shymanskaya, Aliaksandra verfasserin aut Worthoff, Wieland A. verfasserin aut da Silva, Nuno A. verfasserin aut Felder, Jörg verfasserin aut Langen, Karl-Josef verfasserin aut Shah, N. Jon verfasserin aut Enthalten in EJNMMI Physics Berlin : SpringerOpen, 2014 7(2020), 1 vom: 29. Juli (DE-627)785697993 (DE-600)2768912-8 2197-7364 nnns volume:7 year:2020 number:1 day:29 month:07 https://dx.doi.org/10.1186/s40658-020-00319-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 29 07
allfieldsGer	10.1186/s40658-020-00319-6 doi (DE-627)SPR040492885 (SPR)s40658-020-00319-6-e DE-627 ger DE-627 rakwb eng 530 610 ASE Choi, Chang-Hoon verfasserin aut An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters. By then combining this technique with PET, which provides valuable insight into a wide range of metabolic and molecular processes by using of a variety of radioactive tracers, the scope of medical imaging and diagnostics can be significantly increased. While the use of multimodal imaging is undoubtedly advantageous, identifying the optimal combination of these parameters to diagnose a specific dysfunction is very important and is advanced by the use of sophisticated imaging techniques in specific animal models. Methods In this pilot study, rats with intracerebral 9L gliosarcomas were used to explore a combination of sequential multinuclear MRI using a sophisticated switchable coil set in a small animal 9.4 T MRI scanner and, subsequently, a small animal PET with the tumour tracer O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET). This made it possible for in vivo multinuclear MR-PET experiments to be conducted without compromising the performance of either multinuclear MR or PET. Results High-quality in vivo images and spectra including high-resolution 1H imaging, 23Na-weighted imaging, detection of 31P metabolites and [18F]FET uptake were obtained, allowing the characterisation of tumour tissues in comparison to a healthy brain. It has been reported in the literature that these parameters are useful in the identification of the genetic profile of gliomas, particularly concerning the mutation of the isocitrate hydrogenase gene, which is highly relevant for treatment strategy. Conclusions The combination of multinuclear MR and PET in, for example, brain tumour models with specific genetic mutations will enable the physiological background of signal alterations to be explored and the identification of the optimal combination of imaging parameters for the non-invasive characterisation of the molecular profile of tumours. MR PET (dpeaa)DE-He213 PET/MRI (dpeaa)DE-He213 MRI (dpeaa)DE-He213 FET PET (dpeaa)DE-He213 Multinuclear (dpeaa)DE-He213 Multimodal (dpeaa)DE-He213 Small animal (dpeaa)DE-He213 Stegmayr, Carina verfasserin aut Shymanskaya, Aliaksandra verfasserin aut Worthoff, Wieland A. verfasserin aut da Silva, Nuno A. verfasserin aut Felder, Jörg verfasserin aut Langen, Karl-Josef verfasserin aut Shah, N. Jon verfasserin aut Enthalten in EJNMMI Physics Berlin : SpringerOpen, 2014 7(2020), 1 vom: 29. Juli (DE-627)785697993 (DE-600)2768912-8 2197-7364 nnns volume:7 year:2020 number:1 day:29 month:07 https://dx.doi.org/10.1186/s40658-020-00319-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 29 07
allfieldsSound	10.1186/s40658-020-00319-6 doi (DE-627)SPR040492885 (SPR)s40658-020-00319-6-e DE-627 ger DE-627 rakwb eng 530 610 ASE Choi, Chang-Hoon verfasserin aut An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters. By then combining this technique with PET, which provides valuable insight into a wide range of metabolic and molecular processes by using of a variety of radioactive tracers, the scope of medical imaging and diagnostics can be significantly increased. While the use of multimodal imaging is undoubtedly advantageous, identifying the optimal combination of these parameters to diagnose a specific dysfunction is very important and is advanced by the use of sophisticated imaging techniques in specific animal models. Methods In this pilot study, rats with intracerebral 9L gliosarcomas were used to explore a combination of sequential multinuclear MRI using a sophisticated switchable coil set in a small animal 9.4 T MRI scanner and, subsequently, a small animal PET with the tumour tracer O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET). This made it possible for in vivo multinuclear MR-PET experiments to be conducted without compromising the performance of either multinuclear MR or PET. Results High-quality in vivo images and spectra including high-resolution 1H imaging, 23Na-weighted imaging, detection of 31P metabolites and [18F]FET uptake were obtained, allowing the characterisation of tumour tissues in comparison to a healthy brain. It has been reported in the literature that these parameters are useful in the identification of the genetic profile of gliomas, particularly concerning the mutation of the isocitrate hydrogenase gene, which is highly relevant for treatment strategy. Conclusions The combination of multinuclear MR and PET in, for example, brain tumour models with specific genetic mutations will enable the physiological background of signal alterations to be explored and the identification of the optimal combination of imaging parameters for the non-invasive characterisation of the molecular profile of tumours. MR PET (dpeaa)DE-He213 PET/MRI (dpeaa)DE-He213 MRI (dpeaa)DE-He213 FET PET (dpeaa)DE-He213 Multinuclear (dpeaa)DE-He213 Multimodal (dpeaa)DE-He213 Small animal (dpeaa)DE-He213 Stegmayr, Carina verfasserin aut Shymanskaya, Aliaksandra verfasserin aut Worthoff, Wieland A. verfasserin aut da Silva, Nuno A. verfasserin aut Felder, Jörg verfasserin aut Langen, Karl-Josef verfasserin aut Shah, N. Jon verfasserin aut Enthalten in EJNMMI Physics Berlin : SpringerOpen, 2014 7(2020), 1 vom: 29. Juli (DE-627)785697993 (DE-600)2768912-8 2197-7364 nnns volume:7 year:2020 number:1 day:29 month:07 https://dx.doi.org/10.1186/s40658-020-00319-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 29 07
language	English
source	Enthalten in EJNMMI Physics 7(2020), 1 vom: 29. Juli volume:7 year:2020 number:1 day:29 month:07
sourceStr	Enthalten in EJNMMI Physics 7(2020), 1 vom: 29. Juli volume:7 year:2020 number:1 day:29 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	MR PET PET/MRI MRI FET PET Multinuclear Multimodal Small animal
dewey-raw	530
isfreeaccess_bool	true
container_title	EJNMMI Physics
authorswithroles_txt_mv	Choi, Chang-Hoon @@aut@@ Stegmayr, Carina @@aut@@ Shymanskaya, Aliaksandra @@aut@@ Worthoff, Wieland A. @@aut@@ da Silva, Nuno A. @@aut@@ Felder, Jörg @@aut@@ Langen, Karl-Josef @@aut@@ Shah, N. Jon @@aut@@
publishDateDaySort_date	2020-07-29T00:00:00Z
hierarchy_top_id	785697993
dewey-sort	3530
id	SPR040492885
language_de	englisch
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author	Choi, Chang-Hoon
spellingShingle	Choi, Chang-Hoon ddc 530 misc MR PET misc PET/MRI misc MRI misc FET PET misc Multinuclear misc Multimodal misc Small animal An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems
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topic_title	530 610 ASE An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems MR PET (dpeaa)DE-He213 PET/MRI (dpeaa)DE-He213 MRI (dpeaa)DE-He213 FET PET (dpeaa)DE-He213 Multinuclear (dpeaa)DE-He213 Multimodal (dpeaa)DE-He213 Small animal (dpeaa)DE-He213
topic	ddc 530 misc MR PET misc PET/MRI misc MRI misc FET PET misc Multinuclear misc Multimodal misc Small animal
topic_unstemmed	ddc 530 misc MR PET misc PET/MRI misc MRI misc FET PET misc Multinuclear misc Multimodal misc Small animal
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title	An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems
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title_full	An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems
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author_browse	Choi, Chang-Hoon Stegmayr, Carina Shymanskaya, Aliaksandra Worthoff, Wieland A. da Silva, Nuno A. Felder, Jörg Langen, Karl-Josef Shah, N. Jon
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title_sort	in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear mr and pet systems
title_auth	An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems
abstract	Background In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters. By then combining this technique with PET, which provides valuable insight into a wide range of metabolic and molecular processes by using of a variety of radioactive tracers, the scope of medical imaging and diagnostics can be significantly increased. While the use of multimodal imaging is undoubtedly advantageous, identifying the optimal combination of these parameters to diagnose a specific dysfunction is very important and is advanced by the use of sophisticated imaging techniques in specific animal models. Methods In this pilot study, rats with intracerebral 9L gliosarcomas were used to explore a combination of sequential multinuclear MRI using a sophisticated switchable coil set in a small animal 9.4 T MRI scanner and, subsequently, a small animal PET with the tumour tracer O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET). This made it possible for in vivo multinuclear MR-PET experiments to be conducted without compromising the performance of either multinuclear MR or PET. Results High-quality in vivo images and spectra including high-resolution 1H imaging, 23Na-weighted imaging, detection of 31P metabolites and [18F]FET uptake were obtained, allowing the characterisation of tumour tissues in comparison to a healthy brain. It has been reported in the literature that these parameters are useful in the identification of the genetic profile of gliomas, particularly concerning the mutation of the isocitrate hydrogenase gene, which is highly relevant for treatment strategy. Conclusions The combination of multinuclear MR and PET in, for example, brain tumour models with specific genetic mutations will enable the physiological background of signal alterations to be explored and the identification of the optimal combination of imaging parameters for the non-invasive characterisation of the molecular profile of tumours.
abstractGer	Background In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters. By then combining this technique with PET, which provides valuable insight into a wide range of metabolic and molecular processes by using of a variety of radioactive tracers, the scope of medical imaging and diagnostics can be significantly increased. While the use of multimodal imaging is undoubtedly advantageous, identifying the optimal combination of these parameters to diagnose a specific dysfunction is very important and is advanced by the use of sophisticated imaging techniques in specific animal models. Methods In this pilot study, rats with intracerebral 9L gliosarcomas were used to explore a combination of sequential multinuclear MRI using a sophisticated switchable coil set in a small animal 9.4 T MRI scanner and, subsequently, a small animal PET with the tumour tracer O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET). This made it possible for in vivo multinuclear MR-PET experiments to be conducted without compromising the performance of either multinuclear MR or PET. Results High-quality in vivo images and spectra including high-resolution 1H imaging, 23Na-weighted imaging, detection of 31P metabolites and [18F]FET uptake were obtained, allowing the characterisation of tumour tissues in comparison to a healthy brain. It has been reported in the literature that these parameters are useful in the identification of the genetic profile of gliomas, particularly concerning the mutation of the isocitrate hydrogenase gene, which is highly relevant for treatment strategy. Conclusions The combination of multinuclear MR and PET in, for example, brain tumour models with specific genetic mutations will enable the physiological background of signal alterations to be explored and the identification of the optimal combination of imaging parameters for the non-invasive characterisation of the molecular profile of tumours.
abstract_unstemmed	Background In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters. By then combining this technique with PET, which provides valuable insight into a wide range of metabolic and molecular processes by using of a variety of radioactive tracers, the scope of medical imaging and diagnostics can be significantly increased. While the use of multimodal imaging is undoubtedly advantageous, identifying the optimal combination of these parameters to diagnose a specific dysfunction is very important and is advanced by the use of sophisticated imaging techniques in specific animal models. Methods In this pilot study, rats with intracerebral 9L gliosarcomas were used to explore a combination of sequential multinuclear MRI using a sophisticated switchable coil set in a small animal 9.4 T MRI scanner and, subsequently, a small animal PET with the tumour tracer O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET). This made it possible for in vivo multinuclear MR-PET experiments to be conducted without compromising the performance of either multinuclear MR or PET. Results High-quality in vivo images and spectra including high-resolution 1H imaging, 23Na-weighted imaging, detection of 31P metabolites and [18F]FET uptake were obtained, allowing the characterisation of tumour tissues in comparison to a healthy brain. It has been reported in the literature that these parameters are useful in the identification of the genetic profile of gliomas, particularly concerning the mutation of the isocitrate hydrogenase gene, which is highly relevant for treatment strategy. Conclusions The combination of multinuclear MR and PET in, for example, brain tumour models with specific genetic mutations will enable the physiological background of signal alterations to be explored and the identification of the optimal combination of imaging parameters for the non-invasive characterisation of the molecular profile of tumours.
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title_short	An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems
url	https://dx.doi.org/10.1186/s40658-020-00319-6
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author2	Stegmayr, Carina Shymanskaya, Aliaksandra Worthoff, Wieland A. da Silva, Nuno A. Felder, Jörg Langen, Karl-Josef Shah, N. Jon
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