Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness
Abstract Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study should enable the clinician to recognize when treatment of MCAD with omalizumab is contraindicated because of the potential risk of s...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Molderings, G. J. [verfasserIn] Dumoulin, F. L. [verfasserIn] Homann, J. [verfasserIn] Sido, B. [verfasserIn] Textor, J. [verfasserIn] Mücke, M. [verfasserIn] Qagish, G. J. [verfasserIn] Barion, R. [verfasserIn] Raithel, M. [verfasserIn] Klingmüller, D. [verfasserIn] Schäfer, V. S. [verfasserIn] Hertfelder, H. J. [verfasserIn] Berdel, D. [verfasserIn] Tridente, G. [verfasserIn] Weinstock, L. B. [verfasserIn] Afrin, L. B. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Naunyn-Schmiedeberg's archives of pharmacology - Berlin : Springer, 1873, 393(2020), 9 vom: 06. Mai, Seite 1573-1580 |
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| Übergeordnetes Werk: |
volume:393 ; year:2020 ; number:9 ; day:06 ; month:05 ; pages:1573-1580 |
| Links: |
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| DOI / URN: |
10.1007/s00210-020-01886-2 |
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| Katalog-ID: |
SPR040632261 |
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| 100 | 1 | |a Molderings, G. J. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness |
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| 520 | |a Abstract Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study should enable the clinician to recognize when treatment of MCAD with omalizumab is contraindicated because of the potential risk of severe serum sickness and to report our successful therapeutic strategy for such adverse event (AE). Our clinical observations, a review of the literature including the event reports in the FDA AE Reporting System, the European Medicines Agency Eudra-Vigilance databases (preferred search terms: omalizumab, Xolair®, and serum sickness) and information from the manufacturer’s Novartis database were used. Omalizumab therapy may be more likely to cause serum sickness than previously thought. In patients with regular adrenal function, serum sickness can occur after 3 to 10 days which resolves after the antigen and circulating immune complexes are cleared. If the symptoms do not resolve within a week, injection of 20 to 40 mg of prednisolone on two consecutive days could be given. However, in MCAD patients whose adrenal cortical function is completely suppressed by exogenous glucocorticoid therapy, there is a high risk that serum sickness will be masked by the MCAD and evolve in a severe form with pronounced damage of organs and tissues, potentially leading to death. Therefore, before the application of the first omalizumab dose, it is important to ensure that the function of the adrenal cortex is not significantly limited so that any occurring type III allergy can be self-limiting. | ||
| 650 | 4 | |a Omalizumab |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mast cell activation disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Serum sickness |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Complement activation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Serum sickness therapy |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Dumoulin, F. L. |e verfasserin |4 aut | |
| 700 | 1 | |a Homann, J. |e verfasserin |4 aut | |
| 700 | 1 | |a Sido, B. |e verfasserin |4 aut | |
| 700 | 1 | |a Textor, J. |e verfasserin |4 aut | |
| 700 | 1 | |a Mücke, M. |e verfasserin |4 aut | |
| 700 | 1 | |a Qagish, G. J. |e verfasserin |4 aut | |
| 700 | 1 | |a Barion, R. |e verfasserin |4 aut | |
| 700 | 1 | |a Raithel, M. |e verfasserin |4 aut | |
| 700 | 1 | |a Klingmüller, D. |e verfasserin |4 aut | |
| 700 | 1 | |a Schäfer, V. S. |e verfasserin |4 aut | |
| 700 | 1 | |a Hertfelder, H. J. |e verfasserin |4 aut | |
| 700 | 1 | |a Berdel, D. |e verfasserin |4 aut | |
| 700 | 1 | |a Tridente, G. |e verfasserin |4 aut | |
| 700 | 1 | |a Weinstock, L. B. |e verfasserin |4 aut | |
| 700 | 1 | |a Afrin, L. B. |e verfasserin |4 aut | |
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10.1007/s00210-020-01886-2 doi (DE-627)SPR040632261 (SPR)s00210-020-01886-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl 44.38 bkl Molderings, G. J. verfasserin aut Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study should enable the clinician to recognize when treatment of MCAD with omalizumab is contraindicated because of the potential risk of severe serum sickness and to report our successful therapeutic strategy for such adverse event (AE). Our clinical observations, a review of the literature including the event reports in the FDA AE Reporting System, the European Medicines Agency Eudra-Vigilance databases (preferred search terms: omalizumab, Xolair®, and serum sickness) and information from the manufacturer’s Novartis database were used. Omalizumab therapy may be more likely to cause serum sickness than previously thought. In patients with regular adrenal function, serum sickness can occur after 3 to 10 days which resolves after the antigen and circulating immune complexes are cleared. If the symptoms do not resolve within a week, injection of 20 to 40 mg of prednisolone on two consecutive days could be given. However, in MCAD patients whose adrenal cortical function is completely suppressed by exogenous glucocorticoid therapy, there is a high risk that serum sickness will be masked by the MCAD and evolve in a severe form with pronounced damage of organs and tissues, potentially leading to death. Therefore, before the application of the first omalizumab dose, it is important to ensure that the function of the adrenal cortex is not significantly limited so that any occurring type III allergy can be self-limiting. Omalizumab (dpeaa)DE-He213 Mast cell activation disease (dpeaa)DE-He213 Serum sickness (dpeaa)DE-He213 Complement activation (dpeaa)DE-He213 Serum sickness therapy (dpeaa)DE-He213 Dumoulin, F. L. verfasserin aut Homann, J. verfasserin aut Sido, B. verfasserin aut Textor, J. verfasserin aut Mücke, M. verfasserin aut Qagish, G. J. verfasserin aut Barion, R. verfasserin aut Raithel, M. verfasserin aut Klingmüller, D. verfasserin aut Schäfer, V. S. verfasserin aut Hertfelder, H. J. verfasserin aut Berdel, D. verfasserin aut Tridente, G. verfasserin aut Weinstock, L. B. verfasserin aut Afrin, L. B. verfasserin aut Enthalten in Naunyn-Schmiedeberg's archives of pharmacology Berlin : Springer, 1873 393(2020), 9 vom: 06. Mai, Seite 1573-1580 (DE-627)254638309 (DE-600)1462940-9 1432-1912 nnns volume:393 year:2020 number:9 day:06 month:05 pages:1573-1580 https://dx.doi.org/10.1007/s00210-020-01886-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE 44.38 ASE AR 393 2020 9 06 05 1573-1580 |
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10.1007/s00210-020-01886-2 doi (DE-627)SPR040632261 (SPR)s00210-020-01886-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl 44.38 bkl Molderings, G. J. verfasserin aut Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study should enable the clinician to recognize when treatment of MCAD with omalizumab is contraindicated because of the potential risk of severe serum sickness and to report our successful therapeutic strategy for such adverse event (AE). Our clinical observations, a review of the literature including the event reports in the FDA AE Reporting System, the European Medicines Agency Eudra-Vigilance databases (preferred search terms: omalizumab, Xolair®, and serum sickness) and information from the manufacturer’s Novartis database were used. Omalizumab therapy may be more likely to cause serum sickness than previously thought. In patients with regular adrenal function, serum sickness can occur after 3 to 10 days which resolves after the antigen and circulating immune complexes are cleared. If the symptoms do not resolve within a week, injection of 20 to 40 mg of prednisolone on two consecutive days could be given. However, in MCAD patients whose adrenal cortical function is completely suppressed by exogenous glucocorticoid therapy, there is a high risk that serum sickness will be masked by the MCAD and evolve in a severe form with pronounced damage of organs and tissues, potentially leading to death. Therefore, before the application of the first omalizumab dose, it is important to ensure that the function of the adrenal cortex is not significantly limited so that any occurring type III allergy can be self-limiting. Omalizumab (dpeaa)DE-He213 Mast cell activation disease (dpeaa)DE-He213 Serum sickness (dpeaa)DE-He213 Complement activation (dpeaa)DE-He213 Serum sickness therapy (dpeaa)DE-He213 Dumoulin, F. L. verfasserin aut Homann, J. verfasserin aut Sido, B. verfasserin aut Textor, J. verfasserin aut Mücke, M. verfasserin aut Qagish, G. J. verfasserin aut Barion, R. verfasserin aut Raithel, M. verfasserin aut Klingmüller, D. verfasserin aut Schäfer, V. S. verfasserin aut Hertfelder, H. J. verfasserin aut Berdel, D. verfasserin aut Tridente, G. verfasserin aut Weinstock, L. B. verfasserin aut Afrin, L. B. verfasserin aut Enthalten in Naunyn-Schmiedeberg's archives of pharmacology Berlin : Springer, 1873 393(2020), 9 vom: 06. Mai, Seite 1573-1580 (DE-627)254638309 (DE-600)1462940-9 1432-1912 nnns volume:393 year:2020 number:9 day:06 month:05 pages:1573-1580 https://dx.doi.org/10.1007/s00210-020-01886-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE 44.38 ASE AR 393 2020 9 06 05 1573-1580 |
| allfields_unstemmed |
10.1007/s00210-020-01886-2 doi (DE-627)SPR040632261 (SPR)s00210-020-01886-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl 44.38 bkl Molderings, G. J. verfasserin aut Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study should enable the clinician to recognize when treatment of MCAD with omalizumab is contraindicated because of the potential risk of severe serum sickness and to report our successful therapeutic strategy for such adverse event (AE). Our clinical observations, a review of the literature including the event reports in the FDA AE Reporting System, the European Medicines Agency Eudra-Vigilance databases (preferred search terms: omalizumab, Xolair®, and serum sickness) and information from the manufacturer’s Novartis database were used. Omalizumab therapy may be more likely to cause serum sickness than previously thought. In patients with regular adrenal function, serum sickness can occur after 3 to 10 days which resolves after the antigen and circulating immune complexes are cleared. If the symptoms do not resolve within a week, injection of 20 to 40 mg of prednisolone on two consecutive days could be given. However, in MCAD patients whose adrenal cortical function is completely suppressed by exogenous glucocorticoid therapy, there is a high risk that serum sickness will be masked by the MCAD and evolve in a severe form with pronounced damage of organs and tissues, potentially leading to death. Therefore, before the application of the first omalizumab dose, it is important to ensure that the function of the adrenal cortex is not significantly limited so that any occurring type III allergy can be self-limiting. Omalizumab (dpeaa)DE-He213 Mast cell activation disease (dpeaa)DE-He213 Serum sickness (dpeaa)DE-He213 Complement activation (dpeaa)DE-He213 Serum sickness therapy (dpeaa)DE-He213 Dumoulin, F. L. verfasserin aut Homann, J. verfasserin aut Sido, B. verfasserin aut Textor, J. verfasserin aut Mücke, M. verfasserin aut Qagish, G. J. verfasserin aut Barion, R. verfasserin aut Raithel, M. verfasserin aut Klingmüller, D. verfasserin aut Schäfer, V. S. verfasserin aut Hertfelder, H. J. verfasserin aut Berdel, D. verfasserin aut Tridente, G. verfasserin aut Weinstock, L. B. verfasserin aut Afrin, L. B. verfasserin aut Enthalten in Naunyn-Schmiedeberg's archives of pharmacology Berlin : Springer, 1873 393(2020), 9 vom: 06. Mai, Seite 1573-1580 (DE-627)254638309 (DE-600)1462940-9 1432-1912 nnns volume:393 year:2020 number:9 day:06 month:05 pages:1573-1580 https://dx.doi.org/10.1007/s00210-020-01886-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE 44.38 ASE AR 393 2020 9 06 05 1573-1580 |
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10.1007/s00210-020-01886-2 doi (DE-627)SPR040632261 (SPR)s00210-020-01886-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl 44.38 bkl Molderings, G. J. verfasserin aut Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study should enable the clinician to recognize when treatment of MCAD with omalizumab is contraindicated because of the potential risk of severe serum sickness and to report our successful therapeutic strategy for such adverse event (AE). Our clinical observations, a review of the literature including the event reports in the FDA AE Reporting System, the European Medicines Agency Eudra-Vigilance databases (preferred search terms: omalizumab, Xolair®, and serum sickness) and information from the manufacturer’s Novartis database were used. Omalizumab therapy may be more likely to cause serum sickness than previously thought. In patients with regular adrenal function, serum sickness can occur after 3 to 10 days which resolves after the antigen and circulating immune complexes are cleared. If the symptoms do not resolve within a week, injection of 20 to 40 mg of prednisolone on two consecutive days could be given. However, in MCAD patients whose adrenal cortical function is completely suppressed by exogenous glucocorticoid therapy, there is a high risk that serum sickness will be masked by the MCAD and evolve in a severe form with pronounced damage of organs and tissues, potentially leading to death. Therefore, before the application of the first omalizumab dose, it is important to ensure that the function of the adrenal cortex is not significantly limited so that any occurring type III allergy can be self-limiting. Omalizumab (dpeaa)DE-He213 Mast cell activation disease (dpeaa)DE-He213 Serum sickness (dpeaa)DE-He213 Complement activation (dpeaa)DE-He213 Serum sickness therapy (dpeaa)DE-He213 Dumoulin, F. L. verfasserin aut Homann, J. verfasserin aut Sido, B. verfasserin aut Textor, J. verfasserin aut Mücke, M. verfasserin aut Qagish, G. J. verfasserin aut Barion, R. verfasserin aut Raithel, M. verfasserin aut Klingmüller, D. verfasserin aut Schäfer, V. S. verfasserin aut Hertfelder, H. J. verfasserin aut Berdel, D. verfasserin aut Tridente, G. verfasserin aut Weinstock, L. B. verfasserin aut Afrin, L. B. verfasserin aut Enthalten in Naunyn-Schmiedeberg's archives of pharmacology Berlin : Springer, 1873 393(2020), 9 vom: 06. Mai, Seite 1573-1580 (DE-627)254638309 (DE-600)1462940-9 1432-1912 nnns volume:393 year:2020 number:9 day:06 month:05 pages:1573-1580 https://dx.doi.org/10.1007/s00210-020-01886-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE 44.38 ASE AR 393 2020 9 06 05 1573-1580 |
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10.1007/s00210-020-01886-2 doi (DE-627)SPR040632261 (SPR)s00210-020-01886-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl 44.38 bkl Molderings, G. J. verfasserin aut Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study should enable the clinician to recognize when treatment of MCAD with omalizumab is contraindicated because of the potential risk of severe serum sickness and to report our successful therapeutic strategy for such adverse event (AE). Our clinical observations, a review of the literature including the event reports in the FDA AE Reporting System, the European Medicines Agency Eudra-Vigilance databases (preferred search terms: omalizumab, Xolair®, and serum sickness) and information from the manufacturer’s Novartis database were used. Omalizumab therapy may be more likely to cause serum sickness than previously thought. In patients with regular adrenal function, serum sickness can occur after 3 to 10 days which resolves after the antigen and circulating immune complexes are cleared. If the symptoms do not resolve within a week, injection of 20 to 40 mg of prednisolone on two consecutive days could be given. However, in MCAD patients whose adrenal cortical function is completely suppressed by exogenous glucocorticoid therapy, there is a high risk that serum sickness will be masked by the MCAD and evolve in a severe form with pronounced damage of organs and tissues, potentially leading to death. Therefore, before the application of the first omalizumab dose, it is important to ensure that the function of the adrenal cortex is not significantly limited so that any occurring type III allergy can be self-limiting. Omalizumab (dpeaa)DE-He213 Mast cell activation disease (dpeaa)DE-He213 Serum sickness (dpeaa)DE-He213 Complement activation (dpeaa)DE-He213 Serum sickness therapy (dpeaa)DE-He213 Dumoulin, F. L. verfasserin aut Homann, J. verfasserin aut Sido, B. verfasserin aut Textor, J. verfasserin aut Mücke, M. verfasserin aut Qagish, G. J. verfasserin aut Barion, R. verfasserin aut Raithel, M. verfasserin aut Klingmüller, D. verfasserin aut Schäfer, V. S. verfasserin aut Hertfelder, H. J. verfasserin aut Berdel, D. verfasserin aut Tridente, G. verfasserin aut Weinstock, L. B. verfasserin aut Afrin, L. B. verfasserin aut Enthalten in Naunyn-Schmiedeberg's archives of pharmacology Berlin : Springer, 1873 393(2020), 9 vom: 06. Mai, Seite 1573-1580 (DE-627)254638309 (DE-600)1462940-9 1432-1912 nnns volume:393 year:2020 number:9 day:06 month:05 pages:1573-1580 https://dx.doi.org/10.1007/s00210-020-01886-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE 44.38 ASE AR 393 2020 9 06 05 1573-1580 |
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Enthalten in Naunyn-Schmiedeberg's archives of pharmacology 393(2020), 9 vom: 06. Mai, Seite 1573-1580 volume:393 year:2020 number:9 day:06 month:05 pages:1573-1580 |
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Enthalten in Naunyn-Schmiedeberg's archives of pharmacology 393(2020), 9 vom: 06. Mai, Seite 1573-1580 volume:393 year:2020 number:9 day:06 month:05 pages:1573-1580 |
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Omalizumab Mast cell activation disease Serum sickness Complement activation Serum sickness therapy |
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Molderings, G. J. @@aut@@ Dumoulin, F. L. @@aut@@ Homann, J. @@aut@@ Sido, B. @@aut@@ Textor, J. @@aut@@ Mücke, M. @@aut@@ Qagish, G. J. @@aut@@ Barion, R. @@aut@@ Raithel, M. @@aut@@ Klingmüller, D. @@aut@@ Schäfer, V. S. @@aut@@ Hertfelder, H. J. @@aut@@ Berdel, D. @@aut@@ Tridente, G. @@aut@@ Weinstock, L. B. @@aut@@ Afrin, L. B. @@aut@@ |
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3610 |
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SPR040632261 |
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Molderings, G. J. |
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Molderings, G. J. ddc 610 bkl 44.47 bkl 44.38 misc Omalizumab misc Mast cell activation disease misc Serum sickness misc Complement activation misc Serum sickness therapy Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness |
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610 ASE 44.47 bkl 44.38 bkl Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness Omalizumab (dpeaa)DE-He213 Mast cell activation disease (dpeaa)DE-He213 Serum sickness (dpeaa)DE-He213 Complement activation (dpeaa)DE-He213 Serum sickness therapy (dpeaa)DE-He213 |
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ddc 610 bkl 44.47 bkl 44.38 misc Omalizumab misc Mast cell activation disease misc Serum sickness misc Complement activation misc Serum sickness therapy |
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ddc 610 bkl 44.47 bkl 44.38 misc Omalizumab misc Mast cell activation disease misc Serum sickness misc Complement activation misc Serum sickness therapy |
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Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness |
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Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness |
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Molderings, G. J. |
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Molderings, G. J. Dumoulin, F. L. Homann, J. Sido, B. Textor, J. Mücke, M. Qagish, G. J. Barion, R. Raithel, M. Klingmüller, D. Schäfer, V. S. Hertfelder, H. J. Berdel, D. Tridente, G. Weinstock, L. B. Afrin, L. B. |
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Molderings, G. J. |
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10.1007/s00210-020-01886-2 |
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610 |
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verfasserin |
| title_sort |
adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness |
| title_auth |
Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness |
| abstract |
Abstract Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study should enable the clinician to recognize when treatment of MCAD with omalizumab is contraindicated because of the potential risk of severe serum sickness and to report our successful therapeutic strategy for such adverse event (AE). Our clinical observations, a review of the literature including the event reports in the FDA AE Reporting System, the European Medicines Agency Eudra-Vigilance databases (preferred search terms: omalizumab, Xolair®, and serum sickness) and information from the manufacturer’s Novartis database were used. Omalizumab therapy may be more likely to cause serum sickness than previously thought. In patients with regular adrenal function, serum sickness can occur after 3 to 10 days which resolves after the antigen and circulating immune complexes are cleared. If the symptoms do not resolve within a week, injection of 20 to 40 mg of prednisolone on two consecutive days could be given. However, in MCAD patients whose adrenal cortical function is completely suppressed by exogenous glucocorticoid therapy, there is a high risk that serum sickness will be masked by the MCAD and evolve in a severe form with pronounced damage of organs and tissues, potentially leading to death. Therefore, before the application of the first omalizumab dose, it is important to ensure that the function of the adrenal cortex is not significantly limited so that any occurring type III allergy can be self-limiting. |
| abstractGer |
Abstract Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study should enable the clinician to recognize when treatment of MCAD with omalizumab is contraindicated because of the potential risk of severe serum sickness and to report our successful therapeutic strategy for such adverse event (AE). Our clinical observations, a review of the literature including the event reports in the FDA AE Reporting System, the European Medicines Agency Eudra-Vigilance databases (preferred search terms: omalizumab, Xolair®, and serum sickness) and information from the manufacturer’s Novartis database were used. Omalizumab therapy may be more likely to cause serum sickness than previously thought. In patients with regular adrenal function, serum sickness can occur after 3 to 10 days which resolves after the antigen and circulating immune complexes are cleared. If the symptoms do not resolve within a week, injection of 20 to 40 mg of prednisolone on two consecutive days could be given. However, in MCAD patients whose adrenal cortical function is completely suppressed by exogenous glucocorticoid therapy, there is a high risk that serum sickness will be masked by the MCAD and evolve in a severe form with pronounced damage of organs and tissues, potentially leading to death. Therefore, before the application of the first omalizumab dose, it is important to ensure that the function of the adrenal cortex is not significantly limited so that any occurring type III allergy can be self-limiting. |
| abstract_unstemmed |
Abstract Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study should enable the clinician to recognize when treatment of MCAD with omalizumab is contraindicated because of the potential risk of severe serum sickness and to report our successful therapeutic strategy for such adverse event (AE). Our clinical observations, a review of the literature including the event reports in the FDA AE Reporting System, the European Medicines Agency Eudra-Vigilance databases (preferred search terms: omalizumab, Xolair®, and serum sickness) and information from the manufacturer’s Novartis database were used. Omalizumab therapy may be more likely to cause serum sickness than previously thought. In patients with regular adrenal function, serum sickness can occur after 3 to 10 days which resolves after the antigen and circulating immune complexes are cleared. If the symptoms do not resolve within a week, injection of 20 to 40 mg of prednisolone on two consecutive days could be given. However, in MCAD patients whose adrenal cortical function is completely suppressed by exogenous glucocorticoid therapy, there is a high risk that serum sickness will be masked by the MCAD and evolve in a severe form with pronounced damage of organs and tissues, potentially leading to death. Therefore, before the application of the first omalizumab dose, it is important to ensure that the function of the adrenal cortex is not significantly limited so that any occurring type III allergy can be self-limiting. |
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Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness |
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