Defining novel functions for cerebrospinal fluid in ALS pathophysiology
Abstract Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has rece...
Ausführliche Beschreibung
Autor*in: |
Ng Kee Kwong, Koy Chong [verfasserIn] Mehta, Arpan R. [verfasserIn] Nedergaard, Maiken [verfasserIn] Chandran, Siddharthan [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Übergeordnetes Werk: |
Enthalten in: Acta Neuropathologica Communications - London : Biomed Central, 2013, 8(2020), 1 vom: 20. Aug. |
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Übergeordnetes Werk: |
volume:8 ; year:2020 ; number:1 ; day:20 ; month:08 |
Links: |
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DOI / URN: |
10.1186/s40478-020-01018-0 |
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Katalog-ID: |
SPR040708357 |
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10.1186/s40478-020-01018-0 doi (DE-627)SPR040708357 (SPR)s40478-020-01018-0-e DE-627 ger DE-627 rakwb eng 610 ASE Ng Kee Kwong, Koy Chong verfasserin aut Defining novel functions for cerebrospinal fluid in ALS pathophysiology 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has received considerable attention in several neurological conditions, particularly Alzheimer’s disease. Its significance in ALS has, however, been little addressed. This perspective article therefore aims to assess the possibility of CSF contribution in ALS by considering various lines of evidence, including the abnormal composition of ALS-CSF, its toxicity and the evidence for impaired CSF dynamics in ALS patients. We also describe a potential role for CSF circulation in determining disease spread as well as the importance of CSF dynamics in ALS neurotherapeutics. We propose that a CSF model could potentially offer additional avenues to explore currently unexplained features of ALS, ultimately leading to new treatment options for people with ALS. Glymphatic system (dpeaa)DE-He213 Cerebrospinal fluid (dpeaa)DE-He213 Amyotrophic lateral sclerosis (dpeaa)DE-He213 Motor neuron disease (dpeaa)DE-He213 Frontotemporal dementia (dpeaa)DE-He213 Ageing (dpeaa)DE-He213 Mehta, Arpan R. verfasserin aut Nedergaard, Maiken verfasserin aut Chandran, Siddharthan verfasserin aut Enthalten in Acta Neuropathologica Communications London : Biomed Central, 2013 8(2020), 1 vom: 20. Aug. (DE-627)746066465 (DE-600)2715589-4 2051-5960 nnns volume:8 year:2020 number:1 day:20 month:08 https://dx.doi.org/10.1186/s40478-020-01018-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 1 20 08 |
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10.1186/s40478-020-01018-0 doi (DE-627)SPR040708357 (SPR)s40478-020-01018-0-e DE-627 ger DE-627 rakwb eng 610 ASE Ng Kee Kwong, Koy Chong verfasserin aut Defining novel functions for cerebrospinal fluid in ALS pathophysiology 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has received considerable attention in several neurological conditions, particularly Alzheimer’s disease. Its significance in ALS has, however, been little addressed. This perspective article therefore aims to assess the possibility of CSF contribution in ALS by considering various lines of evidence, including the abnormal composition of ALS-CSF, its toxicity and the evidence for impaired CSF dynamics in ALS patients. We also describe a potential role for CSF circulation in determining disease spread as well as the importance of CSF dynamics in ALS neurotherapeutics. We propose that a CSF model could potentially offer additional avenues to explore currently unexplained features of ALS, ultimately leading to new treatment options for people with ALS. Glymphatic system (dpeaa)DE-He213 Cerebrospinal fluid (dpeaa)DE-He213 Amyotrophic lateral sclerosis (dpeaa)DE-He213 Motor neuron disease (dpeaa)DE-He213 Frontotemporal dementia (dpeaa)DE-He213 Ageing (dpeaa)DE-He213 Mehta, Arpan R. verfasserin aut Nedergaard, Maiken verfasserin aut Chandran, Siddharthan verfasserin aut Enthalten in Acta Neuropathologica Communications London : Biomed Central, 2013 8(2020), 1 vom: 20. Aug. (DE-627)746066465 (DE-600)2715589-4 2051-5960 nnns volume:8 year:2020 number:1 day:20 month:08 https://dx.doi.org/10.1186/s40478-020-01018-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 1 20 08 |
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10.1186/s40478-020-01018-0 doi (DE-627)SPR040708357 (SPR)s40478-020-01018-0-e DE-627 ger DE-627 rakwb eng 610 ASE Ng Kee Kwong, Koy Chong verfasserin aut Defining novel functions for cerebrospinal fluid in ALS pathophysiology 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has received considerable attention in several neurological conditions, particularly Alzheimer’s disease. Its significance in ALS has, however, been little addressed. This perspective article therefore aims to assess the possibility of CSF contribution in ALS by considering various lines of evidence, including the abnormal composition of ALS-CSF, its toxicity and the evidence for impaired CSF dynamics in ALS patients. We also describe a potential role for CSF circulation in determining disease spread as well as the importance of CSF dynamics in ALS neurotherapeutics. We propose that a CSF model could potentially offer additional avenues to explore currently unexplained features of ALS, ultimately leading to new treatment options for people with ALS. Glymphatic system (dpeaa)DE-He213 Cerebrospinal fluid (dpeaa)DE-He213 Amyotrophic lateral sclerosis (dpeaa)DE-He213 Motor neuron disease (dpeaa)DE-He213 Frontotemporal dementia (dpeaa)DE-He213 Ageing (dpeaa)DE-He213 Mehta, Arpan R. verfasserin aut Nedergaard, Maiken verfasserin aut Chandran, Siddharthan verfasserin aut Enthalten in Acta Neuropathologica Communications London : Biomed Central, 2013 8(2020), 1 vom: 20. Aug. (DE-627)746066465 (DE-600)2715589-4 2051-5960 nnns volume:8 year:2020 number:1 day:20 month:08 https://dx.doi.org/10.1186/s40478-020-01018-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 1 20 08 |
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10.1186/s40478-020-01018-0 doi (DE-627)SPR040708357 (SPR)s40478-020-01018-0-e DE-627 ger DE-627 rakwb eng 610 ASE Ng Kee Kwong, Koy Chong verfasserin aut Defining novel functions for cerebrospinal fluid in ALS pathophysiology 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has received considerable attention in several neurological conditions, particularly Alzheimer’s disease. Its significance in ALS has, however, been little addressed. This perspective article therefore aims to assess the possibility of CSF contribution in ALS by considering various lines of evidence, including the abnormal composition of ALS-CSF, its toxicity and the evidence for impaired CSF dynamics in ALS patients. We also describe a potential role for CSF circulation in determining disease spread as well as the importance of CSF dynamics in ALS neurotherapeutics. We propose that a CSF model could potentially offer additional avenues to explore currently unexplained features of ALS, ultimately leading to new treatment options for people with ALS. Glymphatic system (dpeaa)DE-He213 Cerebrospinal fluid (dpeaa)DE-He213 Amyotrophic lateral sclerosis (dpeaa)DE-He213 Motor neuron disease (dpeaa)DE-He213 Frontotemporal dementia (dpeaa)DE-He213 Ageing (dpeaa)DE-He213 Mehta, Arpan R. verfasserin aut Nedergaard, Maiken verfasserin aut Chandran, Siddharthan verfasserin aut Enthalten in Acta Neuropathologica Communications London : Biomed Central, 2013 8(2020), 1 vom: 20. Aug. (DE-627)746066465 (DE-600)2715589-4 2051-5960 nnns volume:8 year:2020 number:1 day:20 month:08 https://dx.doi.org/10.1186/s40478-020-01018-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 1 20 08 |
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10.1186/s40478-020-01018-0 doi (DE-627)SPR040708357 (SPR)s40478-020-01018-0-e DE-627 ger DE-627 rakwb eng 610 ASE Ng Kee Kwong, Koy Chong verfasserin aut Defining novel functions for cerebrospinal fluid in ALS pathophysiology 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has received considerable attention in several neurological conditions, particularly Alzheimer’s disease. Its significance in ALS has, however, been little addressed. This perspective article therefore aims to assess the possibility of CSF contribution in ALS by considering various lines of evidence, including the abnormal composition of ALS-CSF, its toxicity and the evidence for impaired CSF dynamics in ALS patients. We also describe a potential role for CSF circulation in determining disease spread as well as the importance of CSF dynamics in ALS neurotherapeutics. We propose that a CSF model could potentially offer additional avenues to explore currently unexplained features of ALS, ultimately leading to new treatment options for people with ALS. Glymphatic system (dpeaa)DE-He213 Cerebrospinal fluid (dpeaa)DE-He213 Amyotrophic lateral sclerosis (dpeaa)DE-He213 Motor neuron disease (dpeaa)DE-He213 Frontotemporal dementia (dpeaa)DE-He213 Ageing (dpeaa)DE-He213 Mehta, Arpan R. verfasserin aut Nedergaard, Maiken verfasserin aut Chandran, Siddharthan verfasserin aut Enthalten in Acta Neuropathologica Communications London : Biomed Central, 2013 8(2020), 1 vom: 20. Aug. (DE-627)746066465 (DE-600)2715589-4 2051-5960 nnns volume:8 year:2020 number:1 day:20 month:08 https://dx.doi.org/10.1186/s40478-020-01018-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 1 20 08 |
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Enthalten in Acta Neuropathologica Communications 8(2020), 1 vom: 20. Aug. volume:8 year:2020 number:1 day:20 month:08 |
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defining novel functions for cerebrospinal fluid in als pathophysiology |
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Defining novel functions for cerebrospinal fluid in ALS pathophysiology |
abstract |
Abstract Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has received considerable attention in several neurological conditions, particularly Alzheimer’s disease. Its significance in ALS has, however, been little addressed. This perspective article therefore aims to assess the possibility of CSF contribution in ALS by considering various lines of evidence, including the abnormal composition of ALS-CSF, its toxicity and the evidence for impaired CSF dynamics in ALS patients. We also describe a potential role for CSF circulation in determining disease spread as well as the importance of CSF dynamics in ALS neurotherapeutics. We propose that a CSF model could potentially offer additional avenues to explore currently unexplained features of ALS, ultimately leading to new treatment options for people with ALS. |
abstractGer |
Abstract Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has received considerable attention in several neurological conditions, particularly Alzheimer’s disease. Its significance in ALS has, however, been little addressed. This perspective article therefore aims to assess the possibility of CSF contribution in ALS by considering various lines of evidence, including the abnormal composition of ALS-CSF, its toxicity and the evidence for impaired CSF dynamics in ALS patients. We also describe a potential role for CSF circulation in determining disease spread as well as the importance of CSF dynamics in ALS neurotherapeutics. We propose that a CSF model could potentially offer additional avenues to explore currently unexplained features of ALS, ultimately leading to new treatment options for people with ALS. |
abstract_unstemmed |
Abstract Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has received considerable attention in several neurological conditions, particularly Alzheimer’s disease. Its significance in ALS has, however, been little addressed. This perspective article therefore aims to assess the possibility of CSF contribution in ALS by considering various lines of evidence, including the abnormal composition of ALS-CSF, its toxicity and the evidence for impaired CSF dynamics in ALS patients. We also describe a potential role for CSF circulation in determining disease spread as well as the importance of CSF dynamics in ALS neurotherapeutics. We propose that a CSF model could potentially offer additional avenues to explore currently unexplained features of ALS, ultimately leading to new treatment options for people with ALS. |
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7.4004526 |