Sarcopenia as a prognostic factor in patients with recurrent pancreatic cancer: a retrospective study
Background Sarcopenia is a prognostic factor in various cancers. However, the impact of sarcopenia in patients with recurrent pancreatic cancer remains unclear. This study evaluated the prognostic significance of sarcopenia in patients with recurrent pancreatic cancer. Methods Seventy-four patients...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sakamoto, Teruhisa [verfasserIn] Yagyu, Takuki [verfasserIn] Uchinaka, Ei [verfasserIn] Miyatani, Kozo [verfasserIn] Hanaki, Takehiko [verfasserIn] Kihara, Kyoichi [verfasserIn] Matsunaga, Tomoyuki [verfasserIn] Yamamoto, Manabu [verfasserIn] Tokuyasu, Naruo [verfasserIn] Honjo, Soichiro [verfasserIn] Fujiwara, Yoshiyuki [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Übergeordnetes Werk: |
Enthalten in: World journal of surgical oncology - London : Biomed Central, 2003, 18(2020), 1 vom: 22. Aug. |
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| Übergeordnetes Werk: |
volume:18 ; year:2020 ; number:1 ; day:22 ; month:08 |
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| DOI / URN: |
10.1186/s12957-020-01981-x |
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| Katalog-ID: |
SPR040726789 |
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| 520 | |a Background Sarcopenia is a prognostic factor in various cancers. However, the impact of sarcopenia in patients with recurrent pancreatic cancer remains unclear. This study evaluated the prognostic significance of sarcopenia in patients with recurrent pancreatic cancer. Methods Seventy-four patients who developed postoperative recurrence of pancreatic cancer after undergoing pancreatectomies were enrolled. Sarcopenia in these patients was defined according to the psoas muscle index (PMI) measured via computed tomography at the third vertebra. Results The mean PMIs at the time of recurrence were 4.47 ± 1.27 $ cm^{2} $/$ m^{2} $ for men and 3.26 ± 0.70 $ cm^{2} $/$ m^{2} $ for women. Of the 74 patients, 65 (87.8%) were diagnosed with sarcopenia with low PMI. The 2-year post-recurrence survival curve in the sarcopenia group was significantly worse than that in the non-sarcopenia group (P = 0.034). Multivariate analysis revealed that sarcopenia at the time of recurrence was an independent prognostic factor (P = 0.043) along with a high neutrophil-to-lymphocyte ratio (P = 0.004), early recurrence (P = 0.001), and chemotherapy after recurrence (P = 0.005) in patients with recurrent pancreatic cancer. Furthermore, the area under the curve (AUC) of the combination of sarcopenia and time to recurrence for predicting 2-year survival was 0.763, which was much higher than that of sarcopenia alone (AUC = 0.622). Conclusions Sarcopenia is a useful prognostic factor in patients with recurrent pancreatic cancer. The combination of sarcopenia and time of recurrence may more accurately predict post-recurrence survival than can sarcopenia alone. | ||
| 650 | 4 | |a Recurrent pancreatic cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Sarcopenia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Prognosis |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Yagyu, Takuki |e verfasserin |4 aut | |
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| 700 | 1 | |a Tokuyasu, Naruo |e verfasserin |4 aut | |
| 700 | 1 | |a Honjo, Soichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Fujiwara, Yoshiyuki |e verfasserin |4 aut | |
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10.1186/s12957-020-01981-x doi (DE-627)SPR040726789 (SPR)s12957-020-01981-x-e DE-627 ger DE-627 rakwb eng 610 ASE Sakamoto, Teruhisa verfasserin aut Sarcopenia as a prognostic factor in patients with recurrent pancreatic cancer: a retrospective study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Sarcopenia is a prognostic factor in various cancers. However, the impact of sarcopenia in patients with recurrent pancreatic cancer remains unclear. This study evaluated the prognostic significance of sarcopenia in patients with recurrent pancreatic cancer. Methods Seventy-four patients who developed postoperative recurrence of pancreatic cancer after undergoing pancreatectomies were enrolled. Sarcopenia in these patients was defined according to the psoas muscle index (PMI) measured via computed tomography at the third vertebra. Results The mean PMIs at the time of recurrence were 4.47 ± 1.27 $ cm^{2} $/$ m^{2} $ for men and 3.26 ± 0.70 $ cm^{2} $/$ m^{2} $ for women. Of the 74 patients, 65 (87.8%) were diagnosed with sarcopenia with low PMI. The 2-year post-recurrence survival curve in the sarcopenia group was significantly worse than that in the non-sarcopenia group (P = 0.034). Multivariate analysis revealed that sarcopenia at the time of recurrence was an independent prognostic factor (P = 0.043) along with a high neutrophil-to-lymphocyte ratio (P = 0.004), early recurrence (P = 0.001), and chemotherapy after recurrence (P = 0.005) in patients with recurrent pancreatic cancer. Furthermore, the area under the curve (AUC) of the combination of sarcopenia and time to recurrence for predicting 2-year survival was 0.763, which was much higher than that of sarcopenia alone (AUC = 0.622). Conclusions Sarcopenia is a useful prognostic factor in patients with recurrent pancreatic cancer. The combination of sarcopenia and time of recurrence may more accurately predict post-recurrence survival than can sarcopenia alone. Recurrent pancreatic cancer (dpeaa)DE-He213 Sarcopenia (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Yagyu, Takuki verfasserin aut Uchinaka, Ei verfasserin aut Miyatani, Kozo verfasserin aut Hanaki, Takehiko verfasserin aut Kihara, Kyoichi verfasserin aut Matsunaga, Tomoyuki verfasserin aut Yamamoto, Manabu verfasserin aut Tokuyasu, Naruo verfasserin aut Honjo, Soichiro verfasserin aut Fujiwara, Yoshiyuki verfasserin aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 18(2020), 1 vom: 22. Aug. (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:18 year:2020 number:1 day:22 month:08 https://dx.doi.org/10.1186/s12957-020-01981-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 1 22 08 |
| spelling |
10.1186/s12957-020-01981-x doi (DE-627)SPR040726789 (SPR)s12957-020-01981-x-e DE-627 ger DE-627 rakwb eng 610 ASE Sakamoto, Teruhisa verfasserin aut Sarcopenia as a prognostic factor in patients with recurrent pancreatic cancer: a retrospective study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Sarcopenia is a prognostic factor in various cancers. However, the impact of sarcopenia in patients with recurrent pancreatic cancer remains unclear. This study evaluated the prognostic significance of sarcopenia in patients with recurrent pancreatic cancer. Methods Seventy-four patients who developed postoperative recurrence of pancreatic cancer after undergoing pancreatectomies were enrolled. Sarcopenia in these patients was defined according to the psoas muscle index (PMI) measured via computed tomography at the third vertebra. Results The mean PMIs at the time of recurrence were 4.47 ± 1.27 $ cm^{2} $/$ m^{2} $ for men and 3.26 ± 0.70 $ cm^{2} $/$ m^{2} $ for women. Of the 74 patients, 65 (87.8%) were diagnosed with sarcopenia with low PMI. The 2-year post-recurrence survival curve in the sarcopenia group was significantly worse than that in the non-sarcopenia group (P = 0.034). Multivariate analysis revealed that sarcopenia at the time of recurrence was an independent prognostic factor (P = 0.043) along with a high neutrophil-to-lymphocyte ratio (P = 0.004), early recurrence (P = 0.001), and chemotherapy after recurrence (P = 0.005) in patients with recurrent pancreatic cancer. Furthermore, the area under the curve (AUC) of the combination of sarcopenia and time to recurrence for predicting 2-year survival was 0.763, which was much higher than that of sarcopenia alone (AUC = 0.622). Conclusions Sarcopenia is a useful prognostic factor in patients with recurrent pancreatic cancer. The combination of sarcopenia and time of recurrence may more accurately predict post-recurrence survival than can sarcopenia alone. Recurrent pancreatic cancer (dpeaa)DE-He213 Sarcopenia (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Yagyu, Takuki verfasserin aut Uchinaka, Ei verfasserin aut Miyatani, Kozo verfasserin aut Hanaki, Takehiko verfasserin aut Kihara, Kyoichi verfasserin aut Matsunaga, Tomoyuki verfasserin aut Yamamoto, Manabu verfasserin aut Tokuyasu, Naruo verfasserin aut Honjo, Soichiro verfasserin aut Fujiwara, Yoshiyuki verfasserin aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 18(2020), 1 vom: 22. Aug. (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:18 year:2020 number:1 day:22 month:08 https://dx.doi.org/10.1186/s12957-020-01981-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 1 22 08 |
| allfields_unstemmed |
10.1186/s12957-020-01981-x doi (DE-627)SPR040726789 (SPR)s12957-020-01981-x-e DE-627 ger DE-627 rakwb eng 610 ASE Sakamoto, Teruhisa verfasserin aut Sarcopenia as a prognostic factor in patients with recurrent pancreatic cancer: a retrospective study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Sarcopenia is a prognostic factor in various cancers. However, the impact of sarcopenia in patients with recurrent pancreatic cancer remains unclear. This study evaluated the prognostic significance of sarcopenia in patients with recurrent pancreatic cancer. Methods Seventy-four patients who developed postoperative recurrence of pancreatic cancer after undergoing pancreatectomies were enrolled. Sarcopenia in these patients was defined according to the psoas muscle index (PMI) measured via computed tomography at the third vertebra. Results The mean PMIs at the time of recurrence were 4.47 ± 1.27 $ cm^{2} $/$ m^{2} $ for men and 3.26 ± 0.70 $ cm^{2} $/$ m^{2} $ for women. Of the 74 patients, 65 (87.8%) were diagnosed with sarcopenia with low PMI. The 2-year post-recurrence survival curve in the sarcopenia group was significantly worse than that in the non-sarcopenia group (P = 0.034). Multivariate analysis revealed that sarcopenia at the time of recurrence was an independent prognostic factor (P = 0.043) along with a high neutrophil-to-lymphocyte ratio (P = 0.004), early recurrence (P = 0.001), and chemotherapy after recurrence (P = 0.005) in patients with recurrent pancreatic cancer. Furthermore, the area under the curve (AUC) of the combination of sarcopenia and time to recurrence for predicting 2-year survival was 0.763, which was much higher than that of sarcopenia alone (AUC = 0.622). Conclusions Sarcopenia is a useful prognostic factor in patients with recurrent pancreatic cancer. The combination of sarcopenia and time of recurrence may more accurately predict post-recurrence survival than can sarcopenia alone. Recurrent pancreatic cancer (dpeaa)DE-He213 Sarcopenia (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Yagyu, Takuki verfasserin aut Uchinaka, Ei verfasserin aut Miyatani, Kozo verfasserin aut Hanaki, Takehiko verfasserin aut Kihara, Kyoichi verfasserin aut Matsunaga, Tomoyuki verfasserin aut Yamamoto, Manabu verfasserin aut Tokuyasu, Naruo verfasserin aut Honjo, Soichiro verfasserin aut Fujiwara, Yoshiyuki verfasserin aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 18(2020), 1 vom: 22. Aug. (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:18 year:2020 number:1 day:22 month:08 https://dx.doi.org/10.1186/s12957-020-01981-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 1 22 08 |
| allfieldsGer |
10.1186/s12957-020-01981-x doi (DE-627)SPR040726789 (SPR)s12957-020-01981-x-e DE-627 ger DE-627 rakwb eng 610 ASE Sakamoto, Teruhisa verfasserin aut Sarcopenia as a prognostic factor in patients with recurrent pancreatic cancer: a retrospective study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Sarcopenia is a prognostic factor in various cancers. However, the impact of sarcopenia in patients with recurrent pancreatic cancer remains unclear. This study evaluated the prognostic significance of sarcopenia in patients with recurrent pancreatic cancer. Methods Seventy-four patients who developed postoperative recurrence of pancreatic cancer after undergoing pancreatectomies were enrolled. Sarcopenia in these patients was defined according to the psoas muscle index (PMI) measured via computed tomography at the third vertebra. Results The mean PMIs at the time of recurrence were 4.47 ± 1.27 $ cm^{2} $/$ m^{2} $ for men and 3.26 ± 0.70 $ cm^{2} $/$ m^{2} $ for women. Of the 74 patients, 65 (87.8%) were diagnosed with sarcopenia with low PMI. The 2-year post-recurrence survival curve in the sarcopenia group was significantly worse than that in the non-sarcopenia group (P = 0.034). Multivariate analysis revealed that sarcopenia at the time of recurrence was an independent prognostic factor (P = 0.043) along with a high neutrophil-to-lymphocyte ratio (P = 0.004), early recurrence (P = 0.001), and chemotherapy after recurrence (P = 0.005) in patients with recurrent pancreatic cancer. Furthermore, the area under the curve (AUC) of the combination of sarcopenia and time to recurrence for predicting 2-year survival was 0.763, which was much higher than that of sarcopenia alone (AUC = 0.622). Conclusions Sarcopenia is a useful prognostic factor in patients with recurrent pancreatic cancer. The combination of sarcopenia and time of recurrence may more accurately predict post-recurrence survival than can sarcopenia alone. Recurrent pancreatic cancer (dpeaa)DE-He213 Sarcopenia (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Yagyu, Takuki verfasserin aut Uchinaka, Ei verfasserin aut Miyatani, Kozo verfasserin aut Hanaki, Takehiko verfasserin aut Kihara, Kyoichi verfasserin aut Matsunaga, Tomoyuki verfasserin aut Yamamoto, Manabu verfasserin aut Tokuyasu, Naruo verfasserin aut Honjo, Soichiro verfasserin aut Fujiwara, Yoshiyuki verfasserin aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 18(2020), 1 vom: 22. Aug. (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:18 year:2020 number:1 day:22 month:08 https://dx.doi.org/10.1186/s12957-020-01981-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 1 22 08 |
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10.1186/s12957-020-01981-x doi (DE-627)SPR040726789 (SPR)s12957-020-01981-x-e DE-627 ger DE-627 rakwb eng 610 ASE Sakamoto, Teruhisa verfasserin aut Sarcopenia as a prognostic factor in patients with recurrent pancreatic cancer: a retrospective study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Sarcopenia is a prognostic factor in various cancers. However, the impact of sarcopenia in patients with recurrent pancreatic cancer remains unclear. This study evaluated the prognostic significance of sarcopenia in patients with recurrent pancreatic cancer. Methods Seventy-four patients who developed postoperative recurrence of pancreatic cancer after undergoing pancreatectomies were enrolled. Sarcopenia in these patients was defined according to the psoas muscle index (PMI) measured via computed tomography at the third vertebra. Results The mean PMIs at the time of recurrence were 4.47 ± 1.27 $ cm^{2} $/$ m^{2} $ for men and 3.26 ± 0.70 $ cm^{2} $/$ m^{2} $ for women. Of the 74 patients, 65 (87.8%) were diagnosed with sarcopenia with low PMI. The 2-year post-recurrence survival curve in the sarcopenia group was significantly worse than that in the non-sarcopenia group (P = 0.034). Multivariate analysis revealed that sarcopenia at the time of recurrence was an independent prognostic factor (P = 0.043) along with a high neutrophil-to-lymphocyte ratio (P = 0.004), early recurrence (P = 0.001), and chemotherapy after recurrence (P = 0.005) in patients with recurrent pancreatic cancer. Furthermore, the area under the curve (AUC) of the combination of sarcopenia and time to recurrence for predicting 2-year survival was 0.763, which was much higher than that of sarcopenia alone (AUC = 0.622). Conclusions Sarcopenia is a useful prognostic factor in patients with recurrent pancreatic cancer. The combination of sarcopenia and time of recurrence may more accurately predict post-recurrence survival than can sarcopenia alone. Recurrent pancreatic cancer (dpeaa)DE-He213 Sarcopenia (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Yagyu, Takuki verfasserin aut Uchinaka, Ei verfasserin aut Miyatani, Kozo verfasserin aut Hanaki, Takehiko verfasserin aut Kihara, Kyoichi verfasserin aut Matsunaga, Tomoyuki verfasserin aut Yamamoto, Manabu verfasserin aut Tokuyasu, Naruo verfasserin aut Honjo, Soichiro verfasserin aut Fujiwara, Yoshiyuki verfasserin aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 18(2020), 1 vom: 22. Aug. (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:18 year:2020 number:1 day:22 month:08 https://dx.doi.org/10.1186/s12957-020-01981-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 1 22 08 |
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Sakamoto, Teruhisa Yagyu, Takuki Uchinaka, Ei Miyatani, Kozo Hanaki, Takehiko Kihara, Kyoichi Matsunaga, Tomoyuki Yamamoto, Manabu Tokuyasu, Naruo Honjo, Soichiro Fujiwara, Yoshiyuki |
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sarcopenia as a prognostic factor in patients with recurrent pancreatic cancer: a retrospective study |
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Sarcopenia as a prognostic factor in patients with recurrent pancreatic cancer: a retrospective study |
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Background Sarcopenia is a prognostic factor in various cancers. However, the impact of sarcopenia in patients with recurrent pancreatic cancer remains unclear. This study evaluated the prognostic significance of sarcopenia in patients with recurrent pancreatic cancer. Methods Seventy-four patients who developed postoperative recurrence of pancreatic cancer after undergoing pancreatectomies were enrolled. Sarcopenia in these patients was defined according to the psoas muscle index (PMI) measured via computed tomography at the third vertebra. Results The mean PMIs at the time of recurrence were 4.47 ± 1.27 $ cm^{2} $/$ m^{2} $ for men and 3.26 ± 0.70 $ cm^{2} $/$ m^{2} $ for women. Of the 74 patients, 65 (87.8%) were diagnosed with sarcopenia with low PMI. The 2-year post-recurrence survival curve in the sarcopenia group was significantly worse than that in the non-sarcopenia group (P = 0.034). Multivariate analysis revealed that sarcopenia at the time of recurrence was an independent prognostic factor (P = 0.043) along with a high neutrophil-to-lymphocyte ratio (P = 0.004), early recurrence (P = 0.001), and chemotherapy after recurrence (P = 0.005) in patients with recurrent pancreatic cancer. Furthermore, the area under the curve (AUC) of the combination of sarcopenia and time to recurrence for predicting 2-year survival was 0.763, which was much higher than that of sarcopenia alone (AUC = 0.622). Conclusions Sarcopenia is a useful prognostic factor in patients with recurrent pancreatic cancer. The combination of sarcopenia and time of recurrence may more accurately predict post-recurrence survival than can sarcopenia alone. |
| abstractGer |
Background Sarcopenia is a prognostic factor in various cancers. However, the impact of sarcopenia in patients with recurrent pancreatic cancer remains unclear. This study evaluated the prognostic significance of sarcopenia in patients with recurrent pancreatic cancer. Methods Seventy-four patients who developed postoperative recurrence of pancreatic cancer after undergoing pancreatectomies were enrolled. Sarcopenia in these patients was defined according to the psoas muscle index (PMI) measured via computed tomography at the third vertebra. Results The mean PMIs at the time of recurrence were 4.47 ± 1.27 $ cm^{2} $/$ m^{2} $ for men and 3.26 ± 0.70 $ cm^{2} $/$ m^{2} $ for women. Of the 74 patients, 65 (87.8%) were diagnosed with sarcopenia with low PMI. The 2-year post-recurrence survival curve in the sarcopenia group was significantly worse than that in the non-sarcopenia group (P = 0.034). Multivariate analysis revealed that sarcopenia at the time of recurrence was an independent prognostic factor (P = 0.043) along with a high neutrophil-to-lymphocyte ratio (P = 0.004), early recurrence (P = 0.001), and chemotherapy after recurrence (P = 0.005) in patients with recurrent pancreatic cancer. Furthermore, the area under the curve (AUC) of the combination of sarcopenia and time to recurrence for predicting 2-year survival was 0.763, which was much higher than that of sarcopenia alone (AUC = 0.622). Conclusions Sarcopenia is a useful prognostic factor in patients with recurrent pancreatic cancer. The combination of sarcopenia and time of recurrence may more accurately predict post-recurrence survival than can sarcopenia alone. |
| abstract_unstemmed |
Background Sarcopenia is a prognostic factor in various cancers. However, the impact of sarcopenia in patients with recurrent pancreatic cancer remains unclear. This study evaluated the prognostic significance of sarcopenia in patients with recurrent pancreatic cancer. Methods Seventy-four patients who developed postoperative recurrence of pancreatic cancer after undergoing pancreatectomies were enrolled. Sarcopenia in these patients was defined according to the psoas muscle index (PMI) measured via computed tomography at the third vertebra. Results The mean PMIs at the time of recurrence were 4.47 ± 1.27 $ cm^{2} $/$ m^{2} $ for men and 3.26 ± 0.70 $ cm^{2} $/$ m^{2} $ for women. Of the 74 patients, 65 (87.8%) were diagnosed with sarcopenia with low PMI. The 2-year post-recurrence survival curve in the sarcopenia group was significantly worse than that in the non-sarcopenia group (P = 0.034). Multivariate analysis revealed that sarcopenia at the time of recurrence was an independent prognostic factor (P = 0.043) along with a high neutrophil-to-lymphocyte ratio (P = 0.004), early recurrence (P = 0.001), and chemotherapy after recurrence (P = 0.005) in patients with recurrent pancreatic cancer. Furthermore, the area under the curve (AUC) of the combination of sarcopenia and time to recurrence for predicting 2-year survival was 0.763, which was much higher than that of sarcopenia alone (AUC = 0.622). Conclusions Sarcopenia is a useful prognostic factor in patients with recurrent pancreatic cancer. The combination of sarcopenia and time of recurrence may more accurately predict post-recurrence survival than can sarcopenia alone. |
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Sarcopenia as a prognostic factor in patients with recurrent pancreatic cancer: a retrospective study |
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Yagyu, Takuki Uchinaka, Ei Miyatani, Kozo Hanaki, Takehiko Kihara, Kyoichi Matsunaga, Tomoyuki Yamamoto, Manabu Tokuyasu, Naruo Honjo, Soichiro Fujiwara, Yoshiyuki |
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Yagyu, Takuki Uchinaka, Ei Miyatani, Kozo Hanaki, Takehiko Kihara, Kyoichi Matsunaga, Tomoyuki Yamamoto, Manabu Tokuyasu, Naruo Honjo, Soichiro Fujiwara, Yoshiyuki |
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