Evaluating the role of vitexin on hematologic and oxidative stress markers in lead-induced toxicity in mice
Objective We aimed to evaluate the effect of vitexin on some hematologic parameters and oxidative stress markers in lead-induced toxicity in mice. Methods Forty adult male albino mice were divided into five groups of eight animals comprising: control; Pb; vitexin; Pb + vitexin; and Pb + vitexin (pos...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Amedu, Nathaniel Ohiemi [verfasserIn] Omotoso, Gabriel Olaiya [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Toxicology and Environmental Health Sciences - Korean Society of Environmental Risk Assessment and Health Science, 2011, 12(2020), 3 vom: 10. März, Seite 257-263 |
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| Übergeordnetes Werk: |
volume:12 ; year:2020 ; number:3 ; day:10 ; month:03 ; pages:257-263 |
| Links: |
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| DOI / URN: |
10.1007/s13530-020-00039-5 |
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SPR040855708 |
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| 100 | 1 | |a Amedu, Nathaniel Ohiemi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluating the role of vitexin on hematologic and oxidative stress markers in lead-induced toxicity in mice |
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| 520 | |a Objective We aimed to evaluate the effect of vitexin on some hematologic parameters and oxidative stress markers in lead-induced toxicity in mice. Methods Forty adult male albino mice were divided into five groups of eight animals comprising: control; Pb; vitexin; Pb + vitexin; and Pb + vitexin (post) groups. Blood samples collected were analyzed using an auto hematology analyzer for sixteen parameters including red cell distribution width (RDW), red blood cell (RBC), and white blood cell (WBC). The levels of oxidative stress markers were also assessed. Results In Pb-treated group, RDW, RBC, MCV, Hb, Hct, granulocytes, and blood lead level were significantly different from the control group as well as Pb + vitexin (post) group. In Pb + vitexin groups, MCHC, platelets, and lymphocytes counts were significantly different from the control group. There was no difference in MPV, MID, and WBC between the groups. MDA level in Pb-treated group was significantly high while SOD and GPx levels were low. In Pb + vitexin-treated groups, SOD and GPx levels were significantly high while MDA was low. Conclusion Pb-induced toxicity caused significant changes in the values of hematologic parameters and oxidative markers measured but vitexin was able to mitigate some of the changes. Some of the values were inconsistent with Pb intoxication. | ||
| 650 | 4 | |a Lead toxicity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Vitexin |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hematologic parameters |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Oxidative stress |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Omotoso, Gabriel Olaiya |e verfasserin |4 aut | |
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10.1007/s13530-020-00039-5 doi (DE-627)SPR040855708 (SPR)s13530-020-00039-5-e DE-627 ger DE-627 rakwb eng Amedu, Nathaniel Ohiemi verfasserin aut Evaluating the role of vitexin on hematologic and oxidative stress markers in lead-induced toxicity in mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective We aimed to evaluate the effect of vitexin on some hematologic parameters and oxidative stress markers in lead-induced toxicity in mice. Methods Forty adult male albino mice were divided into five groups of eight animals comprising: control; Pb; vitexin; Pb + vitexin; and Pb + vitexin (post) groups. Blood samples collected were analyzed using an auto hematology analyzer for sixteen parameters including red cell distribution width (RDW), red blood cell (RBC), and white blood cell (WBC). The levels of oxidative stress markers were also assessed. Results In Pb-treated group, RDW, RBC, MCV, Hb, Hct, granulocytes, and blood lead level were significantly different from the control group as well as Pb + vitexin (post) group. In Pb + vitexin groups, MCHC, platelets, and lymphocytes counts were significantly different from the control group. There was no difference in MPV, MID, and WBC between the groups. MDA level in Pb-treated group was significantly high while SOD and GPx levels were low. In Pb + vitexin-treated groups, SOD and GPx levels were significantly high while MDA was low. Conclusion Pb-induced toxicity caused significant changes in the values of hematologic parameters and oxidative markers measured but vitexin was able to mitigate some of the changes. Some of the values were inconsistent with Pb intoxication. Lead toxicity (dpeaa)DE-He213 Vitexin (dpeaa)DE-He213 Hematologic parameters (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Omotoso, Gabriel Olaiya verfasserin aut Enthalten in Toxicology and Environmental Health Sciences Korean Society of Environmental Risk Assessment and Health Science, 2011 12(2020), 3 vom: 10. März, Seite 257-263 (DE-627)SPR031726593 nnns volume:12 year:2020 number:3 day:10 month:03 pages:257-263 https://dx.doi.org/10.1007/s13530-020-00039-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 12 2020 3 10 03 257-263 |
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10.1007/s13530-020-00039-5 doi (DE-627)SPR040855708 (SPR)s13530-020-00039-5-e DE-627 ger DE-627 rakwb eng Amedu, Nathaniel Ohiemi verfasserin aut Evaluating the role of vitexin on hematologic and oxidative stress markers in lead-induced toxicity in mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective We aimed to evaluate the effect of vitexin on some hematologic parameters and oxidative stress markers in lead-induced toxicity in mice. Methods Forty adult male albino mice were divided into five groups of eight animals comprising: control; Pb; vitexin; Pb + vitexin; and Pb + vitexin (post) groups. Blood samples collected were analyzed using an auto hematology analyzer for sixteen parameters including red cell distribution width (RDW), red blood cell (RBC), and white blood cell (WBC). The levels of oxidative stress markers were also assessed. Results In Pb-treated group, RDW, RBC, MCV, Hb, Hct, granulocytes, and blood lead level were significantly different from the control group as well as Pb + vitexin (post) group. In Pb + vitexin groups, MCHC, platelets, and lymphocytes counts were significantly different from the control group. There was no difference in MPV, MID, and WBC between the groups. MDA level in Pb-treated group was significantly high while SOD and GPx levels were low. In Pb + vitexin-treated groups, SOD and GPx levels were significantly high while MDA was low. Conclusion Pb-induced toxicity caused significant changes in the values of hematologic parameters and oxidative markers measured but vitexin was able to mitigate some of the changes. Some of the values were inconsistent with Pb intoxication. Lead toxicity (dpeaa)DE-He213 Vitexin (dpeaa)DE-He213 Hematologic parameters (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Omotoso, Gabriel Olaiya verfasserin aut Enthalten in Toxicology and Environmental Health Sciences Korean Society of Environmental Risk Assessment and Health Science, 2011 12(2020), 3 vom: 10. März, Seite 257-263 (DE-627)SPR031726593 nnns volume:12 year:2020 number:3 day:10 month:03 pages:257-263 https://dx.doi.org/10.1007/s13530-020-00039-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 12 2020 3 10 03 257-263 |
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10.1007/s13530-020-00039-5 doi (DE-627)SPR040855708 (SPR)s13530-020-00039-5-e DE-627 ger DE-627 rakwb eng Amedu, Nathaniel Ohiemi verfasserin aut Evaluating the role of vitexin on hematologic and oxidative stress markers in lead-induced toxicity in mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective We aimed to evaluate the effect of vitexin on some hematologic parameters and oxidative stress markers in lead-induced toxicity in mice. Methods Forty adult male albino mice were divided into five groups of eight animals comprising: control; Pb; vitexin; Pb + vitexin; and Pb + vitexin (post) groups. Blood samples collected were analyzed using an auto hematology analyzer for sixteen parameters including red cell distribution width (RDW), red blood cell (RBC), and white blood cell (WBC). The levels of oxidative stress markers were also assessed. Results In Pb-treated group, RDW, RBC, MCV, Hb, Hct, granulocytes, and blood lead level were significantly different from the control group as well as Pb + vitexin (post) group. In Pb + vitexin groups, MCHC, platelets, and lymphocytes counts were significantly different from the control group. There was no difference in MPV, MID, and WBC between the groups. MDA level in Pb-treated group was significantly high while SOD and GPx levels were low. In Pb + vitexin-treated groups, SOD and GPx levels were significantly high while MDA was low. Conclusion Pb-induced toxicity caused significant changes in the values of hematologic parameters and oxidative markers measured but vitexin was able to mitigate some of the changes. Some of the values were inconsistent with Pb intoxication. Lead toxicity (dpeaa)DE-He213 Vitexin (dpeaa)DE-He213 Hematologic parameters (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Omotoso, Gabriel Olaiya verfasserin aut Enthalten in Toxicology and Environmental Health Sciences Korean Society of Environmental Risk Assessment and Health Science, 2011 12(2020), 3 vom: 10. März, Seite 257-263 (DE-627)SPR031726593 nnns volume:12 year:2020 number:3 day:10 month:03 pages:257-263 https://dx.doi.org/10.1007/s13530-020-00039-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 12 2020 3 10 03 257-263 |
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10.1007/s13530-020-00039-5 doi (DE-627)SPR040855708 (SPR)s13530-020-00039-5-e DE-627 ger DE-627 rakwb eng Amedu, Nathaniel Ohiemi verfasserin aut Evaluating the role of vitexin on hematologic and oxidative stress markers in lead-induced toxicity in mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective We aimed to evaluate the effect of vitexin on some hematologic parameters and oxidative stress markers in lead-induced toxicity in mice. Methods Forty adult male albino mice were divided into five groups of eight animals comprising: control; Pb; vitexin; Pb + vitexin; and Pb + vitexin (post) groups. Blood samples collected were analyzed using an auto hematology analyzer for sixteen parameters including red cell distribution width (RDW), red blood cell (RBC), and white blood cell (WBC). The levels of oxidative stress markers were also assessed. Results In Pb-treated group, RDW, RBC, MCV, Hb, Hct, granulocytes, and blood lead level were significantly different from the control group as well as Pb + vitexin (post) group. In Pb + vitexin groups, MCHC, platelets, and lymphocytes counts were significantly different from the control group. There was no difference in MPV, MID, and WBC between the groups. MDA level in Pb-treated group was significantly high while SOD and GPx levels were low. In Pb + vitexin-treated groups, SOD and GPx levels were significantly high while MDA was low. Conclusion Pb-induced toxicity caused significant changes in the values of hematologic parameters and oxidative markers measured but vitexin was able to mitigate some of the changes. Some of the values were inconsistent with Pb intoxication. Lead toxicity (dpeaa)DE-He213 Vitexin (dpeaa)DE-He213 Hematologic parameters (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Omotoso, Gabriel Olaiya verfasserin aut Enthalten in Toxicology and Environmental Health Sciences Korean Society of Environmental Risk Assessment and Health Science, 2011 12(2020), 3 vom: 10. März, Seite 257-263 (DE-627)SPR031726593 nnns volume:12 year:2020 number:3 day:10 month:03 pages:257-263 https://dx.doi.org/10.1007/s13530-020-00039-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 12 2020 3 10 03 257-263 |
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10.1007/s13530-020-00039-5 doi (DE-627)SPR040855708 (SPR)s13530-020-00039-5-e DE-627 ger DE-627 rakwb eng Amedu, Nathaniel Ohiemi verfasserin aut Evaluating the role of vitexin on hematologic and oxidative stress markers in lead-induced toxicity in mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective We aimed to evaluate the effect of vitexin on some hematologic parameters and oxidative stress markers in lead-induced toxicity in mice. Methods Forty adult male albino mice were divided into five groups of eight animals comprising: control; Pb; vitexin; Pb + vitexin; and Pb + vitexin (post) groups. Blood samples collected were analyzed using an auto hematology analyzer for sixteen parameters including red cell distribution width (RDW), red blood cell (RBC), and white blood cell (WBC). The levels of oxidative stress markers were also assessed. Results In Pb-treated group, RDW, RBC, MCV, Hb, Hct, granulocytes, and blood lead level were significantly different from the control group as well as Pb + vitexin (post) group. In Pb + vitexin groups, MCHC, platelets, and lymphocytes counts were significantly different from the control group. There was no difference in MPV, MID, and WBC between the groups. MDA level in Pb-treated group was significantly high while SOD and GPx levels were low. In Pb + vitexin-treated groups, SOD and GPx levels were significantly high while MDA was low. Conclusion Pb-induced toxicity caused significant changes in the values of hematologic parameters and oxidative markers measured but vitexin was able to mitigate some of the changes. Some of the values were inconsistent with Pb intoxication. Lead toxicity (dpeaa)DE-He213 Vitexin (dpeaa)DE-He213 Hematologic parameters (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Omotoso, Gabriel Olaiya verfasserin aut Enthalten in Toxicology and Environmental Health Sciences Korean Society of Environmental Risk Assessment and Health Science, 2011 12(2020), 3 vom: 10. März, Seite 257-263 (DE-627)SPR031726593 nnns volume:12 year:2020 number:3 day:10 month:03 pages:257-263 https://dx.doi.org/10.1007/s13530-020-00039-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 12 2020 3 10 03 257-263 |
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evaluating the role of vitexin on hematologic and oxidative stress markers in lead-induced toxicity in mice |
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Evaluating the role of vitexin on hematologic and oxidative stress markers in lead-induced toxicity in mice |
| abstract |
Objective We aimed to evaluate the effect of vitexin on some hematologic parameters and oxidative stress markers in lead-induced toxicity in mice. Methods Forty adult male albino mice were divided into five groups of eight animals comprising: control; Pb; vitexin; Pb + vitexin; and Pb + vitexin (post) groups. Blood samples collected were analyzed using an auto hematology analyzer for sixteen parameters including red cell distribution width (RDW), red blood cell (RBC), and white blood cell (WBC). The levels of oxidative stress markers were also assessed. Results In Pb-treated group, RDW, RBC, MCV, Hb, Hct, granulocytes, and blood lead level were significantly different from the control group as well as Pb + vitexin (post) group. In Pb + vitexin groups, MCHC, platelets, and lymphocytes counts were significantly different from the control group. There was no difference in MPV, MID, and WBC between the groups. MDA level in Pb-treated group was significantly high while SOD and GPx levels were low. In Pb + vitexin-treated groups, SOD and GPx levels were significantly high while MDA was low. Conclusion Pb-induced toxicity caused significant changes in the values of hematologic parameters and oxidative markers measured but vitexin was able to mitigate some of the changes. Some of the values were inconsistent with Pb intoxication. |
| abstractGer |
Objective We aimed to evaluate the effect of vitexin on some hematologic parameters and oxidative stress markers in lead-induced toxicity in mice. Methods Forty adult male albino mice were divided into five groups of eight animals comprising: control; Pb; vitexin; Pb + vitexin; and Pb + vitexin (post) groups. Blood samples collected were analyzed using an auto hematology analyzer for sixteen parameters including red cell distribution width (RDW), red blood cell (RBC), and white blood cell (WBC). The levels of oxidative stress markers were also assessed. Results In Pb-treated group, RDW, RBC, MCV, Hb, Hct, granulocytes, and blood lead level were significantly different from the control group as well as Pb + vitexin (post) group. In Pb + vitexin groups, MCHC, platelets, and lymphocytes counts were significantly different from the control group. There was no difference in MPV, MID, and WBC between the groups. MDA level in Pb-treated group was significantly high while SOD and GPx levels were low. In Pb + vitexin-treated groups, SOD and GPx levels were significantly high while MDA was low. Conclusion Pb-induced toxicity caused significant changes in the values of hematologic parameters and oxidative markers measured but vitexin was able to mitigate some of the changes. Some of the values were inconsistent with Pb intoxication. |
| abstract_unstemmed |
Objective We aimed to evaluate the effect of vitexin on some hematologic parameters and oxidative stress markers in lead-induced toxicity in mice. Methods Forty adult male albino mice were divided into five groups of eight animals comprising: control; Pb; vitexin; Pb + vitexin; and Pb + vitexin (post) groups. Blood samples collected were analyzed using an auto hematology analyzer for sixteen parameters including red cell distribution width (RDW), red blood cell (RBC), and white blood cell (WBC). The levels of oxidative stress markers were also assessed. Results In Pb-treated group, RDW, RBC, MCV, Hb, Hct, granulocytes, and blood lead level were significantly different from the control group as well as Pb + vitexin (post) group. In Pb + vitexin groups, MCHC, platelets, and lymphocytes counts were significantly different from the control group. There was no difference in MPV, MID, and WBC between the groups. MDA level in Pb-treated group was significantly high while SOD and GPx levels were low. In Pb + vitexin-treated groups, SOD and GPx levels were significantly high while MDA was low. Conclusion Pb-induced toxicity caused significant changes in the values of hematologic parameters and oxidative markers measured but vitexin was able to mitigate some of the changes. Some of the values were inconsistent with Pb intoxication. |
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Evaluating the role of vitexin on hematologic and oxidative stress markers in lead-induced toxicity in mice |
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https://dx.doi.org/10.1007/s13530-020-00039-5 |
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Omotoso, Gabriel Olaiya |
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10.1007/s13530-020-00039-5 |
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2024-07-03T18:41:49.770Z |
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