Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study

Abstract Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sardanelli, Francesco [verfasserIn] Trimboli, Rubina M. [verfasserIn] Houssami, Nehmat [verfasserIn] Gilbert, Fiona J. [verfasserIn] Helbich, Thomas H. [verfasserIn] Alvarez Benito, Marina [verfasserIn] Balleyguier, Corinne [verfasserIn] Bazzocchi, Massimo [verfasserIn] Bult, Peter [verfasserIn] Calabrese, Massimo [verfasserIn] Camps Herrero, Julia [verfasserIn] Cartia, Francesco [verfasserIn] Cassano, Enrico [verfasserIn] Clauser, Paola [verfasserIn] de Andrade, Danubia A. [verfasserIn] de Lima Docema, Marcos F. [verfasserIn] Depretto, Catherine [verfasserIn] Forrai, Gabor [verfasserIn] Girometti, Rossano [verfasserIn] Harms, Steven E. [verfasserIn] Hilborne, Sarah [verfasserIn] Ienzi, Raffaele [verfasserIn] Lobbes, Marc B. I. [verfasserIn] Losio, Claudio [verfasserIn] Mann, Ritse M. [verfasserIn] Montemezzi, Stefania [verfasserIn] Obdeijn, Inge-Marie [verfasserIn] Ozcan, Umit Aksoy [verfasserIn] Pediconi, Federica [verfasserIn] Preibsch, Heike [verfasserIn] Raya-Povedano, José L. [verfasserIn] Sacchetto, Daniela [verfasserIn] Scaperrotta, Gianfranco P. [verfasserIn] Schlooz, Margrethe [verfasserIn] Szabo, Botond K. [verfasserIn] Ulus, Ozden S. [verfasserIn] Taylor, Donna B. [verfasserIn] Van Goethem, Mireille [verfasserIn] Veltman, Jeroen [verfasserIn] Weigel, Stefanie [verfasserIn] Wenkel, Evelyn [verfasserIn] Zuiani, Chiara [verfasserIn] Di Leo, Giovanni [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Breast neoplasms Breast-conserving surgery Magnetic resonance imaging Mastectomy Prospective studies

Übergeordnetes Werk:	Enthalten in: European radiology - Berlin : Springer, 1991, 30(2020), 10 vom: 06. Mai, Seite 5427-5436
Übergeordnetes Werk:	volume:30 ; year:2020 ; number:10 ; day:06 ; month:05 ; pages:5427-5436

Links:	Volltext

DOI / URN:	10.1007/s00330-020-06824-7

Katalog-ID:	SPR040898733

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520			\|a Abstract Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase.
650		4	\|a Breast neoplasms \|7 (dpeaa)DE-He213
650		4	\|a Breast-conserving surgery \|7 (dpeaa)DE-He213
650		4	\|a Magnetic resonance imaging \|7 (dpeaa)DE-He213
650		4	\|a Mastectomy \|7 (dpeaa)DE-He213
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700	1		\|a Helbich, Thomas H. \|e verfasserin \|4 aut
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700	1		\|a Ozcan, Umit Aksoy \|e verfasserin \|4 aut
700	1		\|a Pediconi, Federica \|e verfasserin \|4 aut
700	1		\|a Preibsch, Heike \|e verfasserin \|4 aut
700	1		\|a Raya-Povedano, José L. \|e verfasserin \|4 aut
700	1		\|a Sacchetto, Daniela \|e verfasserin \|4 aut
700	1		\|a Scaperrotta, Gianfranco P. \|e verfasserin \|4 aut
700	1		\|a Schlooz, Margrethe \|e verfasserin \|4 aut
700	1		\|a Szabo, Botond K. \|e verfasserin \|4 aut
700	1		\|a Ulus, Ozden S. \|e verfasserin \|4 aut
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700	1		\|a Wenkel, Evelyn \|e verfasserin \|4 aut
700	1		\|a Zuiani, Chiara \|e verfasserin \|4 aut
700	1		\|a Di Leo, Giovanni \|e verfasserin \|4 aut
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allfields	10.1007/s00330-020-06824-7 doi (DE-627)SPR040898733 (SPR)s00330-020-06824-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Sardanelli, Francesco verfasserin aut Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase. Breast neoplasms (dpeaa)DE-He213 Breast-conserving surgery (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Mastectomy (dpeaa)DE-He213 Prospective studies (dpeaa)DE-He213 Trimboli, Rubina M. verfasserin aut Houssami, Nehmat verfasserin aut Gilbert, Fiona J. verfasserin aut Helbich, Thomas H. verfasserin aut Alvarez Benito, Marina verfasserin aut Balleyguier, Corinne verfasserin aut Bazzocchi, Massimo verfasserin aut Bult, Peter verfasserin aut Calabrese, Massimo verfasserin aut Camps Herrero, Julia verfasserin aut Cartia, Francesco verfasserin aut Cassano, Enrico verfasserin aut Clauser, Paola verfasserin aut de Andrade, Danubia A. verfasserin aut de Lima Docema, Marcos F. verfasserin aut Depretto, Catherine verfasserin aut Forrai, Gabor verfasserin aut Girometti, Rossano verfasserin aut Harms, Steven E. verfasserin aut Hilborne, Sarah verfasserin aut Ienzi, Raffaele verfasserin aut Lobbes, Marc B. I. verfasserin aut Losio, Claudio verfasserin aut Mann, Ritse M. verfasserin aut Montemezzi, Stefania verfasserin aut Obdeijn, Inge-Marie verfasserin aut Ozcan, Umit Aksoy verfasserin aut Pediconi, Federica verfasserin aut Preibsch, Heike verfasserin aut Raya-Povedano, José L. verfasserin aut Sacchetto, Daniela verfasserin aut Scaperrotta, Gianfranco P. verfasserin aut Schlooz, Margrethe verfasserin aut Szabo, Botond K. verfasserin aut Ulus, Ozden S. verfasserin aut Taylor, Donna B. verfasserin aut Van Goethem, Mireille verfasserin aut Veltman, Jeroen verfasserin aut Weigel, Stefanie verfasserin aut Wenkel, Evelyn verfasserin aut Zuiani, Chiara verfasserin aut Di Leo, Giovanni verfasserin aut Enthalten in European radiology Berlin : Springer, 1991 30(2020), 10 vom: 06. Mai, Seite 5427-5436 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:30 year:2020 number:10 day:06 month:05 pages:5427-5436 https://dx.doi.org/10.1007/s00330-020-06824-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 30 2020 10 06 05 5427-5436
spelling	10.1007/s00330-020-06824-7 doi (DE-627)SPR040898733 (SPR)s00330-020-06824-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Sardanelli, Francesco verfasserin aut Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase. Breast neoplasms (dpeaa)DE-He213 Breast-conserving surgery (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Mastectomy (dpeaa)DE-He213 Prospective studies (dpeaa)DE-He213 Trimboli, Rubina M. verfasserin aut Houssami, Nehmat verfasserin aut Gilbert, Fiona J. verfasserin aut Helbich, Thomas H. verfasserin aut Alvarez Benito, Marina verfasserin aut Balleyguier, Corinne verfasserin aut Bazzocchi, Massimo verfasserin aut Bult, Peter verfasserin aut Calabrese, Massimo verfasserin aut Camps Herrero, Julia verfasserin aut Cartia, Francesco verfasserin aut Cassano, Enrico verfasserin aut Clauser, Paola verfasserin aut de Andrade, Danubia A. verfasserin aut de Lima Docema, Marcos F. verfasserin aut Depretto, Catherine verfasserin aut Forrai, Gabor verfasserin aut Girometti, Rossano verfasserin aut Harms, Steven E. verfasserin aut Hilborne, Sarah verfasserin aut Ienzi, Raffaele verfasserin aut Lobbes, Marc B. I. verfasserin aut Losio, Claudio verfasserin aut Mann, Ritse M. verfasserin aut Montemezzi, Stefania verfasserin aut Obdeijn, Inge-Marie verfasserin aut Ozcan, Umit Aksoy verfasserin aut Pediconi, Federica verfasserin aut Preibsch, Heike verfasserin aut Raya-Povedano, José L. verfasserin aut Sacchetto, Daniela verfasserin aut Scaperrotta, Gianfranco P. verfasserin aut Schlooz, Margrethe verfasserin aut Szabo, Botond K. verfasserin aut Ulus, Ozden S. verfasserin aut Taylor, Donna B. verfasserin aut Van Goethem, Mireille verfasserin aut Veltman, Jeroen verfasserin aut Weigel, Stefanie verfasserin aut Wenkel, Evelyn verfasserin aut Zuiani, Chiara verfasserin aut Di Leo, Giovanni verfasserin aut Enthalten in European radiology Berlin : Springer, 1991 30(2020), 10 vom: 06. Mai, Seite 5427-5436 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:30 year:2020 number:10 day:06 month:05 pages:5427-5436 https://dx.doi.org/10.1007/s00330-020-06824-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 30 2020 10 06 05 5427-5436
allfields_unstemmed	10.1007/s00330-020-06824-7 doi (DE-627)SPR040898733 (SPR)s00330-020-06824-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Sardanelli, Francesco verfasserin aut Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase. Breast neoplasms (dpeaa)DE-He213 Breast-conserving surgery (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Mastectomy (dpeaa)DE-He213 Prospective studies (dpeaa)DE-He213 Trimboli, Rubina M. verfasserin aut Houssami, Nehmat verfasserin aut Gilbert, Fiona J. verfasserin aut Helbich, Thomas H. verfasserin aut Alvarez Benito, Marina verfasserin aut Balleyguier, Corinne verfasserin aut Bazzocchi, Massimo verfasserin aut Bult, Peter verfasserin aut Calabrese, Massimo verfasserin aut Camps Herrero, Julia verfasserin aut Cartia, Francesco verfasserin aut Cassano, Enrico verfasserin aut Clauser, Paola verfasserin aut de Andrade, Danubia A. verfasserin aut de Lima Docema, Marcos F. verfasserin aut Depretto, Catherine verfasserin aut Forrai, Gabor verfasserin aut Girometti, Rossano verfasserin aut Harms, Steven E. verfasserin aut Hilborne, Sarah verfasserin aut Ienzi, Raffaele verfasserin aut Lobbes, Marc B. I. verfasserin aut Losio, Claudio verfasserin aut Mann, Ritse M. verfasserin aut Montemezzi, Stefania verfasserin aut Obdeijn, Inge-Marie verfasserin aut Ozcan, Umit Aksoy verfasserin aut Pediconi, Federica verfasserin aut Preibsch, Heike verfasserin aut Raya-Povedano, José L. verfasserin aut Sacchetto, Daniela verfasserin aut Scaperrotta, Gianfranco P. verfasserin aut Schlooz, Margrethe verfasserin aut Szabo, Botond K. verfasserin aut Ulus, Ozden S. verfasserin aut Taylor, Donna B. verfasserin aut Van Goethem, Mireille verfasserin aut Veltman, Jeroen verfasserin aut Weigel, Stefanie verfasserin aut Wenkel, Evelyn verfasserin aut Zuiani, Chiara verfasserin aut Di Leo, Giovanni verfasserin aut Enthalten in European radiology Berlin : Springer, 1991 30(2020), 10 vom: 06. Mai, Seite 5427-5436 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:30 year:2020 number:10 day:06 month:05 pages:5427-5436 https://dx.doi.org/10.1007/s00330-020-06824-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 30 2020 10 06 05 5427-5436
allfieldsGer	10.1007/s00330-020-06824-7 doi (DE-627)SPR040898733 (SPR)s00330-020-06824-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Sardanelli, Francesco verfasserin aut Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase. Breast neoplasms (dpeaa)DE-He213 Breast-conserving surgery (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Mastectomy (dpeaa)DE-He213 Prospective studies (dpeaa)DE-He213 Trimboli, Rubina M. verfasserin aut Houssami, Nehmat verfasserin aut Gilbert, Fiona J. verfasserin aut Helbich, Thomas H. verfasserin aut Alvarez Benito, Marina verfasserin aut Balleyguier, Corinne verfasserin aut Bazzocchi, Massimo verfasserin aut Bult, Peter verfasserin aut Calabrese, Massimo verfasserin aut Camps Herrero, Julia verfasserin aut Cartia, Francesco verfasserin aut Cassano, Enrico verfasserin aut Clauser, Paola verfasserin aut de Andrade, Danubia A. verfasserin aut de Lima Docema, Marcos F. verfasserin aut Depretto, Catherine verfasserin aut Forrai, Gabor verfasserin aut Girometti, Rossano verfasserin aut Harms, Steven E. verfasserin aut Hilborne, Sarah verfasserin aut Ienzi, Raffaele verfasserin aut Lobbes, Marc B. I. verfasserin aut Losio, Claudio verfasserin aut Mann, Ritse M. verfasserin aut Montemezzi, Stefania verfasserin aut Obdeijn, Inge-Marie verfasserin aut Ozcan, Umit Aksoy verfasserin aut Pediconi, Federica verfasserin aut Preibsch, Heike verfasserin aut Raya-Povedano, José L. verfasserin aut Sacchetto, Daniela verfasserin aut Scaperrotta, Gianfranco P. verfasserin aut Schlooz, Margrethe verfasserin aut Szabo, Botond K. verfasserin aut Ulus, Ozden S. verfasserin aut Taylor, Donna B. verfasserin aut Van Goethem, Mireille verfasserin aut Veltman, Jeroen verfasserin aut Weigel, Stefanie verfasserin aut Wenkel, Evelyn verfasserin aut Zuiani, Chiara verfasserin aut Di Leo, Giovanni verfasserin aut Enthalten in European radiology Berlin : Springer, 1991 30(2020), 10 vom: 06. Mai, Seite 5427-5436 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:30 year:2020 number:10 day:06 month:05 pages:5427-5436 https://dx.doi.org/10.1007/s00330-020-06824-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 30 2020 10 06 05 5427-5436
allfieldsSound	10.1007/s00330-020-06824-7 doi (DE-627)SPR040898733 (SPR)s00330-020-06824-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Sardanelli, Francesco verfasserin aut Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase. Breast neoplasms (dpeaa)DE-He213 Breast-conserving surgery (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Mastectomy (dpeaa)DE-He213 Prospective studies (dpeaa)DE-He213 Trimboli, Rubina M. verfasserin aut Houssami, Nehmat verfasserin aut Gilbert, Fiona J. verfasserin aut Helbich, Thomas H. verfasserin aut Alvarez Benito, Marina verfasserin aut Balleyguier, Corinne verfasserin aut Bazzocchi, Massimo verfasserin aut Bult, Peter verfasserin aut Calabrese, Massimo verfasserin aut Camps Herrero, Julia verfasserin aut Cartia, Francesco verfasserin aut Cassano, Enrico verfasserin aut Clauser, Paola verfasserin aut de Andrade, Danubia A. verfasserin aut de Lima Docema, Marcos F. verfasserin aut Depretto, Catherine verfasserin aut Forrai, Gabor verfasserin aut Girometti, Rossano verfasserin aut Harms, Steven E. verfasserin aut Hilborne, Sarah verfasserin aut Ienzi, Raffaele verfasserin aut Lobbes, Marc B. I. verfasserin aut Losio, Claudio verfasserin aut Mann, Ritse M. verfasserin aut Montemezzi, Stefania verfasserin aut Obdeijn, Inge-Marie verfasserin aut Ozcan, Umit Aksoy verfasserin aut Pediconi, Federica verfasserin aut Preibsch, Heike verfasserin aut Raya-Povedano, José L. verfasserin aut Sacchetto, Daniela verfasserin aut Scaperrotta, Gianfranco P. verfasserin aut Schlooz, Margrethe verfasserin aut Szabo, Botond K. verfasserin aut Ulus, Ozden S. verfasserin aut Taylor, Donna B. verfasserin aut Van Goethem, Mireille verfasserin aut Veltman, Jeroen verfasserin aut Weigel, Stefanie verfasserin aut Wenkel, Evelyn verfasserin aut Zuiani, Chiara verfasserin aut Di Leo, Giovanni verfasserin aut Enthalten in European radiology Berlin : Springer, 1991 30(2020), 10 vom: 06. Mai, Seite 5427-5436 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:30 year:2020 number:10 day:06 month:05 pages:5427-5436 https://dx.doi.org/10.1007/s00330-020-06824-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 30 2020 10 06 05 5427-5436
language	English
source	Enthalten in European radiology 30(2020), 10 vom: 06. Mai, Seite 5427-5436 volume:30 year:2020 number:10 day:06 month:05 pages:5427-5436
sourceStr	Enthalten in European radiology 30(2020), 10 vom: 06. Mai, Seite 5427-5436 volume:30 year:2020 number:10 day:06 month:05 pages:5427-5436
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Breast neoplasms Breast-conserving surgery Magnetic resonance imaging Mastectomy Prospective studies
dewey-raw	610
isfreeaccess_bool	false
container_title	European radiology
authorswithroles_txt_mv	Sardanelli, Francesco @@aut@@ Trimboli, Rubina M. @@aut@@ Houssami, Nehmat @@aut@@ Gilbert, Fiona J. @@aut@@ Helbich, Thomas H. @@aut@@ Alvarez Benito, Marina @@aut@@ Balleyguier, Corinne @@aut@@ Bazzocchi, Massimo @@aut@@ Bult, Peter @@aut@@ Calabrese, Massimo @@aut@@ Camps Herrero, Julia @@aut@@ Cartia, Francesco @@aut@@ Cassano, Enrico @@aut@@ Clauser, Paola @@aut@@ de Andrade, Danubia A. @@aut@@ de Lima Docema, Marcos F. @@aut@@ Depretto, Catherine @@aut@@ Forrai, Gabor @@aut@@ Girometti, Rossano @@aut@@ Harms, Steven E. @@aut@@ Hilborne, Sarah @@aut@@ Ienzi, Raffaele @@aut@@ Lobbes, Marc B. I. @@aut@@ Losio, Claudio @@aut@@ Mann, Ritse M. @@aut@@ Montemezzi, Stefania @@aut@@ Obdeijn, Inge-Marie @@aut@@ Ozcan, Umit Aksoy @@aut@@ Pediconi, Federica @@aut@@ Preibsch, Heike @@aut@@ Raya-Povedano, José L. @@aut@@ Sacchetto, Daniela @@aut@@ Scaperrotta, Gianfranco P. @@aut@@ Schlooz, Margrethe @@aut@@ Szabo, Botond K. @@aut@@ Ulus, Ozden S. @@aut@@ Taylor, Donna B. @@aut@@ Van Goethem, Mireille @@aut@@ Veltman, Jeroen @@aut@@ Weigel, Stefanie @@aut@@ Wenkel, Evelyn @@aut@@ Zuiani, Chiara @@aut@@ Di Leo, Giovanni @@aut@@
publishDateDaySort_date	2020-05-06T00:00:00Z
hierarchy_top_id	268757526
dewey-sort	3610
id	SPR040898733
language_de	englisch
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It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. 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author	Sardanelli, Francesco
spellingShingle	Sardanelli, Francesco ddc 610 bkl 44.64 misc Breast neoplasms misc Breast-conserving surgery misc Magnetic resonance imaging misc Mastectomy misc Prospective studies Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study
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topic_title	610 ASE 44.64 bkl Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study Breast neoplasms (dpeaa)DE-He213 Breast-conserving surgery (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Mastectomy (dpeaa)DE-He213 Prospective studies (dpeaa)DE-He213
topic	ddc 610 bkl 44.64 misc Breast neoplasms misc Breast-conserving surgery misc Magnetic resonance imaging misc Mastectomy misc Prospective studies
topic_unstemmed	ddc 610 bkl 44.64 misc Breast neoplasms misc Breast-conserving surgery misc Magnetic resonance imaging misc Mastectomy misc Prospective studies
topic_browse	ddc 610 bkl 44.64 misc Breast neoplasms misc Breast-conserving surgery misc Magnetic resonance imaging misc Mastectomy misc Prospective studies
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title	Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study
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title_full	Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study
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author_browse	Sardanelli, Francesco Trimboli, Rubina M. Houssami, Nehmat Gilbert, Fiona J. Helbich, Thomas H. Alvarez Benito, Marina Balleyguier, Corinne Bazzocchi, Massimo Bult, Peter Calabrese, Massimo Camps Herrero, Julia Cartia, Francesco Cassano, Enrico Clauser, Paola de Andrade, Danubia A. de Lima Docema, Marcos F. Depretto, Catherine Forrai, Gabor Girometti, Rossano Harms, Steven E. Hilborne, Sarah Ienzi, Raffaele Lobbes, Marc B. I. Losio, Claudio Mann, Ritse M. Montemezzi, Stefania Obdeijn, Inge-Marie Ozcan, Umit Aksoy Pediconi, Federica Preibsch, Heike Raya-Povedano, José L. Sacchetto, Daniela Scaperrotta, Gianfranco P. Schlooz, Margrethe Szabo, Botond K. Ulus, Ozden S. Taylor, Donna B. Van Goethem, Mireille Veltman, Jeroen Weigel, Stefanie Wenkel, Evelyn Zuiani, Chiara Di Leo, Giovanni
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title_sort	solving the preoperative breast mri conundrum: design and protocol of the mipa study
title_auth	Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study
abstract	Abstract Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase.
abstractGer	Abstract Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase.
abstract_unstemmed	Abstract Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase.
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title_short	Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study
url	https://dx.doi.org/10.1007/s00330-020-06824-7
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author2	Trimboli, Rubina M. Houssami, Nehmat Gilbert, Fiona J. Helbich, Thomas H. Alvarez Benito, Marina Balleyguier, Corinne Bazzocchi, Massimo Bult, Peter Calabrese, Massimo Camps Herrero, Julia Cartia, Francesco Cassano, Enrico Clauser, Paola de Andrade, Danubia A. de Lima Docema, Marcos F. Depretto, Catherine Forrai, Gabor Girometti, Rossano Harms, Steven E. Hilborne, Sarah Ienzi, Raffaele Lobbes, Marc B. I. Losio, Claudio Mann, Ritse M. Montemezzi, Stefania Obdeijn, Inge-Marie Ozcan, Umit Aksoy Pediconi, Federica Preibsch, Heike Raya-Povedano, José L. Sacchetto, Daniela Scaperrotta, Gianfranco P. Schlooz, Margrethe Szabo, Botond K. Ulus, Ozden S. Taylor, Donna B. Van Goethem, Mireille Veltman, Jeroen Weigel, Stefanie Wenkel, Evelyn Zuiani, Chiara Di Leo, Giovanni
author2Str	Trimboli, Rubina M. Houssami, Nehmat Gilbert, Fiona J. Helbich, Thomas H. Alvarez Benito, Marina Balleyguier, Corinne Bazzocchi, Massimo Bult, Peter Calabrese, Massimo Camps Herrero, Julia Cartia, Francesco Cassano, Enrico Clauser, Paola de Andrade, Danubia A. de Lima Docema, Marcos F. Depretto, Catherine Forrai, Gabor Girometti, Rossano Harms, Steven E. Hilborne, Sarah Ienzi, Raffaele Lobbes, Marc B. I. Losio, Claudio Mann, Ritse M. Montemezzi, Stefania Obdeijn, Inge-Marie Ozcan, Umit Aksoy Pediconi, Federica Preibsch, Heike Raya-Povedano, José L. Sacchetto, Daniela Scaperrotta, Gianfranco P. Schlooz, Margrethe Szabo, Botond K. Ulus, Ozden S. Taylor, Donna B. Van Goethem, Mireille Veltman, Jeroen Weigel, Stefanie Wenkel, Evelyn Zuiani, Chiara Di Leo, Giovanni
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doi_str	10.1007/s00330-020-06824-7
up_date	2024-07-03T18:57:58.303Z
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It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. 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Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study

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