Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis

Background The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with this disease. Methods Between 2008 and 2017, 25 patients with...
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Autor*in:	Saito, Shiro [verfasserIn] Aiba, Hisaki [verfasserIn] Yamada, Satoshi [verfasserIn] Okamoto, Hideki [verfasserIn] Hayashi, Katsuhiro [verfasserIn] Kimura, Hiroaki [verfasserIn] Miwa, Shinji [verfasserIn] Otsuka, Takanobu [verfasserIn] Murakami, Hideki [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Chemotherapy Pirarubicin Ifosfamide Etoposide Soft tissue sarcoma

Übergeordnetes Werk:	Enthalten in: BMC cancer - London : BioMed Central, 2001, 20(2020), 1 vom: 09. Sept.
Übergeordnetes Werk:	volume:20 ; year:2020 ; number:1 ; day:09 ; month:09

Links:	Volltext

DOI / URN:	10.1186/s12885-020-07378-z

Katalog-ID:	SPR040924572

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520			\|a Background The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with this disease. Methods Between 2008 and 2017, 25 patients with soft tissue sarcoma were treated with pirarubicin (30 mg/$ m^{2} $, 2 days), ifosfamide (2 g/$ m^{2} $, 5 days), and etoposide (100 mg/$ m^{2} $, 3 days) every 3 weeks. The primary endpoint was overall response, and the secondary endpoint was adverse events of this regimen. Results Responses to this regimen according to RECIST criteria were partial response (n = 9, 36%), stable disease (n = 9, 36%) and progressive disease (n = 7, 28%). During the treatment phase, frequent grade 3 or worse adverse events were hematological toxicities including white blood cell decreases (96%), febrile neutropenia (68%), anemia (68%), and platelet count decreases (48%). No long-term adverse events were reported during the study period. Conclusion This regimen was comparable to previously published doxorubicin-based combination chemotherapy in terms of response rate. Although there were no long-lasting adverse events, based on our results, severe hematological toxicity should be considered.
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700	1		\|a Okamoto, Hideki \|e verfasserin \|4 aut
700	1		\|a Hayashi, Katsuhiro \|e verfasserin \|4 aut
700	1		\|a Kimura, Hiroaki \|e verfasserin \|4 aut
700	1		\|a Miwa, Shinji \|e verfasserin \|4 aut
700	1		\|a Otsuka, Takanobu \|e verfasserin \|4 aut
700	1		\|a Murakami, Hideki \|e verfasserin \|4 aut
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allfields	10.1186/s12885-020-07378-z doi (DE-627)SPR040924572 (SPR)s12885-020-07378-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Saito, Shiro verfasserin aut Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with this disease. Methods Between 2008 and 2017, 25 patients with soft tissue sarcoma were treated with pirarubicin (30 mg/$ m^{2} $, 2 days), ifosfamide (2 g/$ m^{2} $, 5 days), and etoposide (100 mg/$ m^{2} $, 3 days) every 3 weeks. The primary endpoint was overall response, and the secondary endpoint was adverse events of this regimen. Results Responses to this regimen according to RECIST criteria were partial response (n = 9, 36%), stable disease (n = 9, 36%) and progressive disease (n = 7, 28%). During the treatment phase, frequent grade 3 or worse adverse events were hematological toxicities including white blood cell decreases (96%), febrile neutropenia (68%), anemia (68%), and platelet count decreases (48%). No long-term adverse events were reported during the study period. Conclusion This regimen was comparable to previously published doxorubicin-based combination chemotherapy in terms of response rate. Although there were no long-lasting adverse events, based on our results, severe hematological toxicity should be considered. Chemotherapy (dpeaa)DE-He213 Pirarubicin (dpeaa)DE-He213 Ifosfamide (dpeaa)DE-He213 Etoposide (dpeaa)DE-He213 Soft tissue sarcoma (dpeaa)DE-He213 Aiba, Hisaki verfasserin aut Yamada, Satoshi verfasserin aut Okamoto, Hideki verfasserin aut Hayashi, Katsuhiro verfasserin aut Kimura, Hiroaki verfasserin aut Miwa, Shinji verfasserin aut Otsuka, Takanobu verfasserin aut Murakami, Hideki verfasserin aut Enthalten in BMC cancer London : BioMed Central, 2001 20(2020), 1 vom: 09. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:20 year:2020 number:1 day:09 month:09 https://dx.doi.org/10.1186/s12885-020-07378-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 09 09
spelling	10.1186/s12885-020-07378-z doi (DE-627)SPR040924572 (SPR)s12885-020-07378-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Saito, Shiro verfasserin aut Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with this disease. Methods Between 2008 and 2017, 25 patients with soft tissue sarcoma were treated with pirarubicin (30 mg/$ m^{2} $, 2 days), ifosfamide (2 g/$ m^{2} $, 5 days), and etoposide (100 mg/$ m^{2} $, 3 days) every 3 weeks. The primary endpoint was overall response, and the secondary endpoint was adverse events of this regimen. Results Responses to this regimen according to RECIST criteria were partial response (n = 9, 36%), stable disease (n = 9, 36%) and progressive disease (n = 7, 28%). During the treatment phase, frequent grade 3 or worse adverse events were hematological toxicities including white blood cell decreases (96%), febrile neutropenia (68%), anemia (68%), and platelet count decreases (48%). No long-term adverse events were reported during the study period. Conclusion This regimen was comparable to previously published doxorubicin-based combination chemotherapy in terms of response rate. Although there were no long-lasting adverse events, based on our results, severe hematological toxicity should be considered. Chemotherapy (dpeaa)DE-He213 Pirarubicin (dpeaa)DE-He213 Ifosfamide (dpeaa)DE-He213 Etoposide (dpeaa)DE-He213 Soft tissue sarcoma (dpeaa)DE-He213 Aiba, Hisaki verfasserin aut Yamada, Satoshi verfasserin aut Okamoto, Hideki verfasserin aut Hayashi, Katsuhiro verfasserin aut Kimura, Hiroaki verfasserin aut Miwa, Shinji verfasserin aut Otsuka, Takanobu verfasserin aut Murakami, Hideki verfasserin aut Enthalten in BMC cancer London : BioMed Central, 2001 20(2020), 1 vom: 09. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:20 year:2020 number:1 day:09 month:09 https://dx.doi.org/10.1186/s12885-020-07378-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 09 09
allfields_unstemmed	10.1186/s12885-020-07378-z doi (DE-627)SPR040924572 (SPR)s12885-020-07378-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Saito, Shiro verfasserin aut Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with this disease. Methods Between 2008 and 2017, 25 patients with soft tissue sarcoma were treated with pirarubicin (30 mg/$ m^{2} $, 2 days), ifosfamide (2 g/$ m^{2} $, 5 days), and etoposide (100 mg/$ m^{2} $, 3 days) every 3 weeks. The primary endpoint was overall response, and the secondary endpoint was adverse events of this regimen. Results Responses to this regimen according to RECIST criteria were partial response (n = 9, 36%), stable disease (n = 9, 36%) and progressive disease (n = 7, 28%). During the treatment phase, frequent grade 3 or worse adverse events were hematological toxicities including white blood cell decreases (96%), febrile neutropenia (68%), anemia (68%), and platelet count decreases (48%). No long-term adverse events were reported during the study period. Conclusion This regimen was comparable to previously published doxorubicin-based combination chemotherapy in terms of response rate. Although there were no long-lasting adverse events, based on our results, severe hematological toxicity should be considered. Chemotherapy (dpeaa)DE-He213 Pirarubicin (dpeaa)DE-He213 Ifosfamide (dpeaa)DE-He213 Etoposide (dpeaa)DE-He213 Soft tissue sarcoma (dpeaa)DE-He213 Aiba, Hisaki verfasserin aut Yamada, Satoshi verfasserin aut Okamoto, Hideki verfasserin aut Hayashi, Katsuhiro verfasserin aut Kimura, Hiroaki verfasserin aut Miwa, Shinji verfasserin aut Otsuka, Takanobu verfasserin aut Murakami, Hideki verfasserin aut Enthalten in BMC cancer London : BioMed Central, 2001 20(2020), 1 vom: 09. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:20 year:2020 number:1 day:09 month:09 https://dx.doi.org/10.1186/s12885-020-07378-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 09 09
allfieldsGer	10.1186/s12885-020-07378-z doi (DE-627)SPR040924572 (SPR)s12885-020-07378-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Saito, Shiro verfasserin aut Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with this disease. Methods Between 2008 and 2017, 25 patients with soft tissue sarcoma were treated with pirarubicin (30 mg/$ m^{2} $, 2 days), ifosfamide (2 g/$ m^{2} $, 5 days), and etoposide (100 mg/$ m^{2} $, 3 days) every 3 weeks. The primary endpoint was overall response, and the secondary endpoint was adverse events of this regimen. Results Responses to this regimen according to RECIST criteria were partial response (n = 9, 36%), stable disease (n = 9, 36%) and progressive disease (n = 7, 28%). During the treatment phase, frequent grade 3 or worse adverse events were hematological toxicities including white blood cell decreases (96%), febrile neutropenia (68%), anemia (68%), and platelet count decreases (48%). No long-term adverse events were reported during the study period. Conclusion This regimen was comparable to previously published doxorubicin-based combination chemotherapy in terms of response rate. Although there were no long-lasting adverse events, based on our results, severe hematological toxicity should be considered. Chemotherapy (dpeaa)DE-He213 Pirarubicin (dpeaa)DE-He213 Ifosfamide (dpeaa)DE-He213 Etoposide (dpeaa)DE-He213 Soft tissue sarcoma (dpeaa)DE-He213 Aiba, Hisaki verfasserin aut Yamada, Satoshi verfasserin aut Okamoto, Hideki verfasserin aut Hayashi, Katsuhiro verfasserin aut Kimura, Hiroaki verfasserin aut Miwa, Shinji verfasserin aut Otsuka, Takanobu verfasserin aut Murakami, Hideki verfasserin aut Enthalten in BMC cancer London : BioMed Central, 2001 20(2020), 1 vom: 09. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:20 year:2020 number:1 day:09 month:09 https://dx.doi.org/10.1186/s12885-020-07378-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 09 09
allfieldsSound	10.1186/s12885-020-07378-z doi (DE-627)SPR040924572 (SPR)s12885-020-07378-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Saito, Shiro verfasserin aut Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with this disease. Methods Between 2008 and 2017, 25 patients with soft tissue sarcoma were treated with pirarubicin (30 mg/$ m^{2} $, 2 days), ifosfamide (2 g/$ m^{2} $, 5 days), and etoposide (100 mg/$ m^{2} $, 3 days) every 3 weeks. The primary endpoint was overall response, and the secondary endpoint was adverse events of this regimen. Results Responses to this regimen according to RECIST criteria were partial response (n = 9, 36%), stable disease (n = 9, 36%) and progressive disease (n = 7, 28%). During the treatment phase, frequent grade 3 or worse adverse events were hematological toxicities including white blood cell decreases (96%), febrile neutropenia (68%), anemia (68%), and platelet count decreases (48%). No long-term adverse events were reported during the study period. Conclusion This regimen was comparable to previously published doxorubicin-based combination chemotherapy in terms of response rate. Although there were no long-lasting adverse events, based on our results, severe hematological toxicity should be considered. Chemotherapy (dpeaa)DE-He213 Pirarubicin (dpeaa)DE-He213 Ifosfamide (dpeaa)DE-He213 Etoposide (dpeaa)DE-He213 Soft tissue sarcoma (dpeaa)DE-He213 Aiba, Hisaki verfasserin aut Yamada, Satoshi verfasserin aut Okamoto, Hideki verfasserin aut Hayashi, Katsuhiro verfasserin aut Kimura, Hiroaki verfasserin aut Miwa, Shinji verfasserin aut Otsuka, Takanobu verfasserin aut Murakami, Hideki verfasserin aut Enthalten in BMC cancer London : BioMed Central, 2001 20(2020), 1 vom: 09. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:20 year:2020 number:1 day:09 month:09 https://dx.doi.org/10.1186/s12885-020-07378-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 09 09
language	English
source	Enthalten in BMC cancer 20(2020), 1 vom: 09. Sept. volume:20 year:2020 number:1 day:09 month:09
sourceStr	Enthalten in BMC cancer 20(2020), 1 vom: 09. Sept. volume:20 year:2020 number:1 day:09 month:09
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chemotherapy Pirarubicin Ifosfamide Etoposide Soft tissue sarcoma
dewey-raw	610
isfreeaccess_bool	true
container_title	BMC cancer
authorswithroles_txt_mv	Saito, Shiro @@aut@@ Aiba, Hisaki @@aut@@ Yamada, Satoshi @@aut@@ Okamoto, Hideki @@aut@@ Hayashi, Katsuhiro @@aut@@ Kimura, Hiroaki @@aut@@ Miwa, Shinji @@aut@@ Otsuka, Takanobu @@aut@@ Murakami, Hideki @@aut@@
publishDateDaySort_date	2020-09-09T00:00:00Z
hierarchy_top_id	326643710
dewey-sort	3610
id	SPR040924572
language_de	englisch
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This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with this disease. Methods Between 2008 and 2017, 25 patients with soft tissue sarcoma were treated with pirarubicin (30 mg/$ m^{2} $, 2 days), ifosfamide (2 g/$ m^{2} $, 5 days), and etoposide (100 mg/$ m^{2} $, 3 days) every 3 weeks. The primary endpoint was overall response, and the secondary endpoint was adverse events of this regimen. Results Responses to this regimen according to RECIST criteria were partial response (n = 9, 36%), stable disease (n = 9, 36%) and progressive disease (n = 7, 28%). During the treatment phase, frequent grade 3 or worse adverse events were hematological toxicities including white blood cell decreases (96%), febrile neutropenia (68%), anemia (68%), and platelet count decreases (48%). No long-term adverse events were reported during the study period. Conclusion This regimen was comparable to previously published doxorubicin-based combination chemotherapy in terms of response rate. 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author	Saito, Shiro
spellingShingle	Saito, Shiro ddc 610 bkl 44.00 misc Chemotherapy misc Pirarubicin misc Ifosfamide misc Etoposide misc Soft tissue sarcoma Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis
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topic_title	610 ASE 44.00 bkl Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis Chemotherapy (dpeaa)DE-He213 Pirarubicin (dpeaa)DE-He213 Ifosfamide (dpeaa)DE-He213 Etoposide (dpeaa)DE-He213 Soft tissue sarcoma (dpeaa)DE-He213
topic	ddc 610 bkl 44.00 misc Chemotherapy misc Pirarubicin misc Ifosfamide misc Etoposide misc Soft tissue sarcoma
topic_unstemmed	ddc 610 bkl 44.00 misc Chemotherapy misc Pirarubicin misc Ifosfamide misc Etoposide misc Soft tissue sarcoma
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title	Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis
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title_full	Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis
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author_browse	Saito, Shiro Aiba, Hisaki Yamada, Satoshi Okamoto, Hideki Hayashi, Katsuhiro Kimura, Hiroaki Miwa, Shinji Otsuka, Takanobu Murakami, Hideki
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title_sort	efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis
title_auth	Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis
abstract	Background The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with this disease. Methods Between 2008 and 2017, 25 patients with soft tissue sarcoma were treated with pirarubicin (30 mg/$ m^{2} $, 2 days), ifosfamide (2 g/$ m^{2} $, 5 days), and etoposide (100 mg/$ m^{2} $, 3 days) every 3 weeks. The primary endpoint was overall response, and the secondary endpoint was adverse events of this regimen. Results Responses to this regimen according to RECIST criteria were partial response (n = 9, 36%), stable disease (n = 9, 36%) and progressive disease (n = 7, 28%). During the treatment phase, frequent grade 3 or worse adverse events were hematological toxicities including white blood cell decreases (96%), febrile neutropenia (68%), anemia (68%), and platelet count decreases (48%). No long-term adverse events were reported during the study period. Conclusion This regimen was comparable to previously published doxorubicin-based combination chemotherapy in terms of response rate. Although there were no long-lasting adverse events, based on our results, severe hematological toxicity should be considered.
abstractGer	Background The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with this disease. Methods Between 2008 and 2017, 25 patients with soft tissue sarcoma were treated with pirarubicin (30 mg/$ m^{2} $, 2 days), ifosfamide (2 g/$ m^{2} $, 5 days), and etoposide (100 mg/$ m^{2} $, 3 days) every 3 weeks. The primary endpoint was overall response, and the secondary endpoint was adverse events of this regimen. Results Responses to this regimen according to RECIST criteria were partial response (n = 9, 36%), stable disease (n = 9, 36%) and progressive disease (n = 7, 28%). During the treatment phase, frequent grade 3 or worse adverse events were hematological toxicities including white blood cell decreases (96%), febrile neutropenia (68%), anemia (68%), and platelet count decreases (48%). No long-term adverse events were reported during the study period. Conclusion This regimen was comparable to previously published doxorubicin-based combination chemotherapy in terms of response rate. Although there were no long-lasting adverse events, based on our results, severe hematological toxicity should be considered.
abstract_unstemmed	Background The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with this disease. Methods Between 2008 and 2017, 25 patients with soft tissue sarcoma were treated with pirarubicin (30 mg/$ m^{2} $, 2 days), ifosfamide (2 g/$ m^{2} $, 5 days), and etoposide (100 mg/$ m^{2} $, 3 days) every 3 weeks. The primary endpoint was overall response, and the secondary endpoint was adverse events of this regimen. Results Responses to this regimen according to RECIST criteria were partial response (n = 9, 36%), stable disease (n = 9, 36%) and progressive disease (n = 7, 28%). During the treatment phase, frequent grade 3 or worse adverse events were hematological toxicities including white blood cell decreases (96%), febrile neutropenia (68%), anemia (68%), and platelet count decreases (48%). No long-term adverse events were reported during the study period. Conclusion This regimen was comparable to previously published doxorubicin-based combination chemotherapy in terms of response rate. Although there were no long-lasting adverse events, based on our results, severe hematological toxicity should be considered.
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title_short	Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis
url	https://dx.doi.org/10.1186/s12885-020-07378-z
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Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis

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