The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer
Purpose Inflammation-based markers predict long-term outcomes of various malignancies. We investigated the relationship between these markers and the long-term survival in obstructive colorectal cancer (OCRC) patients with self-expandable metallic colonic stents (SEMSs) who subsequently received cur...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sato, Ryuichiro [verfasserIn] Oikawa, Masaya [verfasserIn] Kakita, Tetsuya [verfasserIn] Okada, Takaho [verfasserIn] Abe, Tomoya [verfasserIn] Yazawa, Takashi [verfasserIn] Tsuchiya, Haruyuki [verfasserIn] Akazawa, Naoya [verfasserIn] Sato, Masaki [verfasserIn] Ohira, Tetsuya [verfasserIn] Harada, Yoshihiro [verfasserIn] Okano, Haruka [verfasserIn] Ito, Kei [verfasserIn] Tsuchiya, Takashi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Surgery today - Tokyo : Springer, 1971, 50(2020), 10 vom: 28. Apr., Seite 1272-1281 |
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| Übergeordnetes Werk: |
volume:50 ; year:2020 ; number:10 ; day:28 ; month:04 ; pages:1272-1281 |
| Links: |
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| DOI / URN: |
10.1007/s00595-020-02007-5 |
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| Katalog-ID: |
SPR041020596 |
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| 245 | 1 | 4 | |a The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer |
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| 520 | |a Purpose Inflammation-based markers predict long-term outcomes of various malignancies. We investigated the relationship between these markers and the long-term survival in obstructive colorectal cancer (OCRC) patients with self-expandable metallic colonic stents (SEMSs) who subsequently received curative surgery. Methods We retrospectively analyzed 72 consecutive pathological stage II and III OCRC patients between 2013 and 2019. The prognostic significance of the prognostic nutritional index (PNI), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) was evaluated. Results The overall survival (OS), cancer-specific survival, and disease-free survival (DFS) were significantly shorter in the PNI < 35 group than in the PNI ≥ 35 group (p = 0.006, p < 0.001, and p = 0.003, respectively), and multivariate analyses revealed the PNI to be the only inflammation-based marker independently associated with the survival. A PNI < 35 was significantly associated with an elevated CA 19–9 level (p = 0.04) and longer postoperative hospital stay (p = 0.03). Adjuvant chemotherapy was also significantly associated with the OS (p = 0.040) and DFS (p = 0.011) in multivariate analyses. Conclusion The results showed that the PNI was a potent prognostic indicator. For OCRC patients, both systemic inflammation and the nutrition status seem to be important for predicting the prognosis, and administering adjuvant chemotherapy was very important. | ||
| 650 | 4 | |a Prognostic nutritional index |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neutrophil–lymphocyte ratio |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Colon |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Self-expandable metallic stent |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Oikawa, Masaya |e verfasserin |4 aut | |
| 700 | 1 | |a Kakita, Tetsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Okada, Takaho |e verfasserin |4 aut | |
| 700 | 1 | |a Abe, Tomoya |e verfasserin |4 aut | |
| 700 | 1 | |a Yazawa, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Tsuchiya, Haruyuki |e verfasserin |4 aut | |
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| 700 | 1 | |a Sato, Masaki |e verfasserin |4 aut | |
| 700 | 1 | |a Ohira, Tetsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Harada, Yoshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Okano, Haruka |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Kei |e verfasserin |4 aut | |
| 700 | 1 | |a Tsuchiya, Takashi |e verfasserin |4 aut | |
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10.1007/s00595-020-02007-5 doi (DE-627)SPR041020596 (SPR)s00595-020-02007-5-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Sato, Ryuichiro verfasserin aut The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Inflammation-based markers predict long-term outcomes of various malignancies. We investigated the relationship between these markers and the long-term survival in obstructive colorectal cancer (OCRC) patients with self-expandable metallic colonic stents (SEMSs) who subsequently received curative surgery. Methods We retrospectively analyzed 72 consecutive pathological stage II and III OCRC patients between 2013 and 2019. The prognostic significance of the prognostic nutritional index (PNI), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) was evaluated. Results The overall survival (OS), cancer-specific survival, and disease-free survival (DFS) were significantly shorter in the PNI < 35 group than in the PNI ≥ 35 group (p = 0.006, p < 0.001, and p = 0.003, respectively), and multivariate analyses revealed the PNI to be the only inflammation-based marker independently associated with the survival. A PNI < 35 was significantly associated with an elevated CA 19–9 level (p = 0.04) and longer postoperative hospital stay (p = 0.03). Adjuvant chemotherapy was also significantly associated with the OS (p = 0.040) and DFS (p = 0.011) in multivariate analyses. Conclusion The results showed that the PNI was a potent prognostic indicator. For OCRC patients, both systemic inflammation and the nutrition status seem to be important for predicting the prognosis, and administering adjuvant chemotherapy was very important. Prognostic nutritional index (dpeaa)DE-He213 Neutrophil–lymphocyte ratio (dpeaa)DE-He213 Colon (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Self-expandable metallic stent (dpeaa)DE-He213 Oikawa, Masaya verfasserin aut Kakita, Tetsuya verfasserin aut Okada, Takaho verfasserin aut Abe, Tomoya verfasserin aut Yazawa, Takashi verfasserin aut Tsuchiya, Haruyuki verfasserin aut Akazawa, Naoya verfasserin aut Sato, Masaki verfasserin aut Ohira, Tetsuya verfasserin aut Harada, Yoshihiro verfasserin aut Okano, Haruka verfasserin aut Ito, Kei verfasserin aut Tsuchiya, Takashi verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 50(2020), 10 vom: 28. Apr., Seite 1272-1281 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:50 year:2020 number:10 day:28 month:04 pages:1272-1281 https://dx.doi.org/10.1007/s00595-020-02007-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 50 2020 10 28 04 1272-1281 |
| spelling |
10.1007/s00595-020-02007-5 doi (DE-627)SPR041020596 (SPR)s00595-020-02007-5-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Sato, Ryuichiro verfasserin aut The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Inflammation-based markers predict long-term outcomes of various malignancies. We investigated the relationship between these markers and the long-term survival in obstructive colorectal cancer (OCRC) patients with self-expandable metallic colonic stents (SEMSs) who subsequently received curative surgery. Methods We retrospectively analyzed 72 consecutive pathological stage II and III OCRC patients between 2013 and 2019. The prognostic significance of the prognostic nutritional index (PNI), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) was evaluated. Results The overall survival (OS), cancer-specific survival, and disease-free survival (DFS) were significantly shorter in the PNI < 35 group than in the PNI ≥ 35 group (p = 0.006, p < 0.001, and p = 0.003, respectively), and multivariate analyses revealed the PNI to be the only inflammation-based marker independently associated with the survival. A PNI < 35 was significantly associated with an elevated CA 19–9 level (p = 0.04) and longer postoperative hospital stay (p = 0.03). Adjuvant chemotherapy was also significantly associated with the OS (p = 0.040) and DFS (p = 0.011) in multivariate analyses. Conclusion The results showed that the PNI was a potent prognostic indicator. For OCRC patients, both systemic inflammation and the nutrition status seem to be important for predicting the prognosis, and administering adjuvant chemotherapy was very important. Prognostic nutritional index (dpeaa)DE-He213 Neutrophil–lymphocyte ratio (dpeaa)DE-He213 Colon (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Self-expandable metallic stent (dpeaa)DE-He213 Oikawa, Masaya verfasserin aut Kakita, Tetsuya verfasserin aut Okada, Takaho verfasserin aut Abe, Tomoya verfasserin aut Yazawa, Takashi verfasserin aut Tsuchiya, Haruyuki verfasserin aut Akazawa, Naoya verfasserin aut Sato, Masaki verfasserin aut Ohira, Tetsuya verfasserin aut Harada, Yoshihiro verfasserin aut Okano, Haruka verfasserin aut Ito, Kei verfasserin aut Tsuchiya, Takashi verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 50(2020), 10 vom: 28. Apr., Seite 1272-1281 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:50 year:2020 number:10 day:28 month:04 pages:1272-1281 https://dx.doi.org/10.1007/s00595-020-02007-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 50 2020 10 28 04 1272-1281 |
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10.1007/s00595-020-02007-5 doi (DE-627)SPR041020596 (SPR)s00595-020-02007-5-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Sato, Ryuichiro verfasserin aut The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Inflammation-based markers predict long-term outcomes of various malignancies. We investigated the relationship between these markers and the long-term survival in obstructive colorectal cancer (OCRC) patients with self-expandable metallic colonic stents (SEMSs) who subsequently received curative surgery. Methods We retrospectively analyzed 72 consecutive pathological stage II and III OCRC patients between 2013 and 2019. The prognostic significance of the prognostic nutritional index (PNI), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) was evaluated. Results The overall survival (OS), cancer-specific survival, and disease-free survival (DFS) were significantly shorter in the PNI < 35 group than in the PNI ≥ 35 group (p = 0.006, p < 0.001, and p = 0.003, respectively), and multivariate analyses revealed the PNI to be the only inflammation-based marker independently associated with the survival. A PNI < 35 was significantly associated with an elevated CA 19–9 level (p = 0.04) and longer postoperative hospital stay (p = 0.03). Adjuvant chemotherapy was also significantly associated with the OS (p = 0.040) and DFS (p = 0.011) in multivariate analyses. Conclusion The results showed that the PNI was a potent prognostic indicator. For OCRC patients, both systemic inflammation and the nutrition status seem to be important for predicting the prognosis, and administering adjuvant chemotherapy was very important. Prognostic nutritional index (dpeaa)DE-He213 Neutrophil–lymphocyte ratio (dpeaa)DE-He213 Colon (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Self-expandable metallic stent (dpeaa)DE-He213 Oikawa, Masaya verfasserin aut Kakita, Tetsuya verfasserin aut Okada, Takaho verfasserin aut Abe, Tomoya verfasserin aut Yazawa, Takashi verfasserin aut Tsuchiya, Haruyuki verfasserin aut Akazawa, Naoya verfasserin aut Sato, Masaki verfasserin aut Ohira, Tetsuya verfasserin aut Harada, Yoshihiro verfasserin aut Okano, Haruka verfasserin aut Ito, Kei verfasserin aut Tsuchiya, Takashi verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 50(2020), 10 vom: 28. Apr., Seite 1272-1281 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:50 year:2020 number:10 day:28 month:04 pages:1272-1281 https://dx.doi.org/10.1007/s00595-020-02007-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 50 2020 10 28 04 1272-1281 |
| allfieldsGer |
10.1007/s00595-020-02007-5 doi (DE-627)SPR041020596 (SPR)s00595-020-02007-5-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Sato, Ryuichiro verfasserin aut The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Inflammation-based markers predict long-term outcomes of various malignancies. We investigated the relationship between these markers and the long-term survival in obstructive colorectal cancer (OCRC) patients with self-expandable metallic colonic stents (SEMSs) who subsequently received curative surgery. Methods We retrospectively analyzed 72 consecutive pathological stage II and III OCRC patients between 2013 and 2019. The prognostic significance of the prognostic nutritional index (PNI), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) was evaluated. Results The overall survival (OS), cancer-specific survival, and disease-free survival (DFS) were significantly shorter in the PNI < 35 group than in the PNI ≥ 35 group (p = 0.006, p < 0.001, and p = 0.003, respectively), and multivariate analyses revealed the PNI to be the only inflammation-based marker independently associated with the survival. A PNI < 35 was significantly associated with an elevated CA 19–9 level (p = 0.04) and longer postoperative hospital stay (p = 0.03). Adjuvant chemotherapy was also significantly associated with the OS (p = 0.040) and DFS (p = 0.011) in multivariate analyses. Conclusion The results showed that the PNI was a potent prognostic indicator. For OCRC patients, both systemic inflammation and the nutrition status seem to be important for predicting the prognosis, and administering adjuvant chemotherapy was very important. Prognostic nutritional index (dpeaa)DE-He213 Neutrophil–lymphocyte ratio (dpeaa)DE-He213 Colon (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Self-expandable metallic stent (dpeaa)DE-He213 Oikawa, Masaya verfasserin aut Kakita, Tetsuya verfasserin aut Okada, Takaho verfasserin aut Abe, Tomoya verfasserin aut Yazawa, Takashi verfasserin aut Tsuchiya, Haruyuki verfasserin aut Akazawa, Naoya verfasserin aut Sato, Masaki verfasserin aut Ohira, Tetsuya verfasserin aut Harada, Yoshihiro verfasserin aut Okano, Haruka verfasserin aut Ito, Kei verfasserin aut Tsuchiya, Takashi verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 50(2020), 10 vom: 28. Apr., Seite 1272-1281 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:50 year:2020 number:10 day:28 month:04 pages:1272-1281 https://dx.doi.org/10.1007/s00595-020-02007-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 50 2020 10 28 04 1272-1281 |
| allfieldsSound |
10.1007/s00595-020-02007-5 doi (DE-627)SPR041020596 (SPR)s00595-020-02007-5-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Sato, Ryuichiro verfasserin aut The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Inflammation-based markers predict long-term outcomes of various malignancies. We investigated the relationship between these markers and the long-term survival in obstructive colorectal cancer (OCRC) patients with self-expandable metallic colonic stents (SEMSs) who subsequently received curative surgery. Methods We retrospectively analyzed 72 consecutive pathological stage II and III OCRC patients between 2013 and 2019. The prognostic significance of the prognostic nutritional index (PNI), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) was evaluated. Results The overall survival (OS), cancer-specific survival, and disease-free survival (DFS) were significantly shorter in the PNI < 35 group than in the PNI ≥ 35 group (p = 0.006, p < 0.001, and p = 0.003, respectively), and multivariate analyses revealed the PNI to be the only inflammation-based marker independently associated with the survival. A PNI < 35 was significantly associated with an elevated CA 19–9 level (p = 0.04) and longer postoperative hospital stay (p = 0.03). Adjuvant chemotherapy was also significantly associated with the OS (p = 0.040) and DFS (p = 0.011) in multivariate analyses. Conclusion The results showed that the PNI was a potent prognostic indicator. For OCRC patients, both systemic inflammation and the nutrition status seem to be important for predicting the prognosis, and administering adjuvant chemotherapy was very important. Prognostic nutritional index (dpeaa)DE-He213 Neutrophil–lymphocyte ratio (dpeaa)DE-He213 Colon (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Self-expandable metallic stent (dpeaa)DE-He213 Oikawa, Masaya verfasserin aut Kakita, Tetsuya verfasserin aut Okada, Takaho verfasserin aut Abe, Tomoya verfasserin aut Yazawa, Takashi verfasserin aut Tsuchiya, Haruyuki verfasserin aut Akazawa, Naoya verfasserin aut Sato, Masaki verfasserin aut Ohira, Tetsuya verfasserin aut Harada, Yoshihiro verfasserin aut Okano, Haruka verfasserin aut Ito, Kei verfasserin aut Tsuchiya, Takashi verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 50(2020), 10 vom: 28. Apr., Seite 1272-1281 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:50 year:2020 number:10 day:28 month:04 pages:1272-1281 https://dx.doi.org/10.1007/s00595-020-02007-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 50 2020 10 28 04 1272-1281 |
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Enthalten in Surgery today 50(2020), 10 vom: 28. Apr., Seite 1272-1281 volume:50 year:2020 number:10 day:28 month:04 pages:1272-1281 |
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Enthalten in Surgery today 50(2020), 10 vom: 28. Apr., Seite 1272-1281 volume:50 year:2020 number:10 day:28 month:04 pages:1272-1281 |
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Prognostic nutritional index Neutrophil–lymphocyte ratio Colon Cancer Self-expandable metallic stent |
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Sato, Ryuichiro @@aut@@ Oikawa, Masaya @@aut@@ Kakita, Tetsuya @@aut@@ Okada, Takaho @@aut@@ Abe, Tomoya @@aut@@ Yazawa, Takashi @@aut@@ Tsuchiya, Haruyuki @@aut@@ Akazawa, Naoya @@aut@@ Sato, Masaki @@aut@@ Ohira, Tetsuya @@aut@@ Harada, Yoshihiro @@aut@@ Okano, Haruka @@aut@@ Ito, Kei @@aut@@ Tsuchiya, Takashi @@aut@@ |
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We investigated the relationship between these markers and the long-term survival in obstructive colorectal cancer (OCRC) patients with self-expandable metallic colonic stents (SEMSs) who subsequently received curative surgery. Methods We retrospectively analyzed 72 consecutive pathological stage II and III OCRC patients between 2013 and 2019. The prognostic significance of the prognostic nutritional index (PNI), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) was evaluated. Results The overall survival (OS), cancer-specific survival, and disease-free survival (DFS) were significantly shorter in the PNI < 35 group than in the PNI ≥ 35 group (p = 0.006, p < 0.001, and p = 0.003, respectively), and multivariate analyses revealed the PNI to be the only inflammation-based marker independently associated with the survival. A PNI < 35 was significantly associated with an elevated CA 19–9 level (p = 0.04) and longer postoperative hospital stay (p = 0.03). Adjuvant chemotherapy was also significantly associated with the OS (p = 0.040) and DFS (p = 0.011) in multivariate analyses. Conclusion The results showed that the PNI was a potent prognostic indicator. 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|
| author |
Sato, Ryuichiro |
| spellingShingle |
Sato, Ryuichiro ddc 610 bkl 44.65 misc Prognostic nutritional index misc Neutrophil–lymphocyte ratio misc Colon misc Cancer misc Self-expandable metallic stent The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer |
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Sato, Ryuichiro |
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electronic Article |
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610 - Medicine & health |
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keep |
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1436-2813 |
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610 ASE 44.65 bkl The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer Prognostic nutritional index (dpeaa)DE-He213 Neutrophil–lymphocyte ratio (dpeaa)DE-He213 Colon (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Self-expandable metallic stent (dpeaa)DE-He213 |
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ddc 610 bkl 44.65 misc Prognostic nutritional index misc Neutrophil–lymphocyte ratio misc Colon misc Cancer misc Self-expandable metallic stent |
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ddc 610 bkl 44.65 misc Prognostic nutritional index misc Neutrophil–lymphocyte ratio misc Colon misc Cancer misc Self-expandable metallic stent |
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ddc 610 bkl 44.65 misc Prognostic nutritional index misc Neutrophil–lymphocyte ratio misc Colon misc Cancer misc Self-expandable metallic stent |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer |
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The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer |
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Sato, Ryuichiro |
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Sato, Ryuichiro Oikawa, Masaya Kakita, Tetsuya Okada, Takaho Abe, Tomoya Yazawa, Takashi Tsuchiya, Haruyuki Akazawa, Naoya Sato, Masaki Ohira, Tetsuya Harada, Yoshihiro Okano, Haruka Ito, Kei Tsuchiya, Takashi |
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prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer |
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The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer |
| abstract |
Purpose Inflammation-based markers predict long-term outcomes of various malignancies. We investigated the relationship between these markers and the long-term survival in obstructive colorectal cancer (OCRC) patients with self-expandable metallic colonic stents (SEMSs) who subsequently received curative surgery. Methods We retrospectively analyzed 72 consecutive pathological stage II and III OCRC patients between 2013 and 2019. The prognostic significance of the prognostic nutritional index (PNI), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) was evaluated. Results The overall survival (OS), cancer-specific survival, and disease-free survival (DFS) were significantly shorter in the PNI < 35 group than in the PNI ≥ 35 group (p = 0.006, p < 0.001, and p = 0.003, respectively), and multivariate analyses revealed the PNI to be the only inflammation-based marker independently associated with the survival. A PNI < 35 was significantly associated with an elevated CA 19–9 level (p = 0.04) and longer postoperative hospital stay (p = 0.03). Adjuvant chemotherapy was also significantly associated with the OS (p = 0.040) and DFS (p = 0.011) in multivariate analyses. Conclusion The results showed that the PNI was a potent prognostic indicator. For OCRC patients, both systemic inflammation and the nutrition status seem to be important for predicting the prognosis, and administering adjuvant chemotherapy was very important. |
| abstractGer |
Purpose Inflammation-based markers predict long-term outcomes of various malignancies. We investigated the relationship between these markers and the long-term survival in obstructive colorectal cancer (OCRC) patients with self-expandable metallic colonic stents (SEMSs) who subsequently received curative surgery. Methods We retrospectively analyzed 72 consecutive pathological stage II and III OCRC patients between 2013 and 2019. The prognostic significance of the prognostic nutritional index (PNI), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) was evaluated. Results The overall survival (OS), cancer-specific survival, and disease-free survival (DFS) were significantly shorter in the PNI < 35 group than in the PNI ≥ 35 group (p = 0.006, p < 0.001, and p = 0.003, respectively), and multivariate analyses revealed the PNI to be the only inflammation-based marker independently associated with the survival. A PNI < 35 was significantly associated with an elevated CA 19–9 level (p = 0.04) and longer postoperative hospital stay (p = 0.03). Adjuvant chemotherapy was also significantly associated with the OS (p = 0.040) and DFS (p = 0.011) in multivariate analyses. Conclusion The results showed that the PNI was a potent prognostic indicator. For OCRC patients, both systemic inflammation and the nutrition status seem to be important for predicting the prognosis, and administering adjuvant chemotherapy was very important. |
| abstract_unstemmed |
Purpose Inflammation-based markers predict long-term outcomes of various malignancies. We investigated the relationship between these markers and the long-term survival in obstructive colorectal cancer (OCRC) patients with self-expandable metallic colonic stents (SEMSs) who subsequently received curative surgery. Methods We retrospectively analyzed 72 consecutive pathological stage II and III OCRC patients between 2013 and 2019. The prognostic significance of the prognostic nutritional index (PNI), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) was evaluated. Results The overall survival (OS), cancer-specific survival, and disease-free survival (DFS) were significantly shorter in the PNI < 35 group than in the PNI ≥ 35 group (p = 0.006, p < 0.001, and p = 0.003, respectively), and multivariate analyses revealed the PNI to be the only inflammation-based marker independently associated with the survival. A PNI < 35 was significantly associated with an elevated CA 19–9 level (p = 0.04) and longer postoperative hospital stay (p = 0.03). Adjuvant chemotherapy was also significantly associated with the OS (p = 0.040) and DFS (p = 0.011) in multivariate analyses. Conclusion The results showed that the PNI was a potent prognostic indicator. For OCRC patients, both systemic inflammation and the nutrition status seem to be important for predicting the prognosis, and administering adjuvant chemotherapy was very important. |
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The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer |
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Oikawa, Masaya Kakita, Tetsuya Okada, Takaho Abe, Tomoya Yazawa, Takashi Tsuchiya, Haruyuki Akazawa, Naoya Sato, Masaki Ohira, Tetsuya Harada, Yoshihiro Okano, Haruka Ito, Kei Tsuchiya, Takashi |
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| score |
7.400326 |