Prognostic impact of potassium levels in patients with ventricular tachyarrhythmias
Background The study sought to assess the prognostic impact of potassium levels (K) in patients with ventricular tachyarrhythmias. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachyarrhythmias on admission from 2002 to 2016. Patients...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Schupp, Tobias [verfasserIn] Bertsch, Thomas [verfasserIn] von Zworowsky, Max [verfasserIn] Kim, Seung-Hyun [verfasserIn] Weidner, Kathrin [verfasserIn] Rusnak, Jonas [verfasserIn] Barth, Christian [verfasserIn] Reiser, Linda [verfasserIn] Taton, Gabriel [verfasserIn] Reichelt, Thomas [verfasserIn] Ellguth, Dominik [verfasserIn] Engelke, Niko [verfasserIn] Bollow, Armin [verfasserIn] Akin, Muharrem [verfasserIn] Mashayekhi, Kambis [verfasserIn] Große Meininghaus, Dirk [verfasserIn] Borggrefe, Martin [verfasserIn] Akin, Ibrahim [verfasserIn] Behnes, Michael [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Zeitschrift für Kardiologie - Darmstadt : Steinkopff, 1997, 109(2020), 10 vom: 31. März, Seite 1292-1306 |
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| Übergeordnetes Werk: |
volume:109 ; year:2020 ; number:10 ; day:31 ; month:03 ; pages:1292-1306 |
| Links: |
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| DOI / URN: |
10.1007/s00392-020-01624-x |
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SPR041082133 |
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| 520 | |a Background The study sought to assess the prognostic impact of potassium levels (K) in patients with ventricular tachyarrhythmias. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachyarrhythmias on admission from 2002 to 2016. Patients with hypokalemia (i.e., K < 3.3 mmol/L), normokalemia (i.e., K 3.3–4.5 mmol/L), and hyperkalemia (i.e., K > 4.5 mmol/L) were compared applying multi-variable Cox regression models and propensity-score matching for evaluation of the primary endpoint of all-cause mortality at 3 years. Secondary endpoints were early cardiac death at 24 h, in-hospital death, death at 30 days, as well as the composite endpoint of early cardiac death at 24 h, recurrences of ventricular tachyarrhythmias, and appropriate ICD therapies at 3 years. Results In 1990 consecutive patients with ventricular tachyarrhythmias, 63% of the patients presented with normokalemia, 30% with hyperkalemia, and 7% with hypokalemia. After propensity matching, both hypokalemic (HR = 1.545; 95% CI 0.970–2.459; p = 0.067) and hyperkalemic patients (HR = 1.371; 95% CI 1.094–1.718; p = 0.006) were associated with the primary endpoint of all-cause mortality at 3 years compared to normokalemic patients. Hyperkalemia was associated with even worse prognosis directly compared to hypokalemia (HR = 1.496; 95% CI 1.002–2.233; p = 0.049). In contrast, potassium measurements were not associated with the composite endpoint at 3 years. Conclusion In patients presenting with ventricular tachyarrhythmias, normokalemia was associated with best short- and long-term survival, whereas hyperkalemia and hypokalemia were associated with increased mortality at 30 days and at 3 years. Graphic abstract | ||
| 650 | 4 | |a Ventricular tachyarrhythmias |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Potassium disorders |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hyperkalemia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hypokalemia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Ventricular tachycardia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Ventricular fibrillation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mortality |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Bertsch, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a von Zworowsky, Max |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Seung-Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a Weidner, Kathrin |e verfasserin |4 aut | |
| 700 | 1 | |a Rusnak, Jonas |e verfasserin |4 aut | |
| 700 | 1 | |a Barth, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Reiser, Linda |e verfasserin |4 aut | |
| 700 | 1 | |a Taton, Gabriel |e verfasserin |4 aut | |
| 700 | 1 | |a Reichelt, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Ellguth, Dominik |e verfasserin |4 aut | |
| 700 | 1 | |a Engelke, Niko |e verfasserin |4 aut | |
| 700 | 1 | |a Bollow, Armin |e verfasserin |4 aut | |
| 700 | 1 | |a Akin, Muharrem |e verfasserin |4 aut | |
| 700 | 1 | |a Mashayekhi, Kambis |e verfasserin |4 aut | |
| 700 | 1 | |a Große Meininghaus, Dirk |e verfasserin |4 aut | |
| 700 | 1 | |a Borggrefe, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Akin, Ibrahim |e verfasserin |4 aut | |
| 700 | 1 | |a Behnes, Michael |e verfasserin |4 aut | |
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10.1007/s00392-020-01624-x doi (DE-627)SPR041082133 (SPR)s00392-020-01624-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Schupp, Tobias verfasserin aut Prognostic impact of potassium levels in patients with ventricular tachyarrhythmias 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The study sought to assess the prognostic impact of potassium levels (K) in patients with ventricular tachyarrhythmias. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachyarrhythmias on admission from 2002 to 2016. Patients with hypokalemia (i.e., K < 3.3 mmol/L), normokalemia (i.e., K 3.3–4.5 mmol/L), and hyperkalemia (i.e., K > 4.5 mmol/L) were compared applying multi-variable Cox regression models and propensity-score matching for evaluation of the primary endpoint of all-cause mortality at 3 years. Secondary endpoints were early cardiac death at 24 h, in-hospital death, death at 30 days, as well as the composite endpoint of early cardiac death at 24 h, recurrences of ventricular tachyarrhythmias, and appropriate ICD therapies at 3 years. Results In 1990 consecutive patients with ventricular tachyarrhythmias, 63% of the patients presented with normokalemia, 30% with hyperkalemia, and 7% with hypokalemia. After propensity matching, both hypokalemic (HR = 1.545; 95% CI 0.970–2.459; p = 0.067) and hyperkalemic patients (HR = 1.371; 95% CI 1.094–1.718; p = 0.006) were associated with the primary endpoint of all-cause mortality at 3 years compared to normokalemic patients. Hyperkalemia was associated with even worse prognosis directly compared to hypokalemia (HR = 1.496; 95% CI 1.002–2.233; p = 0.049). In contrast, potassium measurements were not associated with the composite endpoint at 3 years. Conclusion In patients presenting with ventricular tachyarrhythmias, normokalemia was associated with best short- and long-term survival, whereas hyperkalemia and hypokalemia were associated with increased mortality at 30 days and at 3 years. Graphic abstract Ventricular tachyarrhythmias (dpeaa)DE-He213 Potassium disorders (dpeaa)DE-He213 Hyperkalemia (dpeaa)DE-He213 Hypokalemia (dpeaa)DE-He213 Ventricular tachycardia (dpeaa)DE-He213 Ventricular fibrillation (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Bertsch, Thomas verfasserin aut von Zworowsky, Max verfasserin aut Kim, Seung-Hyun verfasserin aut Weidner, Kathrin verfasserin aut Rusnak, Jonas verfasserin aut Barth, Christian verfasserin aut Reiser, Linda verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Bollow, Armin verfasserin aut Akin, Muharrem verfasserin aut Mashayekhi, Kambis verfasserin aut Große Meininghaus, Dirk verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Behnes, Michael verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 109(2020), 10 vom: 31. März, Seite 1292-1306 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:109 year:2020 number:10 day:31 month:03 pages:1292-1306 https://dx.doi.org/10.1007/s00392-020-01624-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 109 2020 10 31 03 1292-1306 |
| spelling |
10.1007/s00392-020-01624-x doi (DE-627)SPR041082133 (SPR)s00392-020-01624-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Schupp, Tobias verfasserin aut Prognostic impact of potassium levels in patients with ventricular tachyarrhythmias 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The study sought to assess the prognostic impact of potassium levels (K) in patients with ventricular tachyarrhythmias. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachyarrhythmias on admission from 2002 to 2016. Patients with hypokalemia (i.e., K < 3.3 mmol/L), normokalemia (i.e., K 3.3–4.5 mmol/L), and hyperkalemia (i.e., K > 4.5 mmol/L) were compared applying multi-variable Cox regression models and propensity-score matching for evaluation of the primary endpoint of all-cause mortality at 3 years. Secondary endpoints were early cardiac death at 24 h, in-hospital death, death at 30 days, as well as the composite endpoint of early cardiac death at 24 h, recurrences of ventricular tachyarrhythmias, and appropriate ICD therapies at 3 years. Results In 1990 consecutive patients with ventricular tachyarrhythmias, 63% of the patients presented with normokalemia, 30% with hyperkalemia, and 7% with hypokalemia. After propensity matching, both hypokalemic (HR = 1.545; 95% CI 0.970–2.459; p = 0.067) and hyperkalemic patients (HR = 1.371; 95% CI 1.094–1.718; p = 0.006) were associated with the primary endpoint of all-cause mortality at 3 years compared to normokalemic patients. Hyperkalemia was associated with even worse prognosis directly compared to hypokalemia (HR = 1.496; 95% CI 1.002–2.233; p = 0.049). In contrast, potassium measurements were not associated with the composite endpoint at 3 years. Conclusion In patients presenting with ventricular tachyarrhythmias, normokalemia was associated with best short- and long-term survival, whereas hyperkalemia and hypokalemia were associated with increased mortality at 30 days and at 3 years. Graphic abstract Ventricular tachyarrhythmias (dpeaa)DE-He213 Potassium disorders (dpeaa)DE-He213 Hyperkalemia (dpeaa)DE-He213 Hypokalemia (dpeaa)DE-He213 Ventricular tachycardia (dpeaa)DE-He213 Ventricular fibrillation (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Bertsch, Thomas verfasserin aut von Zworowsky, Max verfasserin aut Kim, Seung-Hyun verfasserin aut Weidner, Kathrin verfasserin aut Rusnak, Jonas verfasserin aut Barth, Christian verfasserin aut Reiser, Linda verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Bollow, Armin verfasserin aut Akin, Muharrem verfasserin aut Mashayekhi, Kambis verfasserin aut Große Meininghaus, Dirk verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Behnes, Michael verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 109(2020), 10 vom: 31. März, Seite 1292-1306 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:109 year:2020 number:10 day:31 month:03 pages:1292-1306 https://dx.doi.org/10.1007/s00392-020-01624-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 109 2020 10 31 03 1292-1306 |
| allfields_unstemmed |
10.1007/s00392-020-01624-x doi (DE-627)SPR041082133 (SPR)s00392-020-01624-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Schupp, Tobias verfasserin aut Prognostic impact of potassium levels in patients with ventricular tachyarrhythmias 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The study sought to assess the prognostic impact of potassium levels (K) in patients with ventricular tachyarrhythmias. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachyarrhythmias on admission from 2002 to 2016. Patients with hypokalemia (i.e., K < 3.3 mmol/L), normokalemia (i.e., K 3.3–4.5 mmol/L), and hyperkalemia (i.e., K > 4.5 mmol/L) were compared applying multi-variable Cox regression models and propensity-score matching for evaluation of the primary endpoint of all-cause mortality at 3 years. Secondary endpoints were early cardiac death at 24 h, in-hospital death, death at 30 days, as well as the composite endpoint of early cardiac death at 24 h, recurrences of ventricular tachyarrhythmias, and appropriate ICD therapies at 3 years. Results In 1990 consecutive patients with ventricular tachyarrhythmias, 63% of the patients presented with normokalemia, 30% with hyperkalemia, and 7% with hypokalemia. After propensity matching, both hypokalemic (HR = 1.545; 95% CI 0.970–2.459; p = 0.067) and hyperkalemic patients (HR = 1.371; 95% CI 1.094–1.718; p = 0.006) were associated with the primary endpoint of all-cause mortality at 3 years compared to normokalemic patients. Hyperkalemia was associated with even worse prognosis directly compared to hypokalemia (HR = 1.496; 95% CI 1.002–2.233; p = 0.049). In contrast, potassium measurements were not associated with the composite endpoint at 3 years. Conclusion In patients presenting with ventricular tachyarrhythmias, normokalemia was associated with best short- and long-term survival, whereas hyperkalemia and hypokalemia were associated with increased mortality at 30 days and at 3 years. Graphic abstract Ventricular tachyarrhythmias (dpeaa)DE-He213 Potassium disorders (dpeaa)DE-He213 Hyperkalemia (dpeaa)DE-He213 Hypokalemia (dpeaa)DE-He213 Ventricular tachycardia (dpeaa)DE-He213 Ventricular fibrillation (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Bertsch, Thomas verfasserin aut von Zworowsky, Max verfasserin aut Kim, Seung-Hyun verfasserin aut Weidner, Kathrin verfasserin aut Rusnak, Jonas verfasserin aut Barth, Christian verfasserin aut Reiser, Linda verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Bollow, Armin verfasserin aut Akin, Muharrem verfasserin aut Mashayekhi, Kambis verfasserin aut Große Meininghaus, Dirk verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Behnes, Michael verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 109(2020), 10 vom: 31. März, Seite 1292-1306 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:109 year:2020 number:10 day:31 month:03 pages:1292-1306 https://dx.doi.org/10.1007/s00392-020-01624-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 109 2020 10 31 03 1292-1306 |
| allfieldsGer |
10.1007/s00392-020-01624-x doi (DE-627)SPR041082133 (SPR)s00392-020-01624-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Schupp, Tobias verfasserin aut Prognostic impact of potassium levels in patients with ventricular tachyarrhythmias 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The study sought to assess the prognostic impact of potassium levels (K) in patients with ventricular tachyarrhythmias. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachyarrhythmias on admission from 2002 to 2016. Patients with hypokalemia (i.e., K < 3.3 mmol/L), normokalemia (i.e., K 3.3–4.5 mmol/L), and hyperkalemia (i.e., K > 4.5 mmol/L) were compared applying multi-variable Cox regression models and propensity-score matching for evaluation of the primary endpoint of all-cause mortality at 3 years. Secondary endpoints were early cardiac death at 24 h, in-hospital death, death at 30 days, as well as the composite endpoint of early cardiac death at 24 h, recurrences of ventricular tachyarrhythmias, and appropriate ICD therapies at 3 years. Results In 1990 consecutive patients with ventricular tachyarrhythmias, 63% of the patients presented with normokalemia, 30% with hyperkalemia, and 7% with hypokalemia. After propensity matching, both hypokalemic (HR = 1.545; 95% CI 0.970–2.459; p = 0.067) and hyperkalemic patients (HR = 1.371; 95% CI 1.094–1.718; p = 0.006) were associated with the primary endpoint of all-cause mortality at 3 years compared to normokalemic patients. Hyperkalemia was associated with even worse prognosis directly compared to hypokalemia (HR = 1.496; 95% CI 1.002–2.233; p = 0.049). In contrast, potassium measurements were not associated with the composite endpoint at 3 years. Conclusion In patients presenting with ventricular tachyarrhythmias, normokalemia was associated with best short- and long-term survival, whereas hyperkalemia and hypokalemia were associated with increased mortality at 30 days and at 3 years. Graphic abstract Ventricular tachyarrhythmias (dpeaa)DE-He213 Potassium disorders (dpeaa)DE-He213 Hyperkalemia (dpeaa)DE-He213 Hypokalemia (dpeaa)DE-He213 Ventricular tachycardia (dpeaa)DE-He213 Ventricular fibrillation (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Bertsch, Thomas verfasserin aut von Zworowsky, Max verfasserin aut Kim, Seung-Hyun verfasserin aut Weidner, Kathrin verfasserin aut Rusnak, Jonas verfasserin aut Barth, Christian verfasserin aut Reiser, Linda verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Bollow, Armin verfasserin aut Akin, Muharrem verfasserin aut Mashayekhi, Kambis verfasserin aut Große Meininghaus, Dirk verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Behnes, Michael verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 109(2020), 10 vom: 31. März, Seite 1292-1306 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:109 year:2020 number:10 day:31 month:03 pages:1292-1306 https://dx.doi.org/10.1007/s00392-020-01624-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 109 2020 10 31 03 1292-1306 |
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10.1007/s00392-020-01624-x doi (DE-627)SPR041082133 (SPR)s00392-020-01624-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Schupp, Tobias verfasserin aut Prognostic impact of potassium levels in patients with ventricular tachyarrhythmias 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The study sought to assess the prognostic impact of potassium levels (K) in patients with ventricular tachyarrhythmias. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachyarrhythmias on admission from 2002 to 2016. Patients with hypokalemia (i.e., K < 3.3 mmol/L), normokalemia (i.e., K 3.3–4.5 mmol/L), and hyperkalemia (i.e., K > 4.5 mmol/L) were compared applying multi-variable Cox regression models and propensity-score matching for evaluation of the primary endpoint of all-cause mortality at 3 years. Secondary endpoints were early cardiac death at 24 h, in-hospital death, death at 30 days, as well as the composite endpoint of early cardiac death at 24 h, recurrences of ventricular tachyarrhythmias, and appropriate ICD therapies at 3 years. Results In 1990 consecutive patients with ventricular tachyarrhythmias, 63% of the patients presented with normokalemia, 30% with hyperkalemia, and 7% with hypokalemia. After propensity matching, both hypokalemic (HR = 1.545; 95% CI 0.970–2.459; p = 0.067) and hyperkalemic patients (HR = 1.371; 95% CI 1.094–1.718; p = 0.006) were associated with the primary endpoint of all-cause mortality at 3 years compared to normokalemic patients. Hyperkalemia was associated with even worse prognosis directly compared to hypokalemia (HR = 1.496; 95% CI 1.002–2.233; p = 0.049). In contrast, potassium measurements were not associated with the composite endpoint at 3 years. Conclusion In patients presenting with ventricular tachyarrhythmias, normokalemia was associated with best short- and long-term survival, whereas hyperkalemia and hypokalemia were associated with increased mortality at 30 days and at 3 years. Graphic abstract Ventricular tachyarrhythmias (dpeaa)DE-He213 Potassium disorders (dpeaa)DE-He213 Hyperkalemia (dpeaa)DE-He213 Hypokalemia (dpeaa)DE-He213 Ventricular tachycardia (dpeaa)DE-He213 Ventricular fibrillation (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Bertsch, Thomas verfasserin aut von Zworowsky, Max verfasserin aut Kim, Seung-Hyun verfasserin aut Weidner, Kathrin verfasserin aut Rusnak, Jonas verfasserin aut Barth, Christian verfasserin aut Reiser, Linda verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Bollow, Armin verfasserin aut Akin, Muharrem verfasserin aut Mashayekhi, Kambis verfasserin aut Große Meininghaus, Dirk verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Behnes, Michael verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 109(2020), 10 vom: 31. März, Seite 1292-1306 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:109 year:2020 number:10 day:31 month:03 pages:1292-1306 https://dx.doi.org/10.1007/s00392-020-01624-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 109 2020 10 31 03 1292-1306 |
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Prognostic impact of potassium levels in patients with ventricular tachyarrhythmias |
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Prognostic impact of potassium levels in patients with ventricular tachyarrhythmias |
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Schupp, Tobias |
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Schupp, Tobias Bertsch, Thomas von Zworowsky, Max Kim, Seung-Hyun Weidner, Kathrin Rusnak, Jonas Barth, Christian Reiser, Linda Taton, Gabriel Reichelt, Thomas Ellguth, Dominik Engelke, Niko Bollow, Armin Akin, Muharrem Mashayekhi, Kambis Große Meininghaus, Dirk Borggrefe, Martin Akin, Ibrahim Behnes, Michael |
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prognostic impact of potassium levels in patients with ventricular tachyarrhythmias |
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Prognostic impact of potassium levels in patients with ventricular tachyarrhythmias |
| abstract |
Background The study sought to assess the prognostic impact of potassium levels (K) in patients with ventricular tachyarrhythmias. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachyarrhythmias on admission from 2002 to 2016. Patients with hypokalemia (i.e., K < 3.3 mmol/L), normokalemia (i.e., K 3.3–4.5 mmol/L), and hyperkalemia (i.e., K > 4.5 mmol/L) were compared applying multi-variable Cox regression models and propensity-score matching for evaluation of the primary endpoint of all-cause mortality at 3 years. Secondary endpoints were early cardiac death at 24 h, in-hospital death, death at 30 days, as well as the composite endpoint of early cardiac death at 24 h, recurrences of ventricular tachyarrhythmias, and appropriate ICD therapies at 3 years. Results In 1990 consecutive patients with ventricular tachyarrhythmias, 63% of the patients presented with normokalemia, 30% with hyperkalemia, and 7% with hypokalemia. After propensity matching, both hypokalemic (HR = 1.545; 95% CI 0.970–2.459; p = 0.067) and hyperkalemic patients (HR = 1.371; 95% CI 1.094–1.718; p = 0.006) were associated with the primary endpoint of all-cause mortality at 3 years compared to normokalemic patients. Hyperkalemia was associated with even worse prognosis directly compared to hypokalemia (HR = 1.496; 95% CI 1.002–2.233; p = 0.049). In contrast, potassium measurements were not associated with the composite endpoint at 3 years. Conclusion In patients presenting with ventricular tachyarrhythmias, normokalemia was associated with best short- and long-term survival, whereas hyperkalemia and hypokalemia were associated with increased mortality at 30 days and at 3 years. Graphic abstract |
| abstractGer |
Background The study sought to assess the prognostic impact of potassium levels (K) in patients with ventricular tachyarrhythmias. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachyarrhythmias on admission from 2002 to 2016. Patients with hypokalemia (i.e., K < 3.3 mmol/L), normokalemia (i.e., K 3.3–4.5 mmol/L), and hyperkalemia (i.e., K > 4.5 mmol/L) were compared applying multi-variable Cox regression models and propensity-score matching for evaluation of the primary endpoint of all-cause mortality at 3 years. Secondary endpoints were early cardiac death at 24 h, in-hospital death, death at 30 days, as well as the composite endpoint of early cardiac death at 24 h, recurrences of ventricular tachyarrhythmias, and appropriate ICD therapies at 3 years. Results In 1990 consecutive patients with ventricular tachyarrhythmias, 63% of the patients presented with normokalemia, 30% with hyperkalemia, and 7% with hypokalemia. After propensity matching, both hypokalemic (HR = 1.545; 95% CI 0.970–2.459; p = 0.067) and hyperkalemic patients (HR = 1.371; 95% CI 1.094–1.718; p = 0.006) were associated with the primary endpoint of all-cause mortality at 3 years compared to normokalemic patients. Hyperkalemia was associated with even worse prognosis directly compared to hypokalemia (HR = 1.496; 95% CI 1.002–2.233; p = 0.049). In contrast, potassium measurements were not associated with the composite endpoint at 3 years. Conclusion In patients presenting with ventricular tachyarrhythmias, normokalemia was associated with best short- and long-term survival, whereas hyperkalemia and hypokalemia were associated with increased mortality at 30 days and at 3 years. Graphic abstract |
| abstract_unstemmed |
Background The study sought to assess the prognostic impact of potassium levels (K) in patients with ventricular tachyarrhythmias. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachyarrhythmias on admission from 2002 to 2016. Patients with hypokalemia (i.e., K < 3.3 mmol/L), normokalemia (i.e., K 3.3–4.5 mmol/L), and hyperkalemia (i.e., K > 4.5 mmol/L) were compared applying multi-variable Cox regression models and propensity-score matching for evaluation of the primary endpoint of all-cause mortality at 3 years. Secondary endpoints were early cardiac death at 24 h, in-hospital death, death at 30 days, as well as the composite endpoint of early cardiac death at 24 h, recurrences of ventricular tachyarrhythmias, and appropriate ICD therapies at 3 years. Results In 1990 consecutive patients with ventricular tachyarrhythmias, 63% of the patients presented with normokalemia, 30% with hyperkalemia, and 7% with hypokalemia. After propensity matching, both hypokalemic (HR = 1.545; 95% CI 0.970–2.459; p = 0.067) and hyperkalemic patients (HR = 1.371; 95% CI 1.094–1.718; p = 0.006) were associated with the primary endpoint of all-cause mortality at 3 years compared to normokalemic patients. Hyperkalemia was associated with even worse prognosis directly compared to hypokalemia (HR = 1.496; 95% CI 1.002–2.233; p = 0.049). In contrast, potassium measurements were not associated with the composite endpoint at 3 years. Conclusion In patients presenting with ventricular tachyarrhythmias, normokalemia was associated with best short- and long-term survival, whereas hyperkalemia and hypokalemia were associated with increased mortality at 30 days and at 3 years. Graphic abstract |
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Prognostic impact of potassium levels in patients with ventricular tachyarrhythmias |
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Bertsch, Thomas von Zworowsky, Max Kim, Seung-Hyun Weidner, Kathrin Rusnak, Jonas Barth, Christian Reiser, Linda Taton, Gabriel Reichelt, Thomas Ellguth, Dominik Engelke, Niko Bollow, Armin Akin, Muharrem Mashayekhi, Kambis Große Meininghaus, Dirk Borggrefe, Martin Akin, Ibrahim Behnes, Michael |
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