Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking
Abstract Injectable hydrogels are ideal biomaterials for delivering cells, growth factors and drugs specifically to localized lesions and subsequent controlled release. Many factors can affect the efficacy of injectable hydrogels. To avoid potential damage to encapsulated cells or drugs, injectable...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yu, Wenting [verfasserIn] Xue, Bin [verfasserIn] Zhu, Zhenshu [verfasserIn] Shen, Ziqin [verfasserIn] Qin, Meng [verfasserIn] Wang, Wei [verfasserIn] Cao, Yi [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2020 |
|---|
| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
Enthalten in: Chemical Research in Chinese Universities - Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012, 36(2020), 5 vom: 24. Feb., Seite 962-969 |
|---|---|
| Übergeordnetes Werk: |
volume:36 ; year:2020 ; number:5 ; day:24 ; month:02 ; pages:962-969 |
| Links: |
|---|
| DOI / URN: |
10.1007/s40242-020-9100-y |
|---|
| Katalog-ID: |
SPR041309502 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR041309502 | ||
| 003 | DE-627 | ||
| 005 | 20230519194536.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201102s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s40242-020-9100-y |2 doi | |
| 035 | |a (DE-627)SPR041309502 | ||
| 035 | |a (SPR)s40242-020-9100-y-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Yu, Wenting |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract Injectable hydrogels are ideal biomaterials for delivering cells, growth factors and drugs specifically to localized lesions and subsequent controlled release. Many factors can affect the efficacy of injectable hydrogels. To avoid potential damage to encapsulated cells or drugs, injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly reform after injection. However, dynamic hydrogels are often mechanically weak, leading to the leakage of encapsulated cells or drugs. Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds. We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not affected by the formation of multivalent binding. Yet, the mechanical stability of the hydrogels was significantly improved due to the increased thermodynamic stability of the crosslinkers. We further showed that the drug release rates were slowed down by the formation of multivalent crosslinkers. Our results highlight the importance of ligand valency to the mechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels. | ||
| 650 | 4 | |a Peptide-ion coordination |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Ligand cooperativity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Injectable hydrogel |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mechanical response |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Xue, Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Zhenshu |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Ziqin |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Meng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Yi |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Chemical Research in Chinese Universities |d Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 |g 36(2020), 5 vom: 24. Feb., Seite 962-969 |w (DE-627)SPR03290777X |7 nnns |
| 773 | 1 | 8 | |g volume:36 |g year:2020 |g number:5 |g day:24 |g month:02 |g pages:962-969 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s40242-020-9100-y |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |d 36 |j 2020 |e 5 |b 24 |c 02 |h 962-969 | ||
| author_variant |
w y wy b x bx z z zz z s zs m q mq w w ww y c yc |
|---|---|
| matchkey_str |
yuwentingxuebinzhuzhenshushenziqinqinmen:2020----:tognijcalhdoesaeomliaeteain |
| hierarchy_sort_str |
2020 |
| publishDate |
2020 |
| allfields |
10.1007/s40242-020-9100-y doi (DE-627)SPR041309502 (SPR)s40242-020-9100-y-e DE-627 ger DE-627 rakwb eng Yu, Wenting verfasserin aut Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Injectable hydrogels are ideal biomaterials for delivering cells, growth factors and drugs specifically to localized lesions and subsequent controlled release. Many factors can affect the efficacy of injectable hydrogels. To avoid potential damage to encapsulated cells or drugs, injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly reform after injection. However, dynamic hydrogels are often mechanically weak, leading to the leakage of encapsulated cells or drugs. Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds. We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not affected by the formation of multivalent binding. Yet, the mechanical stability of the hydrogels was significantly improved due to the increased thermodynamic stability of the crosslinkers. We further showed that the drug release rates were slowed down by the formation of multivalent crosslinkers. Our results highlight the importance of ligand valency to the mechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels. Peptide-ion coordination (dpeaa)DE-He213 Ligand cooperativity (dpeaa)DE-He213 Injectable hydrogel (dpeaa)DE-He213 Mechanical response (dpeaa)DE-He213 Xue, Bin verfasserin aut Zhu, Zhenshu verfasserin aut Shen, Ziqin verfasserin aut Qin, Meng verfasserin aut Wang, Wei verfasserin aut Cao, Yi verfasserin aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 36(2020), 5 vom: 24. Feb., Seite 962-969 (DE-627)SPR03290777X nnns volume:36 year:2020 number:5 day:24 month:02 pages:962-969 https://dx.doi.org/10.1007/s40242-020-9100-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 36 2020 5 24 02 962-969 |
| spelling |
10.1007/s40242-020-9100-y doi (DE-627)SPR041309502 (SPR)s40242-020-9100-y-e DE-627 ger DE-627 rakwb eng Yu, Wenting verfasserin aut Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Injectable hydrogels are ideal biomaterials for delivering cells, growth factors and drugs specifically to localized lesions and subsequent controlled release. Many factors can affect the efficacy of injectable hydrogels. To avoid potential damage to encapsulated cells or drugs, injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly reform after injection. However, dynamic hydrogels are often mechanically weak, leading to the leakage of encapsulated cells or drugs. Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds. We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not affected by the formation of multivalent binding. Yet, the mechanical stability of the hydrogels was significantly improved due to the increased thermodynamic stability of the crosslinkers. We further showed that the drug release rates were slowed down by the formation of multivalent crosslinkers. Our results highlight the importance of ligand valency to the mechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels. Peptide-ion coordination (dpeaa)DE-He213 Ligand cooperativity (dpeaa)DE-He213 Injectable hydrogel (dpeaa)DE-He213 Mechanical response (dpeaa)DE-He213 Xue, Bin verfasserin aut Zhu, Zhenshu verfasserin aut Shen, Ziqin verfasserin aut Qin, Meng verfasserin aut Wang, Wei verfasserin aut Cao, Yi verfasserin aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 36(2020), 5 vom: 24. Feb., Seite 962-969 (DE-627)SPR03290777X nnns volume:36 year:2020 number:5 day:24 month:02 pages:962-969 https://dx.doi.org/10.1007/s40242-020-9100-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 36 2020 5 24 02 962-969 |
| allfields_unstemmed |
10.1007/s40242-020-9100-y doi (DE-627)SPR041309502 (SPR)s40242-020-9100-y-e DE-627 ger DE-627 rakwb eng Yu, Wenting verfasserin aut Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Injectable hydrogels are ideal biomaterials for delivering cells, growth factors and drugs specifically to localized lesions and subsequent controlled release. Many factors can affect the efficacy of injectable hydrogels. To avoid potential damage to encapsulated cells or drugs, injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly reform after injection. However, dynamic hydrogels are often mechanically weak, leading to the leakage of encapsulated cells or drugs. Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds. We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not affected by the formation of multivalent binding. Yet, the mechanical stability of the hydrogels was significantly improved due to the increased thermodynamic stability of the crosslinkers. We further showed that the drug release rates were slowed down by the formation of multivalent crosslinkers. Our results highlight the importance of ligand valency to the mechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels. Peptide-ion coordination (dpeaa)DE-He213 Ligand cooperativity (dpeaa)DE-He213 Injectable hydrogel (dpeaa)DE-He213 Mechanical response (dpeaa)DE-He213 Xue, Bin verfasserin aut Zhu, Zhenshu verfasserin aut Shen, Ziqin verfasserin aut Qin, Meng verfasserin aut Wang, Wei verfasserin aut Cao, Yi verfasserin aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 36(2020), 5 vom: 24. Feb., Seite 962-969 (DE-627)SPR03290777X nnns volume:36 year:2020 number:5 day:24 month:02 pages:962-969 https://dx.doi.org/10.1007/s40242-020-9100-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 36 2020 5 24 02 962-969 |
| allfieldsGer |
10.1007/s40242-020-9100-y doi (DE-627)SPR041309502 (SPR)s40242-020-9100-y-e DE-627 ger DE-627 rakwb eng Yu, Wenting verfasserin aut Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Injectable hydrogels are ideal biomaterials for delivering cells, growth factors and drugs specifically to localized lesions and subsequent controlled release. Many factors can affect the efficacy of injectable hydrogels. To avoid potential damage to encapsulated cells or drugs, injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly reform after injection. However, dynamic hydrogels are often mechanically weak, leading to the leakage of encapsulated cells or drugs. Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds. We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not affected by the formation of multivalent binding. Yet, the mechanical stability of the hydrogels was significantly improved due to the increased thermodynamic stability of the crosslinkers. We further showed that the drug release rates were slowed down by the formation of multivalent crosslinkers. Our results highlight the importance of ligand valency to the mechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels. Peptide-ion coordination (dpeaa)DE-He213 Ligand cooperativity (dpeaa)DE-He213 Injectable hydrogel (dpeaa)DE-He213 Mechanical response (dpeaa)DE-He213 Xue, Bin verfasserin aut Zhu, Zhenshu verfasserin aut Shen, Ziqin verfasserin aut Qin, Meng verfasserin aut Wang, Wei verfasserin aut Cao, Yi verfasserin aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 36(2020), 5 vom: 24. Feb., Seite 962-969 (DE-627)SPR03290777X nnns volume:36 year:2020 number:5 day:24 month:02 pages:962-969 https://dx.doi.org/10.1007/s40242-020-9100-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 36 2020 5 24 02 962-969 |
| allfieldsSound |
10.1007/s40242-020-9100-y doi (DE-627)SPR041309502 (SPR)s40242-020-9100-y-e DE-627 ger DE-627 rakwb eng Yu, Wenting verfasserin aut Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Injectable hydrogels are ideal biomaterials for delivering cells, growth factors and drugs specifically to localized lesions and subsequent controlled release. Many factors can affect the efficacy of injectable hydrogels. To avoid potential damage to encapsulated cells or drugs, injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly reform after injection. However, dynamic hydrogels are often mechanically weak, leading to the leakage of encapsulated cells or drugs. Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds. We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not affected by the formation of multivalent binding. Yet, the mechanical stability of the hydrogels was significantly improved due to the increased thermodynamic stability of the crosslinkers. We further showed that the drug release rates were slowed down by the formation of multivalent crosslinkers. Our results highlight the importance of ligand valency to the mechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels. Peptide-ion coordination (dpeaa)DE-He213 Ligand cooperativity (dpeaa)DE-He213 Injectable hydrogel (dpeaa)DE-He213 Mechanical response (dpeaa)DE-He213 Xue, Bin verfasserin aut Zhu, Zhenshu verfasserin aut Shen, Ziqin verfasserin aut Qin, Meng verfasserin aut Wang, Wei verfasserin aut Cao, Yi verfasserin aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 36(2020), 5 vom: 24. Feb., Seite 962-969 (DE-627)SPR03290777X nnns volume:36 year:2020 number:5 day:24 month:02 pages:962-969 https://dx.doi.org/10.1007/s40242-020-9100-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 36 2020 5 24 02 962-969 |
| language |
English |
| source |
Enthalten in Chemical Research in Chinese Universities 36(2020), 5 vom: 24. Feb., Seite 962-969 volume:36 year:2020 number:5 day:24 month:02 pages:962-969 |
| sourceStr |
Enthalten in Chemical Research in Chinese Universities 36(2020), 5 vom: 24. Feb., Seite 962-969 volume:36 year:2020 number:5 day:24 month:02 pages:962-969 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Peptide-ion coordination Ligand cooperativity Injectable hydrogel Mechanical response |
| isfreeaccess_bool |
false |
| container_title |
Chemical Research in Chinese Universities |
| authorswithroles_txt_mv |
Yu, Wenting @@aut@@ Xue, Bin @@aut@@ Zhu, Zhenshu @@aut@@ Shen, Ziqin @@aut@@ Qin, Meng @@aut@@ Wang, Wei @@aut@@ Cao, Yi @@aut@@ |
| publishDateDaySort_date |
2020-02-24T00:00:00Z |
| hierarchy_top_id |
SPR03290777X |
| id |
SPR041309502 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR041309502</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519194536.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201102s2020 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s40242-020-9100-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR041309502</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s40242-020-9100-y-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Yu, Wenting</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Injectable hydrogels are ideal biomaterials for delivering cells, growth factors and drugs specifically to localized lesions and subsequent controlled release. Many factors can affect the efficacy of injectable hydrogels. To avoid potential damage to encapsulated cells or drugs, injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly reform after injection. However, dynamic hydrogels are often mechanically weak, leading to the leakage of encapsulated cells or drugs. Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds. We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not affected by the formation of multivalent binding. Yet, the mechanical stability of the hydrogels was significantly improved due to the increased thermodynamic stability of the crosslinkers. We further showed that the drug release rates were slowed down by the formation of multivalent crosslinkers. Our results highlight the importance of ligand valency to the mechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Peptide-ion coordination</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ligand cooperativity</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Injectable hydrogel</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mechanical response</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Xue, Bin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhu, Zhenshu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shen, Ziqin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Qin, Meng</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Wei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cao, Yi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Chemical Research in Chinese Universities</subfield><subfield code="d">Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012</subfield><subfield code="g">36(2020), 5 vom: 24. Feb., Seite 962-969</subfield><subfield code="w">(DE-627)SPR03290777X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:36</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:5</subfield><subfield code="g">day:24</subfield><subfield code="g">month:02</subfield><subfield code="g">pages:962-969</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s40242-020-9100-y</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">36</subfield><subfield code="j">2020</subfield><subfield code="e">5</subfield><subfield code="b">24</subfield><subfield code="c">02</subfield><subfield code="h">962-969</subfield></datafield></record></collection>
|
| author |
Yu, Wenting |
| spellingShingle |
Yu, Wenting misc Peptide-ion coordination misc Ligand cooperativity misc Injectable hydrogel misc Mechanical response Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking |
| authorStr |
Yu, Wenting |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)SPR03290777X |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut aut |
| collection |
springer |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking Peptide-ion coordination (dpeaa)DE-He213 Ligand cooperativity (dpeaa)DE-He213 Injectable hydrogel (dpeaa)DE-He213 Mechanical response (dpeaa)DE-He213 |
| topic |
misc Peptide-ion coordination misc Ligand cooperativity misc Injectable hydrogel misc Mechanical response |
| topic_unstemmed |
misc Peptide-ion coordination misc Ligand cooperativity misc Injectable hydrogel misc Mechanical response |
| topic_browse |
misc Peptide-ion coordination misc Ligand cooperativity misc Injectable hydrogel misc Mechanical response |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Chemical Research in Chinese Universities |
| hierarchy_parent_id |
SPR03290777X |
| hierarchy_top_title |
Chemical Research in Chinese Universities |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)SPR03290777X |
| title |
Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking |
| ctrlnum |
(DE-627)SPR041309502 (SPR)s40242-020-9100-y-e |
| title_full |
Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking |
| author_sort |
Yu, Wenting |
| journal |
Chemical Research in Chinese Universities |
| journalStr |
Chemical Research in Chinese Universities |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
2020 |
| contenttype_str_mv |
txt |
| container_start_page |
962 |
| author_browse |
Yu, Wenting Xue, Bin Zhu, Zhenshu Shen, Ziqin Qin, Meng Wang, Wei Cao, Yi |
| container_volume |
36 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Yu, Wenting |
| doi_str_mv |
10.1007/s40242-020-9100-y |
| author2-role |
verfasserin |
| title_sort |
strong and injectable hydrogels based on multivalent metal ion-peptide cross-linking |
| title_auth |
Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking |
| abstract |
Abstract Injectable hydrogels are ideal biomaterials for delivering cells, growth factors and drugs specifically to localized lesions and subsequent controlled release. Many factors can affect the efficacy of injectable hydrogels. To avoid potential damage to encapsulated cells or drugs, injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly reform after injection. However, dynamic hydrogels are often mechanically weak, leading to the leakage of encapsulated cells or drugs. Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds. We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not affected by the formation of multivalent binding. Yet, the mechanical stability of the hydrogels was significantly improved due to the increased thermodynamic stability of the crosslinkers. We further showed that the drug release rates were slowed down by the formation of multivalent crosslinkers. Our results highlight the importance of ligand valency to the mechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels. |
| abstractGer |
Abstract Injectable hydrogels are ideal biomaterials for delivering cells, growth factors and drugs specifically to localized lesions and subsequent controlled release. Many factors can affect the efficacy of injectable hydrogels. To avoid potential damage to encapsulated cells or drugs, injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly reform after injection. However, dynamic hydrogels are often mechanically weak, leading to the leakage of encapsulated cells or drugs. Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds. We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not affected by the formation of multivalent binding. Yet, the mechanical stability of the hydrogels was significantly improved due to the increased thermodynamic stability of the crosslinkers. We further showed that the drug release rates were slowed down by the formation of multivalent crosslinkers. Our results highlight the importance of ligand valency to the mechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels. |
| abstract_unstemmed |
Abstract Injectable hydrogels are ideal biomaterials for delivering cells, growth factors and drugs specifically to localized lesions and subsequent controlled release. Many factors can affect the efficacy of injectable hydrogels. To avoid potential damage to encapsulated cells or drugs, injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly reform after injection. However, dynamic hydrogels are often mechanically weak, leading to the leakage of encapsulated cells or drugs. Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds. We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not affected by the formation of multivalent binding. Yet, the mechanical stability of the hydrogels was significantly improved due to the increased thermodynamic stability of the crosslinkers. We further showed that the drug release rates were slowed down by the formation of multivalent crosslinkers. Our results highlight the importance of ligand valency to the mechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA |
| container_issue |
5 |
| title_short |
Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking |
| url |
https://dx.doi.org/10.1007/s40242-020-9100-y |
| remote_bool |
true |
| author2 |
Xue, Bin Zhu, Zhenshu Shen, Ziqin Qin, Meng Wang, Wei Cao, Yi |
| author2Str |
Xue, Bin Zhu, Zhenshu Shen, Ziqin Qin, Meng Wang, Wei Cao, Yi |
| ppnlink |
SPR03290777X |
| mediatype_str_mv |
c |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1007/s40242-020-9100-y |
| up_date |
2024-07-03T21:22:54.943Z |
| _version_ |
1803594524204728321 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR041309502</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519194536.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201102s2020 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s40242-020-9100-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR041309502</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s40242-020-9100-y-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Yu, Wenting</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Injectable hydrogels are ideal biomaterials for delivering cells, growth factors and drugs specifically to localized lesions and subsequent controlled release. Many factors can affect the efficacy of injectable hydrogels. To avoid potential damage to encapsulated cells or drugs, injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly reform after injection. However, dynamic hydrogels are often mechanically weak, leading to the leakage of encapsulated cells or drugs. Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds. We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not affected by the formation of multivalent binding. Yet, the mechanical stability of the hydrogels was significantly improved due to the increased thermodynamic stability of the crosslinkers. We further showed that the drug release rates were slowed down by the formation of multivalent crosslinkers. Our results highlight the importance of ligand valency to the mechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Peptide-ion coordination</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ligand cooperativity</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Injectable hydrogel</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mechanical response</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Xue, Bin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhu, Zhenshu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shen, Ziqin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Qin, Meng</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Wei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cao, Yi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Chemical Research in Chinese Universities</subfield><subfield code="d">Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012</subfield><subfield code="g">36(2020), 5 vom: 24. Feb., Seite 962-969</subfield><subfield code="w">(DE-627)SPR03290777X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:36</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:5</subfield><subfield code="g">day:24</subfield><subfield code="g">month:02</subfield><subfield code="g">pages:962-969</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s40242-020-9100-y</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">36</subfield><subfield code="j">2020</subfield><subfield code="e">5</subfield><subfield code="b">24</subfield><subfield code="c">02</subfield><subfield code="h">962-969</subfield></datafield></record></collection>
|
| score |
7.399987 |