SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients

Background Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients. Methods We conducted a binational study merging prospect...
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Autor*in:	Buetti, Niccolò [verfasserIn] Wicky, Paul-Henri [verfasserIn] Le Hingrat, Quentin [verfasserIn] Ruckly, Stéphane [verfasserIn] Mazzuchelli, Timothy [verfasserIn] Loiodice, Ambre [verfasserIn] Trimboli, Pierpaolo [verfasserIn] Forni Ogna, Valentina [verfasserIn] de Montmollin, Etienne [verfasserIn] Bernasconi, Enos [verfasserIn] Visseaux, Benoit [verfasserIn] Timsit, Jean-François [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	SARS-CoV-2 COVID-19 Viral shedding Viral load Lower respiratory tract ICU Mortality

Übergeordnetes Werk:	Enthalten in: Critical care - London : BioMed Central, 1997, 24(2020), 1 vom: 16. Okt.
Übergeordnetes Werk:	volume:24 ; year:2020 ; number:1 ; day:16 ; month:10

Links:	Volltext

DOI / URN:	10.1186/s13054-020-03323-5

Katalog-ID:	SPR041370139

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520			\|a Background Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients. Methods We conducted a binational study merging prospectively collected data from two COVID-19 reference centers in France and Switzerland. First, we described the viral shedding duration (i.e., time to negativity) in LRT samples. Second, we analyzed viral load in LRT samples. Third, we assessed the association between viral presence in LRT and mortality using mixed-effect logistic models for clustered data adjusting for the time between symptoms’ onset and date of sampling. Results From March to May 2020, 267 LRT samples were performed in 90 patients from both centers. The median time to negativity was 29 (IQR 23; 34) days. Prolonged viral shedding was not associated with age, gender, cardiac comorbidities, diabetes, immunosuppression, corticosteroids use, or antiviral therapy. The LRT viral load tended to be higher in non-survivors. This difference was statistically significant after adjusting for the time interval between onset of symptoms and date of sampling (OR 3.78, 95% CI 1.13–12.64, p = 0.03). Conclusions The viral shedding in LRT lasted almost 30 days in median in critically ill patients, and the viral load in the LRT was associated with the 6-week mortality.
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allfields	10.1186/s13054-020-03323-5 doi (DE-627)SPR041370139 (SPR)s13054-020-03323-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Buetti, Niccolò verfasserin aut SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients. Methods We conducted a binational study merging prospectively collected data from two COVID-19 reference centers in France and Switzerland. First, we described the viral shedding duration (i.e., time to negativity) in LRT samples. Second, we analyzed viral load in LRT samples. Third, we assessed the association between viral presence in LRT and mortality using mixed-effect logistic models for clustered data adjusting for the time between symptoms’ onset and date of sampling. Results From March to May 2020, 267 LRT samples were performed in 90 patients from both centers. The median time to negativity was 29 (IQR 23; 34) days. Prolonged viral shedding was not associated with age, gender, cardiac comorbidities, diabetes, immunosuppression, corticosteroids use, or antiviral therapy. The LRT viral load tended to be higher in non-survivors. This difference was statistically significant after adjusting for the time interval between onset of symptoms and date of sampling (OR 3.78, 95% CI 1.13–12.64, p = 0.03). Conclusions The viral shedding in LRT lasted almost 30 days in median in critically ill patients, and the viral load in the LRT was associated with the 6-week mortality. SARS-CoV-2 (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Viral shedding (dpeaa)DE-He213 Viral load (dpeaa)DE-He213 Lower respiratory tract (dpeaa)DE-He213 ICU (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Wicky, Paul-Henri verfasserin aut Le Hingrat, Quentin verfasserin aut Ruckly, Stéphane verfasserin aut Mazzuchelli, Timothy verfasserin aut Loiodice, Ambre verfasserin aut Trimboli, Pierpaolo verfasserin aut Forni Ogna, Valentina verfasserin aut de Montmollin, Etienne verfasserin aut Bernasconi, Enos verfasserin aut Visseaux, Benoit verfasserin aut Timsit, Jean-François verfasserin aut Enthalten in Critical care London : BioMed Central, 1997 24(2020), 1 vom: 16. Okt. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:24 year:2020 number:1 day:16 month:10 https://dx.doi.org/10.1186/s13054-020-03323-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 24 2020 1 16 10
spelling	10.1186/s13054-020-03323-5 doi (DE-627)SPR041370139 (SPR)s13054-020-03323-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Buetti, Niccolò verfasserin aut SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients. Methods We conducted a binational study merging prospectively collected data from two COVID-19 reference centers in France and Switzerland. First, we described the viral shedding duration (i.e., time to negativity) in LRT samples. Second, we analyzed viral load in LRT samples. Third, we assessed the association between viral presence in LRT and mortality using mixed-effect logistic models for clustered data adjusting for the time between symptoms’ onset and date of sampling. Results From March to May 2020, 267 LRT samples were performed in 90 patients from both centers. The median time to negativity was 29 (IQR 23; 34) days. Prolonged viral shedding was not associated with age, gender, cardiac comorbidities, diabetes, immunosuppression, corticosteroids use, or antiviral therapy. The LRT viral load tended to be higher in non-survivors. This difference was statistically significant after adjusting for the time interval between onset of symptoms and date of sampling (OR 3.78, 95% CI 1.13–12.64, p = 0.03). Conclusions The viral shedding in LRT lasted almost 30 days in median in critically ill patients, and the viral load in the LRT was associated with the 6-week mortality. SARS-CoV-2 (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Viral shedding (dpeaa)DE-He213 Viral load (dpeaa)DE-He213 Lower respiratory tract (dpeaa)DE-He213 ICU (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Wicky, Paul-Henri verfasserin aut Le Hingrat, Quentin verfasserin aut Ruckly, Stéphane verfasserin aut Mazzuchelli, Timothy verfasserin aut Loiodice, Ambre verfasserin aut Trimboli, Pierpaolo verfasserin aut Forni Ogna, Valentina verfasserin aut de Montmollin, Etienne verfasserin aut Bernasconi, Enos verfasserin aut Visseaux, Benoit verfasserin aut Timsit, Jean-François verfasserin aut Enthalten in Critical care London : BioMed Central, 1997 24(2020), 1 vom: 16. Okt. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:24 year:2020 number:1 day:16 month:10 https://dx.doi.org/10.1186/s13054-020-03323-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 24 2020 1 16 10
allfields_unstemmed	10.1186/s13054-020-03323-5 doi (DE-627)SPR041370139 (SPR)s13054-020-03323-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Buetti, Niccolò verfasserin aut SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients. Methods We conducted a binational study merging prospectively collected data from two COVID-19 reference centers in France and Switzerland. First, we described the viral shedding duration (i.e., time to negativity) in LRT samples. Second, we analyzed viral load in LRT samples. Third, we assessed the association between viral presence in LRT and mortality using mixed-effect logistic models for clustered data adjusting for the time between symptoms’ onset and date of sampling. Results From March to May 2020, 267 LRT samples were performed in 90 patients from both centers. The median time to negativity was 29 (IQR 23; 34) days. Prolonged viral shedding was not associated with age, gender, cardiac comorbidities, diabetes, immunosuppression, corticosteroids use, or antiviral therapy. The LRT viral load tended to be higher in non-survivors. This difference was statistically significant after adjusting for the time interval between onset of symptoms and date of sampling (OR 3.78, 95% CI 1.13–12.64, p = 0.03). Conclusions The viral shedding in LRT lasted almost 30 days in median in critically ill patients, and the viral load in the LRT was associated with the 6-week mortality. SARS-CoV-2 (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Viral shedding (dpeaa)DE-He213 Viral load (dpeaa)DE-He213 Lower respiratory tract (dpeaa)DE-He213 ICU (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Wicky, Paul-Henri verfasserin aut Le Hingrat, Quentin verfasserin aut Ruckly, Stéphane verfasserin aut Mazzuchelli, Timothy verfasserin aut Loiodice, Ambre verfasserin aut Trimboli, Pierpaolo verfasserin aut Forni Ogna, Valentina verfasserin aut de Montmollin, Etienne verfasserin aut Bernasconi, Enos verfasserin aut Visseaux, Benoit verfasserin aut Timsit, Jean-François verfasserin aut Enthalten in Critical care London : BioMed Central, 1997 24(2020), 1 vom: 16. Okt. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:24 year:2020 number:1 day:16 month:10 https://dx.doi.org/10.1186/s13054-020-03323-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 24 2020 1 16 10
allfieldsGer	10.1186/s13054-020-03323-5 doi (DE-627)SPR041370139 (SPR)s13054-020-03323-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Buetti, Niccolò verfasserin aut SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients. Methods We conducted a binational study merging prospectively collected data from two COVID-19 reference centers in France and Switzerland. First, we described the viral shedding duration (i.e., time to negativity) in LRT samples. Second, we analyzed viral load in LRT samples. Third, we assessed the association between viral presence in LRT and mortality using mixed-effect logistic models for clustered data adjusting for the time between symptoms’ onset and date of sampling. Results From March to May 2020, 267 LRT samples were performed in 90 patients from both centers. The median time to negativity was 29 (IQR 23; 34) days. Prolonged viral shedding was not associated with age, gender, cardiac comorbidities, diabetes, immunosuppression, corticosteroids use, or antiviral therapy. The LRT viral load tended to be higher in non-survivors. This difference was statistically significant after adjusting for the time interval between onset of symptoms and date of sampling (OR 3.78, 95% CI 1.13–12.64, p = 0.03). Conclusions The viral shedding in LRT lasted almost 30 days in median in critically ill patients, and the viral load in the LRT was associated with the 6-week mortality. SARS-CoV-2 (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Viral shedding (dpeaa)DE-He213 Viral load (dpeaa)DE-He213 Lower respiratory tract (dpeaa)DE-He213 ICU (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Wicky, Paul-Henri verfasserin aut Le Hingrat, Quentin verfasserin aut Ruckly, Stéphane verfasserin aut Mazzuchelli, Timothy verfasserin aut Loiodice, Ambre verfasserin aut Trimboli, Pierpaolo verfasserin aut Forni Ogna, Valentina verfasserin aut de Montmollin, Etienne verfasserin aut Bernasconi, Enos verfasserin aut Visseaux, Benoit verfasserin aut Timsit, Jean-François verfasserin aut Enthalten in Critical care London : BioMed Central, 1997 24(2020), 1 vom: 16. Okt. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:24 year:2020 number:1 day:16 month:10 https://dx.doi.org/10.1186/s13054-020-03323-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 24 2020 1 16 10
allfieldsSound	10.1186/s13054-020-03323-5 doi (DE-627)SPR041370139 (SPR)s13054-020-03323-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Buetti, Niccolò verfasserin aut SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients. Methods We conducted a binational study merging prospectively collected data from two COVID-19 reference centers in France and Switzerland. First, we described the viral shedding duration (i.e., time to negativity) in LRT samples. Second, we analyzed viral load in LRT samples. Third, we assessed the association between viral presence in LRT and mortality using mixed-effect logistic models for clustered data adjusting for the time between symptoms’ onset and date of sampling. Results From March to May 2020, 267 LRT samples were performed in 90 patients from both centers. The median time to negativity was 29 (IQR 23; 34) days. Prolonged viral shedding was not associated with age, gender, cardiac comorbidities, diabetes, immunosuppression, corticosteroids use, or antiviral therapy. The LRT viral load tended to be higher in non-survivors. This difference was statistically significant after adjusting for the time interval between onset of symptoms and date of sampling (OR 3.78, 95% CI 1.13–12.64, p = 0.03). Conclusions The viral shedding in LRT lasted almost 30 days in median in critically ill patients, and the viral load in the LRT was associated with the 6-week mortality. SARS-CoV-2 (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Viral shedding (dpeaa)DE-He213 Viral load (dpeaa)DE-He213 Lower respiratory tract (dpeaa)DE-He213 ICU (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Wicky, Paul-Henri verfasserin aut Le Hingrat, Quentin verfasserin aut Ruckly, Stéphane verfasserin aut Mazzuchelli, Timothy verfasserin aut Loiodice, Ambre verfasserin aut Trimboli, Pierpaolo verfasserin aut Forni Ogna, Valentina verfasserin aut de Montmollin, Etienne verfasserin aut Bernasconi, Enos verfasserin aut Visseaux, Benoit verfasserin aut Timsit, Jean-François verfasserin aut Enthalten in Critical care London : BioMed Central, 1997 24(2020), 1 vom: 16. Okt. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:24 year:2020 number:1 day:16 month:10 https://dx.doi.org/10.1186/s13054-020-03323-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 24 2020 1 16 10
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authorswithroles_txt_mv	Buetti, Niccolò @@aut@@ Wicky, Paul-Henri @@aut@@ Le Hingrat, Quentin @@aut@@ Ruckly, Stéphane @@aut@@ Mazzuchelli, Timothy @@aut@@ Loiodice, Ambre @@aut@@ Trimboli, Pierpaolo @@aut@@ Forni Ogna, Valentina @@aut@@ de Montmollin, Etienne @@aut@@ Bernasconi, Enos @@aut@@ Visseaux, Benoit @@aut@@ Timsit, Jean-François @@aut@@
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spellingShingle	Buetti, Niccolò ddc 610 bkl 44.00 misc SARS-CoV-2 misc COVID-19 misc Viral shedding misc Viral load misc Lower respiratory tract misc ICU misc Mortality SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients
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topic_title	610 ASE 44.00 bkl SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients SARS-CoV-2 (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Viral shedding (dpeaa)DE-He213 Viral load (dpeaa)DE-He213 Lower respiratory tract (dpeaa)DE-He213 ICU (dpeaa)DE-He213 Mortality (dpeaa)DE-He213
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title	SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients
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title_full	SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients
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author_browse	Buetti, Niccolò Wicky, Paul-Henri Le Hingrat, Quentin Ruckly, Stéphane Mazzuchelli, Timothy Loiodice, Ambre Trimboli, Pierpaolo Forni Ogna, Valentina de Montmollin, Etienne Bernasconi, Enos Visseaux, Benoit Timsit, Jean-François
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title_sort	sars-cov-2 detection in the lower respiratory tract of invasively ventilated ards patients
title_auth	SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients
abstract	Background Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients. Methods We conducted a binational study merging prospectively collected data from two COVID-19 reference centers in France and Switzerland. First, we described the viral shedding duration (i.e., time to negativity) in LRT samples. Second, we analyzed viral load in LRT samples. Third, we assessed the association between viral presence in LRT and mortality using mixed-effect logistic models for clustered data adjusting for the time between symptoms’ onset and date of sampling. Results From March to May 2020, 267 LRT samples were performed in 90 patients from both centers. The median time to negativity was 29 (IQR 23; 34) days. Prolonged viral shedding was not associated with age, gender, cardiac comorbidities, diabetes, immunosuppression, corticosteroids use, or antiviral therapy. The LRT viral load tended to be higher in non-survivors. This difference was statistically significant after adjusting for the time interval between onset of symptoms and date of sampling (OR 3.78, 95% CI 1.13–12.64, p = 0.03). Conclusions The viral shedding in LRT lasted almost 30 days in median in critically ill patients, and the viral load in the LRT was associated with the 6-week mortality.
abstractGer	Background Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients. Methods We conducted a binational study merging prospectively collected data from two COVID-19 reference centers in France and Switzerland. First, we described the viral shedding duration (i.e., time to negativity) in LRT samples. Second, we analyzed viral load in LRT samples. Third, we assessed the association between viral presence in LRT and mortality using mixed-effect logistic models for clustered data adjusting for the time between symptoms’ onset and date of sampling. Results From March to May 2020, 267 LRT samples were performed in 90 patients from both centers. The median time to negativity was 29 (IQR 23; 34) days. Prolonged viral shedding was not associated with age, gender, cardiac comorbidities, diabetes, immunosuppression, corticosteroids use, or antiviral therapy. The LRT viral load tended to be higher in non-survivors. This difference was statistically significant after adjusting for the time interval between onset of symptoms and date of sampling (OR 3.78, 95% CI 1.13–12.64, p = 0.03). Conclusions The viral shedding in LRT lasted almost 30 days in median in critically ill patients, and the viral load in the LRT was associated with the 6-week mortality.
abstract_unstemmed	Background Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients. Methods We conducted a binational study merging prospectively collected data from two COVID-19 reference centers in France and Switzerland. First, we described the viral shedding duration (i.e., time to negativity) in LRT samples. Second, we analyzed viral load in LRT samples. Third, we assessed the association between viral presence in LRT and mortality using mixed-effect logistic models for clustered data adjusting for the time between symptoms’ onset and date of sampling. Results From March to May 2020, 267 LRT samples were performed in 90 patients from both centers. The median time to negativity was 29 (IQR 23; 34) days. Prolonged viral shedding was not associated with age, gender, cardiac comorbidities, diabetes, immunosuppression, corticosteroids use, or antiviral therapy. The LRT viral load tended to be higher in non-survivors. This difference was statistically significant after adjusting for the time interval between onset of symptoms and date of sampling (OR 3.78, 95% CI 1.13–12.64, p = 0.03). Conclusions The viral shedding in LRT lasted almost 30 days in median in critically ill patients, and the viral load in the LRT was associated with the 6-week mortality.
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title_short	SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients
url	https://dx.doi.org/10.1186/s13054-020-03323-5
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author2	Wicky, Paul-Henri Le Hingrat, Quentin Ruckly, Stéphane Mazzuchelli, Timothy Loiodice, Ambre Trimboli, Pierpaolo Forni Ogna, Valentina de Montmollin, Etienne Bernasconi, Enos Visseaux, Benoit Timsit, Jean-François
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Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients. Methods We conducted a binational study merging prospectively collected data from two COVID-19 reference centers in France and Switzerland. First, we described the viral shedding duration (i.e., time to negativity) in LRT samples. Second, we analyzed viral load in LRT samples. Third, we assessed the association between viral presence in LRT and mortality using mixed-effect logistic models for clustered data adjusting for the time between symptoms’ onset and date of sampling. Results From March to May 2020, 267 LRT samples were performed in 90 patients from both centers. The median time to negativity was 29 (IQR 23; 34) days. Prolonged viral shedding was not associated with age, gender, cardiac comorbidities, diabetes, immunosuppression, corticosteroids use, or antiviral therapy. The LRT viral load tended to be higher in non-survivors. This difference was statistically significant after adjusting for the time interval between onset of symptoms and date of sampling (OR 3.78, 95% CI 1.13–12.64, p = 0.03). 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SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients

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