Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy

Background Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by deteriorated exocrine gland function with associated lymphocytic infiltration. However, there are few pathological studies on bronchial glands in SS. In this study, we aimed to clarify pathological features of bronc...
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Autor*in:	Okabayashi, Hiroko [verfasserIn] Baba, Tomohisa [verfasserIn] Ootoshi, Ryota [verfasserIn] Shintani, Ryota [verfasserIn] Tabata, Erina [verfasserIn] Ikeda, Satoshi [verfasserIn] Niwa, Takashi [verfasserIn] Oda, Tsuneyuki [verfasserIn] Okuda, Ryo [verfasserIn] Sekine, Akimasa [verfasserIn] Kitamura, Hideya [verfasserIn] Komatsu, Shigeru [verfasserIn] Hagiwara, Eri [verfasserIn] Takemura, Tamiko [verfasserIn] Sakagami, Takuro [verfasserIn] Ogura, Takashi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Sjögren’s syndrome Bronchial gland Lymphocytic infiltration Transbronchial lung cryobiopsy

Übergeordnetes Werk:	Enthalten in: BMC pulmonary medicine - London : BioMed Central, 2001, 20(2020), 1 vom: 23. Okt.
Übergeordnetes Werk:	volume:20 ; year:2020 ; number:1 ; day:23 ; month:10

Links:	Volltext

DOI / URN:	10.1186/s12890-020-01318-0

Katalog-ID:	SPR041583558

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520			\|a Background Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by deteriorated exocrine gland function with associated lymphocytic infiltration. However, there are few pathological studies on bronchial glands in SS. In this study, we aimed to clarify pathological features of bronchial glands in SS. Methods We retrospectively evaluated infiltration of lymphocytes in the bronchial glands incidentally collected by transbronchial lung cryobiopsy (TBLC), which were performed for the diagnosis of diffuse lung diseases. The degrees of lymphocyte infiltration in the bronchial glands were classified into four grades (grade 0–3). We compared the degrees of infiltration of SS with those of other diffuse lung diseases. Results TBLC for diagnosis of diffuse lung diseases were performed on 432 cases during the study period. The samples of 50 cases included bronchial glands. Of those, 20 cases were excluded due to insufficient size or influence of therapy. The remaining 30 cases included 17 of idiopathic interstitial pneumonias, 5 of chronic hypersensitivity pneumonia, 6 of connective tissue disease (SS; n = 4, systemic sclerosis; n = 1, dermatomyositis; n = 1) and 2 of other diseases. In SS, infiltration of lymphocytes was observed in all cases; grade 1 in one, grade 2 in one, and grade 3 in two cases. In contrast, 11 of 26 in other diseases showed no lymphocytes infiltration, with the remaining 15 of grade 1 infiltration. Grade 2 or more infiltration were found only in SS but not in other diseases. Conclusion Our results suggested that high-grade lymphocytic infiltration of bronchial glands is a distinct characteristics in SS.
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allfields	10.1186/s12890-020-01318-0 doi (DE-627)SPR041583558 (SPR)s12890-020-01318-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Okabayashi, Hiroko verfasserin aut Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by deteriorated exocrine gland function with associated lymphocytic infiltration. However, there are few pathological studies on bronchial glands in SS. In this study, we aimed to clarify pathological features of bronchial glands in SS. Methods We retrospectively evaluated infiltration of lymphocytes in the bronchial glands incidentally collected by transbronchial lung cryobiopsy (TBLC), which were performed for the diagnosis of diffuse lung diseases. The degrees of lymphocyte infiltration in the bronchial glands were classified into four grades (grade 0–3). We compared the degrees of infiltration of SS with those of other diffuse lung diseases. Results TBLC for diagnosis of diffuse lung diseases were performed on 432 cases during the study period. The samples of 50 cases included bronchial glands. Of those, 20 cases were excluded due to insufficient size or influence of therapy. The remaining 30 cases included 17 of idiopathic interstitial pneumonias, 5 of chronic hypersensitivity pneumonia, 6 of connective tissue disease (SS; n = 4, systemic sclerosis; n = 1, dermatomyositis; n = 1) and 2 of other diseases. In SS, infiltration of lymphocytes was observed in all cases; grade 1 in one, grade 2 in one, and grade 3 in two cases. In contrast, 11 of 26 in other diseases showed no lymphocytes infiltration, with the remaining 15 of grade 1 infiltration. Grade 2 or more infiltration were found only in SS but not in other diseases. Conclusion Our results suggested that high-grade lymphocytic infiltration of bronchial glands is a distinct characteristics in SS. Sjögren’s syndrome (dpeaa)DE-He213 Bronchial gland (dpeaa)DE-He213 Lymphocytic infiltration (dpeaa)DE-He213 Transbronchial lung cryobiopsy (dpeaa)DE-He213 Baba, Tomohisa verfasserin aut Ootoshi, Ryota verfasserin aut Shintani, Ryota verfasserin aut Tabata, Erina verfasserin aut Ikeda, Satoshi verfasserin aut Niwa, Takashi verfasserin aut Oda, Tsuneyuki verfasserin aut Okuda, Ryo verfasserin aut Sekine, Akimasa verfasserin aut Kitamura, Hideya verfasserin aut Komatsu, Shigeru verfasserin aut Hagiwara, Eri verfasserin aut Takemura, Tamiko verfasserin aut Sakagami, Takuro verfasserin aut Ogura, Takashi verfasserin aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 20(2020), 1 vom: 23. Okt. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:20 year:2020 number:1 day:23 month:10 https://dx.doi.org/10.1186/s12890-020-01318-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 23 10
spelling	10.1186/s12890-020-01318-0 doi (DE-627)SPR041583558 (SPR)s12890-020-01318-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Okabayashi, Hiroko verfasserin aut Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by deteriorated exocrine gland function with associated lymphocytic infiltration. However, there are few pathological studies on bronchial glands in SS. In this study, we aimed to clarify pathological features of bronchial glands in SS. Methods We retrospectively evaluated infiltration of lymphocytes in the bronchial glands incidentally collected by transbronchial lung cryobiopsy (TBLC), which were performed for the diagnosis of diffuse lung diseases. The degrees of lymphocyte infiltration in the bronchial glands were classified into four grades (grade 0–3). We compared the degrees of infiltration of SS with those of other diffuse lung diseases. Results TBLC for diagnosis of diffuse lung diseases were performed on 432 cases during the study period. The samples of 50 cases included bronchial glands. Of those, 20 cases were excluded due to insufficient size or influence of therapy. The remaining 30 cases included 17 of idiopathic interstitial pneumonias, 5 of chronic hypersensitivity pneumonia, 6 of connective tissue disease (SS; n = 4, systemic sclerosis; n = 1, dermatomyositis; n = 1) and 2 of other diseases. In SS, infiltration of lymphocytes was observed in all cases; grade 1 in one, grade 2 in one, and grade 3 in two cases. In contrast, 11 of 26 in other diseases showed no lymphocytes infiltration, with the remaining 15 of grade 1 infiltration. Grade 2 or more infiltration were found only in SS but not in other diseases. Conclusion Our results suggested that high-grade lymphocytic infiltration of bronchial glands is a distinct characteristics in SS. Sjögren’s syndrome (dpeaa)DE-He213 Bronchial gland (dpeaa)DE-He213 Lymphocytic infiltration (dpeaa)DE-He213 Transbronchial lung cryobiopsy (dpeaa)DE-He213 Baba, Tomohisa verfasserin aut Ootoshi, Ryota verfasserin aut Shintani, Ryota verfasserin aut Tabata, Erina verfasserin aut Ikeda, Satoshi verfasserin aut Niwa, Takashi verfasserin aut Oda, Tsuneyuki verfasserin aut Okuda, Ryo verfasserin aut Sekine, Akimasa verfasserin aut Kitamura, Hideya verfasserin aut Komatsu, Shigeru verfasserin aut Hagiwara, Eri verfasserin aut Takemura, Tamiko verfasserin aut Sakagami, Takuro verfasserin aut Ogura, Takashi verfasserin aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 20(2020), 1 vom: 23. Okt. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:20 year:2020 number:1 day:23 month:10 https://dx.doi.org/10.1186/s12890-020-01318-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 23 10
allfields_unstemmed	10.1186/s12890-020-01318-0 doi (DE-627)SPR041583558 (SPR)s12890-020-01318-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Okabayashi, Hiroko verfasserin aut Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by deteriorated exocrine gland function with associated lymphocytic infiltration. However, there are few pathological studies on bronchial glands in SS. In this study, we aimed to clarify pathological features of bronchial glands in SS. Methods We retrospectively evaluated infiltration of lymphocytes in the bronchial glands incidentally collected by transbronchial lung cryobiopsy (TBLC), which were performed for the diagnosis of diffuse lung diseases. The degrees of lymphocyte infiltration in the bronchial glands were classified into four grades (grade 0–3). We compared the degrees of infiltration of SS with those of other diffuse lung diseases. Results TBLC for diagnosis of diffuse lung diseases were performed on 432 cases during the study period. The samples of 50 cases included bronchial glands. Of those, 20 cases were excluded due to insufficient size or influence of therapy. The remaining 30 cases included 17 of idiopathic interstitial pneumonias, 5 of chronic hypersensitivity pneumonia, 6 of connective tissue disease (SS; n = 4, systemic sclerosis; n = 1, dermatomyositis; n = 1) and 2 of other diseases. In SS, infiltration of lymphocytes was observed in all cases; grade 1 in one, grade 2 in one, and grade 3 in two cases. In contrast, 11 of 26 in other diseases showed no lymphocytes infiltration, with the remaining 15 of grade 1 infiltration. Grade 2 or more infiltration were found only in SS but not in other diseases. Conclusion Our results suggested that high-grade lymphocytic infiltration of bronchial glands is a distinct characteristics in SS. Sjögren’s syndrome (dpeaa)DE-He213 Bronchial gland (dpeaa)DE-He213 Lymphocytic infiltration (dpeaa)DE-He213 Transbronchial lung cryobiopsy (dpeaa)DE-He213 Baba, Tomohisa verfasserin aut Ootoshi, Ryota verfasserin aut Shintani, Ryota verfasserin aut Tabata, Erina verfasserin aut Ikeda, Satoshi verfasserin aut Niwa, Takashi verfasserin aut Oda, Tsuneyuki verfasserin aut Okuda, Ryo verfasserin aut Sekine, Akimasa verfasserin aut Kitamura, Hideya verfasserin aut Komatsu, Shigeru verfasserin aut Hagiwara, Eri verfasserin aut Takemura, Tamiko verfasserin aut Sakagami, Takuro verfasserin aut Ogura, Takashi verfasserin aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 20(2020), 1 vom: 23. Okt. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:20 year:2020 number:1 day:23 month:10 https://dx.doi.org/10.1186/s12890-020-01318-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 23 10
allfieldsGer	10.1186/s12890-020-01318-0 doi (DE-627)SPR041583558 (SPR)s12890-020-01318-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Okabayashi, Hiroko verfasserin aut Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by deteriorated exocrine gland function with associated lymphocytic infiltration. However, there are few pathological studies on bronchial glands in SS. In this study, we aimed to clarify pathological features of bronchial glands in SS. Methods We retrospectively evaluated infiltration of lymphocytes in the bronchial glands incidentally collected by transbronchial lung cryobiopsy (TBLC), which were performed for the diagnosis of diffuse lung diseases. The degrees of lymphocyte infiltration in the bronchial glands were classified into four grades (grade 0–3). We compared the degrees of infiltration of SS with those of other diffuse lung diseases. Results TBLC for diagnosis of diffuse lung diseases were performed on 432 cases during the study period. The samples of 50 cases included bronchial glands. Of those, 20 cases were excluded due to insufficient size or influence of therapy. The remaining 30 cases included 17 of idiopathic interstitial pneumonias, 5 of chronic hypersensitivity pneumonia, 6 of connective tissue disease (SS; n = 4, systemic sclerosis; n = 1, dermatomyositis; n = 1) and 2 of other diseases. In SS, infiltration of lymphocytes was observed in all cases; grade 1 in one, grade 2 in one, and grade 3 in two cases. In contrast, 11 of 26 in other diseases showed no lymphocytes infiltration, with the remaining 15 of grade 1 infiltration. Grade 2 or more infiltration were found only in SS but not in other diseases. Conclusion Our results suggested that high-grade lymphocytic infiltration of bronchial glands is a distinct characteristics in SS. Sjögren’s syndrome (dpeaa)DE-He213 Bronchial gland (dpeaa)DE-He213 Lymphocytic infiltration (dpeaa)DE-He213 Transbronchial lung cryobiopsy (dpeaa)DE-He213 Baba, Tomohisa verfasserin aut Ootoshi, Ryota verfasserin aut Shintani, Ryota verfasserin aut Tabata, Erina verfasserin aut Ikeda, Satoshi verfasserin aut Niwa, Takashi verfasserin aut Oda, Tsuneyuki verfasserin aut Okuda, Ryo verfasserin aut Sekine, Akimasa verfasserin aut Kitamura, Hideya verfasserin aut Komatsu, Shigeru verfasserin aut Hagiwara, Eri verfasserin aut Takemura, Tamiko verfasserin aut Sakagami, Takuro verfasserin aut Ogura, Takashi verfasserin aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 20(2020), 1 vom: 23. Okt. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:20 year:2020 number:1 day:23 month:10 https://dx.doi.org/10.1186/s12890-020-01318-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 23 10
allfieldsSound	10.1186/s12890-020-01318-0 doi (DE-627)SPR041583558 (SPR)s12890-020-01318-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Okabayashi, Hiroko verfasserin aut Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by deteriorated exocrine gland function with associated lymphocytic infiltration. However, there are few pathological studies on bronchial glands in SS. In this study, we aimed to clarify pathological features of bronchial glands in SS. Methods We retrospectively evaluated infiltration of lymphocytes in the bronchial glands incidentally collected by transbronchial lung cryobiopsy (TBLC), which were performed for the diagnosis of diffuse lung diseases. The degrees of lymphocyte infiltration in the bronchial glands were classified into four grades (grade 0–3). We compared the degrees of infiltration of SS with those of other diffuse lung diseases. Results TBLC for diagnosis of diffuse lung diseases were performed on 432 cases during the study period. The samples of 50 cases included bronchial glands. Of those, 20 cases were excluded due to insufficient size or influence of therapy. The remaining 30 cases included 17 of idiopathic interstitial pneumonias, 5 of chronic hypersensitivity pneumonia, 6 of connective tissue disease (SS; n = 4, systemic sclerosis; n = 1, dermatomyositis; n = 1) and 2 of other diseases. In SS, infiltration of lymphocytes was observed in all cases; grade 1 in one, grade 2 in one, and grade 3 in two cases. In contrast, 11 of 26 in other diseases showed no lymphocytes infiltration, with the remaining 15 of grade 1 infiltration. Grade 2 or more infiltration were found only in SS but not in other diseases. Conclusion Our results suggested that high-grade lymphocytic infiltration of bronchial glands is a distinct characteristics in SS. Sjögren’s syndrome (dpeaa)DE-He213 Bronchial gland (dpeaa)DE-He213 Lymphocytic infiltration (dpeaa)DE-He213 Transbronchial lung cryobiopsy (dpeaa)DE-He213 Baba, Tomohisa verfasserin aut Ootoshi, Ryota verfasserin aut Shintani, Ryota verfasserin aut Tabata, Erina verfasserin aut Ikeda, Satoshi verfasserin aut Niwa, Takashi verfasserin aut Oda, Tsuneyuki verfasserin aut Okuda, Ryo verfasserin aut Sekine, Akimasa verfasserin aut Kitamura, Hideya verfasserin aut Komatsu, Shigeru verfasserin aut Hagiwara, Eri verfasserin aut Takemura, Tamiko verfasserin aut Sakagami, Takuro verfasserin aut Ogura, Takashi verfasserin aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 20(2020), 1 vom: 23. Okt. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:20 year:2020 number:1 day:23 month:10 https://dx.doi.org/10.1186/s12890-020-01318-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 23 10
language	English
source	Enthalten in BMC pulmonary medicine 20(2020), 1 vom: 23. Okt. volume:20 year:2020 number:1 day:23 month:10
sourceStr	Enthalten in BMC pulmonary medicine 20(2020), 1 vom: 23. Okt. volume:20 year:2020 number:1 day:23 month:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Sjögren’s syndrome Bronchial gland Lymphocytic infiltration Transbronchial lung cryobiopsy
dewey-raw	610
isfreeaccess_bool	true
container_title	BMC pulmonary medicine
authorswithroles_txt_mv	Okabayashi, Hiroko @@aut@@ Baba, Tomohisa @@aut@@ Ootoshi, Ryota @@aut@@ Shintani, Ryota @@aut@@ Tabata, Erina @@aut@@ Ikeda, Satoshi @@aut@@ Niwa, Takashi @@aut@@ Oda, Tsuneyuki @@aut@@ Okuda, Ryo @@aut@@ Sekine, Akimasa @@aut@@ Kitamura, Hideya @@aut@@ Komatsu, Shigeru @@aut@@ Hagiwara, Eri @@aut@@ Takemura, Tamiko @@aut@@ Sakagami, Takuro @@aut@@ Ogura, Takashi @@aut@@
publishDateDaySort_date	2020-10-23T00:00:00Z
hierarchy_top_id	335489125
dewey-sort	3610
id	SPR041583558
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR041583558</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520011902.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201102s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12890-020-01318-0</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR041583558</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12890-020-01318-0-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Okabayashi, Hiroko</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by deteriorated exocrine gland function with associated lymphocytic infiltration. However, there are few pathological studies on bronchial glands in SS. In this study, we aimed to clarify pathological features of bronchial glands in SS. Methods We retrospectively evaluated infiltration of lymphocytes in the bronchial glands incidentally collected by transbronchial lung cryobiopsy (TBLC), which were performed for the diagnosis of diffuse lung diseases. The degrees of lymphocyte infiltration in the bronchial glands were classified into four grades (grade 0–3). We compared the degrees of infiltration of SS with those of other diffuse lung diseases. Results TBLC for diagnosis of diffuse lung diseases were performed on 432 cases during the study period. The samples of 50 cases included bronchial glands. Of those, 20 cases were excluded due to insufficient size or influence of therapy. The remaining 30 cases included 17 of idiopathic interstitial pneumonias, 5 of chronic hypersensitivity pneumonia, 6 of connective tissue disease (SS; n = 4, systemic sclerosis; n = 1, dermatomyositis; n = 1) and 2 of other diseases. In SS, infiltration of lymphocytes was observed in all cases; grade 1 in one, grade 2 in one, and grade 3 in two cases. In contrast, 11 of 26 in other diseases showed no lymphocytes infiltration, with the remaining 15 of grade 1 infiltration. Grade 2 or more infiltration were found only in SS but not in other diseases. 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author	Okabayashi, Hiroko
spellingShingle	Okabayashi, Hiroko ddc 610 bkl 44.00 misc Sjögren’s syndrome misc Bronchial gland misc Lymphocytic infiltration misc Transbronchial lung cryobiopsy Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy
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topic_title	610 ASE 44.00 bkl Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy Sjögren’s syndrome (dpeaa)DE-He213 Bronchial gland (dpeaa)DE-He213 Lymphocytic infiltration (dpeaa)DE-He213 Transbronchial lung cryobiopsy (dpeaa)DE-He213
topic	ddc 610 bkl 44.00 misc Sjögren’s syndrome misc Bronchial gland misc Lymphocytic infiltration misc Transbronchial lung cryobiopsy
topic_unstemmed	ddc 610 bkl 44.00 misc Sjögren’s syndrome misc Bronchial gland misc Lymphocytic infiltration misc Transbronchial lung cryobiopsy
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title	Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy
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title_full	Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy
author_sort	Okabayashi, Hiroko
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author_browse	Okabayashi, Hiroko Baba, Tomohisa Ootoshi, Ryota Shintani, Ryota Tabata, Erina Ikeda, Satoshi Niwa, Takashi Oda, Tsuneyuki Okuda, Ryo Sekine, Akimasa Kitamura, Hideya Komatsu, Shigeru Hagiwara, Eri Takemura, Tamiko Sakagami, Takuro Ogura, Takashi
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author-letter	Okabayashi, Hiroko
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author2-role	verfasserin
title_sort	evaluation of lymphocytic infiltration in the bronchial glands of sjögren’s syndrome in transbronchial lung cryobiopsy
title_auth	Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy
abstract	Background Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by deteriorated exocrine gland function with associated lymphocytic infiltration. However, there are few pathological studies on bronchial glands in SS. In this study, we aimed to clarify pathological features of bronchial glands in SS. Methods We retrospectively evaluated infiltration of lymphocytes in the bronchial glands incidentally collected by transbronchial lung cryobiopsy (TBLC), which were performed for the diagnosis of diffuse lung diseases. The degrees of lymphocyte infiltration in the bronchial glands were classified into four grades (grade 0–3). We compared the degrees of infiltration of SS with those of other diffuse lung diseases. Results TBLC for diagnosis of diffuse lung diseases were performed on 432 cases during the study period. The samples of 50 cases included bronchial glands. Of those, 20 cases were excluded due to insufficient size or influence of therapy. The remaining 30 cases included 17 of idiopathic interstitial pneumonias, 5 of chronic hypersensitivity pneumonia, 6 of connective tissue disease (SS; n = 4, systemic sclerosis; n = 1, dermatomyositis; n = 1) and 2 of other diseases. In SS, infiltration of lymphocytes was observed in all cases; grade 1 in one, grade 2 in one, and grade 3 in two cases. In contrast, 11 of 26 in other diseases showed no lymphocytes infiltration, with the remaining 15 of grade 1 infiltration. Grade 2 or more infiltration were found only in SS but not in other diseases. Conclusion Our results suggested that high-grade lymphocytic infiltration of bronchial glands is a distinct characteristics in SS.
abstractGer	Background Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by deteriorated exocrine gland function with associated lymphocytic infiltration. However, there are few pathological studies on bronchial glands in SS. In this study, we aimed to clarify pathological features of bronchial glands in SS. Methods We retrospectively evaluated infiltration of lymphocytes in the bronchial glands incidentally collected by transbronchial lung cryobiopsy (TBLC), which were performed for the diagnosis of diffuse lung diseases. The degrees of lymphocyte infiltration in the bronchial glands were classified into four grades (grade 0–3). We compared the degrees of infiltration of SS with those of other diffuse lung diseases. Results TBLC for diagnosis of diffuse lung diseases were performed on 432 cases during the study period. The samples of 50 cases included bronchial glands. Of those, 20 cases were excluded due to insufficient size or influence of therapy. The remaining 30 cases included 17 of idiopathic interstitial pneumonias, 5 of chronic hypersensitivity pneumonia, 6 of connective tissue disease (SS; n = 4, systemic sclerosis; n = 1, dermatomyositis; n = 1) and 2 of other diseases. In SS, infiltration of lymphocytes was observed in all cases; grade 1 in one, grade 2 in one, and grade 3 in two cases. In contrast, 11 of 26 in other diseases showed no lymphocytes infiltration, with the remaining 15 of grade 1 infiltration. Grade 2 or more infiltration were found only in SS but not in other diseases. Conclusion Our results suggested that high-grade lymphocytic infiltration of bronchial glands is a distinct characteristics in SS.
abstract_unstemmed	Background Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by deteriorated exocrine gland function with associated lymphocytic infiltration. However, there are few pathological studies on bronchial glands in SS. In this study, we aimed to clarify pathological features of bronchial glands in SS. Methods We retrospectively evaluated infiltration of lymphocytes in the bronchial glands incidentally collected by transbronchial lung cryobiopsy (TBLC), which were performed for the diagnosis of diffuse lung diseases. The degrees of lymphocyte infiltration in the bronchial glands were classified into four grades (grade 0–3). We compared the degrees of infiltration of SS with those of other diffuse lung diseases. Results TBLC for diagnosis of diffuse lung diseases were performed on 432 cases during the study period. The samples of 50 cases included bronchial glands. Of those, 20 cases were excluded due to insufficient size or influence of therapy. The remaining 30 cases included 17 of idiopathic interstitial pneumonias, 5 of chronic hypersensitivity pneumonia, 6 of connective tissue disease (SS; n = 4, systemic sclerosis; n = 1, dermatomyositis; n = 1) and 2 of other diseases. In SS, infiltration of lymphocytes was observed in all cases; grade 1 in one, grade 2 in one, and grade 3 in two cases. In contrast, 11 of 26 in other diseases showed no lymphocytes infiltration, with the remaining 15 of grade 1 infiltration. Grade 2 or more infiltration were found only in SS but not in other diseases. Conclusion Our results suggested that high-grade lymphocytic infiltration of bronchial glands is a distinct characteristics in SS.
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title_short	Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy
url	https://dx.doi.org/10.1186/s12890-020-01318-0
remote_bool	true
author2	Baba, Tomohisa Ootoshi, Ryota Shintani, Ryota Tabata, Erina Ikeda, Satoshi Niwa, Takashi Oda, Tsuneyuki Okuda, Ryo Sekine, Akimasa Kitamura, Hideya Komatsu, Shigeru Hagiwara, Eri Takemura, Tamiko Sakagami, Takuro Ogura, Takashi
author2Str	Baba, Tomohisa Ootoshi, Ryota Shintani, Ryota Tabata, Erina Ikeda, Satoshi Niwa, Takashi Oda, Tsuneyuki Okuda, Ryo Sekine, Akimasa Kitamura, Hideya Komatsu, Shigeru Hagiwara, Eri Takemura, Tamiko Sakagami, Takuro Ogura, Takashi
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up_date	2024-07-03T22:44:33.640Z
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Evaluation of lymphocytic infiltration in the bronchial glands of Sjögren’s syndrome in transbronchial lung cryobiopsy

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