Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression

Objectives Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian cancer, EOC. Our study aimed to address this issue. Methods We first examine KBTBD...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Du, Lei [verfasserIn] Li, Cong-Rong [verfasserIn] He, Qi-Feng [verfasserIn] Li, Xiao-Hua [verfasserIn] Yang, Lin-Fei [verfasserIn] Zou, Yuan [verfasserIn] Yang, Zhi-Xia [verfasserIn] Zhang, Dong [verfasserIn] Xing, Xiao-Wei [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	KBTBD8 Ubiquitin ligase Epithelial ovarian cancer Female fertility factor

Übergeordnetes Werk:	Enthalten in: Molecular medicine - [London] : BioMed Central, 1994, 26(2020), 1 vom: 27. Okt.
Übergeordnetes Werk:	volume:26 ; year:2020 ; number:1 ; day:27 ; month:10

Links:	Volltext

DOI / URN:	10.1186/s10020-020-00226-7

Katalog-ID:	SPR041639316

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520			\|a Objectives Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian cancer, EOC. Our study aimed to address this issue. Methods We first examine KBTBD8 expression in EOC tissues and cells. Next, we performed RNA sequencing to reveal the overall mechanism. Then we investigated the roles of KBTBD8 in the proliferation, migration, and health status of cultured EOC cells. Finally, we employed tumor xenograft models to evaluate the role of KBTBD8 in vivo. Results First, KBTBD8 level was significantly higher in EOC tissues and cells. Next, comparative RNA sequencing identified more tumorigenesis-related genes that KBTBD8 might regulate. Then we found that KBTBD8 knockdown significantly decreased EOC cell proliferation, migration, and the activities of multiple tumorigenesis-related kinases. Finally, KBTBD8 knockdown significantly diminished ovarian tumor formation in vivo. Conclusion Proper KBTBD8 level is essential for the healthy growth of ovarian somatic cells, such as ovarian epithelial cells. Excessive KBTBD8 might be a significant impetus for EOC progression. KBTBD8 reduction greatly inhibits EOC proliferation and migration.
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allfields	10.1186/s10020-020-00226-7 doi (DE-627)SPR041639316 (SPR)s10020-020-00226-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.00 bkl Du, Lei verfasserin aut Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian cancer, EOC. Our study aimed to address this issue. Methods We first examine KBTBD8 expression in EOC tissues and cells. Next, we performed RNA sequencing to reveal the overall mechanism. Then we investigated the roles of KBTBD8 in the proliferation, migration, and health status of cultured EOC cells. Finally, we employed tumor xenograft models to evaluate the role of KBTBD8 in vivo. Results First, KBTBD8 level was significantly higher in EOC tissues and cells. Next, comparative RNA sequencing identified more tumorigenesis-related genes that KBTBD8 might regulate. Then we found that KBTBD8 knockdown significantly decreased EOC cell proliferation, migration, and the activities of multiple tumorigenesis-related kinases. Finally, KBTBD8 knockdown significantly diminished ovarian tumor formation in vivo. Conclusion Proper KBTBD8 level is essential for the healthy growth of ovarian somatic cells, such as ovarian epithelial cells. Excessive KBTBD8 might be a significant impetus for EOC progression. KBTBD8 reduction greatly inhibits EOC proliferation and migration. KBTBD8 (dpeaa)DE-He213 Ubiquitin ligase (dpeaa)DE-He213 Epithelial ovarian cancer (dpeaa)DE-He213 Female fertility factor (dpeaa)DE-He213 Li, Cong-Rong verfasserin aut He, Qi-Feng verfasserin aut Li, Xiao-Hua verfasserin aut Yang, Lin-Fei verfasserin aut Zou, Yuan verfasserin aut Yang, Zhi-Xia verfasserin aut Zhang, Dong verfasserin aut Xing, Xiao-Wei verfasserin aut Enthalten in Molecular medicine [London] : BioMed Central, 1994 26(2020), 1 vom: 27. Okt. (DE-627)269539611 (DE-600)1475577-4 1528-3658 nnns volume:26 year:2020 number:1 day:27 month:10 https://dx.doi.org/10.1186/s10020-020-00226-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 26 2020 1 27 10
spelling	10.1186/s10020-020-00226-7 doi (DE-627)SPR041639316 (SPR)s10020-020-00226-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.00 bkl Du, Lei verfasserin aut Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian cancer, EOC. Our study aimed to address this issue. Methods We first examine KBTBD8 expression in EOC tissues and cells. Next, we performed RNA sequencing to reveal the overall mechanism. Then we investigated the roles of KBTBD8 in the proliferation, migration, and health status of cultured EOC cells. Finally, we employed tumor xenograft models to evaluate the role of KBTBD8 in vivo. Results First, KBTBD8 level was significantly higher in EOC tissues and cells. Next, comparative RNA sequencing identified more tumorigenesis-related genes that KBTBD8 might regulate. Then we found that KBTBD8 knockdown significantly decreased EOC cell proliferation, migration, and the activities of multiple tumorigenesis-related kinases. Finally, KBTBD8 knockdown significantly diminished ovarian tumor formation in vivo. Conclusion Proper KBTBD8 level is essential for the healthy growth of ovarian somatic cells, such as ovarian epithelial cells. Excessive KBTBD8 might be a significant impetus for EOC progression. KBTBD8 reduction greatly inhibits EOC proliferation and migration. KBTBD8 (dpeaa)DE-He213 Ubiquitin ligase (dpeaa)DE-He213 Epithelial ovarian cancer (dpeaa)DE-He213 Female fertility factor (dpeaa)DE-He213 Li, Cong-Rong verfasserin aut He, Qi-Feng verfasserin aut Li, Xiao-Hua verfasserin aut Yang, Lin-Fei verfasserin aut Zou, Yuan verfasserin aut Yang, Zhi-Xia verfasserin aut Zhang, Dong verfasserin aut Xing, Xiao-Wei verfasserin aut Enthalten in Molecular medicine [London] : BioMed Central, 1994 26(2020), 1 vom: 27. Okt. (DE-627)269539611 (DE-600)1475577-4 1528-3658 nnns volume:26 year:2020 number:1 day:27 month:10 https://dx.doi.org/10.1186/s10020-020-00226-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 26 2020 1 27 10
allfields_unstemmed	10.1186/s10020-020-00226-7 doi (DE-627)SPR041639316 (SPR)s10020-020-00226-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.00 bkl Du, Lei verfasserin aut Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian cancer, EOC. Our study aimed to address this issue. Methods We first examine KBTBD8 expression in EOC tissues and cells. Next, we performed RNA sequencing to reveal the overall mechanism. Then we investigated the roles of KBTBD8 in the proliferation, migration, and health status of cultured EOC cells. Finally, we employed tumor xenograft models to evaluate the role of KBTBD8 in vivo. Results First, KBTBD8 level was significantly higher in EOC tissues and cells. Next, comparative RNA sequencing identified more tumorigenesis-related genes that KBTBD8 might regulate. Then we found that KBTBD8 knockdown significantly decreased EOC cell proliferation, migration, and the activities of multiple tumorigenesis-related kinases. Finally, KBTBD8 knockdown significantly diminished ovarian tumor formation in vivo. Conclusion Proper KBTBD8 level is essential for the healthy growth of ovarian somatic cells, such as ovarian epithelial cells. Excessive KBTBD8 might be a significant impetus for EOC progression. KBTBD8 reduction greatly inhibits EOC proliferation and migration. KBTBD8 (dpeaa)DE-He213 Ubiquitin ligase (dpeaa)DE-He213 Epithelial ovarian cancer (dpeaa)DE-He213 Female fertility factor (dpeaa)DE-He213 Li, Cong-Rong verfasserin aut He, Qi-Feng verfasserin aut Li, Xiao-Hua verfasserin aut Yang, Lin-Fei verfasserin aut Zou, Yuan verfasserin aut Yang, Zhi-Xia verfasserin aut Zhang, Dong verfasserin aut Xing, Xiao-Wei verfasserin aut Enthalten in Molecular medicine [London] : BioMed Central, 1994 26(2020), 1 vom: 27. Okt. (DE-627)269539611 (DE-600)1475577-4 1528-3658 nnns volume:26 year:2020 number:1 day:27 month:10 https://dx.doi.org/10.1186/s10020-020-00226-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 26 2020 1 27 10
allfieldsGer	10.1186/s10020-020-00226-7 doi (DE-627)SPR041639316 (SPR)s10020-020-00226-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.00 bkl Du, Lei verfasserin aut Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian cancer, EOC. Our study aimed to address this issue. Methods We first examine KBTBD8 expression in EOC tissues and cells. Next, we performed RNA sequencing to reveal the overall mechanism. Then we investigated the roles of KBTBD8 in the proliferation, migration, and health status of cultured EOC cells. Finally, we employed tumor xenograft models to evaluate the role of KBTBD8 in vivo. Results First, KBTBD8 level was significantly higher in EOC tissues and cells. Next, comparative RNA sequencing identified more tumorigenesis-related genes that KBTBD8 might regulate. Then we found that KBTBD8 knockdown significantly decreased EOC cell proliferation, migration, and the activities of multiple tumorigenesis-related kinases. Finally, KBTBD8 knockdown significantly diminished ovarian tumor formation in vivo. Conclusion Proper KBTBD8 level is essential for the healthy growth of ovarian somatic cells, such as ovarian epithelial cells. Excessive KBTBD8 might be a significant impetus for EOC progression. KBTBD8 reduction greatly inhibits EOC proliferation and migration. KBTBD8 (dpeaa)DE-He213 Ubiquitin ligase (dpeaa)DE-He213 Epithelial ovarian cancer (dpeaa)DE-He213 Female fertility factor (dpeaa)DE-He213 Li, Cong-Rong verfasserin aut He, Qi-Feng verfasserin aut Li, Xiao-Hua verfasserin aut Yang, Lin-Fei verfasserin aut Zou, Yuan verfasserin aut Yang, Zhi-Xia verfasserin aut Zhang, Dong verfasserin aut Xing, Xiao-Wei verfasserin aut Enthalten in Molecular medicine [London] : BioMed Central, 1994 26(2020), 1 vom: 27. Okt. (DE-627)269539611 (DE-600)1475577-4 1528-3658 nnns volume:26 year:2020 number:1 day:27 month:10 https://dx.doi.org/10.1186/s10020-020-00226-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 26 2020 1 27 10
allfieldsSound	10.1186/s10020-020-00226-7 doi (DE-627)SPR041639316 (SPR)s10020-020-00226-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.00 bkl Du, Lei verfasserin aut Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian cancer, EOC. Our study aimed to address this issue. Methods We first examine KBTBD8 expression in EOC tissues and cells. Next, we performed RNA sequencing to reveal the overall mechanism. Then we investigated the roles of KBTBD8 in the proliferation, migration, and health status of cultured EOC cells. Finally, we employed tumor xenograft models to evaluate the role of KBTBD8 in vivo. Results First, KBTBD8 level was significantly higher in EOC tissues and cells. Next, comparative RNA sequencing identified more tumorigenesis-related genes that KBTBD8 might regulate. Then we found that KBTBD8 knockdown significantly decreased EOC cell proliferation, migration, and the activities of multiple tumorigenesis-related kinases. Finally, KBTBD8 knockdown significantly diminished ovarian tumor formation in vivo. Conclusion Proper KBTBD8 level is essential for the healthy growth of ovarian somatic cells, such as ovarian epithelial cells. Excessive KBTBD8 might be a significant impetus for EOC progression. KBTBD8 reduction greatly inhibits EOC proliferation and migration. KBTBD8 (dpeaa)DE-He213 Ubiquitin ligase (dpeaa)DE-He213 Epithelial ovarian cancer (dpeaa)DE-He213 Female fertility factor (dpeaa)DE-He213 Li, Cong-Rong verfasserin aut He, Qi-Feng verfasserin aut Li, Xiao-Hua verfasserin aut Yang, Lin-Fei verfasserin aut Zou, Yuan verfasserin aut Yang, Zhi-Xia verfasserin aut Zhang, Dong verfasserin aut Xing, Xiao-Wei verfasserin aut Enthalten in Molecular medicine [London] : BioMed Central, 1994 26(2020), 1 vom: 27. Okt. (DE-627)269539611 (DE-600)1475577-4 1528-3658 nnns volume:26 year:2020 number:1 day:27 month:10 https://dx.doi.org/10.1186/s10020-020-00226-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 26 2020 1 27 10
language	English
source	Enthalten in Molecular medicine 26(2020), 1 vom: 27. Okt. volume:26 year:2020 number:1 day:27 month:10
sourceStr	Enthalten in Molecular medicine 26(2020), 1 vom: 27. Okt. volume:26 year:2020 number:1 day:27 month:10
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topic_facet	KBTBD8 Ubiquitin ligase Epithelial ovarian cancer Female fertility factor
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authorswithroles_txt_mv	Du, Lei @@aut@@ Li, Cong-Rong @@aut@@ He, Qi-Feng @@aut@@ Li, Xiao-Hua @@aut@@ Yang, Lin-Fei @@aut@@ Zou, Yuan @@aut@@ Yang, Zhi-Xia @@aut@@ Zhang, Dong @@aut@@ Xing, Xiao-Wei @@aut@@
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However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian cancer, EOC. Our study aimed to address this issue. Methods We first examine KBTBD8 expression in EOC tissues and cells. Next, we performed RNA sequencing to reveal the overall mechanism. Then we investigated the roles of KBTBD8 in the proliferation, migration, and health status of cultured EOC cells. Finally, we employed tumor xenograft models to evaluate the role of KBTBD8 in vivo. Results First, KBTBD8 level was significantly higher in EOC tissues and cells. Next, comparative RNA sequencing identified more tumorigenesis-related genes that KBTBD8 might regulate. Then we found that KBTBD8 knockdown significantly decreased EOC cell proliferation, migration, and the activities of multiple tumorigenesis-related kinases. Finally, KBTBD8 knockdown significantly diminished ovarian tumor formation in vivo. Conclusion Proper KBTBD8 level is essential for the healthy growth of ovarian somatic cells, such as ovarian epithelial cells. Excessive KBTBD8 might be a significant impetus for EOC progression. KBTBD8 reduction greatly inhibits EOC proliferation and migration.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">KBTBD8</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ubiquitin ligase</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Epithelial ovarian cancer</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Female fertility factor</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Cong-Rong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">He, Qi-Feng</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Xiao-Hua</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yang, Lin-Fei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zou, Yuan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yang, Zhi-Xia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Dong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Xing, Xiao-Wei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Molecular medicine</subfield><subfield code="d">[London] : BioMed Central, 1994</subfield><subfield code="g">26(2020), 1 vom: 27. 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author	Du, Lei
spellingShingle	Du, Lei ddc 610 bkl 44.00 misc KBTBD8 misc Ubiquitin ligase misc Epithelial ovarian cancer misc Female fertility factor Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression
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topic_title	610 ASE 44.00 bkl Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression KBTBD8 (dpeaa)DE-He213 Ubiquitin ligase (dpeaa)DE-He213 Epithelial ovarian cancer (dpeaa)DE-He213 Female fertility factor (dpeaa)DE-He213
topic	ddc 610 bkl 44.00 misc KBTBD8 misc Ubiquitin ligase misc Epithelial ovarian cancer misc Female fertility factor
topic_unstemmed	ddc 610 bkl 44.00 misc KBTBD8 misc Ubiquitin ligase misc Epithelial ovarian cancer misc Female fertility factor
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title	Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression
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title_full	Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression
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author_browse	Du, Lei Li, Cong-Rong He, Qi-Feng Li, Xiao-Hua Yang, Lin-Fei Zou, Yuan Yang, Zhi-Xia Zhang, Dong Xing, Xiao-Wei
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title_sort	downregulation of the ubiquitin ligase kbtbd8 prevented epithelial ovarian cancer progression
title_auth	Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression
abstract	Objectives Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian cancer, EOC. Our study aimed to address this issue. Methods We first examine KBTBD8 expression in EOC tissues and cells. Next, we performed RNA sequencing to reveal the overall mechanism. Then we investigated the roles of KBTBD8 in the proliferation, migration, and health status of cultured EOC cells. Finally, we employed tumor xenograft models to evaluate the role of KBTBD8 in vivo. Results First, KBTBD8 level was significantly higher in EOC tissues and cells. Next, comparative RNA sequencing identified more tumorigenesis-related genes that KBTBD8 might regulate. Then we found that KBTBD8 knockdown significantly decreased EOC cell proliferation, migration, and the activities of multiple tumorigenesis-related kinases. Finally, KBTBD8 knockdown significantly diminished ovarian tumor formation in vivo. Conclusion Proper KBTBD8 level is essential for the healthy growth of ovarian somatic cells, such as ovarian epithelial cells. Excessive KBTBD8 might be a significant impetus for EOC progression. KBTBD8 reduction greatly inhibits EOC proliferation and migration.
abstractGer	Objectives Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian cancer, EOC. Our study aimed to address this issue. Methods We first examine KBTBD8 expression in EOC tissues and cells. Next, we performed RNA sequencing to reveal the overall mechanism. Then we investigated the roles of KBTBD8 in the proliferation, migration, and health status of cultured EOC cells. Finally, we employed tumor xenograft models to evaluate the role of KBTBD8 in vivo. Results First, KBTBD8 level was significantly higher in EOC tissues and cells. Next, comparative RNA sequencing identified more tumorigenesis-related genes that KBTBD8 might regulate. Then we found that KBTBD8 knockdown significantly decreased EOC cell proliferation, migration, and the activities of multiple tumorigenesis-related kinases. Finally, KBTBD8 knockdown significantly diminished ovarian tumor formation in vivo. Conclusion Proper KBTBD8 level is essential for the healthy growth of ovarian somatic cells, such as ovarian epithelial cells. Excessive KBTBD8 might be a significant impetus for EOC progression. KBTBD8 reduction greatly inhibits EOC proliferation and migration.
abstract_unstemmed	Objectives Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian cancer, EOC. Our study aimed to address this issue. Methods We first examine KBTBD8 expression in EOC tissues and cells. Next, we performed RNA sequencing to reveal the overall mechanism. Then we investigated the roles of KBTBD8 in the proliferation, migration, and health status of cultured EOC cells. Finally, we employed tumor xenograft models to evaluate the role of KBTBD8 in vivo. Results First, KBTBD8 level was significantly higher in EOC tissues and cells. Next, comparative RNA sequencing identified more tumorigenesis-related genes that KBTBD8 might regulate. Then we found that KBTBD8 knockdown significantly decreased EOC cell proliferation, migration, and the activities of multiple tumorigenesis-related kinases. Finally, KBTBD8 knockdown significantly diminished ovarian tumor formation in vivo. Conclusion Proper KBTBD8 level is essential for the healthy growth of ovarian somatic cells, such as ovarian epithelial cells. Excessive KBTBD8 might be a significant impetus for EOC progression. KBTBD8 reduction greatly inhibits EOC proliferation and migration.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
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title_short	Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression
url	https://dx.doi.org/10.1186/s10020-020-00226-7
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author2	Li, Cong-Rong He, Qi-Feng Li, Xiao-Hua Yang, Lin-Fei Zou, Yuan Yang, Zhi-Xia Zhang, Dong Xing, Xiao-Wei
author2Str	Li, Cong-Rong He, Qi-Feng Li, Xiao-Hua Yang, Lin-Fei Zou, Yuan Yang, Zhi-Xia Zhang, Dong Xing, Xiao-Wei
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up_date	2024-07-03T22:59:35.515Z
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However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian cancer, EOC. Our study aimed to address this issue. Methods We first examine KBTBD8 expression in EOC tissues and cells. Next, we performed RNA sequencing to reveal the overall mechanism. Then we investigated the roles of KBTBD8 in the proliferation, migration, and health status of cultured EOC cells. Finally, we employed tumor xenograft models to evaluate the role of KBTBD8 in vivo. Results First, KBTBD8 level was significantly higher in EOC tissues and cells. Next, comparative RNA sequencing identified more tumorigenesis-related genes that KBTBD8 might regulate. Then we found that KBTBD8 knockdown significantly decreased EOC cell proliferation, migration, and the activities of multiple tumorigenesis-related kinases. Finally, KBTBD8 knockdown significantly diminished ovarian tumor formation in vivo. Conclusion Proper KBTBD8 level is essential for the healthy growth of ovarian somatic cells, such as ovarian epithelial cells. Excessive KBTBD8 might be a significant impetus for EOC progression. 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Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression

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