Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model
Purpose Topotecan is a camptothecin analogue with potential advantages over irinotecan for transarterial chemoembolization (TACE) of hepatic colorectal metastases including greater anti-neoplastic activity without enzymatic activation. The purpose of this study was to assess safety and tolerability...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mikhail, Andrew S. [verfasserIn] Levy, Elliot B. [verfasserIn] Krishnasamy, Venkatesh P. [verfasserIn] Woods, David L. [verfasserIn] Esparza-Trujillo, Juan A. [verfasserIn] Bakhutashvili, Ivane [verfasserIn] Banovac, Filip [verfasserIn] Wakim, Paul G. [verfasserIn] Negussie, Ayele H. [verfasserIn] Tang, Yiqing [verfasserIn] Henman, Alexander [verfasserIn] Willis, Sean L. [verfasserIn] Karanian, John W. [verfasserIn] Pritchard, William F. [verfasserIn] Lewis, Andrew L. [verfasserIn] Wood, Bradford J. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: CardioVascular and interventional radiology - Berlin : Springer, 1978, 43(2020), 12 vom: 16. Aug., Seite 1918-1924 |
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| Übergeordnetes Werk: |
volume:43 ; year:2020 ; number:12 ; day:16 ; month:08 ; pages:1918-1924 |
| Links: |
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| DOI / URN: |
10.1007/s00270-020-02609-z |
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| Katalog-ID: |
SPR041841328 |
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| 100 | 1 | |a Mikhail, Andrew S. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model |
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| 520 | |a Purpose Topotecan is a camptothecin analogue with potential advantages over irinotecan for transarterial chemoembolization (TACE) of hepatic colorectal metastases including greater anti-neoplastic activity without enzymatic activation. The purpose of this study was to assess safety and tolerability of topotecan-loaded radiopaque microspheres (ROMTOP) administered by TACE in a rabbit model and to compare the in vitro elution of topotecan from microspheres to irinotecan. Materials and Methods Topotecan was loaded into radiopaque microspheres (70–150 µm, DC Bead LUMI™, Biocompatibles UK Ltd—Boston Scientific Corporation) to the maximum capacity of 80 mg/mL of microspheres. Six healthy New Zealand White rabbits underwent hepatic TACE with ROMTOP under fluoroscopic guidance until angiographic stasis. Assessment of toxicities included regular liver function tests and complete blood counts until euthanasia 28 days post-TACE. In vitro topotecan elution from the microspheres was assessed using an open-loop flow-through system and compared to irinotecan. Results The mean bead volume and topotecan dose delivered were 0.086 mL (0.076–0.105 mL) and 1.99 mg/kg (1.51–2.55 mg/kg), respectively. Aspartate aminotransferase and alanine aminotransferase were elevated post-embolization but resolved within 2 weeks. One rabbit died two days after TACE with pyloric duodenal perforation observed at necropsy, potentially due to non-target embolization. In vitro elution of topotecan from ROMTOP was complete in 10 h compared to 3 h for irinotecan-loaded microspheres. Conclusion Selective embolization with ROMTOP was tolerated at a dose of 2 mg/kg (24 mg/$ m^{2} $) in rabbits. In vitro topotecan elution from microspheres was more prolonged compared to irinotecan. | ||
| 650 | 4 | |a Topotecan |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Drug-eluting beads |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Microspheres |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Embolization |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Irinotecan |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Radiopaque beads |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a DEB |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Toxicity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Colorectal metastases |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Chemoembolization |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a TACE |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Rabbit |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a DEBIRI |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Levy, Elliot B. |e verfasserin |4 aut | |
| 700 | 1 | |a Krishnasamy, Venkatesh P. |e verfasserin |4 aut | |
| 700 | 1 | |a Woods, David L. |e verfasserin |4 aut | |
| 700 | 1 | |a Esparza-Trujillo, Juan A. |e verfasserin |4 aut | |
| 700 | 1 | |a Bakhutashvili, Ivane |e verfasserin |4 aut | |
| 700 | 1 | |a Banovac, Filip |e verfasserin |4 aut | |
| 700 | 1 | |a Wakim, Paul G. |e verfasserin |4 aut | |
| 700 | 1 | |a Negussie, Ayele H. |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Yiqing |e verfasserin |4 aut | |
| 700 | 1 | |a Henman, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Willis, Sean L. |e verfasserin |4 aut | |
| 700 | 1 | |a Karanian, John W. |e verfasserin |4 aut | |
| 700 | 1 | |a Pritchard, William F. |e verfasserin |4 aut | |
| 700 | 1 | |a Lewis, Andrew L. |e verfasserin |4 aut | |
| 700 | 1 | |a Wood, Bradford J. |e verfasserin |4 aut | |
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10.1007/s00270-020-02609-z doi (DE-627)SPR041841328 (SPR)s00270-020-02609-z-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.85 bkl Mikhail, Andrew S. verfasserin aut Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Topotecan is a camptothecin analogue with potential advantages over irinotecan for transarterial chemoembolization (TACE) of hepatic colorectal metastases including greater anti-neoplastic activity without enzymatic activation. The purpose of this study was to assess safety and tolerability of topotecan-loaded radiopaque microspheres (ROMTOP) administered by TACE in a rabbit model and to compare the in vitro elution of topotecan from microspheres to irinotecan. Materials and Methods Topotecan was loaded into radiopaque microspheres (70–150 µm, DC Bead LUMI™, Biocompatibles UK Ltd—Boston Scientific Corporation) to the maximum capacity of 80 mg/mL of microspheres. Six healthy New Zealand White rabbits underwent hepatic TACE with ROMTOP under fluoroscopic guidance until angiographic stasis. Assessment of toxicities included regular liver function tests and complete blood counts until euthanasia 28 days post-TACE. In vitro topotecan elution from the microspheres was assessed using an open-loop flow-through system and compared to irinotecan. Results The mean bead volume and topotecan dose delivered were 0.086 mL (0.076–0.105 mL) and 1.99 mg/kg (1.51–2.55 mg/kg), respectively. Aspartate aminotransferase and alanine aminotransferase were elevated post-embolization but resolved within 2 weeks. One rabbit died two days after TACE with pyloric duodenal perforation observed at necropsy, potentially due to non-target embolization. In vitro elution of topotecan from ROMTOP was complete in 10 h compared to 3 h for irinotecan-loaded microspheres. Conclusion Selective embolization with ROMTOP was tolerated at a dose of 2 mg/kg (24 mg/$ m^{2} $) in rabbits. In vitro topotecan elution from microspheres was more prolonged compared to irinotecan. Topotecan (dpeaa)DE-He213 Drug-eluting beads (dpeaa)DE-He213 Microspheres (dpeaa)DE-He213 Embolization (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Radiopaque beads (dpeaa)DE-He213 DEB (dpeaa)DE-He213 Toxicity (dpeaa)DE-He213 Colorectal metastases (dpeaa)DE-He213 Chemoembolization (dpeaa)DE-He213 TACE (dpeaa)DE-He213 Rabbit (dpeaa)DE-He213 DEBIRI (dpeaa)DE-He213 Levy, Elliot B. verfasserin aut Krishnasamy, Venkatesh P. verfasserin aut Woods, David L. verfasserin aut Esparza-Trujillo, Juan A. verfasserin aut Bakhutashvili, Ivane verfasserin aut Banovac, Filip verfasserin aut Wakim, Paul G. verfasserin aut Negussie, Ayele H. verfasserin aut Tang, Yiqing verfasserin aut Henman, Alexander verfasserin aut Willis, Sean L. verfasserin aut Karanian, John W. verfasserin aut Pritchard, William F. verfasserin aut Lewis, Andrew L. verfasserin aut Wood, Bradford J. verfasserin aut Enthalten in CardioVascular and interventional radiology Berlin : Springer, 1978 43(2020), 12 vom: 16. Aug., Seite 1918-1924 (DE-627)253390451 (DE-600)1458490-6 1432-086X nnns volume:43 year:2020 number:12 day:16 month:08 pages:1918-1924 https://dx.doi.org/10.1007/s00270-020-02609-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 43 2020 12 16 08 1918-1924 |
| spelling |
10.1007/s00270-020-02609-z doi (DE-627)SPR041841328 (SPR)s00270-020-02609-z-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.85 bkl Mikhail, Andrew S. verfasserin aut Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Topotecan is a camptothecin analogue with potential advantages over irinotecan for transarterial chemoembolization (TACE) of hepatic colorectal metastases including greater anti-neoplastic activity without enzymatic activation. The purpose of this study was to assess safety and tolerability of topotecan-loaded radiopaque microspheres (ROMTOP) administered by TACE in a rabbit model and to compare the in vitro elution of topotecan from microspheres to irinotecan. Materials and Methods Topotecan was loaded into radiopaque microspheres (70–150 µm, DC Bead LUMI™, Biocompatibles UK Ltd—Boston Scientific Corporation) to the maximum capacity of 80 mg/mL of microspheres. Six healthy New Zealand White rabbits underwent hepatic TACE with ROMTOP under fluoroscopic guidance until angiographic stasis. Assessment of toxicities included regular liver function tests and complete blood counts until euthanasia 28 days post-TACE. In vitro topotecan elution from the microspheres was assessed using an open-loop flow-through system and compared to irinotecan. Results The mean bead volume and topotecan dose delivered were 0.086 mL (0.076–0.105 mL) and 1.99 mg/kg (1.51–2.55 mg/kg), respectively. Aspartate aminotransferase and alanine aminotransferase were elevated post-embolization but resolved within 2 weeks. One rabbit died two days after TACE with pyloric duodenal perforation observed at necropsy, potentially due to non-target embolization. In vitro elution of topotecan from ROMTOP was complete in 10 h compared to 3 h for irinotecan-loaded microspheres. Conclusion Selective embolization with ROMTOP was tolerated at a dose of 2 mg/kg (24 mg/$ m^{2} $) in rabbits. In vitro topotecan elution from microspheres was more prolonged compared to irinotecan. Topotecan (dpeaa)DE-He213 Drug-eluting beads (dpeaa)DE-He213 Microspheres (dpeaa)DE-He213 Embolization (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Radiopaque beads (dpeaa)DE-He213 DEB (dpeaa)DE-He213 Toxicity (dpeaa)DE-He213 Colorectal metastases (dpeaa)DE-He213 Chemoembolization (dpeaa)DE-He213 TACE (dpeaa)DE-He213 Rabbit (dpeaa)DE-He213 DEBIRI (dpeaa)DE-He213 Levy, Elliot B. verfasserin aut Krishnasamy, Venkatesh P. verfasserin aut Woods, David L. verfasserin aut Esparza-Trujillo, Juan A. verfasserin aut Bakhutashvili, Ivane verfasserin aut Banovac, Filip verfasserin aut Wakim, Paul G. verfasserin aut Negussie, Ayele H. verfasserin aut Tang, Yiqing verfasserin aut Henman, Alexander verfasserin aut Willis, Sean L. verfasserin aut Karanian, John W. verfasserin aut Pritchard, William F. verfasserin aut Lewis, Andrew L. verfasserin aut Wood, Bradford J. verfasserin aut Enthalten in CardioVascular and interventional radiology Berlin : Springer, 1978 43(2020), 12 vom: 16. Aug., Seite 1918-1924 (DE-627)253390451 (DE-600)1458490-6 1432-086X nnns volume:43 year:2020 number:12 day:16 month:08 pages:1918-1924 https://dx.doi.org/10.1007/s00270-020-02609-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 43 2020 12 16 08 1918-1924 |
| allfields_unstemmed |
10.1007/s00270-020-02609-z doi (DE-627)SPR041841328 (SPR)s00270-020-02609-z-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.85 bkl Mikhail, Andrew S. verfasserin aut Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Topotecan is a camptothecin analogue with potential advantages over irinotecan for transarterial chemoembolization (TACE) of hepatic colorectal metastases including greater anti-neoplastic activity without enzymatic activation. The purpose of this study was to assess safety and tolerability of topotecan-loaded radiopaque microspheres (ROMTOP) administered by TACE in a rabbit model and to compare the in vitro elution of topotecan from microspheres to irinotecan. Materials and Methods Topotecan was loaded into radiopaque microspheres (70–150 µm, DC Bead LUMI™, Biocompatibles UK Ltd—Boston Scientific Corporation) to the maximum capacity of 80 mg/mL of microspheres. Six healthy New Zealand White rabbits underwent hepatic TACE with ROMTOP under fluoroscopic guidance until angiographic stasis. Assessment of toxicities included regular liver function tests and complete blood counts until euthanasia 28 days post-TACE. In vitro topotecan elution from the microspheres was assessed using an open-loop flow-through system and compared to irinotecan. Results The mean bead volume and topotecan dose delivered were 0.086 mL (0.076–0.105 mL) and 1.99 mg/kg (1.51–2.55 mg/kg), respectively. Aspartate aminotransferase and alanine aminotransferase were elevated post-embolization but resolved within 2 weeks. One rabbit died two days after TACE with pyloric duodenal perforation observed at necropsy, potentially due to non-target embolization. In vitro elution of topotecan from ROMTOP was complete in 10 h compared to 3 h for irinotecan-loaded microspheres. Conclusion Selective embolization with ROMTOP was tolerated at a dose of 2 mg/kg (24 mg/$ m^{2} $) in rabbits. In vitro topotecan elution from microspheres was more prolonged compared to irinotecan. Topotecan (dpeaa)DE-He213 Drug-eluting beads (dpeaa)DE-He213 Microspheres (dpeaa)DE-He213 Embolization (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Radiopaque beads (dpeaa)DE-He213 DEB (dpeaa)DE-He213 Toxicity (dpeaa)DE-He213 Colorectal metastases (dpeaa)DE-He213 Chemoembolization (dpeaa)DE-He213 TACE (dpeaa)DE-He213 Rabbit (dpeaa)DE-He213 DEBIRI (dpeaa)DE-He213 Levy, Elliot B. verfasserin aut Krishnasamy, Venkatesh P. verfasserin aut Woods, David L. verfasserin aut Esparza-Trujillo, Juan A. verfasserin aut Bakhutashvili, Ivane verfasserin aut Banovac, Filip verfasserin aut Wakim, Paul G. verfasserin aut Negussie, Ayele H. verfasserin aut Tang, Yiqing verfasserin aut Henman, Alexander verfasserin aut Willis, Sean L. verfasserin aut Karanian, John W. verfasserin aut Pritchard, William F. verfasserin aut Lewis, Andrew L. verfasserin aut Wood, Bradford J. verfasserin aut Enthalten in CardioVascular and interventional radiology Berlin : Springer, 1978 43(2020), 12 vom: 16. Aug., Seite 1918-1924 (DE-627)253390451 (DE-600)1458490-6 1432-086X nnns volume:43 year:2020 number:12 day:16 month:08 pages:1918-1924 https://dx.doi.org/10.1007/s00270-020-02609-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 43 2020 12 16 08 1918-1924 |
| allfieldsGer |
10.1007/s00270-020-02609-z doi (DE-627)SPR041841328 (SPR)s00270-020-02609-z-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.85 bkl Mikhail, Andrew S. verfasserin aut Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Topotecan is a camptothecin analogue with potential advantages over irinotecan for transarterial chemoembolization (TACE) of hepatic colorectal metastases including greater anti-neoplastic activity without enzymatic activation. The purpose of this study was to assess safety and tolerability of topotecan-loaded radiopaque microspheres (ROMTOP) administered by TACE in a rabbit model and to compare the in vitro elution of topotecan from microspheres to irinotecan. Materials and Methods Topotecan was loaded into radiopaque microspheres (70–150 µm, DC Bead LUMI™, Biocompatibles UK Ltd—Boston Scientific Corporation) to the maximum capacity of 80 mg/mL of microspheres. Six healthy New Zealand White rabbits underwent hepatic TACE with ROMTOP under fluoroscopic guidance until angiographic stasis. Assessment of toxicities included regular liver function tests and complete blood counts until euthanasia 28 days post-TACE. In vitro topotecan elution from the microspheres was assessed using an open-loop flow-through system and compared to irinotecan. Results The mean bead volume and topotecan dose delivered were 0.086 mL (0.076–0.105 mL) and 1.99 mg/kg (1.51–2.55 mg/kg), respectively. Aspartate aminotransferase and alanine aminotransferase were elevated post-embolization but resolved within 2 weeks. One rabbit died two days after TACE with pyloric duodenal perforation observed at necropsy, potentially due to non-target embolization. In vitro elution of topotecan from ROMTOP was complete in 10 h compared to 3 h for irinotecan-loaded microspheres. Conclusion Selective embolization with ROMTOP was tolerated at a dose of 2 mg/kg (24 mg/$ m^{2} $) in rabbits. In vitro topotecan elution from microspheres was more prolonged compared to irinotecan. Topotecan (dpeaa)DE-He213 Drug-eluting beads (dpeaa)DE-He213 Microspheres (dpeaa)DE-He213 Embolization (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Radiopaque beads (dpeaa)DE-He213 DEB (dpeaa)DE-He213 Toxicity (dpeaa)DE-He213 Colorectal metastases (dpeaa)DE-He213 Chemoembolization (dpeaa)DE-He213 TACE (dpeaa)DE-He213 Rabbit (dpeaa)DE-He213 DEBIRI (dpeaa)DE-He213 Levy, Elliot B. verfasserin aut Krishnasamy, Venkatesh P. verfasserin aut Woods, David L. verfasserin aut Esparza-Trujillo, Juan A. verfasserin aut Bakhutashvili, Ivane verfasserin aut Banovac, Filip verfasserin aut Wakim, Paul G. verfasserin aut Negussie, Ayele H. verfasserin aut Tang, Yiqing verfasserin aut Henman, Alexander verfasserin aut Willis, Sean L. verfasserin aut Karanian, John W. verfasserin aut Pritchard, William F. verfasserin aut Lewis, Andrew L. verfasserin aut Wood, Bradford J. verfasserin aut Enthalten in CardioVascular and interventional radiology Berlin : Springer, 1978 43(2020), 12 vom: 16. Aug., Seite 1918-1924 (DE-627)253390451 (DE-600)1458490-6 1432-086X nnns volume:43 year:2020 number:12 day:16 month:08 pages:1918-1924 https://dx.doi.org/10.1007/s00270-020-02609-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 43 2020 12 16 08 1918-1924 |
| allfieldsSound |
10.1007/s00270-020-02609-z doi (DE-627)SPR041841328 (SPR)s00270-020-02609-z-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.85 bkl Mikhail, Andrew S. verfasserin aut Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Topotecan is a camptothecin analogue with potential advantages over irinotecan for transarterial chemoembolization (TACE) of hepatic colorectal metastases including greater anti-neoplastic activity without enzymatic activation. The purpose of this study was to assess safety and tolerability of topotecan-loaded radiopaque microspheres (ROMTOP) administered by TACE in a rabbit model and to compare the in vitro elution of topotecan from microspheres to irinotecan. Materials and Methods Topotecan was loaded into radiopaque microspheres (70–150 µm, DC Bead LUMI™, Biocompatibles UK Ltd—Boston Scientific Corporation) to the maximum capacity of 80 mg/mL of microspheres. Six healthy New Zealand White rabbits underwent hepatic TACE with ROMTOP under fluoroscopic guidance until angiographic stasis. Assessment of toxicities included regular liver function tests and complete blood counts until euthanasia 28 days post-TACE. In vitro topotecan elution from the microspheres was assessed using an open-loop flow-through system and compared to irinotecan. Results The mean bead volume and topotecan dose delivered were 0.086 mL (0.076–0.105 mL) and 1.99 mg/kg (1.51–2.55 mg/kg), respectively. Aspartate aminotransferase and alanine aminotransferase were elevated post-embolization but resolved within 2 weeks. One rabbit died two days after TACE with pyloric duodenal perforation observed at necropsy, potentially due to non-target embolization. In vitro elution of topotecan from ROMTOP was complete in 10 h compared to 3 h for irinotecan-loaded microspheres. Conclusion Selective embolization with ROMTOP was tolerated at a dose of 2 mg/kg (24 mg/$ m^{2} $) in rabbits. In vitro topotecan elution from microspheres was more prolonged compared to irinotecan. Topotecan (dpeaa)DE-He213 Drug-eluting beads (dpeaa)DE-He213 Microspheres (dpeaa)DE-He213 Embolization (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Radiopaque beads (dpeaa)DE-He213 DEB (dpeaa)DE-He213 Toxicity (dpeaa)DE-He213 Colorectal metastases (dpeaa)DE-He213 Chemoembolization (dpeaa)DE-He213 TACE (dpeaa)DE-He213 Rabbit (dpeaa)DE-He213 DEBIRI (dpeaa)DE-He213 Levy, Elliot B. verfasserin aut Krishnasamy, Venkatesh P. verfasserin aut Woods, David L. verfasserin aut Esparza-Trujillo, Juan A. verfasserin aut Bakhutashvili, Ivane verfasserin aut Banovac, Filip verfasserin aut Wakim, Paul G. verfasserin aut Negussie, Ayele H. verfasserin aut Tang, Yiqing verfasserin aut Henman, Alexander verfasserin aut Willis, Sean L. verfasserin aut Karanian, John W. verfasserin aut Pritchard, William F. verfasserin aut Lewis, Andrew L. verfasserin aut Wood, Bradford J. verfasserin aut Enthalten in CardioVascular and interventional radiology Berlin : Springer, 1978 43(2020), 12 vom: 16. Aug., Seite 1918-1924 (DE-627)253390451 (DE-600)1458490-6 1432-086X nnns volume:43 year:2020 number:12 day:16 month:08 pages:1918-1924 https://dx.doi.org/10.1007/s00270-020-02609-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 43 2020 12 16 08 1918-1924 |
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Enthalten in CardioVascular and interventional radiology 43(2020), 12 vom: 16. Aug., Seite 1918-1924 volume:43 year:2020 number:12 day:16 month:08 pages:1918-1924 |
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Enthalten in CardioVascular and interventional radiology 43(2020), 12 vom: 16. Aug., Seite 1918-1924 volume:43 year:2020 number:12 day:16 month:08 pages:1918-1924 |
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Topotecan Drug-eluting beads Microspheres Embolization Irinotecan Radiopaque beads DEB Toxicity Colorectal metastases Chemoembolization TACE Rabbit DEBIRI |
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Mikhail, Andrew S. @@aut@@ Levy, Elliot B. @@aut@@ Krishnasamy, Venkatesh P. @@aut@@ Woods, David L. @@aut@@ Esparza-Trujillo, Juan A. @@aut@@ Bakhutashvili, Ivane @@aut@@ Banovac, Filip @@aut@@ Wakim, Paul G. @@aut@@ Negussie, Ayele H. @@aut@@ Tang, Yiqing @@aut@@ Henman, Alexander @@aut@@ Willis, Sean L. @@aut@@ Karanian, John W. @@aut@@ Pritchard, William F. @@aut@@ Lewis, Andrew L. @@aut@@ Wood, Bradford J. @@aut@@ |
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| dewey-sort |
3610 |
| id |
SPR041841328 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR041841328</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519182452.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201109s2020 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00270-020-02609-z</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR041841328</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00270-020-02609-z-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.85</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Mikhail, Andrew S.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose Topotecan is a camptothecin analogue with potential advantages over irinotecan for transarterial chemoembolization (TACE) of hepatic colorectal metastases including greater anti-neoplastic activity without enzymatic activation. The purpose of this study was to assess safety and tolerability of topotecan-loaded radiopaque microspheres (ROMTOP) administered by TACE in a rabbit model and to compare the in vitro elution of topotecan from microspheres to irinotecan. Materials and Methods Topotecan was loaded into radiopaque microspheres (70–150 µm, DC Bead LUMI™, Biocompatibles UK Ltd—Boston Scientific Corporation) to the maximum capacity of 80 mg/mL of microspheres. Six healthy New Zealand White rabbits underwent hepatic TACE with ROMTOP under fluoroscopic guidance until angiographic stasis. Assessment of toxicities included regular liver function tests and complete blood counts until euthanasia 28 days post-TACE. In vitro topotecan elution from the microspheres was assessed using an open-loop flow-through system and compared to irinotecan. Results The mean bead volume and topotecan dose delivered were 0.086 mL (0.076–0.105 mL) and 1.99 mg/kg (1.51–2.55 mg/kg), respectively. Aspartate aminotransferase and alanine aminotransferase were elevated post-embolization but resolved within 2 weeks. One rabbit died two days after TACE with pyloric duodenal perforation observed at necropsy, potentially due to non-target embolization. In vitro elution of topotecan from ROMTOP was complete in 10 h compared to 3 h for irinotecan-loaded microspheres. Conclusion Selective embolization with ROMTOP was tolerated at a dose of 2 mg/kg (24 mg/$ m^{2} $) in rabbits. 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Mikhail, Andrew S. ddc 610 bkl 44.85 misc Topotecan misc Drug-eluting beads misc Microspheres misc Embolization misc Irinotecan misc Radiopaque beads misc DEB misc Toxicity misc Colorectal metastases misc Chemoembolization misc TACE misc Rabbit misc DEBIRI Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model |
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610 ASE 44.85 bkl Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model Topotecan (dpeaa)DE-He213 Drug-eluting beads (dpeaa)DE-He213 Microspheres (dpeaa)DE-He213 Embolization (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Radiopaque beads (dpeaa)DE-He213 DEB (dpeaa)DE-He213 Toxicity (dpeaa)DE-He213 Colorectal metastases (dpeaa)DE-He213 Chemoembolization (dpeaa)DE-He213 TACE (dpeaa)DE-He213 Rabbit (dpeaa)DE-He213 DEBIRI (dpeaa)DE-He213 |
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ddc 610 bkl 44.85 misc Topotecan misc Drug-eluting beads misc Microspheres misc Embolization misc Irinotecan misc Radiopaque beads misc DEB misc Toxicity misc Colorectal metastases misc Chemoembolization misc TACE misc Rabbit misc DEBIRI |
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ddc 610 bkl 44.85 misc Topotecan misc Drug-eluting beads misc Microspheres misc Embolization misc Irinotecan misc Radiopaque beads misc DEB misc Toxicity misc Colorectal metastases misc Chemoembolization misc TACE misc Rabbit misc DEBIRI |
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Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model |
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Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model |
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Mikhail, Andrew S. Levy, Elliot B. Krishnasamy, Venkatesh P. Woods, David L. Esparza-Trujillo, Juan A. Bakhutashvili, Ivane Banovac, Filip Wakim, Paul G. Negussie, Ayele H. Tang, Yiqing Henman, Alexander Willis, Sean L. Karanian, John W. Pritchard, William F. Lewis, Andrew L. Wood, Bradford J. |
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safety and tolerability of topotecan-eluting radiopaque microspheres for hepatic chemoembolization in a rabbit preclinical model |
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Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model |
| abstract |
Purpose Topotecan is a camptothecin analogue with potential advantages over irinotecan for transarterial chemoembolization (TACE) of hepatic colorectal metastases including greater anti-neoplastic activity without enzymatic activation. The purpose of this study was to assess safety and tolerability of topotecan-loaded radiopaque microspheres (ROMTOP) administered by TACE in a rabbit model and to compare the in vitro elution of topotecan from microspheres to irinotecan. Materials and Methods Topotecan was loaded into radiopaque microspheres (70–150 µm, DC Bead LUMI™, Biocompatibles UK Ltd—Boston Scientific Corporation) to the maximum capacity of 80 mg/mL of microspheres. Six healthy New Zealand White rabbits underwent hepatic TACE with ROMTOP under fluoroscopic guidance until angiographic stasis. Assessment of toxicities included regular liver function tests and complete blood counts until euthanasia 28 days post-TACE. In vitro topotecan elution from the microspheres was assessed using an open-loop flow-through system and compared to irinotecan. Results The mean bead volume and topotecan dose delivered were 0.086 mL (0.076–0.105 mL) and 1.99 mg/kg (1.51–2.55 mg/kg), respectively. Aspartate aminotransferase and alanine aminotransferase were elevated post-embolization but resolved within 2 weeks. One rabbit died two days after TACE with pyloric duodenal perforation observed at necropsy, potentially due to non-target embolization. In vitro elution of topotecan from ROMTOP was complete in 10 h compared to 3 h for irinotecan-loaded microspheres. Conclusion Selective embolization with ROMTOP was tolerated at a dose of 2 mg/kg (24 mg/$ m^{2} $) in rabbits. In vitro topotecan elution from microspheres was more prolonged compared to irinotecan. |
| abstractGer |
Purpose Topotecan is a camptothecin analogue with potential advantages over irinotecan for transarterial chemoembolization (TACE) of hepatic colorectal metastases including greater anti-neoplastic activity without enzymatic activation. The purpose of this study was to assess safety and tolerability of topotecan-loaded radiopaque microspheres (ROMTOP) administered by TACE in a rabbit model and to compare the in vitro elution of topotecan from microspheres to irinotecan. Materials and Methods Topotecan was loaded into radiopaque microspheres (70–150 µm, DC Bead LUMI™, Biocompatibles UK Ltd—Boston Scientific Corporation) to the maximum capacity of 80 mg/mL of microspheres. Six healthy New Zealand White rabbits underwent hepatic TACE with ROMTOP under fluoroscopic guidance until angiographic stasis. Assessment of toxicities included regular liver function tests and complete blood counts until euthanasia 28 days post-TACE. In vitro topotecan elution from the microspheres was assessed using an open-loop flow-through system and compared to irinotecan. Results The mean bead volume and topotecan dose delivered were 0.086 mL (0.076–0.105 mL) and 1.99 mg/kg (1.51–2.55 mg/kg), respectively. Aspartate aminotransferase and alanine aminotransferase were elevated post-embolization but resolved within 2 weeks. One rabbit died two days after TACE with pyloric duodenal perforation observed at necropsy, potentially due to non-target embolization. In vitro elution of topotecan from ROMTOP was complete in 10 h compared to 3 h for irinotecan-loaded microspheres. Conclusion Selective embolization with ROMTOP was tolerated at a dose of 2 mg/kg (24 mg/$ m^{2} $) in rabbits. In vitro topotecan elution from microspheres was more prolonged compared to irinotecan. |
| abstract_unstemmed |
Purpose Topotecan is a camptothecin analogue with potential advantages over irinotecan for transarterial chemoembolization (TACE) of hepatic colorectal metastases including greater anti-neoplastic activity without enzymatic activation. The purpose of this study was to assess safety and tolerability of topotecan-loaded radiopaque microspheres (ROMTOP) administered by TACE in a rabbit model and to compare the in vitro elution of topotecan from microspheres to irinotecan. Materials and Methods Topotecan was loaded into radiopaque microspheres (70–150 µm, DC Bead LUMI™, Biocompatibles UK Ltd—Boston Scientific Corporation) to the maximum capacity of 80 mg/mL of microspheres. Six healthy New Zealand White rabbits underwent hepatic TACE with ROMTOP under fluoroscopic guidance until angiographic stasis. Assessment of toxicities included regular liver function tests and complete blood counts until euthanasia 28 days post-TACE. In vitro topotecan elution from the microspheres was assessed using an open-loop flow-through system and compared to irinotecan. Results The mean bead volume and topotecan dose delivered were 0.086 mL (0.076–0.105 mL) and 1.99 mg/kg (1.51–2.55 mg/kg), respectively. Aspartate aminotransferase and alanine aminotransferase were elevated post-embolization but resolved within 2 weeks. One rabbit died two days after TACE with pyloric duodenal perforation observed at necropsy, potentially due to non-target embolization. In vitro elution of topotecan from ROMTOP was complete in 10 h compared to 3 h for irinotecan-loaded microspheres. Conclusion Selective embolization with ROMTOP was tolerated at a dose of 2 mg/kg (24 mg/$ m^{2} $) in rabbits. In vitro topotecan elution from microspheres was more prolonged compared to irinotecan. |
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Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model |
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Levy, Elliot B. Krishnasamy, Venkatesh P. Woods, David L. Esparza-Trujillo, Juan A. Bakhutashvili, Ivane Banovac, Filip Wakim, Paul G. Negussie, Ayele H. Tang, Yiqing Henman, Alexander Willis, Sean L. Karanian, John W. Pritchard, William F. Lewis, Andrew L. Wood, Bradford J. |
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The purpose of this study was to assess safety and tolerability of topotecan-loaded radiopaque microspheres (ROMTOP) administered by TACE in a rabbit model and to compare the in vitro elution of topotecan from microspheres to irinotecan. Materials and Methods Topotecan was loaded into radiopaque microspheres (70–150 µm, DC Bead LUMI™, Biocompatibles UK Ltd—Boston Scientific Corporation) to the maximum capacity of 80 mg/mL of microspheres. Six healthy New Zealand White rabbits underwent hepatic TACE with ROMTOP under fluoroscopic guidance until angiographic stasis. Assessment of toxicities included regular liver function tests and complete blood counts until euthanasia 28 days post-TACE. In vitro topotecan elution from the microspheres was assessed using an open-loop flow-through system and compared to irinotecan. Results The mean bead volume and topotecan dose delivered were 0.086 mL (0.076–0.105 mL) and 1.99 mg/kg (1.51–2.55 mg/kg), respectively. Aspartate aminotransferase and alanine aminotransferase were elevated post-embolization but resolved within 2 weeks. One rabbit died two days after TACE with pyloric duodenal perforation observed at necropsy, potentially due to non-target embolization. In vitro elution of topotecan from ROMTOP was complete in 10 h compared to 3 h for irinotecan-loaded microspheres. Conclusion Selective embolization with ROMTOP was tolerated at a dose of 2 mg/kg (24 mg/$ m^{2} $) in rabbits. 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