Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents

Background Morus alba L. fruits are consumed since long for their nutritional and medicinal values. Although there were studies on the neuroprotective activity of the fruit extract, safety profile of the fruit extract is not yet explored as per the recommended standard guidelines over the central ne...
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Autor*in:	Paul, Arpita [verfasserIn] Shakya, Anshul [verfasserIn] Zaman, Md Kamaruz [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Mulberry fruit Functional food Flavonoids Neurotoxicity Neurobehavioural response Safety assessment

Übergeordnetes Werk:	Enthalten in: Future Journal of Pharmaceutical Sciences - Berlin : SpringerOpen, 2015, 6(2020), 1 vom: 18. Nov.
Übergeordnetes Werk:	volume:6 ; year:2020 ; number:1 ; day:18 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s43094-020-00110-5

Katalog-ID:	SPR042034442

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520			\|a Background Morus alba L. fruits are consumed since long for their nutritional and medicinal values. Although there were studies on the neuroprotective activity of the fruit extract, safety profile of the fruit extract is not yet explored as per the recommended standard guidelines over the central nervous system (CNS). The present work was aimed to assess the neurotoxicity profile of chemically characterized extract of M. alba L. fruits (MA) using validated OECD guidelines, i.e., 425 and 424 in rodents. Results Neurobehavioural parameters were examined for motor, sensory and behavioural responses using actophotometer, hot plate and light and dark box test, respectively as per OECD 424. Interestingly, no sign of mortality and/or adversity on mice treated per-orally with MA (2000 mg/kg) was observed during the limit test as per OECD 425. Further, rats treated with MA (1000, 300 and 100 mg/kg, p.o.) for 28 days, showed insignificant (p < 0.05) changes in body weight, food consumption, neurobehavioural responses, organ weights and biochemical, haematological and histopathological features when compared with vehicle-treated animals. Conclusion The outcome of findings suggests that MA is safe in acute oral as well as sub-chronic (28 days) administration in mice and rats respectively. MA (1000 mg/kg) did not pose any toxic sign and symptoms on neurobehavioural responses in rats even after 28 days repeated treatment in compliance with OECD 424.
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allfields	10.1186/s43094-020-00110-5 doi (DE-627)SPR042034442 (SPR)s43094-020-00110-5-e DE-627 ger DE-627 rakwb eng Paul, Arpita verfasserin aut Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Morus alba L. fruits are consumed since long for their nutritional and medicinal values. Although there were studies on the neuroprotective activity of the fruit extract, safety profile of the fruit extract is not yet explored as per the recommended standard guidelines over the central nervous system (CNS). The present work was aimed to assess the neurotoxicity profile of chemically characterized extract of M. alba L. fruits (MA) using validated OECD guidelines, i.e., 425 and 424 in rodents. Results Neurobehavioural parameters were examined for motor, sensory and behavioural responses using actophotometer, hot plate and light and dark box test, respectively as per OECD 424. Interestingly, no sign of mortality and/or adversity on mice treated per-orally with MA (2000 mg/kg) was observed during the limit test as per OECD 425. Further, rats treated with MA (1000, 300 and 100 mg/kg, p.o.) for 28 days, showed insignificant (p < 0.05) changes in body weight, food consumption, neurobehavioural responses, organ weights and biochemical, haematological and histopathological features when compared with vehicle-treated animals. Conclusion The outcome of findings suggests that MA is safe in acute oral as well as sub-chronic (28 days) administration in mice and rats respectively. MA (1000 mg/kg) did not pose any toxic sign and symptoms on neurobehavioural responses in rats even after 28 days repeated treatment in compliance with OECD 424. Mulberry fruit (dpeaa)DE-He213 Functional food (dpeaa)DE-He213 Flavonoids (dpeaa)DE-He213 Neurotoxicity (dpeaa)DE-He213 Neurobehavioural response (dpeaa)DE-He213 Safety assessment (dpeaa)DE-He213 Shakya, Anshul verfasserin aut Zaman, Md Kamaruz verfasserin aut Enthalten in Future Journal of Pharmaceutical Sciences Berlin : SpringerOpen, 2015 6(2020), 1 vom: 18. Nov. (DE-627)835143171 (DE-600)2834845-X 2314-7253 nnns volume:6 year:2020 number:1 day:18 month:11 https://dx.doi.org/10.1186/s43094-020-00110-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 1 18 11
spelling	10.1186/s43094-020-00110-5 doi (DE-627)SPR042034442 (SPR)s43094-020-00110-5-e DE-627 ger DE-627 rakwb eng Paul, Arpita verfasserin aut Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Morus alba L. fruits are consumed since long for their nutritional and medicinal values. Although there were studies on the neuroprotective activity of the fruit extract, safety profile of the fruit extract is not yet explored as per the recommended standard guidelines over the central nervous system (CNS). The present work was aimed to assess the neurotoxicity profile of chemically characterized extract of M. alba L. fruits (MA) using validated OECD guidelines, i.e., 425 and 424 in rodents. Results Neurobehavioural parameters were examined for motor, sensory and behavioural responses using actophotometer, hot plate and light and dark box test, respectively as per OECD 424. Interestingly, no sign of mortality and/or adversity on mice treated per-orally with MA (2000 mg/kg) was observed during the limit test as per OECD 425. Further, rats treated with MA (1000, 300 and 100 mg/kg, p.o.) for 28 days, showed insignificant (p < 0.05) changes in body weight, food consumption, neurobehavioural responses, organ weights and biochemical, haematological and histopathological features when compared with vehicle-treated animals. Conclusion The outcome of findings suggests that MA is safe in acute oral as well as sub-chronic (28 days) administration in mice and rats respectively. MA (1000 mg/kg) did not pose any toxic sign and symptoms on neurobehavioural responses in rats even after 28 days repeated treatment in compliance with OECD 424. Mulberry fruit (dpeaa)DE-He213 Functional food (dpeaa)DE-He213 Flavonoids (dpeaa)DE-He213 Neurotoxicity (dpeaa)DE-He213 Neurobehavioural response (dpeaa)DE-He213 Safety assessment (dpeaa)DE-He213 Shakya, Anshul verfasserin aut Zaman, Md Kamaruz verfasserin aut Enthalten in Future Journal of Pharmaceutical Sciences Berlin : SpringerOpen, 2015 6(2020), 1 vom: 18. Nov. (DE-627)835143171 (DE-600)2834845-X 2314-7253 nnns volume:6 year:2020 number:1 day:18 month:11 https://dx.doi.org/10.1186/s43094-020-00110-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 1 18 11
allfields_unstemmed	10.1186/s43094-020-00110-5 doi (DE-627)SPR042034442 (SPR)s43094-020-00110-5-e DE-627 ger DE-627 rakwb eng Paul, Arpita verfasserin aut Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Morus alba L. fruits are consumed since long for their nutritional and medicinal values. Although there were studies on the neuroprotective activity of the fruit extract, safety profile of the fruit extract is not yet explored as per the recommended standard guidelines over the central nervous system (CNS). The present work was aimed to assess the neurotoxicity profile of chemically characterized extract of M. alba L. fruits (MA) using validated OECD guidelines, i.e., 425 and 424 in rodents. Results Neurobehavioural parameters were examined for motor, sensory and behavioural responses using actophotometer, hot plate and light and dark box test, respectively as per OECD 424. Interestingly, no sign of mortality and/or adversity on mice treated per-orally with MA (2000 mg/kg) was observed during the limit test as per OECD 425. Further, rats treated with MA (1000, 300 and 100 mg/kg, p.o.) for 28 days, showed insignificant (p < 0.05) changes in body weight, food consumption, neurobehavioural responses, organ weights and biochemical, haematological and histopathological features when compared with vehicle-treated animals. Conclusion The outcome of findings suggests that MA is safe in acute oral as well as sub-chronic (28 days) administration in mice and rats respectively. MA (1000 mg/kg) did not pose any toxic sign and symptoms on neurobehavioural responses in rats even after 28 days repeated treatment in compliance with OECD 424. Mulberry fruit (dpeaa)DE-He213 Functional food (dpeaa)DE-He213 Flavonoids (dpeaa)DE-He213 Neurotoxicity (dpeaa)DE-He213 Neurobehavioural response (dpeaa)DE-He213 Safety assessment (dpeaa)DE-He213 Shakya, Anshul verfasserin aut Zaman, Md Kamaruz verfasserin aut Enthalten in Future Journal of Pharmaceutical Sciences Berlin : SpringerOpen, 2015 6(2020), 1 vom: 18. Nov. (DE-627)835143171 (DE-600)2834845-X 2314-7253 nnns volume:6 year:2020 number:1 day:18 month:11 https://dx.doi.org/10.1186/s43094-020-00110-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 1 18 11
allfieldsGer	10.1186/s43094-020-00110-5 doi (DE-627)SPR042034442 (SPR)s43094-020-00110-5-e DE-627 ger DE-627 rakwb eng Paul, Arpita verfasserin aut Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Morus alba L. fruits are consumed since long for their nutritional and medicinal values. Although there were studies on the neuroprotective activity of the fruit extract, safety profile of the fruit extract is not yet explored as per the recommended standard guidelines over the central nervous system (CNS). The present work was aimed to assess the neurotoxicity profile of chemically characterized extract of M. alba L. fruits (MA) using validated OECD guidelines, i.e., 425 and 424 in rodents. Results Neurobehavioural parameters were examined for motor, sensory and behavioural responses using actophotometer, hot plate and light and dark box test, respectively as per OECD 424. Interestingly, no sign of mortality and/or adversity on mice treated per-orally with MA (2000 mg/kg) was observed during the limit test as per OECD 425. Further, rats treated with MA (1000, 300 and 100 mg/kg, p.o.) for 28 days, showed insignificant (p < 0.05) changes in body weight, food consumption, neurobehavioural responses, organ weights and biochemical, haematological and histopathological features when compared with vehicle-treated animals. Conclusion The outcome of findings suggests that MA is safe in acute oral as well as sub-chronic (28 days) administration in mice and rats respectively. MA (1000 mg/kg) did not pose any toxic sign and symptoms on neurobehavioural responses in rats even after 28 days repeated treatment in compliance with OECD 424. Mulberry fruit (dpeaa)DE-He213 Functional food (dpeaa)DE-He213 Flavonoids (dpeaa)DE-He213 Neurotoxicity (dpeaa)DE-He213 Neurobehavioural response (dpeaa)DE-He213 Safety assessment (dpeaa)DE-He213 Shakya, Anshul verfasserin aut Zaman, Md Kamaruz verfasserin aut Enthalten in Future Journal of Pharmaceutical Sciences Berlin : SpringerOpen, 2015 6(2020), 1 vom: 18. Nov. (DE-627)835143171 (DE-600)2834845-X 2314-7253 nnns volume:6 year:2020 number:1 day:18 month:11 https://dx.doi.org/10.1186/s43094-020-00110-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 1 18 11
allfieldsSound	10.1186/s43094-020-00110-5 doi (DE-627)SPR042034442 (SPR)s43094-020-00110-5-e DE-627 ger DE-627 rakwb eng Paul, Arpita verfasserin aut Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Morus alba L. fruits are consumed since long for their nutritional and medicinal values. Although there were studies on the neuroprotective activity of the fruit extract, safety profile of the fruit extract is not yet explored as per the recommended standard guidelines over the central nervous system (CNS). The present work was aimed to assess the neurotoxicity profile of chemically characterized extract of M. alba L. fruits (MA) using validated OECD guidelines, i.e., 425 and 424 in rodents. Results Neurobehavioural parameters were examined for motor, sensory and behavioural responses using actophotometer, hot plate and light and dark box test, respectively as per OECD 424. Interestingly, no sign of mortality and/or adversity on mice treated per-orally with MA (2000 mg/kg) was observed during the limit test as per OECD 425. Further, rats treated with MA (1000, 300 and 100 mg/kg, p.o.) for 28 days, showed insignificant (p < 0.05) changes in body weight, food consumption, neurobehavioural responses, organ weights and biochemical, haematological and histopathological features when compared with vehicle-treated animals. Conclusion The outcome of findings suggests that MA is safe in acute oral as well as sub-chronic (28 days) administration in mice and rats respectively. MA (1000 mg/kg) did not pose any toxic sign and symptoms on neurobehavioural responses in rats even after 28 days repeated treatment in compliance with OECD 424. Mulberry fruit (dpeaa)DE-He213 Functional food (dpeaa)DE-He213 Flavonoids (dpeaa)DE-He213 Neurotoxicity (dpeaa)DE-He213 Neurobehavioural response (dpeaa)DE-He213 Safety assessment (dpeaa)DE-He213 Shakya, Anshul verfasserin aut Zaman, Md Kamaruz verfasserin aut Enthalten in Future Journal of Pharmaceutical Sciences Berlin : SpringerOpen, 2015 6(2020), 1 vom: 18. Nov. (DE-627)835143171 (DE-600)2834845-X 2314-7253 nnns volume:6 year:2020 number:1 day:18 month:11 https://dx.doi.org/10.1186/s43094-020-00110-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 1 18 11
language	English
source	Enthalten in Future Journal of Pharmaceutical Sciences 6(2020), 1 vom: 18. Nov. volume:6 year:2020 number:1 day:18 month:11
sourceStr	Enthalten in Future Journal of Pharmaceutical Sciences 6(2020), 1 vom: 18. Nov. volume:6 year:2020 number:1 day:18 month:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Mulberry fruit Functional food Flavonoids Neurotoxicity Neurobehavioural response Safety assessment
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container_title	Future Journal of Pharmaceutical Sciences
authorswithroles_txt_mv	Paul, Arpita @@aut@@ Shakya, Anshul @@aut@@ Zaman, Md Kamaruz @@aut@@
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Although there were studies on the neuroprotective activity of the fruit extract, safety profile of the fruit extract is not yet explored as per the recommended standard guidelines over the central nervous system (CNS). The present work was aimed to assess the neurotoxicity profile of chemically characterized extract of M. alba L. fruits (MA) using validated OECD guidelines, i.e., 425 and 424 in rodents. Results Neurobehavioural parameters were examined for motor, sensory and behavioural responses using actophotometer, hot plate and light and dark box test, respectively as per OECD 424. Interestingly, no sign of mortality and/or adversity on mice treated per-orally with MA (2000 mg/kg) was observed during the limit test as per OECD 425. Further, rats treated with MA (1000, 300 and 100 mg/kg, p.o.) for 28 days, showed insignificant (p < 0.05) changes in body weight, food consumption, neurobehavioural responses, organ weights and biochemical, haematological and histopathological features when compared with vehicle-treated animals. Conclusion The outcome of findings suggests that MA is safe in acute oral as well as sub-chronic (28 days) administration in mice and rats respectively. 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author	Paul, Arpita
spellingShingle	Paul, Arpita misc Mulberry fruit misc Functional food misc Flavonoids misc Neurotoxicity misc Neurobehavioural response misc Safety assessment Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents
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topic_title	Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents Mulberry fruit (dpeaa)DE-He213 Functional food (dpeaa)DE-He213 Flavonoids (dpeaa)DE-He213 Neurotoxicity (dpeaa)DE-He213 Neurobehavioural response (dpeaa)DE-He213 Safety assessment (dpeaa)DE-He213
topic	misc Mulberry fruit misc Functional food misc Flavonoids misc Neurotoxicity misc Neurobehavioural response misc Safety assessment
topic_unstemmed	misc Mulberry fruit misc Functional food misc Flavonoids misc Neurotoxicity misc Neurobehavioural response misc Safety assessment
topic_browse	misc Mulberry fruit misc Functional food misc Flavonoids misc Neurotoxicity misc Neurobehavioural response misc Safety assessment
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title	Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents
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title_full	Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents
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author_browse	Paul, Arpita Shakya, Anshul Zaman, Md Kamaruz
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title_sort	assessment of acute and sub-chronic neurotoxicity of morus alba l. fruits in rodents
title_auth	Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents
abstract	Background Morus alba L. fruits are consumed since long for their nutritional and medicinal values. Although there were studies on the neuroprotective activity of the fruit extract, safety profile of the fruit extract is not yet explored as per the recommended standard guidelines over the central nervous system (CNS). The present work was aimed to assess the neurotoxicity profile of chemically characterized extract of M. alba L. fruits (MA) using validated OECD guidelines, i.e., 425 and 424 in rodents. Results Neurobehavioural parameters were examined for motor, sensory and behavioural responses using actophotometer, hot plate and light and dark box test, respectively as per OECD 424. Interestingly, no sign of mortality and/or adversity on mice treated per-orally with MA (2000 mg/kg) was observed during the limit test as per OECD 425. Further, rats treated with MA (1000, 300 and 100 mg/kg, p.o.) for 28 days, showed insignificant (p < 0.05) changes in body weight, food consumption, neurobehavioural responses, organ weights and biochemical, haematological and histopathological features when compared with vehicle-treated animals. Conclusion The outcome of findings suggests that MA is safe in acute oral as well as sub-chronic (28 days) administration in mice and rats respectively. MA (1000 mg/kg) did not pose any toxic sign and symptoms on neurobehavioural responses in rats even after 28 days repeated treatment in compliance with OECD 424.
abstractGer	Background Morus alba L. fruits are consumed since long for their nutritional and medicinal values. Although there were studies on the neuroprotective activity of the fruit extract, safety profile of the fruit extract is not yet explored as per the recommended standard guidelines over the central nervous system (CNS). The present work was aimed to assess the neurotoxicity profile of chemically characterized extract of M. alba L. fruits (MA) using validated OECD guidelines, i.e., 425 and 424 in rodents. Results Neurobehavioural parameters were examined for motor, sensory and behavioural responses using actophotometer, hot plate and light and dark box test, respectively as per OECD 424. Interestingly, no sign of mortality and/or adversity on mice treated per-orally with MA (2000 mg/kg) was observed during the limit test as per OECD 425. Further, rats treated with MA (1000, 300 and 100 mg/kg, p.o.) for 28 days, showed insignificant (p < 0.05) changes in body weight, food consumption, neurobehavioural responses, organ weights and biochemical, haematological and histopathological features when compared with vehicle-treated animals. Conclusion The outcome of findings suggests that MA is safe in acute oral as well as sub-chronic (28 days) administration in mice and rats respectively. MA (1000 mg/kg) did not pose any toxic sign and symptoms on neurobehavioural responses in rats even after 28 days repeated treatment in compliance with OECD 424.
abstract_unstemmed	Background Morus alba L. fruits are consumed since long for their nutritional and medicinal values. Although there were studies on the neuroprotective activity of the fruit extract, safety profile of the fruit extract is not yet explored as per the recommended standard guidelines over the central nervous system (CNS). The present work was aimed to assess the neurotoxicity profile of chemically characterized extract of M. alba L. fruits (MA) using validated OECD guidelines, i.e., 425 and 424 in rodents. Results Neurobehavioural parameters were examined for motor, sensory and behavioural responses using actophotometer, hot plate and light and dark box test, respectively as per OECD 424. Interestingly, no sign of mortality and/or adversity on mice treated per-orally with MA (2000 mg/kg) was observed during the limit test as per OECD 425. Further, rats treated with MA (1000, 300 and 100 mg/kg, p.o.) for 28 days, showed insignificant (p < 0.05) changes in body weight, food consumption, neurobehavioural responses, organ weights and biochemical, haematological and histopathological features when compared with vehicle-treated animals. Conclusion The outcome of findings suggests that MA is safe in acute oral as well as sub-chronic (28 days) administration in mice and rats respectively. MA (1000 mg/kg) did not pose any toxic sign and symptoms on neurobehavioural responses in rats even after 28 days repeated treatment in compliance with OECD 424.
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title_short	Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents
url	https://dx.doi.org/10.1186/s43094-020-00110-5
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up_date	2024-07-04T00:32:24.771Z
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Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents

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