Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist
Purpose of Review Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors are immunotherapeutic agents associated with a range of auto-inflammatory cutaneous toxicities. This paper reviews the clinical approach to the diagnosis and management of immune-related cutaneous...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chadha, Simran [verfasserIn] Para, Andrew J. [verfasserIn] Choi, Jennifer [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Current dermatology reports - New York, NY : Springer, 2012, 9(2020), 4 vom: 29. Sept., Seite 231-243 |
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| Übergeordnetes Werk: |
volume:9 ; year:2020 ; number:4 ; day:29 ; month:09 ; pages:231-243 |
| Links: |
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| DOI / URN: |
10.1007/s13671-020-00314-1 |
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| Katalog-ID: |
SPR042117879 |
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| 100 | 1 | |a Chadha, Simran |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist |
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| 520 | |a Purpose of Review Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors are immunotherapeutic agents associated with a range of auto-inflammatory cutaneous toxicities. This paper reviews the clinical approach to the diagnosis and management of immune-related cutaneous adverse events (irCAEs) to PD-1 and PD-L1 inhibitors, with emphasis on disease processes practitioners may encounter in hospitalized patients. Recent Findings A systematic approach for suspected irCAEs has been well-detailed in recent clinical guidelines. However, the breadth of irCAE manifestations and treatment options continues to be actively delineated in the literature. Summary The characterization and management of irCAEs is an ever-evolving realm of oncodermatology. The dermatologist’s role is to limit morbidity and mortality, maximize quality of life, and prevent discontinuation of immunotherapy. Non-steroidal immunomodulatory agents are being increasingly utilized for moderate to severe cutaneous reactions and present an opportunity for further research into safe and effective therapies. | ||
| 650 | 4 | |a Immune-related adverse event |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Immune-related cutaneous adverse event |7 (dpeaa)DE-He213 | |
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| 650 | 4 | |a PD-1 inhibitor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a PD-L1 inhibitor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Oncodermatology |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Para, Andrew J. |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Jennifer |e verfasserin |4 aut | |
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| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_636 | ||
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| 912 | |a GBV_ILN_2001 | ||
| 912 | |a GBV_ILN_2003 | ||
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| 912 | |a GBV_ILN_2007 | ||
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| 912 | |a GBV_ILN_2010 | ||
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| 912 | |a GBV_ILN_2020 | ||
| 912 | |a GBV_ILN_2021 | ||
| 912 | |a GBV_ILN_2025 | ||
| 912 | |a GBV_ILN_2026 | ||
| 912 | |a GBV_ILN_2027 | ||
| 912 | |a GBV_ILN_2031 | ||
| 912 | |a GBV_ILN_2034 | ||
| 912 | |a GBV_ILN_2037 | ||
| 912 | |a GBV_ILN_2038 | ||
| 912 | |a GBV_ILN_2039 | ||
| 912 | |a GBV_ILN_2044 | ||
| 912 | |a GBV_ILN_2048 | ||
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| 912 | |a GBV_ILN_2055 | ||
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| 912 | |a GBV_ILN_2057 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2093 | ||
| 912 | |a GBV_ILN_2106 | ||
| 912 | |a GBV_ILN_2107 | ||
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| 912 | |a GBV_ILN_2110 | ||
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10.1007/s13671-020-00314-1 doi (DE-627)SPR042117879 (SPR)s13671-020-00314-1-e DE-627 ger DE-627 rakwb eng 610 ASE Chadha, Simran verfasserin aut Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors are immunotherapeutic agents associated with a range of auto-inflammatory cutaneous toxicities. This paper reviews the clinical approach to the diagnosis and management of immune-related cutaneous adverse events (irCAEs) to PD-1 and PD-L1 inhibitors, with emphasis on disease processes practitioners may encounter in hospitalized patients. Recent Findings A systematic approach for suspected irCAEs has been well-detailed in recent clinical guidelines. However, the breadth of irCAE manifestations and treatment options continues to be actively delineated in the literature. Summary The characterization and management of irCAEs is an ever-evolving realm of oncodermatology. The dermatologist’s role is to limit morbidity and mortality, maximize quality of life, and prevent discontinuation of immunotherapy. Non-steroidal immunomodulatory agents are being increasingly utilized for moderate to severe cutaneous reactions and present an opportunity for further research into safe and effective therapies. Immune-related adverse event (dpeaa)DE-He213 Immune-related cutaneous adverse event (dpeaa)DE-He213 Immune checkpoint inhibitor (dpeaa)DE-He213 PD-1 inhibitor (dpeaa)DE-He213 PD-L1 inhibitor (dpeaa)DE-He213 Oncodermatology (dpeaa)DE-He213 Para, Andrew J. verfasserin aut Choi, Jennifer verfasserin aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 9(2020), 4 vom: 29. Sept., Seite 231-243 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:9 year:2020 number:4 day:29 month:09 pages:231-243 https://dx.doi.org/10.1007/s13671-020-00314-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2020 4 29 09 231-243 |
| spelling |
10.1007/s13671-020-00314-1 doi (DE-627)SPR042117879 (SPR)s13671-020-00314-1-e DE-627 ger DE-627 rakwb eng 610 ASE Chadha, Simran verfasserin aut Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors are immunotherapeutic agents associated with a range of auto-inflammatory cutaneous toxicities. This paper reviews the clinical approach to the diagnosis and management of immune-related cutaneous adverse events (irCAEs) to PD-1 and PD-L1 inhibitors, with emphasis on disease processes practitioners may encounter in hospitalized patients. Recent Findings A systematic approach for suspected irCAEs has been well-detailed in recent clinical guidelines. However, the breadth of irCAE manifestations and treatment options continues to be actively delineated in the literature. Summary The characterization and management of irCAEs is an ever-evolving realm of oncodermatology. The dermatologist’s role is to limit morbidity and mortality, maximize quality of life, and prevent discontinuation of immunotherapy. Non-steroidal immunomodulatory agents are being increasingly utilized for moderate to severe cutaneous reactions and present an opportunity for further research into safe and effective therapies. Immune-related adverse event (dpeaa)DE-He213 Immune-related cutaneous adverse event (dpeaa)DE-He213 Immune checkpoint inhibitor (dpeaa)DE-He213 PD-1 inhibitor (dpeaa)DE-He213 PD-L1 inhibitor (dpeaa)DE-He213 Oncodermatology (dpeaa)DE-He213 Para, Andrew J. verfasserin aut Choi, Jennifer verfasserin aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 9(2020), 4 vom: 29. Sept., Seite 231-243 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:9 year:2020 number:4 day:29 month:09 pages:231-243 https://dx.doi.org/10.1007/s13671-020-00314-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2020 4 29 09 231-243 |
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10.1007/s13671-020-00314-1 doi (DE-627)SPR042117879 (SPR)s13671-020-00314-1-e DE-627 ger DE-627 rakwb eng 610 ASE Chadha, Simran verfasserin aut Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors are immunotherapeutic agents associated with a range of auto-inflammatory cutaneous toxicities. This paper reviews the clinical approach to the diagnosis and management of immune-related cutaneous adverse events (irCAEs) to PD-1 and PD-L1 inhibitors, with emphasis on disease processes practitioners may encounter in hospitalized patients. Recent Findings A systematic approach for suspected irCAEs has been well-detailed in recent clinical guidelines. However, the breadth of irCAE manifestations and treatment options continues to be actively delineated in the literature. Summary The characterization and management of irCAEs is an ever-evolving realm of oncodermatology. The dermatologist’s role is to limit morbidity and mortality, maximize quality of life, and prevent discontinuation of immunotherapy. Non-steroidal immunomodulatory agents are being increasingly utilized for moderate to severe cutaneous reactions and present an opportunity for further research into safe and effective therapies. Immune-related adverse event (dpeaa)DE-He213 Immune-related cutaneous adverse event (dpeaa)DE-He213 Immune checkpoint inhibitor (dpeaa)DE-He213 PD-1 inhibitor (dpeaa)DE-He213 PD-L1 inhibitor (dpeaa)DE-He213 Oncodermatology (dpeaa)DE-He213 Para, Andrew J. verfasserin aut Choi, Jennifer verfasserin aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 9(2020), 4 vom: 29. Sept., Seite 231-243 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:9 year:2020 number:4 day:29 month:09 pages:231-243 https://dx.doi.org/10.1007/s13671-020-00314-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2020 4 29 09 231-243 |
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10.1007/s13671-020-00314-1 doi (DE-627)SPR042117879 (SPR)s13671-020-00314-1-e DE-627 ger DE-627 rakwb eng 610 ASE Chadha, Simran verfasserin aut Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors are immunotherapeutic agents associated with a range of auto-inflammatory cutaneous toxicities. This paper reviews the clinical approach to the diagnosis and management of immune-related cutaneous adverse events (irCAEs) to PD-1 and PD-L1 inhibitors, with emphasis on disease processes practitioners may encounter in hospitalized patients. Recent Findings A systematic approach for suspected irCAEs has been well-detailed in recent clinical guidelines. However, the breadth of irCAE manifestations and treatment options continues to be actively delineated in the literature. Summary The characterization and management of irCAEs is an ever-evolving realm of oncodermatology. The dermatologist’s role is to limit morbidity and mortality, maximize quality of life, and prevent discontinuation of immunotherapy. Non-steroidal immunomodulatory agents are being increasingly utilized for moderate to severe cutaneous reactions and present an opportunity for further research into safe and effective therapies. Immune-related adverse event (dpeaa)DE-He213 Immune-related cutaneous adverse event (dpeaa)DE-He213 Immune checkpoint inhibitor (dpeaa)DE-He213 PD-1 inhibitor (dpeaa)DE-He213 PD-L1 inhibitor (dpeaa)DE-He213 Oncodermatology (dpeaa)DE-He213 Para, Andrew J. verfasserin aut Choi, Jennifer verfasserin aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 9(2020), 4 vom: 29. Sept., Seite 231-243 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:9 year:2020 number:4 day:29 month:09 pages:231-243 https://dx.doi.org/10.1007/s13671-020-00314-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2020 4 29 09 231-243 |
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10.1007/s13671-020-00314-1 doi (DE-627)SPR042117879 (SPR)s13671-020-00314-1-e DE-627 ger DE-627 rakwb eng 610 ASE Chadha, Simran verfasserin aut Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors are immunotherapeutic agents associated with a range of auto-inflammatory cutaneous toxicities. This paper reviews the clinical approach to the diagnosis and management of immune-related cutaneous adverse events (irCAEs) to PD-1 and PD-L1 inhibitors, with emphasis on disease processes practitioners may encounter in hospitalized patients. Recent Findings A systematic approach for suspected irCAEs has been well-detailed in recent clinical guidelines. However, the breadth of irCAE manifestations and treatment options continues to be actively delineated in the literature. Summary The characterization and management of irCAEs is an ever-evolving realm of oncodermatology. The dermatologist’s role is to limit morbidity and mortality, maximize quality of life, and prevent discontinuation of immunotherapy. Non-steroidal immunomodulatory agents are being increasingly utilized for moderate to severe cutaneous reactions and present an opportunity for further research into safe and effective therapies. Immune-related adverse event (dpeaa)DE-He213 Immune-related cutaneous adverse event (dpeaa)DE-He213 Immune checkpoint inhibitor (dpeaa)DE-He213 PD-1 inhibitor (dpeaa)DE-He213 PD-L1 inhibitor (dpeaa)DE-He213 Oncodermatology (dpeaa)DE-He213 Para, Andrew J. verfasserin aut Choi, Jennifer verfasserin aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 9(2020), 4 vom: 29. Sept., Seite 231-243 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:9 year:2020 number:4 day:29 month:09 pages:231-243 https://dx.doi.org/10.1007/s13671-020-00314-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2020 4 29 09 231-243 |
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Enthalten in Current dermatology reports 9(2020), 4 vom: 29. Sept., Seite 231-243 volume:9 year:2020 number:4 day:29 month:09 pages:231-243 |
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Immune-related adverse event Immune-related cutaneous adverse event Immune checkpoint inhibitor PD-1 inhibitor PD-L1 inhibitor Oncodermatology |
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Chadha, Simran @@aut@@ Para, Andrew J. @@aut@@ Choi, Jennifer @@aut@@ |
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Chadha, Simran |
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610 ASE Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist Immune-related adverse event (dpeaa)DE-He213 Immune-related cutaneous adverse event (dpeaa)DE-He213 Immune checkpoint inhibitor (dpeaa)DE-He213 PD-1 inhibitor (dpeaa)DE-He213 PD-L1 inhibitor (dpeaa)DE-He213 Oncodermatology (dpeaa)DE-He213 |
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ddc 610 misc Immune-related adverse event misc Immune-related cutaneous adverse event misc Immune checkpoint inhibitor misc PD-1 inhibitor misc PD-L1 inhibitor misc Oncodermatology |
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Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist |
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Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist |
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management of immune-related cutaneous adverse reactions to pd-1 and pd-l1 inhibitors for the inpatient dermatologist |
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Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist |
| abstract |
Purpose of Review Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors are immunotherapeutic agents associated with a range of auto-inflammatory cutaneous toxicities. This paper reviews the clinical approach to the diagnosis and management of immune-related cutaneous adverse events (irCAEs) to PD-1 and PD-L1 inhibitors, with emphasis on disease processes practitioners may encounter in hospitalized patients. Recent Findings A systematic approach for suspected irCAEs has been well-detailed in recent clinical guidelines. However, the breadth of irCAE manifestations and treatment options continues to be actively delineated in the literature. Summary The characterization and management of irCAEs is an ever-evolving realm of oncodermatology. The dermatologist’s role is to limit morbidity and mortality, maximize quality of life, and prevent discontinuation of immunotherapy. Non-steroidal immunomodulatory agents are being increasingly utilized for moderate to severe cutaneous reactions and present an opportunity for further research into safe and effective therapies. |
| abstractGer |
Purpose of Review Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors are immunotherapeutic agents associated with a range of auto-inflammatory cutaneous toxicities. This paper reviews the clinical approach to the diagnosis and management of immune-related cutaneous adverse events (irCAEs) to PD-1 and PD-L1 inhibitors, with emphasis on disease processes practitioners may encounter in hospitalized patients. Recent Findings A systematic approach for suspected irCAEs has been well-detailed in recent clinical guidelines. However, the breadth of irCAE manifestations and treatment options continues to be actively delineated in the literature. Summary The characterization and management of irCAEs is an ever-evolving realm of oncodermatology. The dermatologist’s role is to limit morbidity and mortality, maximize quality of life, and prevent discontinuation of immunotherapy. Non-steroidal immunomodulatory agents are being increasingly utilized for moderate to severe cutaneous reactions and present an opportunity for further research into safe and effective therapies. |
| abstract_unstemmed |
Purpose of Review Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors are immunotherapeutic agents associated with a range of auto-inflammatory cutaneous toxicities. This paper reviews the clinical approach to the diagnosis and management of immune-related cutaneous adverse events (irCAEs) to PD-1 and PD-L1 inhibitors, with emphasis on disease processes practitioners may encounter in hospitalized patients. Recent Findings A systematic approach for suspected irCAEs has been well-detailed in recent clinical guidelines. However, the breadth of irCAE manifestations and treatment options continues to be actively delineated in the literature. Summary The characterization and management of irCAEs is an ever-evolving realm of oncodermatology. The dermatologist’s role is to limit morbidity and mortality, maximize quality of life, and prevent discontinuation of immunotherapy. Non-steroidal immunomodulatory agents are being increasingly utilized for moderate to severe cutaneous reactions and present an opportunity for further research into safe and effective therapies. |
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| title_short |
Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist |
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https://dx.doi.org/10.1007/s13671-020-00314-1 |
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Para, Andrew J. Choi, Jennifer |
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Para, Andrew J. Choi, Jennifer |
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| doi_str |
10.1007/s13671-020-00314-1 |
| up_date |
2024-07-04T00:53:38.390Z |
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|
| score |
7.39935 |