DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications f...
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Englisch |
| Erschienen: |
2020 |
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Enthalten in: Genome medicine - London : BioMed Central, 2009, 12(2020), 1 vom: 25. Nov. |
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| Übergeordnetes Werk: |
volume:12 ; year:2020 ; number:1 ; day:25 ; month:11 |
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| DOI / URN: |
10.1186/s13073-020-00810-w |
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SPR042150396 |
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| 100 | 1 | |a Vehmeijer, Florianne O. L. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies |
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| 520 | |a Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × $ 10^{−7} $, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × $ 10^{−4} $; adolescence Penrichment = 2.10 × $ 10^{−7} $). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity. | ||
| 650 | 4 | |a Body mass index |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Childhood obesity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a DNA methylation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Epigenetics |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Küpers, Leanne K. |e verfasserin |4 aut | |
| 700 | 1 | |a Sharp, Gemma C. |e verfasserin |4 aut | |
| 700 | 1 | |a Salas, Lucas A. |e verfasserin |4 aut | |
| 700 | 1 | |a Lent, Samantha |e verfasserin |4 aut | |
| 700 | 1 | |a Jima, Dereje D. |e verfasserin |4 aut | |
| 700 | 1 | |a Tindula, Gwen |e verfasserin |4 aut | |
| 700 | 1 | |a Reese, Sarah |e verfasserin |4 aut | |
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| 700 | 1 | |a Tuominen, Samuli T. |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Lu |e verfasserin |4 aut | |
| 700 | 1 | |a Ross, Jason P. |e verfasserin |4 aut | |
| 700 | 1 | |a Starling, Anne P. |e verfasserin |4 aut | |
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10.1186/s13073-020-00810-w doi (DE-627)SPR042150396 (SPR)s13073-020-00810-w-e DE-627 ger DE-627 rakwb eng 610 ASE Vehmeijer, Florianne O. L. verfasserin aut DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × $ 10^{−7} $, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × $ 10^{−4} $; adolescence Penrichment = 2.10 × $ 10^{−7} $). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity. Body mass index (dpeaa)DE-He213 Childhood obesity (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Küpers, Leanne K. verfasserin aut Sharp, Gemma C. verfasserin aut Salas, Lucas A. verfasserin aut Lent, Samantha verfasserin aut Jima, Dereje D. verfasserin aut Tindula, Gwen verfasserin aut Reese, Sarah verfasserin aut Qi, Cancan verfasserin aut Gruzieva, Olena verfasserin aut Page, Christian verfasserin aut Rezwan, Faisal I. verfasserin aut Melton, Philip E. verfasserin aut Nohr, Ellen verfasserin aut Escaramís, Geòrgia verfasserin aut Rzehak, Peter verfasserin aut Heiskala, Anni verfasserin aut Gong, Tong verfasserin aut Tuominen, Samuli T. verfasserin aut Gao, Lu verfasserin aut Ross, Jason P. verfasserin aut Starling, Anne P. verfasserin aut Holloway, John W. verfasserin aut Yousefi, Paul verfasserin aut Aasvang, Gunn Marit verfasserin aut Beilin, Lawrence J. verfasserin aut Bergström, Anna verfasserin aut Binder, Elisabeth verfasserin aut Chatzi, Leda verfasserin aut Corpeleijn, Eva verfasserin aut Czamara, Darina verfasserin aut Eskenazi, Brenda verfasserin aut Ewart, Susan verfasserin aut Ferre, Natalia verfasserin aut Grote, Veit verfasserin aut Gruszfeld, Dariusz verfasserin aut Håberg, Siri E. verfasserin aut Hoyo, Cathrine verfasserin aut Huen, Karen verfasserin aut Karlsson, Robert verfasserin aut Kull, Inger verfasserin aut Langhendries, Jean-Paul verfasserin aut Lepeule, Johanna verfasserin aut Magnus, Maria C. verfasserin aut Maguire, Rachel L. verfasserin aut Molloy, Peter L. verfasserin aut Monnereau, Claire verfasserin aut Mori, Trevor A. verfasserin aut Oken, Emily verfasserin aut Räikkönen, Katri verfasserin aut Rifas-Shiman, Sheryl verfasserin aut Ruiz-Arenas, Carlos verfasserin aut Sebert, Sylvain verfasserin aut Ullemar, Vilhelmina verfasserin aut Verduci, Elvira verfasserin aut Vonk, Judith M. verfasserin aut Xu, Cheng-jian verfasserin aut Yang, Ivana V. verfasserin aut Zhang, Hongmei verfasserin aut Zhang, Weiming verfasserin aut Karmaus, Wilfried verfasserin aut Dabelea, Dana verfasserin aut Muhlhausler, Beverly S. verfasserin aut Breton, Carrie V. verfasserin aut Lahti, Jari verfasserin aut Almqvist, Catarina verfasserin aut Jarvelin, Marjo-Riitta verfasserin aut Koletzko, Berthold verfasserin aut Vrijheid, Martine verfasserin aut Sørensen, Thorkild I. A. verfasserin aut Huang, Rae-Chi verfasserin aut Arshad, Syed Hasan verfasserin aut Nystad, Wenche verfasserin aut Melén, Erik verfasserin aut Koppelman, Gerard H. verfasserin aut London, Stephanie J. verfasserin aut Holland, Nina verfasserin aut Bustamante, Mariona verfasserin aut Murphy, Susan K. verfasserin aut Hivert, Marie-France verfasserin aut Baccarelli, Andrea verfasserin aut Relton, Caroline L. verfasserin aut Snieder, Harold verfasserin aut Jaddoe, Vincent W. V. verfasserin aut Felix, Janine F. verfasserin aut Enthalten in Genome medicine London : BioMed Central, 2009 12(2020), 1 vom: 25. Nov. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:12 year:2020 number:1 day:25 month:11 https://dx.doi.org/10.1186/s13073-020-00810-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 1 25 11 |
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10.1186/s13073-020-00810-w doi (DE-627)SPR042150396 (SPR)s13073-020-00810-w-e DE-627 ger DE-627 rakwb eng 610 ASE Vehmeijer, Florianne O. L. verfasserin aut DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × $ 10^{−7} $, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × $ 10^{−4} $; adolescence Penrichment = 2.10 × $ 10^{−7} $). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity. Body mass index (dpeaa)DE-He213 Childhood obesity (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Küpers, Leanne K. verfasserin aut Sharp, Gemma C. verfasserin aut Salas, Lucas A. verfasserin aut Lent, Samantha verfasserin aut Jima, Dereje D. verfasserin aut Tindula, Gwen verfasserin aut Reese, Sarah verfasserin aut Qi, Cancan verfasserin aut Gruzieva, Olena verfasserin aut Page, Christian verfasserin aut Rezwan, Faisal I. verfasserin aut Melton, Philip E. verfasserin aut Nohr, Ellen verfasserin aut Escaramís, Geòrgia verfasserin aut Rzehak, Peter verfasserin aut Heiskala, Anni verfasserin aut Gong, Tong verfasserin aut Tuominen, Samuli T. verfasserin aut Gao, Lu verfasserin aut Ross, Jason P. verfasserin aut Starling, Anne P. verfasserin aut Holloway, John W. verfasserin aut Yousefi, Paul verfasserin aut Aasvang, Gunn Marit verfasserin aut Beilin, Lawrence J. verfasserin aut Bergström, Anna verfasserin aut Binder, Elisabeth verfasserin aut Chatzi, Leda verfasserin aut Corpeleijn, Eva verfasserin aut Czamara, Darina verfasserin aut Eskenazi, Brenda verfasserin aut Ewart, Susan verfasserin aut Ferre, Natalia verfasserin aut Grote, Veit verfasserin aut Gruszfeld, Dariusz verfasserin aut Håberg, Siri E. verfasserin aut Hoyo, Cathrine verfasserin aut Huen, Karen verfasserin aut Karlsson, Robert verfasserin aut Kull, Inger verfasserin aut Langhendries, Jean-Paul verfasserin aut Lepeule, Johanna verfasserin aut Magnus, Maria C. verfasserin aut Maguire, Rachel L. verfasserin aut Molloy, Peter L. verfasserin aut Monnereau, Claire verfasserin aut Mori, Trevor A. verfasserin aut Oken, Emily verfasserin aut Räikkönen, Katri verfasserin aut Rifas-Shiman, Sheryl verfasserin aut Ruiz-Arenas, Carlos verfasserin aut Sebert, Sylvain verfasserin aut Ullemar, Vilhelmina verfasserin aut Verduci, Elvira verfasserin aut Vonk, Judith M. verfasserin aut Xu, Cheng-jian verfasserin aut Yang, Ivana V. verfasserin aut Zhang, Hongmei verfasserin aut Zhang, Weiming verfasserin aut Karmaus, Wilfried verfasserin aut Dabelea, Dana verfasserin aut Muhlhausler, Beverly S. verfasserin aut Breton, Carrie V. verfasserin aut Lahti, Jari verfasserin aut Almqvist, Catarina verfasserin aut Jarvelin, Marjo-Riitta verfasserin aut Koletzko, Berthold verfasserin aut Vrijheid, Martine verfasserin aut Sørensen, Thorkild I. A. verfasserin aut Huang, Rae-Chi verfasserin aut Arshad, Syed Hasan verfasserin aut Nystad, Wenche verfasserin aut Melén, Erik verfasserin aut Koppelman, Gerard H. verfasserin aut London, Stephanie J. verfasserin aut Holland, Nina verfasserin aut Bustamante, Mariona verfasserin aut Murphy, Susan K. verfasserin aut Hivert, Marie-France verfasserin aut Baccarelli, Andrea verfasserin aut Relton, Caroline L. verfasserin aut Snieder, Harold verfasserin aut Jaddoe, Vincent W. V. verfasserin aut Felix, Janine F. verfasserin aut Enthalten in Genome medicine London : BioMed Central, 2009 12(2020), 1 vom: 25. Nov. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:12 year:2020 number:1 day:25 month:11 https://dx.doi.org/10.1186/s13073-020-00810-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 1 25 11 |
| allfields_unstemmed |
10.1186/s13073-020-00810-w doi (DE-627)SPR042150396 (SPR)s13073-020-00810-w-e DE-627 ger DE-627 rakwb eng 610 ASE Vehmeijer, Florianne O. L. verfasserin aut DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × $ 10^{−7} $, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × $ 10^{−4} $; adolescence Penrichment = 2.10 × $ 10^{−7} $). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity. Body mass index (dpeaa)DE-He213 Childhood obesity (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Küpers, Leanne K. verfasserin aut Sharp, Gemma C. verfasserin aut Salas, Lucas A. verfasserin aut Lent, Samantha verfasserin aut Jima, Dereje D. verfasserin aut Tindula, Gwen verfasserin aut Reese, Sarah verfasserin aut Qi, Cancan verfasserin aut Gruzieva, Olena verfasserin aut Page, Christian verfasserin aut Rezwan, Faisal I. verfasserin aut Melton, Philip E. verfasserin aut Nohr, Ellen verfasserin aut Escaramís, Geòrgia verfasserin aut Rzehak, Peter verfasserin aut Heiskala, Anni verfasserin aut Gong, Tong verfasserin aut Tuominen, Samuli T. verfasserin aut Gao, Lu verfasserin aut Ross, Jason P. verfasserin aut Starling, Anne P. verfasserin aut Holloway, John W. verfasserin aut Yousefi, Paul verfasserin aut Aasvang, Gunn Marit verfasserin aut Beilin, Lawrence J. verfasserin aut Bergström, Anna verfasserin aut Binder, Elisabeth verfasserin aut Chatzi, Leda verfasserin aut Corpeleijn, Eva verfasserin aut Czamara, Darina verfasserin aut Eskenazi, Brenda verfasserin aut Ewart, Susan verfasserin aut Ferre, Natalia verfasserin aut Grote, Veit verfasserin aut Gruszfeld, Dariusz verfasserin aut Håberg, Siri E. verfasserin aut Hoyo, Cathrine verfasserin aut Huen, Karen verfasserin aut Karlsson, Robert verfasserin aut Kull, Inger verfasserin aut Langhendries, Jean-Paul verfasserin aut Lepeule, Johanna verfasserin aut Magnus, Maria C. verfasserin aut Maguire, Rachel L. verfasserin aut Molloy, Peter L. verfasserin aut Monnereau, Claire verfasserin aut Mori, Trevor A. verfasserin aut Oken, Emily verfasserin aut Räikkönen, Katri verfasserin aut Rifas-Shiman, Sheryl verfasserin aut Ruiz-Arenas, Carlos verfasserin aut Sebert, Sylvain verfasserin aut Ullemar, Vilhelmina verfasserin aut Verduci, Elvira verfasserin aut Vonk, Judith M. verfasserin aut Xu, Cheng-jian verfasserin aut Yang, Ivana V. verfasserin aut Zhang, Hongmei verfasserin aut Zhang, Weiming verfasserin aut Karmaus, Wilfried verfasserin aut Dabelea, Dana verfasserin aut Muhlhausler, Beverly S. verfasserin aut Breton, Carrie V. verfasserin aut Lahti, Jari verfasserin aut Almqvist, Catarina verfasserin aut Jarvelin, Marjo-Riitta verfasserin aut Koletzko, Berthold verfasserin aut Vrijheid, Martine verfasserin aut Sørensen, Thorkild I. A. verfasserin aut Huang, Rae-Chi verfasserin aut Arshad, Syed Hasan verfasserin aut Nystad, Wenche verfasserin aut Melén, Erik verfasserin aut Koppelman, Gerard H. verfasserin aut London, Stephanie J. verfasserin aut Holland, Nina verfasserin aut Bustamante, Mariona verfasserin aut Murphy, Susan K. verfasserin aut Hivert, Marie-France verfasserin aut Baccarelli, Andrea verfasserin aut Relton, Caroline L. verfasserin aut Snieder, Harold verfasserin aut Jaddoe, Vincent W. V. verfasserin aut Felix, Janine F. verfasserin aut Enthalten in Genome medicine London : BioMed Central, 2009 12(2020), 1 vom: 25. Nov. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:12 year:2020 number:1 day:25 month:11 https://dx.doi.org/10.1186/s13073-020-00810-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 1 25 11 |
| allfieldsGer |
10.1186/s13073-020-00810-w doi (DE-627)SPR042150396 (SPR)s13073-020-00810-w-e DE-627 ger DE-627 rakwb eng 610 ASE Vehmeijer, Florianne O. L. verfasserin aut DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × $ 10^{−7} $, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × $ 10^{−4} $; adolescence Penrichment = 2.10 × $ 10^{−7} $). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity. Body mass index (dpeaa)DE-He213 Childhood obesity (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Küpers, Leanne K. verfasserin aut Sharp, Gemma C. verfasserin aut Salas, Lucas A. verfasserin aut Lent, Samantha verfasserin aut Jima, Dereje D. verfasserin aut Tindula, Gwen verfasserin aut Reese, Sarah verfasserin aut Qi, Cancan verfasserin aut Gruzieva, Olena verfasserin aut Page, Christian verfasserin aut Rezwan, Faisal I. verfasserin aut Melton, Philip E. verfasserin aut Nohr, Ellen verfasserin aut Escaramís, Geòrgia verfasserin aut Rzehak, Peter verfasserin aut Heiskala, Anni verfasserin aut Gong, Tong verfasserin aut Tuominen, Samuli T. verfasserin aut Gao, Lu verfasserin aut Ross, Jason P. verfasserin aut Starling, Anne P. verfasserin aut Holloway, John W. verfasserin aut Yousefi, Paul verfasserin aut Aasvang, Gunn Marit verfasserin aut Beilin, Lawrence J. verfasserin aut Bergström, Anna verfasserin aut Binder, Elisabeth verfasserin aut Chatzi, Leda verfasserin aut Corpeleijn, Eva verfasserin aut Czamara, Darina verfasserin aut Eskenazi, Brenda verfasserin aut Ewart, Susan verfasserin aut Ferre, Natalia verfasserin aut Grote, Veit verfasserin aut Gruszfeld, Dariusz verfasserin aut Håberg, Siri E. verfasserin aut Hoyo, Cathrine verfasserin aut Huen, Karen verfasserin aut Karlsson, Robert verfasserin aut Kull, Inger verfasserin aut Langhendries, Jean-Paul verfasserin aut Lepeule, Johanna verfasserin aut Magnus, Maria C. verfasserin aut Maguire, Rachel L. verfasserin aut Molloy, Peter L. verfasserin aut Monnereau, Claire verfasserin aut Mori, Trevor A. verfasserin aut Oken, Emily verfasserin aut Räikkönen, Katri verfasserin aut Rifas-Shiman, Sheryl verfasserin aut Ruiz-Arenas, Carlos verfasserin aut Sebert, Sylvain verfasserin aut Ullemar, Vilhelmina verfasserin aut Verduci, Elvira verfasserin aut Vonk, Judith M. verfasserin aut Xu, Cheng-jian verfasserin aut Yang, Ivana V. verfasserin aut Zhang, Hongmei verfasserin aut Zhang, Weiming verfasserin aut Karmaus, Wilfried verfasserin aut Dabelea, Dana verfasserin aut Muhlhausler, Beverly S. verfasserin aut Breton, Carrie V. verfasserin aut Lahti, Jari verfasserin aut Almqvist, Catarina verfasserin aut Jarvelin, Marjo-Riitta verfasserin aut Koletzko, Berthold verfasserin aut Vrijheid, Martine verfasserin aut Sørensen, Thorkild I. A. verfasserin aut Huang, Rae-Chi verfasserin aut Arshad, Syed Hasan verfasserin aut Nystad, Wenche verfasserin aut Melén, Erik verfasserin aut Koppelman, Gerard H. verfasserin aut London, Stephanie J. verfasserin aut Holland, Nina verfasserin aut Bustamante, Mariona verfasserin aut Murphy, Susan K. verfasserin aut Hivert, Marie-France verfasserin aut Baccarelli, Andrea verfasserin aut Relton, Caroline L. verfasserin aut Snieder, Harold verfasserin aut Jaddoe, Vincent W. V. verfasserin aut Felix, Janine F. verfasserin aut Enthalten in Genome medicine London : BioMed Central, 2009 12(2020), 1 vom: 25. Nov. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:12 year:2020 number:1 day:25 month:11 https://dx.doi.org/10.1186/s13073-020-00810-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 1 25 11 |
| allfieldsSound |
10.1186/s13073-020-00810-w doi (DE-627)SPR042150396 (SPR)s13073-020-00810-w-e DE-627 ger DE-627 rakwb eng 610 ASE Vehmeijer, Florianne O. L. verfasserin aut DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × $ 10^{−7} $, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × $ 10^{−4} $; adolescence Penrichment = 2.10 × $ 10^{−7} $). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity. Body mass index (dpeaa)DE-He213 Childhood obesity (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Küpers, Leanne K. verfasserin aut Sharp, Gemma C. verfasserin aut Salas, Lucas A. verfasserin aut Lent, Samantha verfasserin aut Jima, Dereje D. verfasserin aut Tindula, Gwen verfasserin aut Reese, Sarah verfasserin aut Qi, Cancan verfasserin aut Gruzieva, Olena verfasserin aut Page, Christian verfasserin aut Rezwan, Faisal I. verfasserin aut Melton, Philip E. verfasserin aut Nohr, Ellen verfasserin aut Escaramís, Geòrgia verfasserin aut Rzehak, Peter verfasserin aut Heiskala, Anni verfasserin aut Gong, Tong verfasserin aut Tuominen, Samuli T. verfasserin aut Gao, Lu verfasserin aut Ross, Jason P. verfasserin aut Starling, Anne P. verfasserin aut Holloway, John W. verfasserin aut Yousefi, Paul verfasserin aut Aasvang, Gunn Marit verfasserin aut Beilin, Lawrence J. verfasserin aut Bergström, Anna verfasserin aut Binder, Elisabeth verfasserin aut Chatzi, Leda verfasserin aut Corpeleijn, Eva verfasserin aut Czamara, Darina verfasserin aut Eskenazi, Brenda verfasserin aut Ewart, Susan verfasserin aut Ferre, Natalia verfasserin aut Grote, Veit verfasserin aut Gruszfeld, Dariusz verfasserin aut Håberg, Siri E. verfasserin aut Hoyo, Cathrine verfasserin aut Huen, Karen verfasserin aut Karlsson, Robert verfasserin aut Kull, Inger verfasserin aut Langhendries, Jean-Paul verfasserin aut Lepeule, Johanna verfasserin aut Magnus, Maria C. verfasserin aut Maguire, Rachel L. verfasserin aut Molloy, Peter L. verfasserin aut Monnereau, Claire verfasserin aut Mori, Trevor A. verfasserin aut Oken, Emily verfasserin aut Räikkönen, Katri verfasserin aut Rifas-Shiman, Sheryl verfasserin aut Ruiz-Arenas, Carlos verfasserin aut Sebert, Sylvain verfasserin aut Ullemar, Vilhelmina verfasserin aut Verduci, Elvira verfasserin aut Vonk, Judith M. verfasserin aut Xu, Cheng-jian verfasserin aut Yang, Ivana V. verfasserin aut Zhang, Hongmei verfasserin aut Zhang, Weiming verfasserin aut Karmaus, Wilfried verfasserin aut Dabelea, Dana verfasserin aut Muhlhausler, Beverly S. verfasserin aut Breton, Carrie V. verfasserin aut Lahti, Jari verfasserin aut Almqvist, Catarina verfasserin aut Jarvelin, Marjo-Riitta verfasserin aut Koletzko, Berthold verfasserin aut Vrijheid, Martine verfasserin aut Sørensen, Thorkild I. A. verfasserin aut Huang, Rae-Chi verfasserin aut Arshad, Syed Hasan verfasserin aut Nystad, Wenche verfasserin aut Melén, Erik verfasserin aut Koppelman, Gerard H. verfasserin aut London, Stephanie J. verfasserin aut Holland, Nina verfasserin aut Bustamante, Mariona verfasserin aut Murphy, Susan K. verfasserin aut Hivert, Marie-France verfasserin aut Baccarelli, Andrea verfasserin aut Relton, Caroline L. verfasserin aut Snieder, Harold verfasserin aut Jaddoe, Vincent W. V. verfasserin aut Felix, Janine F. verfasserin aut Enthalten in Genome medicine London : BioMed Central, 2009 12(2020), 1 vom: 25. Nov. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:12 year:2020 number:1 day:25 month:11 https://dx.doi.org/10.1186/s13073-020-00810-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 1 25 11 |
| language |
English |
| source |
Enthalten in Genome medicine 12(2020), 1 vom: 25. Nov. volume:12 year:2020 number:1 day:25 month:11 |
| sourceStr |
Enthalten in Genome medicine 12(2020), 1 vom: 25. Nov. volume:12 year:2020 number:1 day:25 month:11 |
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Article |
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findex.gbv.de |
| topic_facet |
Body mass index Childhood obesity DNA methylation Epigenetics |
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610 |
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true |
| container_title |
Genome medicine |
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Vehmeijer, Florianne O. L. @@aut@@ Küpers, Leanne K. @@aut@@ Sharp, Gemma C. @@aut@@ Salas, Lucas A. @@aut@@ Lent, Samantha @@aut@@ Jima, Dereje D. @@aut@@ Tindula, Gwen @@aut@@ Reese, Sarah @@aut@@ Qi, Cancan @@aut@@ Gruzieva, Olena @@aut@@ Page, Christian @@aut@@ Rezwan, Faisal I. @@aut@@ Melton, Philip E. @@aut@@ Nohr, Ellen @@aut@@ Escaramís, Geòrgia @@aut@@ Rzehak, Peter @@aut@@ Heiskala, Anni @@aut@@ Gong, Tong @@aut@@ Tuominen, Samuli T. @@aut@@ Gao, Lu @@aut@@ Ross, Jason P. @@aut@@ Starling, Anne P. @@aut@@ Holloway, John W. @@aut@@ Yousefi, Paul @@aut@@ Aasvang, Gunn Marit @@aut@@ Beilin, Lawrence J. @@aut@@ Bergström, Anna @@aut@@ Binder, Elisabeth @@aut@@ Chatzi, Leda @@aut@@ Corpeleijn, Eva @@aut@@ Czamara, Darina @@aut@@ Eskenazi, Brenda @@aut@@ Ewart, Susan @@aut@@ Ferre, Natalia @@aut@@ Grote, Veit @@aut@@ Gruszfeld, Dariusz @@aut@@ Håberg, Siri E. @@aut@@ Hoyo, Cathrine @@aut@@ Huen, Karen @@aut@@ Karlsson, Robert @@aut@@ Kull, Inger @@aut@@ Langhendries, Jean-Paul @@aut@@ Lepeule, Johanna @@aut@@ Magnus, Maria C. @@aut@@ Maguire, Rachel L. @@aut@@ Molloy, Peter L. @@aut@@ Monnereau, Claire @@aut@@ Mori, Trevor A. @@aut@@ Oken, Emily @@aut@@ Räikkönen, Katri @@aut@@ Rifas-Shiman, Sheryl @@aut@@ Ruiz-Arenas, Carlos @@aut@@ Sebert, Sylvain @@aut@@ Ullemar, Vilhelmina @@aut@@ Verduci, Elvira @@aut@@ Vonk, Judith M. @@aut@@ Xu, Cheng-jian @@aut@@ Yang, Ivana V. @@aut@@ Zhang, Hongmei @@aut@@ Zhang, Weiming @@aut@@ Karmaus, Wilfried @@aut@@ Dabelea, Dana @@aut@@ Muhlhausler, Beverly S. @@aut@@ Breton, Carrie V. @@aut@@ Lahti, Jari @@aut@@ Almqvist, Catarina @@aut@@ Jarvelin, Marjo-Riitta @@aut@@ Koletzko, Berthold @@aut@@ Vrijheid, Martine @@aut@@ Sørensen, Thorkild I. A. @@aut@@ Huang, Rae-Chi @@aut@@ Arshad, Syed Hasan @@aut@@ Nystad, Wenche @@aut@@ Melén, Erik @@aut@@ Koppelman, Gerard H. @@aut@@ London, Stephanie J. @@aut@@ Holland, Nina @@aut@@ Bustamante, Mariona @@aut@@ Murphy, Susan K. @@aut@@ Hivert, Marie-France @@aut@@ Baccarelli, Andrea @@aut@@ Relton, Caroline L. @@aut@@ Snieder, Harold @@aut@@ Jaddoe, Vincent W. V. @@aut@@ Felix, Janine F. @@aut@@ |
| publishDateDaySort_date |
2020-11-25T00:00:00Z |
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594424275 |
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3610 |
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SPR042150396 |
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englisch |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR042150396</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519191634.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201126s2020 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s13073-020-00810-w</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR042150396</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13073-020-00810-w-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Vehmeijer, Florianne O. L.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × $ 10^{−7} $, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × $ 10^{−4} $; adolescence Penrichment = 2.10 × $ 10^{−7} $). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. 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Vehmeijer, Florianne O. L. Küpers, Leanne K. Sharp, Gemma C. Salas, Lucas A. Lent, Samantha Jima, Dereje D. Tindula, Gwen Reese, Sarah Qi, Cancan Gruzieva, Olena Page, Christian Rezwan, Faisal I. Melton, Philip E. Nohr, Ellen Escaramís, Geòrgia Rzehak, Peter Heiskala, Anni Gong, Tong Tuominen, Samuli T. Gao, Lu Ross, Jason P. Starling, Anne P. Holloway, John W. Yousefi, Paul Aasvang, Gunn Marit Beilin, Lawrence J. Bergström, Anna Binder, Elisabeth Chatzi, Leda Corpeleijn, Eva Czamara, Darina Eskenazi, Brenda Ewart, Susan Ferre, Natalia Grote, Veit Gruszfeld, Dariusz Håberg, Siri E. Hoyo, Cathrine Huen, Karen Karlsson, Robert Kull, Inger Langhendries, Jean-Paul Lepeule, Johanna Magnus, Maria C. Maguire, Rachel L. Molloy, Peter L. Monnereau, Claire Mori, Trevor A. Oken, Emily Räikkönen, Katri Rifas-Shiman, Sheryl Ruiz-Arenas, Carlos Sebert, Sylvain Ullemar, Vilhelmina Verduci, Elvira Vonk, Judith M. Xu, Cheng-jian Yang, Ivana V. Zhang, Hongmei Zhang, Weiming Karmaus, Wilfried Dabelea, Dana Muhlhausler, Beverly S. Breton, Carrie V. Lahti, Jari Almqvist, Catarina Jarvelin, Marjo-Riitta Koletzko, Berthold Vrijheid, Martine Sørensen, Thorkild I. A. Huang, Rae-Chi Arshad, Syed Hasan Nystad, Wenche Melén, Erik Koppelman, Gerard H. London, Stephanie J. Holland, Nina Bustamante, Mariona Murphy, Susan K. Hivert, Marie-France Baccarelli, Andrea Relton, Caroline L. Snieder, Harold Jaddoe, Vincent W. V. Felix, Janine F. |
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dna methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies |
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DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies |
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Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × $ 10^{−7} $, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × $ 10^{−4} $; adolescence Penrichment = 2.10 × $ 10^{−7} $). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity. |
| abstractGer |
Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × $ 10^{−7} $, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × $ 10^{−4} $; adolescence Penrichment = 2.10 × $ 10^{−7} $). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity. |
| abstract_unstemmed |
Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × $ 10^{−7} $, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × $ 10^{−4} $; adolescence Penrichment = 2.10 × $ 10^{−7} $). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity. |
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Küpers, Leanne K. Sharp, Gemma C. Salas, Lucas A. Lent, Samantha Jima, Dereje D. Tindula, Gwen Reese, Sarah Qi, Cancan Gruzieva, Olena Page, Christian Rezwan, Faisal I. Melton, Philip E. Nohr, Ellen Escaramís, Geòrgia Rzehak, Peter Heiskala, Anni Gong, Tong Tuominen, Samuli T. Gao, Lu Ross, Jason P. Starling, Anne P. Holloway, John W. Yousefi, Paul Aasvang, Gunn Marit Beilin, Lawrence J. Bergström, Anna Binder, Elisabeth Chatzi, Leda Corpeleijn, Eva Czamara, Darina Eskenazi, Brenda Ewart, Susan Ferre, Natalia Grote, Veit Gruszfeld, Dariusz Håberg, Siri E. Hoyo, Cathrine Huen, Karen Karlsson, Robert Kull, Inger Langhendries, Jean-Paul Lepeule, Johanna Magnus, Maria C. Maguire, Rachel L. Molloy, Peter L. Monnereau, Claire Mori, Trevor A. Oken, Emily Räikkönen, Katri Rifas-Shiman, Sheryl Ruiz-Arenas, Carlos Sebert, Sylvain Ullemar, Vilhelmina Verduci, Elvira Vonk, Judith M. Xu, Cheng-jian Yang, Ivana V. Zhang, Hongmei Zhang, Weiming Karmaus, Wilfried Dabelea, Dana Muhlhausler, Beverly S. Breton, Carrie V. Lahti, Jari Almqvist, Catarina Jarvelin, Marjo-Riitta Koletzko, Berthold Vrijheid, Martine Sørensen, Thorkild I. A. Huang, Rae-Chi Arshad, Syed Hasan Nystad, Wenche Melén, Erik Koppelman, Gerard H. London, Stephanie J. Holland, Nina Bustamante, Mariona Murphy, Susan K. Hivert, Marie-France Baccarelli, Andrea Relton, Caroline L. Snieder, Harold Jaddoe, Vincent W. V. Felix, Janine F. |
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L.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × $ 10^{−7} $, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × $ 10^{−4} $; adolescence Penrichment = 2.10 × $ 10^{−7} $). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. 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| score |
7.4003096 |