Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study

Background Integration of imaging and clinical parameters could improve the stratification of COVID-19 patients on emergency department (ED) admission. We aimed to assess the extent of COVID-19 pulmonary abnormalities on chest x-ray (CXR) using a semiquantitative severity score, correlating it with...
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Autor*in:	Monaco, Cristian Giuseppe [verfasserIn] Zaottini, Federico [verfasserIn] Schiaffino, Simone [verfasserIn] Villa, Alessandro [verfasserIn] Della Pepa, Gianmarco [verfasserIn] Carbonaro, Luca Alessandro [verfasserIn] Menicagli, Laura [verfasserIn] Cozzi, Andrea [verfasserIn] Carriero, Serena [verfasserIn] Arpaia, Francesco [verfasserIn] Di Leo, Giovanni [verfasserIn] Astengo, Davide [verfasserIn] Rosenberg, Ilan [verfasserIn] Sardanelli, Francesco [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	COVID-19 COVID-19 diagnostic testing Diagnostic imaging Chest x-ray Severity score

Übergeordnetes Werk:	Enthalten in: European radiology experimental - [Cham] : Springer International Publishing, 2017, 4(2020), 1 vom: 15. Dez.
Übergeordnetes Werk:	volume:4 ; year:2020 ; number:1 ; day:15 ; month:12

Links:	Volltext

DOI / URN:	10.1186/s41747-020-00195-w

Katalog-ID:	SPR042402611

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520			\|a Background Integration of imaging and clinical parameters could improve the stratification of COVID-19 patients on emergency department (ED) admission. We aimed to assess the extent of COVID-19 pulmonary abnormalities on chest x-ray (CXR) using a semiquantitative severity score, correlating it with clinical data and testing its interobserver agreement. Methods From February 22 to April 8, 2020, 926 consecutive patients referring to ED of two institutions in Northern Italy for suspected SARS-CoV-2 infection were reviewed. Patients with reverse transcriptase-polymerase chain reaction positive for SARS-CoV-2 and CXR images on ED admission were included (295 patients, median age 69 years, 199 males). Five readers independently and blindly reviewed all CXRs, rating pulmonary parenchymal involvement using a 0–3 semiquantitative score in 1-point increments on 6 lung zones (range 0–18). Interobserver agreement was assessed with weighted Cohen’s κ, correlations between median CXR score and clinical data with Spearman’s ρ, and the Mann-Whitney U test. Results Median score showed negative correlation with $ SpO_{2} $ (ρ = -0.242, p < 0.001), positive correlation with white cell count (ρ = 0.277, p < 0.001), lactate dehydrogenase (ρ = 0.308, p < 0.001), and C-reactive protein (ρ = 0.367, p < 0.001), being significantly higher in subsequently dead patients (p = 0.003). Considering overall scores, readers’ pairings yielded moderate (κ = 0.449, p < 0.001) to almost perfect interobserver agreement (κ = 0.872, p < 0.001), with better interobserver agreement between readers of centre 2 (up to κ = 0.872, p < 0.001) than centre 1 (κ = 0.764, p < 0.001). Conclusions Proposed CXR pulmonary severity score in COVID-19 showed moderate to almost perfect interobserver agreement and significant but weak correlations with clinical parameters, potentially furthering CXR integration in patients’ stratification.
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allfields	10.1186/s41747-020-00195-w doi (DE-627)SPR042402611 (DE-599)SPRs41747-020-00195-w-e (SPR)s41747-020-00195-w-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE Monaco, Cristian Giuseppe verfasserin aut Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Integration of imaging and clinical parameters could improve the stratification of COVID-19 patients on emergency department (ED) admission. We aimed to assess the extent of COVID-19 pulmonary abnormalities on chest x-ray (CXR) using a semiquantitative severity score, correlating it with clinical data and testing its interobserver agreement. Methods From February 22 to April 8, 2020, 926 consecutive patients referring to ED of two institutions in Northern Italy for suspected SARS-CoV-2 infection were reviewed. Patients with reverse transcriptase-polymerase chain reaction positive for SARS-CoV-2 and CXR images on ED admission were included (295 patients, median age 69 years, 199 males). Five readers independently and blindly reviewed all CXRs, rating pulmonary parenchymal involvement using a 0–3 semiquantitative score in 1-point increments on 6 lung zones (range 0–18). Interobserver agreement was assessed with weighted Cohen’s κ, correlations between median CXR score and clinical data with Spearman’s ρ, and the Mann-Whitney U test. Results Median score showed negative correlation with $ SpO_{2} $ (ρ = -0.242, p < 0.001), positive correlation with white cell count (ρ = 0.277, p < 0.001), lactate dehydrogenase (ρ = 0.308, p < 0.001), and C-reactive protein (ρ = 0.367, p < 0.001), being significantly higher in subsequently dead patients (p = 0.003). Considering overall scores, readers’ pairings yielded moderate (κ = 0.449, p < 0.001) to almost perfect interobserver agreement (κ = 0.872, p < 0.001), with better interobserver agreement between readers of centre 2 (up to κ = 0.872, p < 0.001) than centre 1 (κ = 0.764, p < 0.001). Conclusions Proposed CXR pulmonary severity score in COVID-19 showed moderate to almost perfect interobserver agreement and significant but weak correlations with clinical parameters, potentially furthering CXR integration in patients’ stratification. COVID-19 (dpeaa)DE-He213 COVID-19 diagnostic testing (dpeaa)DE-He213 Diagnostic imaging (dpeaa)DE-He213 Chest x-ray (dpeaa)DE-He213 Severity score (dpeaa)DE-He213 Zaottini, Federico verfasserin aut Schiaffino, Simone verfasserin aut Villa, Alessandro verfasserin aut Della Pepa, Gianmarco verfasserin aut Carbonaro, Luca Alessandro verfasserin aut Menicagli, Laura verfasserin aut Cozzi, Andrea verfasserin aut Carriero, Serena verfasserin aut Arpaia, Francesco verfasserin aut Di Leo, Giovanni verfasserin aut Astengo, Davide verfasserin aut Rosenberg, Ilan verfasserin aut Sardanelli, Francesco verfasserin aut Enthalten in European radiology experimental [Cham] : Springer International Publishing, 2017 4(2020), 1 vom: 15. Dez. (DE-627)898118557 (DE-600)2905812-0 2509-9280 nnns volume:4 year:2020 number:1 day:15 month:12 https://dx.doi.org/10.1186/s41747-020-00195-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2020 1 15 12
spelling	10.1186/s41747-020-00195-w doi (DE-627)SPR042402611 (DE-599)SPRs41747-020-00195-w-e (SPR)s41747-020-00195-w-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE Monaco, Cristian Giuseppe verfasserin aut Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Integration of imaging and clinical parameters could improve the stratification of COVID-19 patients on emergency department (ED) admission. We aimed to assess the extent of COVID-19 pulmonary abnormalities on chest x-ray (CXR) using a semiquantitative severity score, correlating it with clinical data and testing its interobserver agreement. Methods From February 22 to April 8, 2020, 926 consecutive patients referring to ED of two institutions in Northern Italy for suspected SARS-CoV-2 infection were reviewed. Patients with reverse transcriptase-polymerase chain reaction positive for SARS-CoV-2 and CXR images on ED admission were included (295 patients, median age 69 years, 199 males). Five readers independently and blindly reviewed all CXRs, rating pulmonary parenchymal involvement using a 0–3 semiquantitative score in 1-point increments on 6 lung zones (range 0–18). Interobserver agreement was assessed with weighted Cohen’s κ, correlations between median CXR score and clinical data with Spearman’s ρ, and the Mann-Whitney U test. Results Median score showed negative correlation with $ SpO_{2} $ (ρ = -0.242, p < 0.001), positive correlation with white cell count (ρ = 0.277, p < 0.001), lactate dehydrogenase (ρ = 0.308, p < 0.001), and C-reactive protein (ρ = 0.367, p < 0.001), being significantly higher in subsequently dead patients (p = 0.003). Considering overall scores, readers’ pairings yielded moderate (κ = 0.449, p < 0.001) to almost perfect interobserver agreement (κ = 0.872, p < 0.001), with better interobserver agreement between readers of centre 2 (up to κ = 0.872, p < 0.001) than centre 1 (κ = 0.764, p < 0.001). Conclusions Proposed CXR pulmonary severity score in COVID-19 showed moderate to almost perfect interobserver agreement and significant but weak correlations with clinical parameters, potentially furthering CXR integration in patients’ stratification. COVID-19 (dpeaa)DE-He213 COVID-19 diagnostic testing (dpeaa)DE-He213 Diagnostic imaging (dpeaa)DE-He213 Chest x-ray (dpeaa)DE-He213 Severity score (dpeaa)DE-He213 Zaottini, Federico verfasserin aut Schiaffino, Simone verfasserin aut Villa, Alessandro verfasserin aut Della Pepa, Gianmarco verfasserin aut Carbonaro, Luca Alessandro verfasserin aut Menicagli, Laura verfasserin aut Cozzi, Andrea verfasserin aut Carriero, Serena verfasserin aut Arpaia, Francesco verfasserin aut Di Leo, Giovanni verfasserin aut Astengo, Davide verfasserin aut Rosenberg, Ilan verfasserin aut Sardanelli, Francesco verfasserin aut Enthalten in European radiology experimental [Cham] : Springer International Publishing, 2017 4(2020), 1 vom: 15. Dez. (DE-627)898118557 (DE-600)2905812-0 2509-9280 nnns volume:4 year:2020 number:1 day:15 month:12 https://dx.doi.org/10.1186/s41747-020-00195-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2020 1 15 12
allfields_unstemmed	10.1186/s41747-020-00195-w doi (DE-627)SPR042402611 (DE-599)SPRs41747-020-00195-w-e (SPR)s41747-020-00195-w-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE Monaco, Cristian Giuseppe verfasserin aut Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Integration of imaging and clinical parameters could improve the stratification of COVID-19 patients on emergency department (ED) admission. We aimed to assess the extent of COVID-19 pulmonary abnormalities on chest x-ray (CXR) using a semiquantitative severity score, correlating it with clinical data and testing its interobserver agreement. Methods From February 22 to April 8, 2020, 926 consecutive patients referring to ED of two institutions in Northern Italy for suspected SARS-CoV-2 infection were reviewed. Patients with reverse transcriptase-polymerase chain reaction positive for SARS-CoV-2 and CXR images on ED admission were included (295 patients, median age 69 years, 199 males). Five readers independently and blindly reviewed all CXRs, rating pulmonary parenchymal involvement using a 0–3 semiquantitative score in 1-point increments on 6 lung zones (range 0–18). Interobserver agreement was assessed with weighted Cohen’s κ, correlations between median CXR score and clinical data with Spearman’s ρ, and the Mann-Whitney U test. Results Median score showed negative correlation with $ SpO_{2} $ (ρ = -0.242, p < 0.001), positive correlation with white cell count (ρ = 0.277, p < 0.001), lactate dehydrogenase (ρ = 0.308, p < 0.001), and C-reactive protein (ρ = 0.367, p < 0.001), being significantly higher in subsequently dead patients (p = 0.003). Considering overall scores, readers’ pairings yielded moderate (κ = 0.449, p < 0.001) to almost perfect interobserver agreement (κ = 0.872, p < 0.001), with better interobserver agreement between readers of centre 2 (up to κ = 0.872, p < 0.001) than centre 1 (κ = 0.764, p < 0.001). Conclusions Proposed CXR pulmonary severity score in COVID-19 showed moderate to almost perfect interobserver agreement and significant but weak correlations with clinical parameters, potentially furthering CXR integration in patients’ stratification. COVID-19 (dpeaa)DE-He213 COVID-19 diagnostic testing (dpeaa)DE-He213 Diagnostic imaging (dpeaa)DE-He213 Chest x-ray (dpeaa)DE-He213 Severity score (dpeaa)DE-He213 Zaottini, Federico verfasserin aut Schiaffino, Simone verfasserin aut Villa, Alessandro verfasserin aut Della Pepa, Gianmarco verfasserin aut Carbonaro, Luca Alessandro verfasserin aut Menicagli, Laura verfasserin aut Cozzi, Andrea verfasserin aut Carriero, Serena verfasserin aut Arpaia, Francesco verfasserin aut Di Leo, Giovanni verfasserin aut Astengo, Davide verfasserin aut Rosenberg, Ilan verfasserin aut Sardanelli, Francesco verfasserin aut Enthalten in European radiology experimental [Cham] : Springer International Publishing, 2017 4(2020), 1 vom: 15. Dez. (DE-627)898118557 (DE-600)2905812-0 2509-9280 nnns volume:4 year:2020 number:1 day:15 month:12 https://dx.doi.org/10.1186/s41747-020-00195-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2020 1 15 12
allfieldsGer	10.1186/s41747-020-00195-w doi (DE-627)SPR042402611 (DE-599)SPRs41747-020-00195-w-e (SPR)s41747-020-00195-w-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE Monaco, Cristian Giuseppe verfasserin aut Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Integration of imaging and clinical parameters could improve the stratification of COVID-19 patients on emergency department (ED) admission. We aimed to assess the extent of COVID-19 pulmonary abnormalities on chest x-ray (CXR) using a semiquantitative severity score, correlating it with clinical data and testing its interobserver agreement. Methods From February 22 to April 8, 2020, 926 consecutive patients referring to ED of two institutions in Northern Italy for suspected SARS-CoV-2 infection were reviewed. Patients with reverse transcriptase-polymerase chain reaction positive for SARS-CoV-2 and CXR images on ED admission were included (295 patients, median age 69 years, 199 males). Five readers independently and blindly reviewed all CXRs, rating pulmonary parenchymal involvement using a 0–3 semiquantitative score in 1-point increments on 6 lung zones (range 0–18). Interobserver agreement was assessed with weighted Cohen’s κ, correlations between median CXR score and clinical data with Spearman’s ρ, and the Mann-Whitney U test. Results Median score showed negative correlation with $ SpO_{2} $ (ρ = -0.242, p < 0.001), positive correlation with white cell count (ρ = 0.277, p < 0.001), lactate dehydrogenase (ρ = 0.308, p < 0.001), and C-reactive protein (ρ = 0.367, p < 0.001), being significantly higher in subsequently dead patients (p = 0.003). Considering overall scores, readers’ pairings yielded moderate (κ = 0.449, p < 0.001) to almost perfect interobserver agreement (κ = 0.872, p < 0.001), with better interobserver agreement between readers of centre 2 (up to κ = 0.872, p < 0.001) than centre 1 (κ = 0.764, p < 0.001). Conclusions Proposed CXR pulmonary severity score in COVID-19 showed moderate to almost perfect interobserver agreement and significant but weak correlations with clinical parameters, potentially furthering CXR integration in patients’ stratification. COVID-19 (dpeaa)DE-He213 COVID-19 diagnostic testing (dpeaa)DE-He213 Diagnostic imaging (dpeaa)DE-He213 Chest x-ray (dpeaa)DE-He213 Severity score (dpeaa)DE-He213 Zaottini, Federico verfasserin aut Schiaffino, Simone verfasserin aut Villa, Alessandro verfasserin aut Della Pepa, Gianmarco verfasserin aut Carbonaro, Luca Alessandro verfasserin aut Menicagli, Laura verfasserin aut Cozzi, Andrea verfasserin aut Carriero, Serena verfasserin aut Arpaia, Francesco verfasserin aut Di Leo, Giovanni verfasserin aut Astengo, Davide verfasserin aut Rosenberg, Ilan verfasserin aut Sardanelli, Francesco verfasserin aut Enthalten in European radiology experimental [Cham] : Springer International Publishing, 2017 4(2020), 1 vom: 15. Dez. (DE-627)898118557 (DE-600)2905812-0 2509-9280 nnns volume:4 year:2020 number:1 day:15 month:12 https://dx.doi.org/10.1186/s41747-020-00195-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2020 1 15 12
allfieldsSound	10.1186/s41747-020-00195-w doi (DE-627)SPR042402611 (DE-599)SPRs41747-020-00195-w-e (SPR)s41747-020-00195-w-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE Monaco, Cristian Giuseppe verfasserin aut Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Integration of imaging and clinical parameters could improve the stratification of COVID-19 patients on emergency department (ED) admission. We aimed to assess the extent of COVID-19 pulmonary abnormalities on chest x-ray (CXR) using a semiquantitative severity score, correlating it with clinical data and testing its interobserver agreement. Methods From February 22 to April 8, 2020, 926 consecutive patients referring to ED of two institutions in Northern Italy for suspected SARS-CoV-2 infection were reviewed. Patients with reverse transcriptase-polymerase chain reaction positive for SARS-CoV-2 and CXR images on ED admission were included (295 patients, median age 69 years, 199 males). Five readers independently and blindly reviewed all CXRs, rating pulmonary parenchymal involvement using a 0–3 semiquantitative score in 1-point increments on 6 lung zones (range 0–18). Interobserver agreement was assessed with weighted Cohen’s κ, correlations between median CXR score and clinical data with Spearman’s ρ, and the Mann-Whitney U test. Results Median score showed negative correlation with $ SpO_{2} $ (ρ = -0.242, p < 0.001), positive correlation with white cell count (ρ = 0.277, p < 0.001), lactate dehydrogenase (ρ = 0.308, p < 0.001), and C-reactive protein (ρ = 0.367, p < 0.001), being significantly higher in subsequently dead patients (p = 0.003). Considering overall scores, readers’ pairings yielded moderate (κ = 0.449, p < 0.001) to almost perfect interobserver agreement (κ = 0.872, p < 0.001), with better interobserver agreement between readers of centre 2 (up to κ = 0.872, p < 0.001) than centre 1 (κ = 0.764, p < 0.001). Conclusions Proposed CXR pulmonary severity score in COVID-19 showed moderate to almost perfect interobserver agreement and significant but weak correlations with clinical parameters, potentially furthering CXR integration in patients’ stratification. COVID-19 (dpeaa)DE-He213 COVID-19 diagnostic testing (dpeaa)DE-He213 Diagnostic imaging (dpeaa)DE-He213 Chest x-ray (dpeaa)DE-He213 Severity score (dpeaa)DE-He213 Zaottini, Federico verfasserin aut Schiaffino, Simone verfasserin aut Villa, Alessandro verfasserin aut Della Pepa, Gianmarco verfasserin aut Carbonaro, Luca Alessandro verfasserin aut Menicagli, Laura verfasserin aut Cozzi, Andrea verfasserin aut Carriero, Serena verfasserin aut Arpaia, Francesco verfasserin aut Di Leo, Giovanni verfasserin aut Astengo, Davide verfasserin aut Rosenberg, Ilan verfasserin aut Sardanelli, Francesco verfasserin aut Enthalten in European radiology experimental [Cham] : Springer International Publishing, 2017 4(2020), 1 vom: 15. Dez. (DE-627)898118557 (DE-600)2905812-0 2509-9280 nnns volume:4 year:2020 number:1 day:15 month:12 https://dx.doi.org/10.1186/s41747-020-00195-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2020 1 15 12
language	English
source	Enthalten in European radiology experimental 4(2020), 1 vom: 15. Dez. volume:4 year:2020 number:1 day:15 month:12
sourceStr	Enthalten in European radiology experimental 4(2020), 1 vom: 15. Dez. volume:4 year:2020 number:1 day:15 month:12
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	COVID-19 COVID-19 diagnostic testing Diagnostic imaging Chest x-ray Severity score
dewey-raw	610
isfreeaccess_bool	true
container_title	European radiology experimental
authorswithroles_txt_mv	Monaco, Cristian Giuseppe @@aut@@ Zaottini, Federico @@aut@@ Schiaffino, Simone @@aut@@ Villa, Alessandro @@aut@@ Della Pepa, Gianmarco @@aut@@ Carbonaro, Luca Alessandro @@aut@@ Menicagli, Laura @@aut@@ Cozzi, Andrea @@aut@@ Carriero, Serena @@aut@@ Arpaia, Francesco @@aut@@ Di Leo, Giovanni @@aut@@ Astengo, Davide @@aut@@ Rosenberg, Ilan @@aut@@ Sardanelli, Francesco @@aut@@
publishDateDaySort_date	2020-12-15T00:00:00Z
hierarchy_top_id	898118557
dewey-sort	3610
id	SPR042402611
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR042402611</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519074112.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201215s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s41747-020-00195-w</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR042402611</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)SPRs41747-020-00195-w-e</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s41747-020-00195-w-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Monaco, Cristian Giuseppe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Integration of imaging and clinical parameters could improve the stratification of COVID-19 patients on emergency department (ED) admission. We aimed to assess the extent of COVID-19 pulmonary abnormalities on chest x-ray (CXR) using a semiquantitative severity score, correlating it with clinical data and testing its interobserver agreement. Methods From February 22 to April 8, 2020, 926 consecutive patients referring to ED of two institutions in Northern Italy for suspected SARS-CoV-2 infection were reviewed. Patients with reverse transcriptase-polymerase chain reaction positive for SARS-CoV-2 and CXR images on ED admission were included (295 patients, median age 69 years, 199 males). Five readers independently and blindly reviewed all CXRs, rating pulmonary parenchymal involvement using a 0–3 semiquantitative score in 1-point increments on 6 lung zones (range 0–18). Interobserver agreement was assessed with weighted Cohen’s κ, correlations between median CXR score and clinical data with Spearman’s ρ, and the Mann-Whitney U test. Results Median score showed negative correlation with $ SpO_{2} $ (ρ = -0.242, p < 0.001), positive correlation with white cell count (ρ = 0.277, p < 0.001), lactate dehydrogenase (ρ = 0.308, p < 0.001), and C-reactive protein (ρ = 0.367, p < 0.001), being significantly higher in subsequently dead patients (p = 0.003). Considering overall scores, readers’ pairings yielded moderate (κ = 0.449, p < 0.001) to almost perfect interobserver agreement (κ = 0.872, p < 0.001), with better interobserver agreement between readers of centre 2 (up to κ = 0.872, p < 0.001) than centre 1 (κ = 0.764, p < 0.001). 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author	Monaco, Cristian Giuseppe
spellingShingle	Monaco, Cristian Giuseppe ddc 610 misc COVID-19 misc COVID-19 diagnostic testing misc Diagnostic imaging misc Chest x-ray misc Severity score Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study
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topic_title	610 ASE Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study COVID-19 (dpeaa)DE-He213 COVID-19 diagnostic testing (dpeaa)DE-He213 Diagnostic imaging (dpeaa)DE-He213 Chest x-ray (dpeaa)DE-He213 Severity score (dpeaa)DE-He213
topic	ddc 610 misc COVID-19 misc COVID-19 diagnostic testing misc Diagnostic imaging misc Chest x-ray misc Severity score
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title	Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study
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title_full	Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study
author_sort	Monaco, Cristian Giuseppe
journal	European radiology experimental
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author_browse	Monaco, Cristian Giuseppe Zaottini, Federico Schiaffino, Simone Villa, Alessandro Della Pepa, Gianmarco Carbonaro, Luca Alessandro Menicagli, Laura Cozzi, Andrea Carriero, Serena Arpaia, Francesco Di Leo, Giovanni Astengo, Davide Rosenberg, Ilan Sardanelli, Francesco
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title_sort	chest x-ray severity score in covid-19 patients on emergency department admission: a two-centre study
title_auth	Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study
abstract	Background Integration of imaging and clinical parameters could improve the stratification of COVID-19 patients on emergency department (ED) admission. We aimed to assess the extent of COVID-19 pulmonary abnormalities on chest x-ray (CXR) using a semiquantitative severity score, correlating it with clinical data and testing its interobserver agreement. Methods From February 22 to April 8, 2020, 926 consecutive patients referring to ED of two institutions in Northern Italy for suspected SARS-CoV-2 infection were reviewed. Patients with reverse transcriptase-polymerase chain reaction positive for SARS-CoV-2 and CXR images on ED admission were included (295 patients, median age 69 years, 199 males). Five readers independently and blindly reviewed all CXRs, rating pulmonary parenchymal involvement using a 0–3 semiquantitative score in 1-point increments on 6 lung zones (range 0–18). Interobserver agreement was assessed with weighted Cohen’s κ, correlations between median CXR score and clinical data with Spearman’s ρ, and the Mann-Whitney U test. Results Median score showed negative correlation with $ SpO_{2} $ (ρ = -0.242, p < 0.001), positive correlation with white cell count (ρ = 0.277, p < 0.001), lactate dehydrogenase (ρ = 0.308, p < 0.001), and C-reactive protein (ρ = 0.367, p < 0.001), being significantly higher in subsequently dead patients (p = 0.003). Considering overall scores, readers’ pairings yielded moderate (κ = 0.449, p < 0.001) to almost perfect interobserver agreement (κ = 0.872, p < 0.001), with better interobserver agreement between readers of centre 2 (up to κ = 0.872, p < 0.001) than centre 1 (κ = 0.764, p < 0.001). Conclusions Proposed CXR pulmonary severity score in COVID-19 showed moderate to almost perfect interobserver agreement and significant but weak correlations with clinical parameters, potentially furthering CXR integration in patients’ stratification.
abstractGer	Background Integration of imaging and clinical parameters could improve the stratification of COVID-19 patients on emergency department (ED) admission. We aimed to assess the extent of COVID-19 pulmonary abnormalities on chest x-ray (CXR) using a semiquantitative severity score, correlating it with clinical data and testing its interobserver agreement. Methods From February 22 to April 8, 2020, 926 consecutive patients referring to ED of two institutions in Northern Italy for suspected SARS-CoV-2 infection were reviewed. Patients with reverse transcriptase-polymerase chain reaction positive for SARS-CoV-2 and CXR images on ED admission were included (295 patients, median age 69 years, 199 males). Five readers independently and blindly reviewed all CXRs, rating pulmonary parenchymal involvement using a 0–3 semiquantitative score in 1-point increments on 6 lung zones (range 0–18). Interobserver agreement was assessed with weighted Cohen’s κ, correlations between median CXR score and clinical data with Spearman’s ρ, and the Mann-Whitney U test. Results Median score showed negative correlation with $ SpO_{2} $ (ρ = -0.242, p < 0.001), positive correlation with white cell count (ρ = 0.277, p < 0.001), lactate dehydrogenase (ρ = 0.308, p < 0.001), and C-reactive protein (ρ = 0.367, p < 0.001), being significantly higher in subsequently dead patients (p = 0.003). Considering overall scores, readers’ pairings yielded moderate (κ = 0.449, p < 0.001) to almost perfect interobserver agreement (κ = 0.872, p < 0.001), with better interobserver agreement between readers of centre 2 (up to κ = 0.872, p < 0.001) than centre 1 (κ = 0.764, p < 0.001). Conclusions Proposed CXR pulmonary severity score in COVID-19 showed moderate to almost perfect interobserver agreement and significant but weak correlations with clinical parameters, potentially furthering CXR integration in patients’ stratification.
abstract_unstemmed	Background Integration of imaging and clinical parameters could improve the stratification of COVID-19 patients on emergency department (ED) admission. We aimed to assess the extent of COVID-19 pulmonary abnormalities on chest x-ray (CXR) using a semiquantitative severity score, correlating it with clinical data and testing its interobserver agreement. Methods From February 22 to April 8, 2020, 926 consecutive patients referring to ED of two institutions in Northern Italy for suspected SARS-CoV-2 infection were reviewed. Patients with reverse transcriptase-polymerase chain reaction positive for SARS-CoV-2 and CXR images on ED admission were included (295 patients, median age 69 years, 199 males). Five readers independently and blindly reviewed all CXRs, rating pulmonary parenchymal involvement using a 0–3 semiquantitative score in 1-point increments on 6 lung zones (range 0–18). Interobserver agreement was assessed with weighted Cohen’s κ, correlations between median CXR score and clinical data with Spearman’s ρ, and the Mann-Whitney U test. Results Median score showed negative correlation with $ SpO_{2} $ (ρ = -0.242, p < 0.001), positive correlation with white cell count (ρ = 0.277, p < 0.001), lactate dehydrogenase (ρ = 0.308, p < 0.001), and C-reactive protein (ρ = 0.367, p < 0.001), being significantly higher in subsequently dead patients (p = 0.003). Considering overall scores, readers’ pairings yielded moderate (κ = 0.449, p < 0.001) to almost perfect interobserver agreement (κ = 0.872, p < 0.001), with better interobserver agreement between readers of centre 2 (up to κ = 0.872, p < 0.001) than centre 1 (κ = 0.764, p < 0.001). Conclusions Proposed CXR pulmonary severity score in COVID-19 showed moderate to almost perfect interobserver agreement and significant but weak correlations with clinical parameters, potentially furthering CXR integration in patients’ stratification.
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title_short	Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study
url	https://dx.doi.org/10.1186/s41747-020-00195-w
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author2	Zaottini, Federico Schiaffino, Simone Villa, Alessandro Della Pepa, Gianmarco Carbonaro, Luca Alessandro Menicagli, Laura Cozzi, Andrea Carriero, Serena Arpaia, Francesco Di Leo, Giovanni Astengo, Davide Rosenberg, Ilan Sardanelli, Francesco
author2Str	Zaottini, Federico Schiaffino, Simone Villa, Alessandro Della Pepa, Gianmarco Carbonaro, Luca Alessandro Menicagli, Laura Cozzi, Andrea Carriero, Serena Arpaia, Francesco Di Leo, Giovanni Astengo, Davide Rosenberg, Ilan Sardanelli, Francesco
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