Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project

Purpose We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood. Methods Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. Results Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (− 0.14; 95% CI − 0.01, − 0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100 kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (− 1.67; 95% CI − 0.42, − 2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake. Conclusion Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease. Clinical trial registry ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Aumueller, Nicole [verfasserIn] Gruszfeld, Dariusz [verfasserIn] Gradowska, Kinga [verfasserIn] Escribano, Joaquín [verfasserIn] Ferré, Natalia [verfasserIn] Martin, Françoise [verfasserIn] Poncelet, Pascale [verfasserIn] Verduci, Elvira [verfasserIn] ReDionigi, Alice [verfasserIn] Koletzko, Berthold [verfasserIn] Grote, Veit [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Sugar intake Children Blood lipids Blood sugars HDL

Übergeordnetes Werk:	Enthalten in: Zeitschrift für Ernährungswissenschaft - Darmstadt : Steinkopff, 1960, 60(2020), 1 vom: 06. Mai, Seite 435-442
Übergeordnetes Werk:	volume:60 ; year:2020 ; number:1 ; day:06 ; month:05 ; pages:435-442

Links:	Volltext

DOI / URN:	10.1007/s00394-020-02229-w

Katalog-ID:	SPR043050468

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520			\|a Purpose We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood. Methods Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. Results Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (− 0.14; 95% CI − 0.01, − 0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100 kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (− 1.67; 95% CI − 0.42, − 2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake. Conclusion Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease. Clinical trial registry ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1.
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allfields	10.1007/s00394-020-02229-w doi (DE-627)SPR043050468 (DE-599)SPRs00394-020-02229-w-e (SPR)s00394-020-02229-w-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Aumueller, Nicole verfasserin aut Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood. Methods Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. Results Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (− 0.14; 95% CI − 0.01, − 0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100 kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (− 1.67; 95% CI − 0.42, − 2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake. Conclusion Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease. Clinical trial registry ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1. Sugar intake (dpeaa)DE-He213 Children (dpeaa)DE-He213 Blood lipids (dpeaa)DE-He213 Blood sugars (dpeaa)DE-He213 HDL (dpeaa)DE-He213 Gruszfeld, Dariusz verfasserin aut Gradowska, Kinga verfasserin aut Escribano, Joaquín verfasserin aut Ferré, Natalia verfasserin aut Martin, Françoise verfasserin aut Poncelet, Pascale verfasserin aut Verduci, Elvira verfasserin aut ReDionigi, Alice verfasserin aut Koletzko, Berthold verfasserin aut Grote, Veit verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 60(2020), 1 vom: 06. Mai, Seite 435-442 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:60 year:2020 number:1 day:06 month:05 pages:435-442 https://dx.doi.org/10.1007/s00394-020-02229-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 60 2020 1 06 05 435-442
spelling	10.1007/s00394-020-02229-w doi (DE-627)SPR043050468 (DE-599)SPRs00394-020-02229-w-e (SPR)s00394-020-02229-w-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Aumueller, Nicole verfasserin aut Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood. Methods Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. Results Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (− 0.14; 95% CI − 0.01, − 0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100 kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (− 1.67; 95% CI − 0.42, − 2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake. Conclusion Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease. Clinical trial registry ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1. Sugar intake (dpeaa)DE-He213 Children (dpeaa)DE-He213 Blood lipids (dpeaa)DE-He213 Blood sugars (dpeaa)DE-He213 HDL (dpeaa)DE-He213 Gruszfeld, Dariusz verfasserin aut Gradowska, Kinga verfasserin aut Escribano, Joaquín verfasserin aut Ferré, Natalia verfasserin aut Martin, Françoise verfasserin aut Poncelet, Pascale verfasserin aut Verduci, Elvira verfasserin aut ReDionigi, Alice verfasserin aut Koletzko, Berthold verfasserin aut Grote, Veit verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 60(2020), 1 vom: 06. Mai, Seite 435-442 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:60 year:2020 number:1 day:06 month:05 pages:435-442 https://dx.doi.org/10.1007/s00394-020-02229-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 60 2020 1 06 05 435-442
allfields_unstemmed	10.1007/s00394-020-02229-w doi (DE-627)SPR043050468 (DE-599)SPRs00394-020-02229-w-e (SPR)s00394-020-02229-w-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Aumueller, Nicole verfasserin aut Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood. Methods Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. Results Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (− 0.14; 95% CI − 0.01, − 0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100 kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (− 1.67; 95% CI − 0.42, − 2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake. Conclusion Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease. Clinical trial registry ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1. Sugar intake (dpeaa)DE-He213 Children (dpeaa)DE-He213 Blood lipids (dpeaa)DE-He213 Blood sugars (dpeaa)DE-He213 HDL (dpeaa)DE-He213 Gruszfeld, Dariusz verfasserin aut Gradowska, Kinga verfasserin aut Escribano, Joaquín verfasserin aut Ferré, Natalia verfasserin aut Martin, Françoise verfasserin aut Poncelet, Pascale verfasserin aut Verduci, Elvira verfasserin aut ReDionigi, Alice verfasserin aut Koletzko, Berthold verfasserin aut Grote, Veit verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 60(2020), 1 vom: 06. Mai, Seite 435-442 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:60 year:2020 number:1 day:06 month:05 pages:435-442 https://dx.doi.org/10.1007/s00394-020-02229-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 60 2020 1 06 05 435-442
allfieldsGer	10.1007/s00394-020-02229-w doi (DE-627)SPR043050468 (DE-599)SPRs00394-020-02229-w-e (SPR)s00394-020-02229-w-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Aumueller, Nicole verfasserin aut Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood. Methods Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. Results Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (− 0.14; 95% CI − 0.01, − 0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100 kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (− 1.67; 95% CI − 0.42, − 2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake. Conclusion Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease. Clinical trial registry ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1. Sugar intake (dpeaa)DE-He213 Children (dpeaa)DE-He213 Blood lipids (dpeaa)DE-He213 Blood sugars (dpeaa)DE-He213 HDL (dpeaa)DE-He213 Gruszfeld, Dariusz verfasserin aut Gradowska, Kinga verfasserin aut Escribano, Joaquín verfasserin aut Ferré, Natalia verfasserin aut Martin, Françoise verfasserin aut Poncelet, Pascale verfasserin aut Verduci, Elvira verfasserin aut ReDionigi, Alice verfasserin aut Koletzko, Berthold verfasserin aut Grote, Veit verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 60(2020), 1 vom: 06. Mai, Seite 435-442 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:60 year:2020 number:1 day:06 month:05 pages:435-442 https://dx.doi.org/10.1007/s00394-020-02229-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 60 2020 1 06 05 435-442
allfieldsSound	10.1007/s00394-020-02229-w doi (DE-627)SPR043050468 (DE-599)SPRs00394-020-02229-w-e (SPR)s00394-020-02229-w-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Aumueller, Nicole verfasserin aut Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood. Methods Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. Results Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (− 0.14; 95% CI − 0.01, − 0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100 kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (− 1.67; 95% CI − 0.42, − 2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake. Conclusion Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease. Clinical trial registry ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1. Sugar intake (dpeaa)DE-He213 Children (dpeaa)DE-He213 Blood lipids (dpeaa)DE-He213 Blood sugars (dpeaa)DE-He213 HDL (dpeaa)DE-He213 Gruszfeld, Dariusz verfasserin aut Gradowska, Kinga verfasserin aut Escribano, Joaquín verfasserin aut Ferré, Natalia verfasserin aut Martin, Françoise verfasserin aut Poncelet, Pascale verfasserin aut Verduci, Elvira verfasserin aut ReDionigi, Alice verfasserin aut Koletzko, Berthold verfasserin aut Grote, Veit verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 60(2020), 1 vom: 06. Mai, Seite 435-442 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:60 year:2020 number:1 day:06 month:05 pages:435-442 https://dx.doi.org/10.1007/s00394-020-02229-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 60 2020 1 06 05 435-442
language	English
source	Enthalten in Zeitschrift für Ernährungswissenschaft 60(2020), 1 vom: 06. Mai, Seite 435-442 volume:60 year:2020 number:1 day:06 month:05 pages:435-442
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topic_facet	Sugar intake Children Blood lipids Blood sugars HDL
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authorswithroles_txt_mv	Aumueller, Nicole @@aut@@ Gruszfeld, Dariusz @@aut@@ Gradowska, Kinga @@aut@@ Escribano, Joaquín @@aut@@ Ferré, Natalia @@aut@@ Martin, Françoise @@aut@@ Poncelet, Pascale @@aut@@ Verduci, Elvira @@aut@@ ReDionigi, Alice @@aut@@ Koletzko, Berthold @@aut@@ Grote, Veit @@aut@@
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Methods Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. Results Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (− 0.14; 95% CI − 0.01, − 0.27; p value = 0.031). 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author	Aumueller, Nicole
spellingShingle	Aumueller, Nicole ddc 630 bkl 44.21 misc Sugar intake misc Children misc Blood lipids misc Blood sugars misc HDL Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project
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topic_title	630 640 610 ASE 44.21 bkl Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project Sugar intake (dpeaa)DE-He213 Children (dpeaa)DE-He213 Blood lipids (dpeaa)DE-He213 Blood sugars (dpeaa)DE-He213 HDL (dpeaa)DE-He213
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title	Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project
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title_full	Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project
author_sort	Aumueller, Nicole
journal	Zeitschrift für Ernährungswissenschaft
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author_browse	Aumueller, Nicole Gruszfeld, Dariusz Gradowska, Kinga Escribano, Joaquín Ferré, Natalia Martin, Françoise Poncelet, Pascale Verduci, Elvira ReDionigi, Alice Koletzko, Berthold Grote, Veit
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title_sort	influence of total sugar intake on metabolic blood markers at 8 years of age in the childhood obesity project
title_auth	Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project
abstract	Purpose We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood. Methods Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. Results Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (− 0.14; 95% CI − 0.01, − 0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100 kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (− 1.67; 95% CI − 0.42, − 2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake. Conclusion Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease. Clinical trial registry ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1.
abstractGer	Purpose We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood. Methods Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. Results Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (− 0.14; 95% CI − 0.01, − 0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100 kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (− 1.67; 95% CI − 0.42, − 2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake. Conclusion Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease. Clinical trial registry ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1.
abstract_unstemmed	Purpose We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood. Methods Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. Results Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (− 0.14; 95% CI − 0.01, − 0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100 kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (− 1.67; 95% CI − 0.42, − 2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake. Conclusion Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease. Clinical trial registry ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1.
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title_short	Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project
url	https://dx.doi.org/10.1007/s00394-020-02229-w
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author2	Gruszfeld, Dariusz Gradowska, Kinga Escribano, Joaquín Ferré, Natalia Martin, Françoise Poncelet, Pascale Verduci, Elvira ReDionigi, Alice Koletzko, Berthold Grote, Veit
author2Str	Gruszfeld, Dariusz Gradowska, Kinga Escribano, Joaquín Ferré, Natalia Martin, Françoise Poncelet, Pascale Verduci, Elvira ReDionigi, Alice Koletzko, Berthold Grote, Veit
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