Airway inflammation and lung function recovery after lobectomy in patients with primary lung cancer
Objective Fractional exhaled nitric oxide (FeNO), which represents airway inflammation, is an indicator of postoperative complication after lung surgery. However, its effects in the late postoperative period are unknown. The aim of this prospective study was to clarify the impact of FeNO on postoper...
Ausführliche Beschreibung
Autor*in: |
Okamoto, Keigo [verfasserIn] Hayashi, Kazuki [verfasserIn] Kaku, Ryosuke [verfasserIn] Kawaguchi, Yo [verfasserIn] Oshio, Yasuhiko [verfasserIn] Hanaoka, Jun [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2020 |
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Übergeordnetes Werk: |
Enthalten in: The Japanese journal of thoracic and cardiovascular surgery - Tōkyō : Springer Japan, 1998, 69(2020), 2 vom: 28. Aug., Seite 297-302 |
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Übergeordnetes Werk: |
volume:69 ; year:2020 ; number:2 ; day:28 ; month:08 ; pages:297-302 |
Links: |
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DOI / URN: |
10.1007/s11748-020-01464-6 |
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Katalog-ID: |
SPR043059295 |
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520 | |a Objective Fractional exhaled nitric oxide (FeNO), which represents airway inflammation, is an indicator of postoperative complication after lung surgery. However, its effects in the late postoperative period are unknown. The aim of this prospective study was to clarify the impact of FeNO on postoperative lung function in patients with lung cancer. Methods We measured preoperative FeNO using NIOX VERO® in patients with primary lung cancer. Patients were divided into two groups according to their potential airway inflammatory status: preoperative FeNO levels below 25 ppb (N group) and above 25 ppb (H group). They were evaluated by spirometry at 3 and 6 months after surgery during follow-up. The relationship between postoperative lung function and preoperative FeNO was evaluated. Results Between September 2017 and March 2019, 61 participants were enrolled. All of them underwent lobectomy as a curative surgery. There were no significant background variables between the two groups. Postoperative vital capacity (VC) and forced expiratory volume in 1 s (FEV1) in the H group achieved less predictive values than those in the N group, which were not significant. The postoperative VC and FEV1 from 3 to 6 months in the H group were significantly increased as compared to those in the N group (p < 0.001). Conclusions Preoperative FeNO is a predictor of delayed lung function recovery 3 months after lobectomy in lung cancer patients. The impact had extended to VC and FEV1. Although this impact is temporary, early postoperative intervention is expected to reduce the adverse effect. | ||
650 | 4 | |a Lung cancer |7 (dpeaa)DE-He213 | |
650 | 4 | |a Pulmonary disease |7 (dpeaa)DE-He213 | |
650 | 4 | |a Chronic obstructive pulmonary disease |7 (dpeaa)DE-He213 | |
650 | 4 | |a Nitric oxide |7 (dpeaa)DE-He213 | |
650 | 4 | |a Postoperative pulmonary function |7 (dpeaa)DE-He213 | |
700 | 1 | |a Hayashi, Kazuki |e verfasserin |4 aut | |
700 | 1 | |a Kaku, Ryosuke |e verfasserin |4 aut | |
700 | 1 | |a Kawaguchi, Yo |e verfasserin |4 aut | |
700 | 1 | |a Oshio, Yasuhiko |e verfasserin |4 aut | |
700 | 1 | |a Hanaoka, Jun |e verfasserin |4 aut | |
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10.1007/s11748-020-01464-6 doi (DE-627)SPR043059295 (DE-599)SPRs11748-020-01464-6-e (SPR)s11748-020-01464-6-e DE-627 ger DE-627 rakwb eng 610 ASE Okamoto, Keigo verfasserin aut Airway inflammation and lung function recovery after lobectomy in patients with primary lung cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Fractional exhaled nitric oxide (FeNO), which represents airway inflammation, is an indicator of postoperative complication after lung surgery. However, its effects in the late postoperative period are unknown. The aim of this prospective study was to clarify the impact of FeNO on postoperative lung function in patients with lung cancer. Methods We measured preoperative FeNO using NIOX VERO® in patients with primary lung cancer. Patients were divided into two groups according to their potential airway inflammatory status: preoperative FeNO levels below 25 ppb (N group) and above 25 ppb (H group). They were evaluated by spirometry at 3 and 6 months after surgery during follow-up. The relationship between postoperative lung function and preoperative FeNO was evaluated. Results Between September 2017 and March 2019, 61 participants were enrolled. All of them underwent lobectomy as a curative surgery. There were no significant background variables between the two groups. Postoperative vital capacity (VC) and forced expiratory volume in 1 s (FEV1) in the H group achieved less predictive values than those in the N group, which were not significant. The postoperative VC and FEV1 from 3 to 6 months in the H group were significantly increased as compared to those in the N group (p < 0.001). Conclusions Preoperative FeNO is a predictor of delayed lung function recovery 3 months after lobectomy in lung cancer patients. The impact had extended to VC and FEV1. Although this impact is temporary, early postoperative intervention is expected to reduce the adverse effect. Lung cancer (dpeaa)DE-He213 Pulmonary disease (dpeaa)DE-He213 Chronic obstructive pulmonary disease (dpeaa)DE-He213 Nitric oxide (dpeaa)DE-He213 Postoperative pulmonary function (dpeaa)DE-He213 Hayashi, Kazuki verfasserin aut Kaku, Ryosuke verfasserin aut Kawaguchi, Yo verfasserin aut Oshio, Yasuhiko verfasserin aut Hanaoka, Jun verfasserin aut Enthalten in The Japanese journal of thoracic and cardiovascular surgery Tōkyō : Springer Japan, 1998 69(2020), 2 vom: 28. Aug., Seite 297-302 (DE-627)539545104 (DE-600)2381600-4 1863-2092 nnns volume:69 year:2020 number:2 day:28 month:08 pages:297-302 https://dx.doi.org/10.1007/s11748-020-01464-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 69 2020 2 28 08 297-302 |
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10.1007/s11748-020-01464-6 doi (DE-627)SPR043059295 (DE-599)SPRs11748-020-01464-6-e (SPR)s11748-020-01464-6-e DE-627 ger DE-627 rakwb eng 610 ASE Okamoto, Keigo verfasserin aut Airway inflammation and lung function recovery after lobectomy in patients with primary lung cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Fractional exhaled nitric oxide (FeNO), which represents airway inflammation, is an indicator of postoperative complication after lung surgery. However, its effects in the late postoperative period are unknown. The aim of this prospective study was to clarify the impact of FeNO on postoperative lung function in patients with lung cancer. Methods We measured preoperative FeNO using NIOX VERO® in patients with primary lung cancer. Patients were divided into two groups according to their potential airway inflammatory status: preoperative FeNO levels below 25 ppb (N group) and above 25 ppb (H group). They were evaluated by spirometry at 3 and 6 months after surgery during follow-up. The relationship between postoperative lung function and preoperative FeNO was evaluated. Results Between September 2017 and March 2019, 61 participants were enrolled. All of them underwent lobectomy as a curative surgery. There were no significant background variables between the two groups. Postoperative vital capacity (VC) and forced expiratory volume in 1 s (FEV1) in the H group achieved less predictive values than those in the N group, which were not significant. The postoperative VC and FEV1 from 3 to 6 months in the H group were significantly increased as compared to those in the N group (p < 0.001). Conclusions Preoperative FeNO is a predictor of delayed lung function recovery 3 months after lobectomy in lung cancer patients. The impact had extended to VC and FEV1. Although this impact is temporary, early postoperative intervention is expected to reduce the adverse effect. Lung cancer (dpeaa)DE-He213 Pulmonary disease (dpeaa)DE-He213 Chronic obstructive pulmonary disease (dpeaa)DE-He213 Nitric oxide (dpeaa)DE-He213 Postoperative pulmonary function (dpeaa)DE-He213 Hayashi, Kazuki verfasserin aut Kaku, Ryosuke verfasserin aut Kawaguchi, Yo verfasserin aut Oshio, Yasuhiko verfasserin aut Hanaoka, Jun verfasserin aut Enthalten in The Japanese journal of thoracic and cardiovascular surgery Tōkyō : Springer Japan, 1998 69(2020), 2 vom: 28. Aug., Seite 297-302 (DE-627)539545104 (DE-600)2381600-4 1863-2092 nnns volume:69 year:2020 number:2 day:28 month:08 pages:297-302 https://dx.doi.org/10.1007/s11748-020-01464-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 69 2020 2 28 08 297-302 |
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10.1007/s11748-020-01464-6 doi (DE-627)SPR043059295 (DE-599)SPRs11748-020-01464-6-e (SPR)s11748-020-01464-6-e DE-627 ger DE-627 rakwb eng 610 ASE Okamoto, Keigo verfasserin aut Airway inflammation and lung function recovery after lobectomy in patients with primary lung cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Fractional exhaled nitric oxide (FeNO), which represents airway inflammation, is an indicator of postoperative complication after lung surgery. However, its effects in the late postoperative period are unknown. The aim of this prospective study was to clarify the impact of FeNO on postoperative lung function in patients with lung cancer. Methods We measured preoperative FeNO using NIOX VERO® in patients with primary lung cancer. Patients were divided into two groups according to their potential airway inflammatory status: preoperative FeNO levels below 25 ppb (N group) and above 25 ppb (H group). They were evaluated by spirometry at 3 and 6 months after surgery during follow-up. The relationship between postoperative lung function and preoperative FeNO was evaluated. Results Between September 2017 and March 2019, 61 participants were enrolled. All of them underwent lobectomy as a curative surgery. There were no significant background variables between the two groups. Postoperative vital capacity (VC) and forced expiratory volume in 1 s (FEV1) in the H group achieved less predictive values than those in the N group, which were not significant. The postoperative VC and FEV1 from 3 to 6 months in the H group were significantly increased as compared to those in the N group (p < 0.001). Conclusions Preoperative FeNO is a predictor of delayed lung function recovery 3 months after lobectomy in lung cancer patients. The impact had extended to VC and FEV1. Although this impact is temporary, early postoperative intervention is expected to reduce the adverse effect. Lung cancer (dpeaa)DE-He213 Pulmonary disease (dpeaa)DE-He213 Chronic obstructive pulmonary disease (dpeaa)DE-He213 Nitric oxide (dpeaa)DE-He213 Postoperative pulmonary function (dpeaa)DE-He213 Hayashi, Kazuki verfasserin aut Kaku, Ryosuke verfasserin aut Kawaguchi, Yo verfasserin aut Oshio, Yasuhiko verfasserin aut Hanaoka, Jun verfasserin aut Enthalten in The Japanese journal of thoracic and cardiovascular surgery Tōkyō : Springer Japan, 1998 69(2020), 2 vom: 28. Aug., Seite 297-302 (DE-627)539545104 (DE-600)2381600-4 1863-2092 nnns volume:69 year:2020 number:2 day:28 month:08 pages:297-302 https://dx.doi.org/10.1007/s11748-020-01464-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 69 2020 2 28 08 297-302 |
allfieldsGer |
10.1007/s11748-020-01464-6 doi (DE-627)SPR043059295 (DE-599)SPRs11748-020-01464-6-e (SPR)s11748-020-01464-6-e DE-627 ger DE-627 rakwb eng 610 ASE Okamoto, Keigo verfasserin aut Airway inflammation and lung function recovery after lobectomy in patients with primary lung cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Fractional exhaled nitric oxide (FeNO), which represents airway inflammation, is an indicator of postoperative complication after lung surgery. However, its effects in the late postoperative period are unknown. The aim of this prospective study was to clarify the impact of FeNO on postoperative lung function in patients with lung cancer. Methods We measured preoperative FeNO using NIOX VERO® in patients with primary lung cancer. Patients were divided into two groups according to their potential airway inflammatory status: preoperative FeNO levels below 25 ppb (N group) and above 25 ppb (H group). They were evaluated by spirometry at 3 and 6 months after surgery during follow-up. The relationship between postoperative lung function and preoperative FeNO was evaluated. Results Between September 2017 and March 2019, 61 participants were enrolled. All of them underwent lobectomy as a curative surgery. There were no significant background variables between the two groups. Postoperative vital capacity (VC) and forced expiratory volume in 1 s (FEV1) in the H group achieved less predictive values than those in the N group, which were not significant. The postoperative VC and FEV1 from 3 to 6 months in the H group were significantly increased as compared to those in the N group (p < 0.001). Conclusions Preoperative FeNO is a predictor of delayed lung function recovery 3 months after lobectomy in lung cancer patients. The impact had extended to VC and FEV1. Although this impact is temporary, early postoperative intervention is expected to reduce the adverse effect. Lung cancer (dpeaa)DE-He213 Pulmonary disease (dpeaa)DE-He213 Chronic obstructive pulmonary disease (dpeaa)DE-He213 Nitric oxide (dpeaa)DE-He213 Postoperative pulmonary function (dpeaa)DE-He213 Hayashi, Kazuki verfasserin aut Kaku, Ryosuke verfasserin aut Kawaguchi, Yo verfasserin aut Oshio, Yasuhiko verfasserin aut Hanaoka, Jun verfasserin aut Enthalten in The Japanese journal of thoracic and cardiovascular surgery Tōkyō : Springer Japan, 1998 69(2020), 2 vom: 28. Aug., Seite 297-302 (DE-627)539545104 (DE-600)2381600-4 1863-2092 nnns volume:69 year:2020 number:2 day:28 month:08 pages:297-302 https://dx.doi.org/10.1007/s11748-020-01464-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 69 2020 2 28 08 297-302 |
allfieldsSound |
10.1007/s11748-020-01464-6 doi (DE-627)SPR043059295 (DE-599)SPRs11748-020-01464-6-e (SPR)s11748-020-01464-6-e DE-627 ger DE-627 rakwb eng 610 ASE Okamoto, Keigo verfasserin aut Airway inflammation and lung function recovery after lobectomy in patients with primary lung cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Fractional exhaled nitric oxide (FeNO), which represents airway inflammation, is an indicator of postoperative complication after lung surgery. However, its effects in the late postoperative period are unknown. The aim of this prospective study was to clarify the impact of FeNO on postoperative lung function in patients with lung cancer. Methods We measured preoperative FeNO using NIOX VERO® in patients with primary lung cancer. Patients were divided into two groups according to their potential airway inflammatory status: preoperative FeNO levels below 25 ppb (N group) and above 25 ppb (H group). They were evaluated by spirometry at 3 and 6 months after surgery during follow-up. The relationship between postoperative lung function and preoperative FeNO was evaluated. Results Between September 2017 and March 2019, 61 participants were enrolled. All of them underwent lobectomy as a curative surgery. There were no significant background variables between the two groups. Postoperative vital capacity (VC) and forced expiratory volume in 1 s (FEV1) in the H group achieved less predictive values than those in the N group, which were not significant. The postoperative VC and FEV1 from 3 to 6 months in the H group were significantly increased as compared to those in the N group (p < 0.001). Conclusions Preoperative FeNO is a predictor of delayed lung function recovery 3 months after lobectomy in lung cancer patients. The impact had extended to VC and FEV1. Although this impact is temporary, early postoperative intervention is expected to reduce the adverse effect. Lung cancer (dpeaa)DE-He213 Pulmonary disease (dpeaa)DE-He213 Chronic obstructive pulmonary disease (dpeaa)DE-He213 Nitric oxide (dpeaa)DE-He213 Postoperative pulmonary function (dpeaa)DE-He213 Hayashi, Kazuki verfasserin aut Kaku, Ryosuke verfasserin aut Kawaguchi, Yo verfasserin aut Oshio, Yasuhiko verfasserin aut Hanaoka, Jun verfasserin aut Enthalten in The Japanese journal of thoracic and cardiovascular surgery Tōkyō : Springer Japan, 1998 69(2020), 2 vom: 28. Aug., Seite 297-302 (DE-627)539545104 (DE-600)2381600-4 1863-2092 nnns volume:69 year:2020 number:2 day:28 month:08 pages:297-302 https://dx.doi.org/10.1007/s11748-020-01464-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 69 2020 2 28 08 297-302 |
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However, its effects in the late postoperative period are unknown. The aim of this prospective study was to clarify the impact of FeNO on postoperative lung function in patients with lung cancer. Methods We measured preoperative FeNO using NIOX VERO® in patients with primary lung cancer. Patients were divided into two groups according to their potential airway inflammatory status: preoperative FeNO levels below 25 ppb (N group) and above 25 ppb (H group). They were evaluated by spirometry at 3 and 6 months after surgery during follow-up. The relationship between postoperative lung function and preoperative FeNO was evaluated. Results Between September 2017 and March 2019, 61 participants were enrolled. All of them underwent lobectomy as a curative surgery. There were no significant background variables between the two groups. Postoperative vital capacity (VC) and forced expiratory volume in 1 s (FEV1) in the H group achieved less predictive values than those in the N group, which were not significant. The postoperative VC and FEV1 from 3 to 6 months in the H group were significantly increased as compared to those in the N group (p < 0.001). Conclusions Preoperative FeNO is a predictor of delayed lung function recovery 3 months after lobectomy in lung cancer patients. The impact had extended to VC and FEV1. 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airway inflammation and lung function recovery after lobectomy in patients with primary lung cancer |
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Airway inflammation and lung function recovery after lobectomy in patients with primary lung cancer |
abstract |
Objective Fractional exhaled nitric oxide (FeNO), which represents airway inflammation, is an indicator of postoperative complication after lung surgery. However, its effects in the late postoperative period are unknown. The aim of this prospective study was to clarify the impact of FeNO on postoperative lung function in patients with lung cancer. Methods We measured preoperative FeNO using NIOX VERO® in patients with primary lung cancer. Patients were divided into two groups according to their potential airway inflammatory status: preoperative FeNO levels below 25 ppb (N group) and above 25 ppb (H group). They were evaluated by spirometry at 3 and 6 months after surgery during follow-up. The relationship between postoperative lung function and preoperative FeNO was evaluated. Results Between September 2017 and March 2019, 61 participants were enrolled. All of them underwent lobectomy as a curative surgery. There were no significant background variables between the two groups. Postoperative vital capacity (VC) and forced expiratory volume in 1 s (FEV1) in the H group achieved less predictive values than those in the N group, which were not significant. The postoperative VC and FEV1 from 3 to 6 months in the H group were significantly increased as compared to those in the N group (p < 0.001). Conclusions Preoperative FeNO is a predictor of delayed lung function recovery 3 months after lobectomy in lung cancer patients. The impact had extended to VC and FEV1. Although this impact is temporary, early postoperative intervention is expected to reduce the adverse effect. |
abstractGer |
Objective Fractional exhaled nitric oxide (FeNO), which represents airway inflammation, is an indicator of postoperative complication after lung surgery. However, its effects in the late postoperative period are unknown. The aim of this prospective study was to clarify the impact of FeNO on postoperative lung function in patients with lung cancer. Methods We measured preoperative FeNO using NIOX VERO® in patients with primary lung cancer. Patients were divided into two groups according to their potential airway inflammatory status: preoperative FeNO levels below 25 ppb (N group) and above 25 ppb (H group). They were evaluated by spirometry at 3 and 6 months after surgery during follow-up. The relationship between postoperative lung function and preoperative FeNO was evaluated. Results Between September 2017 and March 2019, 61 participants were enrolled. All of them underwent lobectomy as a curative surgery. There were no significant background variables between the two groups. Postoperative vital capacity (VC) and forced expiratory volume in 1 s (FEV1) in the H group achieved less predictive values than those in the N group, which were not significant. The postoperative VC and FEV1 from 3 to 6 months in the H group were significantly increased as compared to those in the N group (p < 0.001). Conclusions Preoperative FeNO is a predictor of delayed lung function recovery 3 months after lobectomy in lung cancer patients. The impact had extended to VC and FEV1. Although this impact is temporary, early postoperative intervention is expected to reduce the adverse effect. |
abstract_unstemmed |
Objective Fractional exhaled nitric oxide (FeNO), which represents airway inflammation, is an indicator of postoperative complication after lung surgery. However, its effects in the late postoperative period are unknown. The aim of this prospective study was to clarify the impact of FeNO on postoperative lung function in patients with lung cancer. Methods We measured preoperative FeNO using NIOX VERO® in patients with primary lung cancer. Patients were divided into two groups according to their potential airway inflammatory status: preoperative FeNO levels below 25 ppb (N group) and above 25 ppb (H group). They were evaluated by spirometry at 3 and 6 months after surgery during follow-up. The relationship between postoperative lung function and preoperative FeNO was evaluated. Results Between September 2017 and March 2019, 61 participants were enrolled. All of them underwent lobectomy as a curative surgery. There were no significant background variables between the two groups. Postoperative vital capacity (VC) and forced expiratory volume in 1 s (FEV1) in the H group achieved less predictive values than those in the N group, which were not significant. The postoperative VC and FEV1 from 3 to 6 months in the H group were significantly increased as compared to those in the N group (p < 0.001). Conclusions Preoperative FeNO is a predictor of delayed lung function recovery 3 months after lobectomy in lung cancer patients. The impact had extended to VC and FEV1. Although this impact is temporary, early postoperative intervention is expected to reduce the adverse effect. |
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Airway inflammation and lung function recovery after lobectomy in patients with primary lung cancer |
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Postoperative vital capacity (VC) and forced expiratory volume in 1 s (FEV1) in the H group achieved less predictive values than those in the N group, which were not significant. The postoperative VC and FEV1 from 3 to 6 months in the H group were significantly increased as compared to those in the N group (p < 0.001). Conclusions Preoperative FeNO is a predictor of delayed lung function recovery 3 months after lobectomy in lung cancer patients. The impact had extended to VC and FEV1. 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