Pulmonary function in stereotactic body radiotherapy with helical tomotherapy for primary and metastatic lung lesions
Aims This retrospective study reports outcomes after stereotactic body radiation therapy (SBRT) as delivered by helical tomotherapy (HT) for lung lesions. It promotes a dose escalation program. Methods Histological and/or radiological findings and/or case histories identified 41 primary and 15 metas...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Falcinelli, Lorenzo [verfasserIn] Mendichi, Monia [verfasserIn] Chierchini, Sara [verfasserIn] Tenti, Maria Valentina [verfasserIn] Bellavita, Rita [verfasserIn] Saldi, Simonetta [verfasserIn] Ingrosso, Gianluca [verfasserIn] Reggioli, Valentina [verfasserIn] Bini, Vittorio [verfasserIn] Aristei, Cynthia [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: La Radiologia medica - Milan : Springer Milan, 2006, 126(2020), 1 vom: 15. Mai, Seite 163-169 |
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| Übergeordnetes Werk: |
volume:126 ; year:2020 ; number:1 ; day:15 ; month:05 ; pages:163-169 |
| Links: |
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| DOI / URN: |
10.1007/s11547-020-01223-w |
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| Katalog-ID: |
SPR043085660 |
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| 245 | 1 | 0 | |a Pulmonary function in stereotactic body radiotherapy with helical tomotherapy for primary and metastatic lung lesions |
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| 520 | |a Aims This retrospective study reports outcomes after stereotactic body radiation therapy (SBRT) as delivered by helical tomotherapy (HT) for lung lesions. It promotes a dose escalation program. Methods Histological and/or radiological findings and/or case histories identified 41 primary and 15 metastatic lesions. Thirty patients received 40 Gy in 5 fractions (BED 72 $ Gy_{10Gy} $) and 26 50 Gy in 5 fractions (BED $ 100Gy_{10Gy} $). Primary end point was lung toxicity. Secondary end points were respiratory function, local control and local progression-free survival. Results Acute toxicity developed in 18/56 patients and late toxicity in 8/54. Median FEV-1 variations versus baseline were − 0.5% (range − 16 to + 43%) at 6 months and − 4.00% (range − 42 to + 18%) at 24 months. Median DLCO variations versus baseline were − 1% (range − 38 to + 36%) at 6 months and − 12.2% (range − 48 to + 11%) at 24 months. At 6 months, a significant positive correlation emerged between FEV-1 change and KPS (p = 0.047). At 24 months, a significant negative correlation emerged between FEV-1 change and the ipsilateral lung V5 (p = 0.006). A low baseline DLCO correlated with more marked DLCO worsening at 6 months (p = 0.012). At 24 months, DLCO worsening correlated significantly with the median contralateral lung dose (p = 0.003). At the last checkup, 23 patients were in complete remission, 16 were in partial remission, 5 had stable disease, and 7 were in relapse. Median follow-up was 12 months (range 5–56). Conclusions In patients with lung disease, SBRT, as delivered by HT, was well tolerated and provided good local control. | ||
| 650 | 4 | |a Lung |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Stereotactic body radiotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Tomotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Respiratory function |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Mendichi, Monia |e verfasserin |4 aut | |
| 700 | 1 | |a Chierchini, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Tenti, Maria Valentina |e verfasserin |4 aut | |
| 700 | 1 | |a Bellavita, Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Saldi, Simonetta |e verfasserin |4 aut | |
| 700 | 1 | |a Ingrosso, Gianluca |e verfasserin |4 aut | |
| 700 | 1 | |a Reggioli, Valentina |e verfasserin |4 aut | |
| 700 | 1 | |a Bini, Vittorio |e verfasserin |4 aut | |
| 700 | 1 | |a Aristei, Cynthia |e verfasserin |4 aut | |
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10.1007/s11547-020-01223-w doi (DE-627)SPR043085660 (DE-599)SPRs11547-020-01223-w-e (SPR)s11547-020-01223-w-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Falcinelli, Lorenzo verfasserin aut Pulmonary function in stereotactic body radiotherapy with helical tomotherapy for primary and metastatic lung lesions 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims This retrospective study reports outcomes after stereotactic body radiation therapy (SBRT) as delivered by helical tomotherapy (HT) for lung lesions. It promotes a dose escalation program. Methods Histological and/or radiological findings and/or case histories identified 41 primary and 15 metastatic lesions. Thirty patients received 40 Gy in 5 fractions (BED 72 $ Gy_{10Gy} $) and 26 50 Gy in 5 fractions (BED $ 100Gy_{10Gy} $). Primary end point was lung toxicity. Secondary end points were respiratory function, local control and local progression-free survival. Results Acute toxicity developed in 18/56 patients and late toxicity in 8/54. Median FEV-1 variations versus baseline were − 0.5% (range − 16 to + 43%) at 6 months and − 4.00% (range − 42 to + 18%) at 24 months. Median DLCO variations versus baseline were − 1% (range − 38 to + 36%) at 6 months and − 12.2% (range − 48 to + 11%) at 24 months. At 6 months, a significant positive correlation emerged between FEV-1 change and KPS (p = 0.047). At 24 months, a significant negative correlation emerged between FEV-1 change and the ipsilateral lung V5 (p = 0.006). A low baseline DLCO correlated with more marked DLCO worsening at 6 months (p = 0.012). At 24 months, DLCO worsening correlated significantly with the median contralateral lung dose (p = 0.003). At the last checkup, 23 patients were in complete remission, 16 were in partial remission, 5 had stable disease, and 7 were in relapse. Median follow-up was 12 months (range 5–56). Conclusions In patients with lung disease, SBRT, as delivered by HT, was well tolerated and provided good local control. Lung (dpeaa)DE-He213 Stereotactic body radiotherapy (dpeaa)DE-He213 Tomotherapy (dpeaa)DE-He213 Respiratory function (dpeaa)DE-He213 Mendichi, Monia verfasserin aut Chierchini, Sara verfasserin aut Tenti, Maria Valentina verfasserin aut Bellavita, Rita verfasserin aut Saldi, Simonetta verfasserin aut Ingrosso, Gianluca verfasserin aut Reggioli, Valentina verfasserin aut Bini, Vittorio verfasserin aut Aristei, Cynthia verfasserin aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 126(2020), 1 vom: 15. Mai, Seite 163-169 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:126 year:2020 number:1 day:15 month:05 pages:163-169 https://dx.doi.org/10.1007/s11547-020-01223-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 126 2020 1 15 05 163-169 |
| spelling |
10.1007/s11547-020-01223-w doi (DE-627)SPR043085660 (DE-599)SPRs11547-020-01223-w-e (SPR)s11547-020-01223-w-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Falcinelli, Lorenzo verfasserin aut Pulmonary function in stereotactic body radiotherapy with helical tomotherapy for primary and metastatic lung lesions 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims This retrospective study reports outcomes after stereotactic body radiation therapy (SBRT) as delivered by helical tomotherapy (HT) for lung lesions. It promotes a dose escalation program. Methods Histological and/or radiological findings and/or case histories identified 41 primary and 15 metastatic lesions. Thirty patients received 40 Gy in 5 fractions (BED 72 $ Gy_{10Gy} $) and 26 50 Gy in 5 fractions (BED $ 100Gy_{10Gy} $). Primary end point was lung toxicity. Secondary end points were respiratory function, local control and local progression-free survival. Results Acute toxicity developed in 18/56 patients and late toxicity in 8/54. Median FEV-1 variations versus baseline were − 0.5% (range − 16 to + 43%) at 6 months and − 4.00% (range − 42 to + 18%) at 24 months. Median DLCO variations versus baseline were − 1% (range − 38 to + 36%) at 6 months and − 12.2% (range − 48 to + 11%) at 24 months. At 6 months, a significant positive correlation emerged between FEV-1 change and KPS (p = 0.047). At 24 months, a significant negative correlation emerged between FEV-1 change and the ipsilateral lung V5 (p = 0.006). A low baseline DLCO correlated with more marked DLCO worsening at 6 months (p = 0.012). At 24 months, DLCO worsening correlated significantly with the median contralateral lung dose (p = 0.003). At the last checkup, 23 patients were in complete remission, 16 were in partial remission, 5 had stable disease, and 7 were in relapse. Median follow-up was 12 months (range 5–56). Conclusions In patients with lung disease, SBRT, as delivered by HT, was well tolerated and provided good local control. Lung (dpeaa)DE-He213 Stereotactic body radiotherapy (dpeaa)DE-He213 Tomotherapy (dpeaa)DE-He213 Respiratory function (dpeaa)DE-He213 Mendichi, Monia verfasserin aut Chierchini, Sara verfasserin aut Tenti, Maria Valentina verfasserin aut Bellavita, Rita verfasserin aut Saldi, Simonetta verfasserin aut Ingrosso, Gianluca verfasserin aut Reggioli, Valentina verfasserin aut Bini, Vittorio verfasserin aut Aristei, Cynthia verfasserin aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 126(2020), 1 vom: 15. Mai, Seite 163-169 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:126 year:2020 number:1 day:15 month:05 pages:163-169 https://dx.doi.org/10.1007/s11547-020-01223-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 126 2020 1 15 05 163-169 |
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10.1007/s11547-020-01223-w doi (DE-627)SPR043085660 (DE-599)SPRs11547-020-01223-w-e (SPR)s11547-020-01223-w-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Falcinelli, Lorenzo verfasserin aut Pulmonary function in stereotactic body radiotherapy with helical tomotherapy for primary and metastatic lung lesions 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims This retrospective study reports outcomes after stereotactic body radiation therapy (SBRT) as delivered by helical tomotherapy (HT) for lung lesions. It promotes a dose escalation program. Methods Histological and/or radiological findings and/or case histories identified 41 primary and 15 metastatic lesions. Thirty patients received 40 Gy in 5 fractions (BED 72 $ Gy_{10Gy} $) and 26 50 Gy in 5 fractions (BED $ 100Gy_{10Gy} $). Primary end point was lung toxicity. Secondary end points were respiratory function, local control and local progression-free survival. Results Acute toxicity developed in 18/56 patients and late toxicity in 8/54. Median FEV-1 variations versus baseline were − 0.5% (range − 16 to + 43%) at 6 months and − 4.00% (range − 42 to + 18%) at 24 months. Median DLCO variations versus baseline were − 1% (range − 38 to + 36%) at 6 months and − 12.2% (range − 48 to + 11%) at 24 months. At 6 months, a significant positive correlation emerged between FEV-1 change and KPS (p = 0.047). At 24 months, a significant negative correlation emerged between FEV-1 change and the ipsilateral lung V5 (p = 0.006). A low baseline DLCO correlated with more marked DLCO worsening at 6 months (p = 0.012). At 24 months, DLCO worsening correlated significantly with the median contralateral lung dose (p = 0.003). At the last checkup, 23 patients were in complete remission, 16 were in partial remission, 5 had stable disease, and 7 were in relapse. Median follow-up was 12 months (range 5–56). Conclusions In patients with lung disease, SBRT, as delivered by HT, was well tolerated and provided good local control. Lung (dpeaa)DE-He213 Stereotactic body radiotherapy (dpeaa)DE-He213 Tomotherapy (dpeaa)DE-He213 Respiratory function (dpeaa)DE-He213 Mendichi, Monia verfasserin aut Chierchini, Sara verfasserin aut Tenti, Maria Valentina verfasserin aut Bellavita, Rita verfasserin aut Saldi, Simonetta verfasserin aut Ingrosso, Gianluca verfasserin aut Reggioli, Valentina verfasserin aut Bini, Vittorio verfasserin aut Aristei, Cynthia verfasserin aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 126(2020), 1 vom: 15. Mai, Seite 163-169 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:126 year:2020 number:1 day:15 month:05 pages:163-169 https://dx.doi.org/10.1007/s11547-020-01223-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 126 2020 1 15 05 163-169 |
| allfieldsGer |
10.1007/s11547-020-01223-w doi (DE-627)SPR043085660 (DE-599)SPRs11547-020-01223-w-e (SPR)s11547-020-01223-w-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Falcinelli, Lorenzo verfasserin aut Pulmonary function in stereotactic body radiotherapy with helical tomotherapy for primary and metastatic lung lesions 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims This retrospective study reports outcomes after stereotactic body radiation therapy (SBRT) as delivered by helical tomotherapy (HT) for lung lesions. It promotes a dose escalation program. Methods Histological and/or radiological findings and/or case histories identified 41 primary and 15 metastatic lesions. Thirty patients received 40 Gy in 5 fractions (BED 72 $ Gy_{10Gy} $) and 26 50 Gy in 5 fractions (BED $ 100Gy_{10Gy} $). Primary end point was lung toxicity. Secondary end points were respiratory function, local control and local progression-free survival. Results Acute toxicity developed in 18/56 patients and late toxicity in 8/54. Median FEV-1 variations versus baseline were − 0.5% (range − 16 to + 43%) at 6 months and − 4.00% (range − 42 to + 18%) at 24 months. Median DLCO variations versus baseline were − 1% (range − 38 to + 36%) at 6 months and − 12.2% (range − 48 to + 11%) at 24 months. At 6 months, a significant positive correlation emerged between FEV-1 change and KPS (p = 0.047). At 24 months, a significant negative correlation emerged between FEV-1 change and the ipsilateral lung V5 (p = 0.006). A low baseline DLCO correlated with more marked DLCO worsening at 6 months (p = 0.012). At 24 months, DLCO worsening correlated significantly with the median contralateral lung dose (p = 0.003). At the last checkup, 23 patients were in complete remission, 16 were in partial remission, 5 had stable disease, and 7 were in relapse. Median follow-up was 12 months (range 5–56). Conclusions In patients with lung disease, SBRT, as delivered by HT, was well tolerated and provided good local control. Lung (dpeaa)DE-He213 Stereotactic body radiotherapy (dpeaa)DE-He213 Tomotherapy (dpeaa)DE-He213 Respiratory function (dpeaa)DE-He213 Mendichi, Monia verfasserin aut Chierchini, Sara verfasserin aut Tenti, Maria Valentina verfasserin aut Bellavita, Rita verfasserin aut Saldi, Simonetta verfasserin aut Ingrosso, Gianluca verfasserin aut Reggioli, Valentina verfasserin aut Bini, Vittorio verfasserin aut Aristei, Cynthia verfasserin aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 126(2020), 1 vom: 15. Mai, Seite 163-169 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:126 year:2020 number:1 day:15 month:05 pages:163-169 https://dx.doi.org/10.1007/s11547-020-01223-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 126 2020 1 15 05 163-169 |
| allfieldsSound |
10.1007/s11547-020-01223-w doi (DE-627)SPR043085660 (DE-599)SPRs11547-020-01223-w-e (SPR)s11547-020-01223-w-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Falcinelli, Lorenzo verfasserin aut Pulmonary function in stereotactic body radiotherapy with helical tomotherapy for primary and metastatic lung lesions 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims This retrospective study reports outcomes after stereotactic body radiation therapy (SBRT) as delivered by helical tomotherapy (HT) for lung lesions. It promotes a dose escalation program. Methods Histological and/or radiological findings and/or case histories identified 41 primary and 15 metastatic lesions. Thirty patients received 40 Gy in 5 fractions (BED 72 $ Gy_{10Gy} $) and 26 50 Gy in 5 fractions (BED $ 100Gy_{10Gy} $). Primary end point was lung toxicity. Secondary end points were respiratory function, local control and local progression-free survival. Results Acute toxicity developed in 18/56 patients and late toxicity in 8/54. Median FEV-1 variations versus baseline were − 0.5% (range − 16 to + 43%) at 6 months and − 4.00% (range − 42 to + 18%) at 24 months. Median DLCO variations versus baseline were − 1% (range − 38 to + 36%) at 6 months and − 12.2% (range − 48 to + 11%) at 24 months. At 6 months, a significant positive correlation emerged between FEV-1 change and KPS (p = 0.047). At 24 months, a significant negative correlation emerged between FEV-1 change and the ipsilateral lung V5 (p = 0.006). A low baseline DLCO correlated with more marked DLCO worsening at 6 months (p = 0.012). At 24 months, DLCO worsening correlated significantly with the median contralateral lung dose (p = 0.003). At the last checkup, 23 patients were in complete remission, 16 were in partial remission, 5 had stable disease, and 7 were in relapse. Median follow-up was 12 months (range 5–56). Conclusions In patients with lung disease, SBRT, as delivered by HT, was well tolerated and provided good local control. Lung (dpeaa)DE-He213 Stereotactic body radiotherapy (dpeaa)DE-He213 Tomotherapy (dpeaa)DE-He213 Respiratory function (dpeaa)DE-He213 Mendichi, Monia verfasserin aut Chierchini, Sara verfasserin aut Tenti, Maria Valentina verfasserin aut Bellavita, Rita verfasserin aut Saldi, Simonetta verfasserin aut Ingrosso, Gianluca verfasserin aut Reggioli, Valentina verfasserin aut Bini, Vittorio verfasserin aut Aristei, Cynthia verfasserin aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 126(2020), 1 vom: 15. Mai, Seite 163-169 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:126 year:2020 number:1 day:15 month:05 pages:163-169 https://dx.doi.org/10.1007/s11547-020-01223-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 126 2020 1 15 05 163-169 |
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English |
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Enthalten in La Radiologia medica 126(2020), 1 vom: 15. Mai, Seite 163-169 volume:126 year:2020 number:1 day:15 month:05 pages:163-169 |
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Enthalten in La Radiologia medica 126(2020), 1 vom: 15. Mai, Seite 163-169 volume:126 year:2020 number:1 day:15 month:05 pages:163-169 |
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findex.gbv.de |
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Lung Stereotactic body radiotherapy Tomotherapy Respiratory function |
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La Radiologia medica |
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Falcinelli, Lorenzo @@aut@@ Mendichi, Monia @@aut@@ Chierchini, Sara @@aut@@ Tenti, Maria Valentina @@aut@@ Bellavita, Rita @@aut@@ Saldi, Simonetta @@aut@@ Ingrosso, Gianluca @@aut@@ Reggioli, Valentina @@aut@@ Bini, Vittorio @@aut@@ Aristei, Cynthia @@aut@@ |
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2020-05-15T00:00:00Z |
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It promotes a dose escalation program. Methods Histological and/or radiological findings and/or case histories identified 41 primary and 15 metastatic lesions. Thirty patients received 40 Gy in 5 fractions (BED 72 $ Gy_{10Gy} $) and 26 50 Gy in 5 fractions (BED $ 100Gy_{10Gy} $). Primary end point was lung toxicity. Secondary end points were respiratory function, local control and local progression-free survival. Results Acute toxicity developed in 18/56 patients and late toxicity in 8/54. Median FEV-1 variations versus baseline were − 0.5% (range − 16 to + 43%) at 6 months and − 4.00% (range − 42 to + 18%) at 24 months. Median DLCO variations versus baseline were − 1% (range − 38 to + 36%) at 6 months and − 12.2% (range − 48 to + 11%) at 24 months. At 6 months, a significant positive correlation emerged between FEV-1 change and KPS (p = 0.047). At 24 months, a significant negative correlation emerged between FEV-1 change and the ipsilateral lung V5 (p = 0.006). A low baseline DLCO correlated with more marked DLCO worsening at 6 months (p = 0.012). At 24 months, DLCO worsening correlated significantly with the median contralateral lung dose (p = 0.003). At the last checkup, 23 patients were in complete remission, 16 were in partial remission, 5 had stable disease, and 7 were in relapse. Median follow-up was 12 months (range 5–56). 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Falcinelli, Lorenzo |
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Falcinelli, Lorenzo ddc 610 bkl 44.64 misc Lung misc Stereotactic body radiotherapy misc Tomotherapy misc Respiratory function Pulmonary function in stereotactic body radiotherapy with helical tomotherapy for primary and metastatic lung lesions |
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610 ASE 44.64 bkl Pulmonary function in stereotactic body radiotherapy with helical tomotherapy for primary and metastatic lung lesions Lung (dpeaa)DE-He213 Stereotactic body radiotherapy (dpeaa)DE-He213 Tomotherapy (dpeaa)DE-He213 Respiratory function (dpeaa)DE-He213 |
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Pulmonary function in stereotactic body radiotherapy with helical tomotherapy for primary and metastatic lung lesions |
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Falcinelli, Lorenzo Mendichi, Monia Chierchini, Sara Tenti, Maria Valentina Bellavita, Rita Saldi, Simonetta Ingrosso, Gianluca Reggioli, Valentina Bini, Vittorio Aristei, Cynthia |
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Falcinelli, Lorenzo |
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pulmonary function in stereotactic body radiotherapy with helical tomotherapy for primary and metastatic lung lesions |
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Pulmonary function in stereotactic body radiotherapy with helical tomotherapy for primary and metastatic lung lesions |
| abstract |
Aims This retrospective study reports outcomes after stereotactic body radiation therapy (SBRT) as delivered by helical tomotherapy (HT) for lung lesions. It promotes a dose escalation program. Methods Histological and/or radiological findings and/or case histories identified 41 primary and 15 metastatic lesions. Thirty patients received 40 Gy in 5 fractions (BED 72 $ Gy_{10Gy} $) and 26 50 Gy in 5 fractions (BED $ 100Gy_{10Gy} $). Primary end point was lung toxicity. Secondary end points were respiratory function, local control and local progression-free survival. Results Acute toxicity developed in 18/56 patients and late toxicity in 8/54. Median FEV-1 variations versus baseline were − 0.5% (range − 16 to + 43%) at 6 months and − 4.00% (range − 42 to + 18%) at 24 months. Median DLCO variations versus baseline were − 1% (range − 38 to + 36%) at 6 months and − 12.2% (range − 48 to + 11%) at 24 months. At 6 months, a significant positive correlation emerged between FEV-1 change and KPS (p = 0.047). At 24 months, a significant negative correlation emerged between FEV-1 change and the ipsilateral lung V5 (p = 0.006). A low baseline DLCO correlated with more marked DLCO worsening at 6 months (p = 0.012). At 24 months, DLCO worsening correlated significantly with the median contralateral lung dose (p = 0.003). At the last checkup, 23 patients were in complete remission, 16 were in partial remission, 5 had stable disease, and 7 were in relapse. Median follow-up was 12 months (range 5–56). Conclusions In patients with lung disease, SBRT, as delivered by HT, was well tolerated and provided good local control. |
| abstractGer |
Aims This retrospective study reports outcomes after stereotactic body radiation therapy (SBRT) as delivered by helical tomotherapy (HT) for lung lesions. It promotes a dose escalation program. Methods Histological and/or radiological findings and/or case histories identified 41 primary and 15 metastatic lesions. Thirty patients received 40 Gy in 5 fractions (BED 72 $ Gy_{10Gy} $) and 26 50 Gy in 5 fractions (BED $ 100Gy_{10Gy} $). Primary end point was lung toxicity. Secondary end points were respiratory function, local control and local progression-free survival. Results Acute toxicity developed in 18/56 patients and late toxicity in 8/54. Median FEV-1 variations versus baseline were − 0.5% (range − 16 to + 43%) at 6 months and − 4.00% (range − 42 to + 18%) at 24 months. Median DLCO variations versus baseline were − 1% (range − 38 to + 36%) at 6 months and − 12.2% (range − 48 to + 11%) at 24 months. At 6 months, a significant positive correlation emerged between FEV-1 change and KPS (p = 0.047). At 24 months, a significant negative correlation emerged between FEV-1 change and the ipsilateral lung V5 (p = 0.006). A low baseline DLCO correlated with more marked DLCO worsening at 6 months (p = 0.012). At 24 months, DLCO worsening correlated significantly with the median contralateral lung dose (p = 0.003). At the last checkup, 23 patients were in complete remission, 16 were in partial remission, 5 had stable disease, and 7 were in relapse. Median follow-up was 12 months (range 5–56). Conclusions In patients with lung disease, SBRT, as delivered by HT, was well tolerated and provided good local control. |
| abstract_unstemmed |
Aims This retrospective study reports outcomes after stereotactic body radiation therapy (SBRT) as delivered by helical tomotherapy (HT) for lung lesions. It promotes a dose escalation program. Methods Histological and/or radiological findings and/or case histories identified 41 primary and 15 metastatic lesions. Thirty patients received 40 Gy in 5 fractions (BED 72 $ Gy_{10Gy} $) and 26 50 Gy in 5 fractions (BED $ 100Gy_{10Gy} $). Primary end point was lung toxicity. Secondary end points were respiratory function, local control and local progression-free survival. Results Acute toxicity developed in 18/56 patients and late toxicity in 8/54. Median FEV-1 variations versus baseline were − 0.5% (range − 16 to + 43%) at 6 months and − 4.00% (range − 42 to + 18%) at 24 months. Median DLCO variations versus baseline were − 1% (range − 38 to + 36%) at 6 months and − 12.2% (range − 48 to + 11%) at 24 months. At 6 months, a significant positive correlation emerged between FEV-1 change and KPS (p = 0.047). At 24 months, a significant negative correlation emerged between FEV-1 change and the ipsilateral lung V5 (p = 0.006). A low baseline DLCO correlated with more marked DLCO worsening at 6 months (p = 0.012). At 24 months, DLCO worsening correlated significantly with the median contralateral lung dose (p = 0.003). At the last checkup, 23 patients were in complete remission, 16 were in partial remission, 5 had stable disease, and 7 were in relapse. Median follow-up was 12 months (range 5–56). Conclusions In patients with lung disease, SBRT, as delivered by HT, was well tolerated and provided good local control. |
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| score |
7.4027834 |