Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices

Introduction The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. Methods Clini...
Ausführliche Beschreibung

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Autor*in:	Bodro, Marta [verfasserIn] Hernández-Meneses, Marta [verfasserIn] Ambrosioni, Juan [verfasserIn] Linares, Laura [verfasserIn] Moreno, Asunción [verfasserIn] Sandoval, Elena [verfasserIn] Olivas, Pol [verfasserIn] Hernández-Tejero, María [verfasserIn] Miró, José M. [verfasserIn] Marco, Francesc [verfasserIn] Soriano, Alex [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Cefiderocol Foreign body infections Gram-negative bacteria Multidrug resistance

Übergeordnetes Werk:	Enthalten in: Infectious diseases and therapy - Heidelberg : Springer, 2012, 10(2021), 1 vom: 08. Jan., Seite 575-581
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:1 ; day:08 ; month:01 ; pages:575-581

Links:	Volltext

DOI / URN:	10.1007/s40121-020-00385-4

Katalog-ID:	SPR043483550

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520			\|a Introduction The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. Methods Clinical charts and microbiological reports of the clinical cases. Results Case 1 included a left ventricular assist device (HEARTMATE 3™$ Abbot^{®} $) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. Conclusion Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens.
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spelling	10.1007/s40121-020-00385-4 doi (DE-627)SPR043483550 (DE-599)SPRs40121-020-00385-4-e (SPR)s40121-020-00385-4-e DE-627 ger DE-627 rakwb eng 610 ASE Bodro, Marta verfasserin aut Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. Methods Clinical charts and microbiological reports of the clinical cases. Results Case 1 included a left ventricular assist device (HEARTMATE 3™$ Abbot^{®} $) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. Conclusion Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens. Cefiderocol (dpeaa)DE-He213 Foreign body infections (dpeaa)DE-He213 Gram-negative bacteria (dpeaa)DE-He213 Multidrug resistance (dpeaa)DE-He213 Hernández-Meneses, Marta verfasserin aut Ambrosioni, Juan verfasserin aut Linares, Laura verfasserin aut Moreno, Asunción verfasserin aut Sandoval, Elena verfasserin aut Olivas, Pol verfasserin aut Hernández-Tejero, María verfasserin aut Miró, José M. verfasserin aut Marco, Francesc verfasserin aut Soriano, Alex verfasserin aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 10(2021), 1 vom: 08. Jan., Seite 575-581 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:10 year:2021 number:1 day:08 month:01 pages:575-581 https://dx.doi.org/10.1007/s40121-020-00385-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1 08 01 575-581
allfields_unstemmed	10.1007/s40121-020-00385-4 doi (DE-627)SPR043483550 (DE-599)SPRs40121-020-00385-4-e (SPR)s40121-020-00385-4-e DE-627 ger DE-627 rakwb eng 610 ASE Bodro, Marta verfasserin aut Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. Methods Clinical charts and microbiological reports of the clinical cases. Results Case 1 included a left ventricular assist device (HEARTMATE 3™$ Abbot^{®} $) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. Conclusion Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens. Cefiderocol (dpeaa)DE-He213 Foreign body infections (dpeaa)DE-He213 Gram-negative bacteria (dpeaa)DE-He213 Multidrug resistance (dpeaa)DE-He213 Hernández-Meneses, Marta verfasserin aut Ambrosioni, Juan verfasserin aut Linares, Laura verfasserin aut Moreno, Asunción verfasserin aut Sandoval, Elena verfasserin aut Olivas, Pol verfasserin aut Hernández-Tejero, María verfasserin aut Miró, José M. verfasserin aut Marco, Francesc verfasserin aut Soriano, Alex verfasserin aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 10(2021), 1 vom: 08. Jan., Seite 575-581 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:10 year:2021 number:1 day:08 month:01 pages:575-581 https://dx.doi.org/10.1007/s40121-020-00385-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1 08 01 575-581
allfieldsGer	10.1007/s40121-020-00385-4 doi (DE-627)SPR043483550 (DE-599)SPRs40121-020-00385-4-e (SPR)s40121-020-00385-4-e DE-627 ger DE-627 rakwb eng 610 ASE Bodro, Marta verfasserin aut Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. Methods Clinical charts and microbiological reports of the clinical cases. Results Case 1 included a left ventricular assist device (HEARTMATE 3™$ Abbot^{®} $) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. Conclusion Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens. Cefiderocol (dpeaa)DE-He213 Foreign body infections (dpeaa)DE-He213 Gram-negative bacteria (dpeaa)DE-He213 Multidrug resistance (dpeaa)DE-He213 Hernández-Meneses, Marta verfasserin aut Ambrosioni, Juan verfasserin aut Linares, Laura verfasserin aut Moreno, Asunción verfasserin aut Sandoval, Elena verfasserin aut Olivas, Pol verfasserin aut Hernández-Tejero, María verfasserin aut Miró, José M. verfasserin aut Marco, Francesc verfasserin aut Soriano, Alex verfasserin aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 10(2021), 1 vom: 08. Jan., Seite 575-581 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:10 year:2021 number:1 day:08 month:01 pages:575-581 https://dx.doi.org/10.1007/s40121-020-00385-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1 08 01 575-581
allfieldsSound	10.1007/s40121-020-00385-4 doi (DE-627)SPR043483550 (DE-599)SPRs40121-020-00385-4-e (SPR)s40121-020-00385-4-e DE-627 ger DE-627 rakwb eng 610 ASE Bodro, Marta verfasserin aut Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. Methods Clinical charts and microbiological reports of the clinical cases. Results Case 1 included a left ventricular assist device (HEARTMATE 3™$ Abbot^{®} $) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. Conclusion Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens. Cefiderocol (dpeaa)DE-He213 Foreign body infections (dpeaa)DE-He213 Gram-negative bacteria (dpeaa)DE-He213 Multidrug resistance (dpeaa)DE-He213 Hernández-Meneses, Marta verfasserin aut Ambrosioni, Juan verfasserin aut Linares, Laura verfasserin aut Moreno, Asunción verfasserin aut Sandoval, Elena verfasserin aut Olivas, Pol verfasserin aut Hernández-Tejero, María verfasserin aut Miró, José M. verfasserin aut Marco, Francesc verfasserin aut Soriano, Alex verfasserin aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 10(2021), 1 vom: 08. Jan., Seite 575-581 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:10 year:2021 number:1 day:08 month:01 pages:575-581 https://dx.doi.org/10.1007/s40121-020-00385-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1 08 01 575-581
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Methods Clinical charts and microbiological reports of the clinical cases. Results Case 1 included a left ventricular assist device (HEARTMATE 3™$ Abbot^{®} $) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. 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author	Bodro, Marta
spellingShingle	Bodro, Marta ddc 610 misc Cefiderocol misc Foreign body infections misc Gram-negative bacteria misc Multidrug resistance Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices
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topic_title	610 ASE Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices Cefiderocol (dpeaa)DE-He213 Foreign body infections (dpeaa)DE-He213 Gram-negative bacteria (dpeaa)DE-He213 Multidrug resistance (dpeaa)DE-He213
topic	ddc 610 misc Cefiderocol misc Foreign body infections misc Gram-negative bacteria misc Multidrug resistance
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title	Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices
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title_full	Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices
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author_browse	Bodro, Marta Hernández-Meneses, Marta Ambrosioni, Juan Linares, Laura Moreno, Asunción Sandoval, Elena Olivas, Pol Hernández-Tejero, María Miró, José M. Marco, Francesc Soriano, Alex
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title_sort	salvage treatment with cefiderocol regimens in two intravascular foreign body infections by mdr gram-negative pathogens, involving non-removable devices
title_auth	Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices
abstract	Introduction The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. Methods Clinical charts and microbiological reports of the clinical cases. Results Case 1 included a left ventricular assist device (HEARTMATE 3™$ Abbot^{®} $) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. Conclusion Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens.
abstractGer	Introduction The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. Methods Clinical charts and microbiological reports of the clinical cases. Results Case 1 included a left ventricular assist device (HEARTMATE 3™$ Abbot^{®} $) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. Conclusion Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens.
abstract_unstemmed	Introduction The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. Methods Clinical charts and microbiological reports of the clinical cases. Results Case 1 included a left ventricular assist device (HEARTMATE 3™$ Abbot^{®} $) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. Conclusion Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens.
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title_short	Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices
url	https://dx.doi.org/10.1007/s40121-020-00385-4
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author2	Hernández-Meneses, Marta Ambrosioni, Juan Linares, Laura Moreno, Asunción Sandoval, Elena Olivas, Pol Hernández-Tejero, María Miró, José M. Marco, Francesc Soriano, Alex
author2Str	Hernández-Meneses, Marta Ambrosioni, Juan Linares, Laura Moreno, Asunción Sandoval, Elena Olivas, Pol Hernández-Tejero, María Miró, José M. Marco, Francesc Soriano, Alex
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up_date	2024-07-03T18:58:26.824Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR043483550</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520000234.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">210313s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s40121-020-00385-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR043483550</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)SPRs40121-020-00385-4-e</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s40121-020-00385-4-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bodro, Marta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. Methods Clinical charts and microbiological reports of the clinical cases. Results Case 1 included a left ventricular assist device (HEARTMATE 3™$ Abbot^{®} $) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. 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Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices

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