Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity
Abstract Renal cell carcinoma with leiomyomatous stroma (RCCLS) is an emerging entity frequently associated with tuberous sclerosis complex (TSC). We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified betw...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Gournay, Marjorie [verfasserIn] Dugay, Frédéric [verfasserIn] Belaud-Rotureau, Marc-Antoine [verfasserIn] Peyronnet, Benoit [verfasserIn] Mathieu, Romain [verfasserIn] Verhoest, Gregory [verfasserIn] Bensalah, Karim [verfasserIn] Odent, Sylvie [verfasserIn] Denizeau, Philippe [verfasserIn] Vigneau, Cécile [verfasserIn] Morini, Aurélien [verfasserIn] Rioux-Leclercq, Nathalie [verfasserIn] Kammerer-Jacquet, Solène-Florence [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Virchows Archiv - Berlin : Springer, 1847, 478(2020), 4 vom: 26. Aug., Seite 793-799 |
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| Übergeordnetes Werk: |
volume:478 ; year:2020 ; number:4 ; day:26 ; month:08 ; pages:793-799 |
| Links: |
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| DOI / URN: |
10.1007/s00428-020-02910-9 |
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| Katalog-ID: |
SPR043598633 |
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| 520 | |a Abstract Renal cell carcinoma with leiomyomatous stroma (RCCLS) is an emerging entity frequently associated with tuberous sclerosis complex (TSC). We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified between 2000 and 2019 at the University Hospital of Rennes. Histologically, the architecture was tubulo-papillary with thick bundles of smooth muscle cells. The tumor cells showed clear cytoplasm with eosinophilic globules. The immunohistochemical profile was identical with an intense positivity of CK7, CAIX, and CD10 and a heterogeneous positivity of CK20. SDHB was low but positive and TFE3 was not expressed. Comparative genomic hybridization (CGH) did not show any quantitative chromosome abnormality. No recurrence was observed with a median follow-up of 4 years. RCCLS in TSC patients has morphological, immunohistochemical, and cytogenetic distinct features that could constitute a distinct entity and a sentinel manifestation for the diagnosis of TSC. | ||
| 650 | 4 | |a Renal cell carcinoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Leiomyomatous stroma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Tuberous sclerosis complex |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a TSC1 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a TSC2 |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Dugay, Frédéric |e verfasserin |4 aut | |
| 700 | 1 | |a Belaud-Rotureau, Marc-Antoine |e verfasserin |4 aut | |
| 700 | 1 | |a Peyronnet, Benoit |e verfasserin |4 aut | |
| 700 | 1 | |a Mathieu, Romain |e verfasserin |4 aut | |
| 700 | 1 | |a Verhoest, Gregory |e verfasserin |4 aut | |
| 700 | 1 | |a Bensalah, Karim |e verfasserin |4 aut | |
| 700 | 1 | |a Odent, Sylvie |e verfasserin |4 aut | |
| 700 | 1 | |a Denizeau, Philippe |e verfasserin |4 aut | |
| 700 | 1 | |a Vigneau, Cécile |e verfasserin |4 aut | |
| 700 | 1 | |a Morini, Aurélien |e verfasserin |4 aut | |
| 700 | 1 | |a Rioux-Leclercq, Nathalie |e verfasserin |4 aut | |
| 700 | 1 | |a Kammerer-Jacquet, Solène-Florence |e verfasserin |4 aut | |
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10.1007/s00428-020-02910-9 doi (DE-627)SPR043598633 (DE-599)SPRs00428-020-02910-9-e (SPR)s00428-020-02910-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Gournay, Marjorie verfasserin aut Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Renal cell carcinoma with leiomyomatous stroma (RCCLS) is an emerging entity frequently associated with tuberous sclerosis complex (TSC). We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified between 2000 and 2019 at the University Hospital of Rennes. Histologically, the architecture was tubulo-papillary with thick bundles of smooth muscle cells. The tumor cells showed clear cytoplasm with eosinophilic globules. The immunohistochemical profile was identical with an intense positivity of CK7, CAIX, and CD10 and a heterogeneous positivity of CK20. SDHB was low but positive and TFE3 was not expressed. Comparative genomic hybridization (CGH) did not show any quantitative chromosome abnormality. No recurrence was observed with a median follow-up of 4 years. RCCLS in TSC patients has morphological, immunohistochemical, and cytogenetic distinct features that could constitute a distinct entity and a sentinel manifestation for the diagnosis of TSC. Renal cell carcinoma (dpeaa)DE-He213 Leiomyomatous stroma (dpeaa)DE-He213 Tuberous sclerosis complex (dpeaa)DE-He213 TSC1 (dpeaa)DE-He213 TSC2 (dpeaa)DE-He213 Dugay, Frédéric verfasserin aut Belaud-Rotureau, Marc-Antoine verfasserin aut Peyronnet, Benoit verfasserin aut Mathieu, Romain verfasserin aut Verhoest, Gregory verfasserin aut Bensalah, Karim verfasserin aut Odent, Sylvie verfasserin aut Denizeau, Philippe verfasserin aut Vigneau, Cécile verfasserin aut Morini, Aurélien verfasserin aut Rioux-Leclercq, Nathalie verfasserin aut Kammerer-Jacquet, Solène-Florence verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 478(2020), 4 vom: 26. Aug., Seite 793-799 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:478 year:2020 number:4 day:26 month:08 pages:793-799 https://dx.doi.org/10.1007/s00428-020-02910-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 478 2020 4 26 08 793-799 |
| spelling |
10.1007/s00428-020-02910-9 doi (DE-627)SPR043598633 (DE-599)SPRs00428-020-02910-9-e (SPR)s00428-020-02910-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Gournay, Marjorie verfasserin aut Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Renal cell carcinoma with leiomyomatous stroma (RCCLS) is an emerging entity frequently associated with tuberous sclerosis complex (TSC). We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified between 2000 and 2019 at the University Hospital of Rennes. Histologically, the architecture was tubulo-papillary with thick bundles of smooth muscle cells. The tumor cells showed clear cytoplasm with eosinophilic globules. The immunohistochemical profile was identical with an intense positivity of CK7, CAIX, and CD10 and a heterogeneous positivity of CK20. SDHB was low but positive and TFE3 was not expressed. Comparative genomic hybridization (CGH) did not show any quantitative chromosome abnormality. No recurrence was observed with a median follow-up of 4 years. RCCLS in TSC patients has morphological, immunohistochemical, and cytogenetic distinct features that could constitute a distinct entity and a sentinel manifestation for the diagnosis of TSC. Renal cell carcinoma (dpeaa)DE-He213 Leiomyomatous stroma (dpeaa)DE-He213 Tuberous sclerosis complex (dpeaa)DE-He213 TSC1 (dpeaa)DE-He213 TSC2 (dpeaa)DE-He213 Dugay, Frédéric verfasserin aut Belaud-Rotureau, Marc-Antoine verfasserin aut Peyronnet, Benoit verfasserin aut Mathieu, Romain verfasserin aut Verhoest, Gregory verfasserin aut Bensalah, Karim verfasserin aut Odent, Sylvie verfasserin aut Denizeau, Philippe verfasserin aut Vigneau, Cécile verfasserin aut Morini, Aurélien verfasserin aut Rioux-Leclercq, Nathalie verfasserin aut Kammerer-Jacquet, Solène-Florence verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 478(2020), 4 vom: 26. Aug., Seite 793-799 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:478 year:2020 number:4 day:26 month:08 pages:793-799 https://dx.doi.org/10.1007/s00428-020-02910-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 478 2020 4 26 08 793-799 |
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10.1007/s00428-020-02910-9 doi (DE-627)SPR043598633 (DE-599)SPRs00428-020-02910-9-e (SPR)s00428-020-02910-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Gournay, Marjorie verfasserin aut Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Renal cell carcinoma with leiomyomatous stroma (RCCLS) is an emerging entity frequently associated with tuberous sclerosis complex (TSC). We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified between 2000 and 2019 at the University Hospital of Rennes. Histologically, the architecture was tubulo-papillary with thick bundles of smooth muscle cells. The tumor cells showed clear cytoplasm with eosinophilic globules. The immunohistochemical profile was identical with an intense positivity of CK7, CAIX, and CD10 and a heterogeneous positivity of CK20. SDHB was low but positive and TFE3 was not expressed. Comparative genomic hybridization (CGH) did not show any quantitative chromosome abnormality. No recurrence was observed with a median follow-up of 4 years. RCCLS in TSC patients has morphological, immunohistochemical, and cytogenetic distinct features that could constitute a distinct entity and a sentinel manifestation for the diagnosis of TSC. Renal cell carcinoma (dpeaa)DE-He213 Leiomyomatous stroma (dpeaa)DE-He213 Tuberous sclerosis complex (dpeaa)DE-He213 TSC1 (dpeaa)DE-He213 TSC2 (dpeaa)DE-He213 Dugay, Frédéric verfasserin aut Belaud-Rotureau, Marc-Antoine verfasserin aut Peyronnet, Benoit verfasserin aut Mathieu, Romain verfasserin aut Verhoest, Gregory verfasserin aut Bensalah, Karim verfasserin aut Odent, Sylvie verfasserin aut Denizeau, Philippe verfasserin aut Vigneau, Cécile verfasserin aut Morini, Aurélien verfasserin aut Rioux-Leclercq, Nathalie verfasserin aut Kammerer-Jacquet, Solène-Florence verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 478(2020), 4 vom: 26. Aug., Seite 793-799 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:478 year:2020 number:4 day:26 month:08 pages:793-799 https://dx.doi.org/10.1007/s00428-020-02910-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 478 2020 4 26 08 793-799 |
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10.1007/s00428-020-02910-9 doi (DE-627)SPR043598633 (DE-599)SPRs00428-020-02910-9-e (SPR)s00428-020-02910-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Gournay, Marjorie verfasserin aut Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Renal cell carcinoma with leiomyomatous stroma (RCCLS) is an emerging entity frequently associated with tuberous sclerosis complex (TSC). We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified between 2000 and 2019 at the University Hospital of Rennes. Histologically, the architecture was tubulo-papillary with thick bundles of smooth muscle cells. The tumor cells showed clear cytoplasm with eosinophilic globules. The immunohistochemical profile was identical with an intense positivity of CK7, CAIX, and CD10 and a heterogeneous positivity of CK20. SDHB was low but positive and TFE3 was not expressed. Comparative genomic hybridization (CGH) did not show any quantitative chromosome abnormality. No recurrence was observed with a median follow-up of 4 years. RCCLS in TSC patients has morphological, immunohistochemical, and cytogenetic distinct features that could constitute a distinct entity and a sentinel manifestation for the diagnosis of TSC. Renal cell carcinoma (dpeaa)DE-He213 Leiomyomatous stroma (dpeaa)DE-He213 Tuberous sclerosis complex (dpeaa)DE-He213 TSC1 (dpeaa)DE-He213 TSC2 (dpeaa)DE-He213 Dugay, Frédéric verfasserin aut Belaud-Rotureau, Marc-Antoine verfasserin aut Peyronnet, Benoit verfasserin aut Mathieu, Romain verfasserin aut Verhoest, Gregory verfasserin aut Bensalah, Karim verfasserin aut Odent, Sylvie verfasserin aut Denizeau, Philippe verfasserin aut Vigneau, Cécile verfasserin aut Morini, Aurélien verfasserin aut Rioux-Leclercq, Nathalie verfasserin aut Kammerer-Jacquet, Solène-Florence verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 478(2020), 4 vom: 26. Aug., Seite 793-799 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:478 year:2020 number:4 day:26 month:08 pages:793-799 https://dx.doi.org/10.1007/s00428-020-02910-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 478 2020 4 26 08 793-799 |
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10.1007/s00428-020-02910-9 doi (DE-627)SPR043598633 (DE-599)SPRs00428-020-02910-9-e (SPR)s00428-020-02910-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Gournay, Marjorie verfasserin aut Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Renal cell carcinoma with leiomyomatous stroma (RCCLS) is an emerging entity frequently associated with tuberous sclerosis complex (TSC). We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified between 2000 and 2019 at the University Hospital of Rennes. Histologically, the architecture was tubulo-papillary with thick bundles of smooth muscle cells. The tumor cells showed clear cytoplasm with eosinophilic globules. The immunohistochemical profile was identical with an intense positivity of CK7, CAIX, and CD10 and a heterogeneous positivity of CK20. SDHB was low but positive and TFE3 was not expressed. Comparative genomic hybridization (CGH) did not show any quantitative chromosome abnormality. No recurrence was observed with a median follow-up of 4 years. RCCLS in TSC patients has morphological, immunohistochemical, and cytogenetic distinct features that could constitute a distinct entity and a sentinel manifestation for the diagnosis of TSC. Renal cell carcinoma (dpeaa)DE-He213 Leiomyomatous stroma (dpeaa)DE-He213 Tuberous sclerosis complex (dpeaa)DE-He213 TSC1 (dpeaa)DE-He213 TSC2 (dpeaa)DE-He213 Dugay, Frédéric verfasserin aut Belaud-Rotureau, Marc-Antoine verfasserin aut Peyronnet, Benoit verfasserin aut Mathieu, Romain verfasserin aut Verhoest, Gregory verfasserin aut Bensalah, Karim verfasserin aut Odent, Sylvie verfasserin aut Denizeau, Philippe verfasserin aut Vigneau, Cécile verfasserin aut Morini, Aurélien verfasserin aut Rioux-Leclercq, Nathalie verfasserin aut Kammerer-Jacquet, Solène-Florence verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 478(2020), 4 vom: 26. Aug., Seite 793-799 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:478 year:2020 number:4 day:26 month:08 pages:793-799 https://dx.doi.org/10.1007/s00428-020-02910-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 478 2020 4 26 08 793-799 |
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English |
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Enthalten in Virchows Archiv 478(2020), 4 vom: 26. Aug., Seite 793-799 volume:478 year:2020 number:4 day:26 month:08 pages:793-799 |
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Enthalten in Virchows Archiv 478(2020), 4 vom: 26. Aug., Seite 793-799 volume:478 year:2020 number:4 day:26 month:08 pages:793-799 |
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Renal cell carcinoma Leiomyomatous stroma Tuberous sclerosis complex TSC1 TSC2 |
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Gournay, Marjorie @@aut@@ Dugay, Frédéric @@aut@@ Belaud-Rotureau, Marc-Antoine @@aut@@ Peyronnet, Benoit @@aut@@ Mathieu, Romain @@aut@@ Verhoest, Gregory @@aut@@ Bensalah, Karim @@aut@@ Odent, Sylvie @@aut@@ Denizeau, Philippe @@aut@@ Vigneau, Cécile @@aut@@ Morini, Aurélien @@aut@@ Rioux-Leclercq, Nathalie @@aut@@ Kammerer-Jacquet, Solène-Florence @@aut@@ |
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2020-08-26T00:00:00Z |
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We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified between 2000 and 2019 at the University Hospital of Rennes. Histologically, the architecture was tubulo-papillary with thick bundles of smooth muscle cells. The tumor cells showed clear cytoplasm with eosinophilic globules. The immunohistochemical profile was identical with an intense positivity of CK7, CAIX, and CD10 and a heterogeneous positivity of CK20. SDHB was low but positive and TFE3 was not expressed. Comparative genomic hybridization (CGH) did not show any quantitative chromosome abnormality. No recurrence was observed with a median follow-up of 4 years. 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|
| author |
Gournay, Marjorie |
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Gournay, Marjorie ddc 610 bkl 44.47 misc Renal cell carcinoma misc Leiomyomatous stroma misc Tuberous sclerosis complex misc TSC1 misc TSC2 Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity |
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Gournay, Marjorie |
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1432-2307 |
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610 ASE 44.47 bkl Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity Renal cell carcinoma (dpeaa)DE-He213 Leiomyomatous stroma (dpeaa)DE-He213 Tuberous sclerosis complex (dpeaa)DE-He213 TSC1 (dpeaa)DE-He213 TSC2 (dpeaa)DE-He213 |
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ddc 610 bkl 44.47 misc Renal cell carcinoma misc Leiomyomatous stroma misc Tuberous sclerosis complex misc TSC1 misc TSC2 |
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ddc 610 bkl 44.47 misc Renal cell carcinoma misc Leiomyomatous stroma misc Tuberous sclerosis complex misc TSC1 misc TSC2 |
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ddc 610 bkl 44.47 misc Renal cell carcinoma misc Leiomyomatous stroma misc Tuberous sclerosis complex misc TSC1 misc TSC2 |
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Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity |
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Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity |
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Gournay, Marjorie |
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Virchows Archiv |
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Gournay, Marjorie Dugay, Frédéric Belaud-Rotureau, Marc-Antoine Peyronnet, Benoit Mathieu, Romain Verhoest, Gregory Bensalah, Karim Odent, Sylvie Denizeau, Philippe Vigneau, Cécile Morini, Aurélien Rioux-Leclercq, Nathalie Kammerer-Jacquet, Solène-Florence |
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Gournay, Marjorie |
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10.1007/s00428-020-02910-9 |
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renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity |
| title_auth |
Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity |
| abstract |
Abstract Renal cell carcinoma with leiomyomatous stroma (RCCLS) is an emerging entity frequently associated with tuberous sclerosis complex (TSC). We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified between 2000 and 2019 at the University Hospital of Rennes. Histologically, the architecture was tubulo-papillary with thick bundles of smooth muscle cells. The tumor cells showed clear cytoplasm with eosinophilic globules. The immunohistochemical profile was identical with an intense positivity of CK7, CAIX, and CD10 and a heterogeneous positivity of CK20. SDHB was low but positive and TFE3 was not expressed. Comparative genomic hybridization (CGH) did not show any quantitative chromosome abnormality. No recurrence was observed with a median follow-up of 4 years. RCCLS in TSC patients has morphological, immunohistochemical, and cytogenetic distinct features that could constitute a distinct entity and a sentinel manifestation for the diagnosis of TSC. |
| abstractGer |
Abstract Renal cell carcinoma with leiomyomatous stroma (RCCLS) is an emerging entity frequently associated with tuberous sclerosis complex (TSC). We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified between 2000 and 2019 at the University Hospital of Rennes. Histologically, the architecture was tubulo-papillary with thick bundles of smooth muscle cells. The tumor cells showed clear cytoplasm with eosinophilic globules. The immunohistochemical profile was identical with an intense positivity of CK7, CAIX, and CD10 and a heterogeneous positivity of CK20. SDHB was low but positive and TFE3 was not expressed. Comparative genomic hybridization (CGH) did not show any quantitative chromosome abnormality. No recurrence was observed with a median follow-up of 4 years. RCCLS in TSC patients has morphological, immunohistochemical, and cytogenetic distinct features that could constitute a distinct entity and a sentinel manifestation for the diagnosis of TSC. |
| abstract_unstemmed |
Abstract Renal cell carcinoma with leiomyomatous stroma (RCCLS) is an emerging entity frequently associated with tuberous sclerosis complex (TSC). We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified between 2000 and 2019 at the University Hospital of Rennes. Histologically, the architecture was tubulo-papillary with thick bundles of smooth muscle cells. The tumor cells showed clear cytoplasm with eosinophilic globules. The immunohistochemical profile was identical with an intense positivity of CK7, CAIX, and CD10 and a heterogeneous positivity of CK20. SDHB was low but positive and TFE3 was not expressed. Comparative genomic hybridization (CGH) did not show any quantitative chromosome abnormality. No recurrence was observed with a median follow-up of 4 years. RCCLS in TSC patients has morphological, immunohistochemical, and cytogenetic distinct features that could constitute a distinct entity and a sentinel manifestation for the diagnosis of TSC. |
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Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity |
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Dugay, Frédéric Belaud-Rotureau, Marc-Antoine Peyronnet, Benoit Mathieu, Romain Verhoest, Gregory Bensalah, Karim Odent, Sylvie Denizeau, Philippe Vigneau, Cécile Morini, Aurélien Rioux-Leclercq, Nathalie Kammerer-Jacquet, Solène-Florence |
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Dugay, Frédéric Belaud-Rotureau, Marc-Antoine Peyronnet, Benoit Mathieu, Romain Verhoest, Gregory Bensalah, Karim Odent, Sylvie Denizeau, Philippe Vigneau, Cécile Morini, Aurélien Rioux-Leclercq, Nathalie Kammerer-Jacquet, Solène-Florence |
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| score |
7.402135 |