Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea
Abstract A previous study reported the in vivo anti-inflammatory and antinociceptive activities of essential oil of the underground stem bark of Duguetia furfuracea, termed EODf. This study aimed to obtain a phenylpropanoid-enriched fraction from the D. furfuracea (EFDf) essential oil and to investi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Saldanha, Aline Aparecida [verfasserIn] Vieira, Letícia [verfasserIn] Maia, Débora Soares da Silva [verfasserIn] de Oliveira, Flávio Martins [verfasserIn] Ribeiro, Rosy Iara Maciel de Azambuja [verfasserIn] Thomé, Ralph Gruppi [verfasserIn] dos Santos, Hélio Batista [verfasserIn] Lopes, Débora de Oliveira [verfasserIn] Carollo, Carlos Alexandre [verfasserIn] Silva, Denise Brentan [verfasserIn] Soares, Adriana Cristina [verfasserIn] de Siqueira, João Máximo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Inflammopharmacology - Cham : Springer International Publishing AG, 1991, 29(2020), 2 vom: 06. Nov., Seite 409-422 |
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| Übergeordnetes Werk: |
volume:29 ; year:2020 ; number:2 ; day:06 ; month:11 ; pages:409-422 |
| Links: |
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| DOI / URN: |
10.1007/s10787-020-00775-7 |
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| Katalog-ID: |
SPR043624294 |
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| 245 | 1 | 0 | |a Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea |
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| 520 | |a Abstract A previous study reported the in vivo anti-inflammatory and antinociceptive activities of essential oil of the underground stem bark of Duguetia furfuracea, termed EODf. This study aimed to obtain a phenylpropanoid-enriched fraction from the D. furfuracea (EFDf) essential oil and to investigate its anti-inflammatory and antinociceptive effects. The chemical composition of the EFDf was determined by gas chromatography–mass spectrometry (GC–MS). The in vivo anti-inflammatory activity was evaluated with a lipopolysaccharide (LPS)-induced paw oedema model. The effects of the EFDf on the polymorphonuclear leukocyte recruitment and the inducible nitric oxide synthase (iNOS) expression were evaluated in mice footpads. Moreover, the in vivo antinociceptive effect was assayed using the formalin test and the LPS-induced thermal hyperalgesia model. In the EFDf, 8 major compounds were identified, with α-asarone (36.4%) and 2,4,5-trimethoxystyrene (27.8%) the main constituents. A higher concentration of phenylpropanoid derivatives was found in the EFDf, 64.2% compared to the EODf (38%). The oral (p.o.) treatment with the EFDf at a dose of 3 mg/kg significantly attenuated the paw oedema, polymorphonuclear leukocyte migration, iNOS expression, and tumour necrosis factor alpha (TNF-α) production. The EFDf (10 and 30 mg/kg) also inhibited both phases of the formalin test and caused a significant increase in the reaction time in the LPS-induced thermal hyperalgesia model. Finally, EFDf-treated animals did not show any alteration of motor coordination. The results suggest that the enrichment of 2,4,5-trimethoxystyrene and α-asarone enhances the anti-inflammatory activity of the EFDf compared to the EODf. In contrast, the antinociception promoted by the EFDf was similar to the EODf and was mediated via activation of adenosinergic and opioidergic receptors. | ||
| 650 | 4 | |a Antinociceptive |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Anti-inflammatory |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Enriched fraction |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a α-Asarone |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a 2,4,5-Trimethoxystyrene |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Vieira, Letícia |e verfasserin |4 aut | |
| 700 | 1 | |a Maia, Débora Soares da Silva |e verfasserin |4 aut | |
| 700 | 1 | |a de Oliveira, Flávio Martins |e verfasserin |4 aut | |
| 700 | 1 | |a Ribeiro, Rosy Iara Maciel de Azambuja |e verfasserin |4 aut | |
| 700 | 1 | |a Thomé, Ralph Gruppi |e verfasserin |4 aut | |
| 700 | 1 | |a dos Santos, Hélio Batista |e verfasserin |4 aut | |
| 700 | 1 | |a Lopes, Débora de Oliveira |e verfasserin |4 aut | |
| 700 | 1 | |a Carollo, Carlos Alexandre |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Denise Brentan |e verfasserin |4 aut | |
| 700 | 1 | |a Soares, Adriana Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a de Siqueira, João Máximo |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Inflammopharmacology |d Cham : Springer International Publishing AG, 1991 |g 29(2020), 2 vom: 06. Nov., Seite 409-422 |w (DE-627)329558315 |w (DE-600)2047989-X |x 1568-5608 |7 nnns |
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10.1007/s10787-020-00775-7 doi (DE-627)SPR043624294 (DE-599)SPRs10787-020-00775-7-e (SPR)s10787-020-00775-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.38 bkl Saldanha, Aline Aparecida verfasserin aut Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A previous study reported the in vivo anti-inflammatory and antinociceptive activities of essential oil of the underground stem bark of Duguetia furfuracea, termed EODf. This study aimed to obtain a phenylpropanoid-enriched fraction from the D. furfuracea (EFDf) essential oil and to investigate its anti-inflammatory and antinociceptive effects. The chemical composition of the EFDf was determined by gas chromatography–mass spectrometry (GC–MS). The in vivo anti-inflammatory activity was evaluated with a lipopolysaccharide (LPS)-induced paw oedema model. The effects of the EFDf on the polymorphonuclear leukocyte recruitment and the inducible nitric oxide synthase (iNOS) expression were evaluated in mice footpads. Moreover, the in vivo antinociceptive effect was assayed using the formalin test and the LPS-induced thermal hyperalgesia model. In the EFDf, 8 major compounds were identified, with α-asarone (36.4%) and 2,4,5-trimethoxystyrene (27.8%) the main constituents. A higher concentration of phenylpropanoid derivatives was found in the EFDf, 64.2% compared to the EODf (38%). The oral (p.o.) treatment with the EFDf at a dose of 3 mg/kg significantly attenuated the paw oedema, polymorphonuclear leukocyte migration, iNOS expression, and tumour necrosis factor alpha (TNF-α) production. The EFDf (10 and 30 mg/kg) also inhibited both phases of the formalin test and caused a significant increase in the reaction time in the LPS-induced thermal hyperalgesia model. Finally, EFDf-treated animals did not show any alteration of motor coordination. The results suggest that the enrichment of 2,4,5-trimethoxystyrene and α-asarone enhances the anti-inflammatory activity of the EFDf compared to the EODf. In contrast, the antinociception promoted by the EFDf was similar to the EODf and was mediated via activation of adenosinergic and opioidergic receptors. Antinociceptive (dpeaa)DE-He213 Anti-inflammatory (dpeaa)DE-He213 Enriched fraction (dpeaa)DE-He213 α-Asarone (dpeaa)DE-He213 2,4,5-Trimethoxystyrene (dpeaa)DE-He213 Vieira, Letícia verfasserin aut Maia, Débora Soares da Silva verfasserin aut de Oliveira, Flávio Martins verfasserin aut Ribeiro, Rosy Iara Maciel de Azambuja verfasserin aut Thomé, Ralph Gruppi verfasserin aut dos Santos, Hélio Batista verfasserin aut Lopes, Débora de Oliveira verfasserin aut Carollo, Carlos Alexandre verfasserin aut Silva, Denise Brentan verfasserin aut Soares, Adriana Cristina verfasserin aut de Siqueira, João Máximo verfasserin aut Enthalten in Inflammopharmacology Cham : Springer International Publishing AG, 1991 29(2020), 2 vom: 06. Nov., Seite 409-422 (DE-627)329558315 (DE-600)2047989-X 1568-5608 nnns volume:29 year:2020 number:2 day:06 month:11 pages:409-422 https://dx.doi.org/10.1007/s10787-020-00775-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 ASE AR 29 2020 2 06 11 409-422 |
| spelling |
10.1007/s10787-020-00775-7 doi (DE-627)SPR043624294 (DE-599)SPRs10787-020-00775-7-e (SPR)s10787-020-00775-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.38 bkl Saldanha, Aline Aparecida verfasserin aut Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A previous study reported the in vivo anti-inflammatory and antinociceptive activities of essential oil of the underground stem bark of Duguetia furfuracea, termed EODf. This study aimed to obtain a phenylpropanoid-enriched fraction from the D. furfuracea (EFDf) essential oil and to investigate its anti-inflammatory and antinociceptive effects. The chemical composition of the EFDf was determined by gas chromatography–mass spectrometry (GC–MS). The in vivo anti-inflammatory activity was evaluated with a lipopolysaccharide (LPS)-induced paw oedema model. The effects of the EFDf on the polymorphonuclear leukocyte recruitment and the inducible nitric oxide synthase (iNOS) expression were evaluated in mice footpads. Moreover, the in vivo antinociceptive effect was assayed using the formalin test and the LPS-induced thermal hyperalgesia model. In the EFDf, 8 major compounds were identified, with α-asarone (36.4%) and 2,4,5-trimethoxystyrene (27.8%) the main constituents. A higher concentration of phenylpropanoid derivatives was found in the EFDf, 64.2% compared to the EODf (38%). The oral (p.o.) treatment with the EFDf at a dose of 3 mg/kg significantly attenuated the paw oedema, polymorphonuclear leukocyte migration, iNOS expression, and tumour necrosis factor alpha (TNF-α) production. The EFDf (10 and 30 mg/kg) also inhibited both phases of the formalin test and caused a significant increase in the reaction time in the LPS-induced thermal hyperalgesia model. Finally, EFDf-treated animals did not show any alteration of motor coordination. The results suggest that the enrichment of 2,4,5-trimethoxystyrene and α-asarone enhances the anti-inflammatory activity of the EFDf compared to the EODf. In contrast, the antinociception promoted by the EFDf was similar to the EODf and was mediated via activation of adenosinergic and opioidergic receptors. Antinociceptive (dpeaa)DE-He213 Anti-inflammatory (dpeaa)DE-He213 Enriched fraction (dpeaa)DE-He213 α-Asarone (dpeaa)DE-He213 2,4,5-Trimethoxystyrene (dpeaa)DE-He213 Vieira, Letícia verfasserin aut Maia, Débora Soares da Silva verfasserin aut de Oliveira, Flávio Martins verfasserin aut Ribeiro, Rosy Iara Maciel de Azambuja verfasserin aut Thomé, Ralph Gruppi verfasserin aut dos Santos, Hélio Batista verfasserin aut Lopes, Débora de Oliveira verfasserin aut Carollo, Carlos Alexandre verfasserin aut Silva, Denise Brentan verfasserin aut Soares, Adriana Cristina verfasserin aut de Siqueira, João Máximo verfasserin aut Enthalten in Inflammopharmacology Cham : Springer International Publishing AG, 1991 29(2020), 2 vom: 06. Nov., Seite 409-422 (DE-627)329558315 (DE-600)2047989-X 1568-5608 nnns volume:29 year:2020 number:2 day:06 month:11 pages:409-422 https://dx.doi.org/10.1007/s10787-020-00775-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 ASE AR 29 2020 2 06 11 409-422 |
| allfields_unstemmed |
10.1007/s10787-020-00775-7 doi (DE-627)SPR043624294 (DE-599)SPRs10787-020-00775-7-e (SPR)s10787-020-00775-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.38 bkl Saldanha, Aline Aparecida verfasserin aut Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A previous study reported the in vivo anti-inflammatory and antinociceptive activities of essential oil of the underground stem bark of Duguetia furfuracea, termed EODf. This study aimed to obtain a phenylpropanoid-enriched fraction from the D. furfuracea (EFDf) essential oil and to investigate its anti-inflammatory and antinociceptive effects. The chemical composition of the EFDf was determined by gas chromatography–mass spectrometry (GC–MS). The in vivo anti-inflammatory activity was evaluated with a lipopolysaccharide (LPS)-induced paw oedema model. The effects of the EFDf on the polymorphonuclear leukocyte recruitment and the inducible nitric oxide synthase (iNOS) expression were evaluated in mice footpads. Moreover, the in vivo antinociceptive effect was assayed using the formalin test and the LPS-induced thermal hyperalgesia model. In the EFDf, 8 major compounds were identified, with α-asarone (36.4%) and 2,4,5-trimethoxystyrene (27.8%) the main constituents. A higher concentration of phenylpropanoid derivatives was found in the EFDf, 64.2% compared to the EODf (38%). The oral (p.o.) treatment with the EFDf at a dose of 3 mg/kg significantly attenuated the paw oedema, polymorphonuclear leukocyte migration, iNOS expression, and tumour necrosis factor alpha (TNF-α) production. The EFDf (10 and 30 mg/kg) also inhibited both phases of the formalin test and caused a significant increase in the reaction time in the LPS-induced thermal hyperalgesia model. Finally, EFDf-treated animals did not show any alteration of motor coordination. The results suggest that the enrichment of 2,4,5-trimethoxystyrene and α-asarone enhances the anti-inflammatory activity of the EFDf compared to the EODf. In contrast, the antinociception promoted by the EFDf was similar to the EODf and was mediated via activation of adenosinergic and opioidergic receptors. Antinociceptive (dpeaa)DE-He213 Anti-inflammatory (dpeaa)DE-He213 Enriched fraction (dpeaa)DE-He213 α-Asarone (dpeaa)DE-He213 2,4,5-Trimethoxystyrene (dpeaa)DE-He213 Vieira, Letícia verfasserin aut Maia, Débora Soares da Silva verfasserin aut de Oliveira, Flávio Martins verfasserin aut Ribeiro, Rosy Iara Maciel de Azambuja verfasserin aut Thomé, Ralph Gruppi verfasserin aut dos Santos, Hélio Batista verfasserin aut Lopes, Débora de Oliveira verfasserin aut Carollo, Carlos Alexandre verfasserin aut Silva, Denise Brentan verfasserin aut Soares, Adriana Cristina verfasserin aut de Siqueira, João Máximo verfasserin aut Enthalten in Inflammopharmacology Cham : Springer International Publishing AG, 1991 29(2020), 2 vom: 06. Nov., Seite 409-422 (DE-627)329558315 (DE-600)2047989-X 1568-5608 nnns volume:29 year:2020 number:2 day:06 month:11 pages:409-422 https://dx.doi.org/10.1007/s10787-020-00775-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 ASE AR 29 2020 2 06 11 409-422 |
| allfieldsGer |
10.1007/s10787-020-00775-7 doi (DE-627)SPR043624294 (DE-599)SPRs10787-020-00775-7-e (SPR)s10787-020-00775-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.38 bkl Saldanha, Aline Aparecida verfasserin aut Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A previous study reported the in vivo anti-inflammatory and antinociceptive activities of essential oil of the underground stem bark of Duguetia furfuracea, termed EODf. This study aimed to obtain a phenylpropanoid-enriched fraction from the D. furfuracea (EFDf) essential oil and to investigate its anti-inflammatory and antinociceptive effects. The chemical composition of the EFDf was determined by gas chromatography–mass spectrometry (GC–MS). The in vivo anti-inflammatory activity was evaluated with a lipopolysaccharide (LPS)-induced paw oedema model. The effects of the EFDf on the polymorphonuclear leukocyte recruitment and the inducible nitric oxide synthase (iNOS) expression were evaluated in mice footpads. Moreover, the in vivo antinociceptive effect was assayed using the formalin test and the LPS-induced thermal hyperalgesia model. In the EFDf, 8 major compounds were identified, with α-asarone (36.4%) and 2,4,5-trimethoxystyrene (27.8%) the main constituents. A higher concentration of phenylpropanoid derivatives was found in the EFDf, 64.2% compared to the EODf (38%). The oral (p.o.) treatment with the EFDf at a dose of 3 mg/kg significantly attenuated the paw oedema, polymorphonuclear leukocyte migration, iNOS expression, and tumour necrosis factor alpha (TNF-α) production. The EFDf (10 and 30 mg/kg) also inhibited both phases of the formalin test and caused a significant increase in the reaction time in the LPS-induced thermal hyperalgesia model. Finally, EFDf-treated animals did not show any alteration of motor coordination. The results suggest that the enrichment of 2,4,5-trimethoxystyrene and α-asarone enhances the anti-inflammatory activity of the EFDf compared to the EODf. In contrast, the antinociception promoted by the EFDf was similar to the EODf and was mediated via activation of adenosinergic and opioidergic receptors. Antinociceptive (dpeaa)DE-He213 Anti-inflammatory (dpeaa)DE-He213 Enriched fraction (dpeaa)DE-He213 α-Asarone (dpeaa)DE-He213 2,4,5-Trimethoxystyrene (dpeaa)DE-He213 Vieira, Letícia verfasserin aut Maia, Débora Soares da Silva verfasserin aut de Oliveira, Flávio Martins verfasserin aut Ribeiro, Rosy Iara Maciel de Azambuja verfasserin aut Thomé, Ralph Gruppi verfasserin aut dos Santos, Hélio Batista verfasserin aut Lopes, Débora de Oliveira verfasserin aut Carollo, Carlos Alexandre verfasserin aut Silva, Denise Brentan verfasserin aut Soares, Adriana Cristina verfasserin aut de Siqueira, João Máximo verfasserin aut Enthalten in Inflammopharmacology Cham : Springer International Publishing AG, 1991 29(2020), 2 vom: 06. Nov., Seite 409-422 (DE-627)329558315 (DE-600)2047989-X 1568-5608 nnns volume:29 year:2020 number:2 day:06 month:11 pages:409-422 https://dx.doi.org/10.1007/s10787-020-00775-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 ASE AR 29 2020 2 06 11 409-422 |
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10.1007/s10787-020-00775-7 doi (DE-627)SPR043624294 (DE-599)SPRs10787-020-00775-7-e (SPR)s10787-020-00775-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.38 bkl Saldanha, Aline Aparecida verfasserin aut Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A previous study reported the in vivo anti-inflammatory and antinociceptive activities of essential oil of the underground stem bark of Duguetia furfuracea, termed EODf. This study aimed to obtain a phenylpropanoid-enriched fraction from the D. furfuracea (EFDf) essential oil and to investigate its anti-inflammatory and antinociceptive effects. The chemical composition of the EFDf was determined by gas chromatography–mass spectrometry (GC–MS). The in vivo anti-inflammatory activity was evaluated with a lipopolysaccharide (LPS)-induced paw oedema model. The effects of the EFDf on the polymorphonuclear leukocyte recruitment and the inducible nitric oxide synthase (iNOS) expression were evaluated in mice footpads. Moreover, the in vivo antinociceptive effect was assayed using the formalin test and the LPS-induced thermal hyperalgesia model. In the EFDf, 8 major compounds were identified, with α-asarone (36.4%) and 2,4,5-trimethoxystyrene (27.8%) the main constituents. A higher concentration of phenylpropanoid derivatives was found in the EFDf, 64.2% compared to the EODf (38%). The oral (p.o.) treatment with the EFDf at a dose of 3 mg/kg significantly attenuated the paw oedema, polymorphonuclear leukocyte migration, iNOS expression, and tumour necrosis factor alpha (TNF-α) production. The EFDf (10 and 30 mg/kg) also inhibited both phases of the formalin test and caused a significant increase in the reaction time in the LPS-induced thermal hyperalgesia model. Finally, EFDf-treated animals did not show any alteration of motor coordination. The results suggest that the enrichment of 2,4,5-trimethoxystyrene and α-asarone enhances the anti-inflammatory activity of the EFDf compared to the EODf. In contrast, the antinociception promoted by the EFDf was similar to the EODf and was mediated via activation of adenosinergic and opioidergic receptors. Antinociceptive (dpeaa)DE-He213 Anti-inflammatory (dpeaa)DE-He213 Enriched fraction (dpeaa)DE-He213 α-Asarone (dpeaa)DE-He213 2,4,5-Trimethoxystyrene (dpeaa)DE-He213 Vieira, Letícia verfasserin aut Maia, Débora Soares da Silva verfasserin aut de Oliveira, Flávio Martins verfasserin aut Ribeiro, Rosy Iara Maciel de Azambuja verfasserin aut Thomé, Ralph Gruppi verfasserin aut dos Santos, Hélio Batista verfasserin aut Lopes, Débora de Oliveira verfasserin aut Carollo, Carlos Alexandre verfasserin aut Silva, Denise Brentan verfasserin aut Soares, Adriana Cristina verfasserin aut de Siqueira, João Máximo verfasserin aut Enthalten in Inflammopharmacology Cham : Springer International Publishing AG, 1991 29(2020), 2 vom: 06. Nov., Seite 409-422 (DE-627)329558315 (DE-600)2047989-X 1568-5608 nnns volume:29 year:2020 number:2 day:06 month:11 pages:409-422 https://dx.doi.org/10.1007/s10787-020-00775-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 ASE AR 29 2020 2 06 11 409-422 |
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Enthalten in Inflammopharmacology 29(2020), 2 vom: 06. Nov., Seite 409-422 volume:29 year:2020 number:2 day:06 month:11 pages:409-422 |
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Enthalten in Inflammopharmacology 29(2020), 2 vom: 06. Nov., Seite 409-422 volume:29 year:2020 number:2 day:06 month:11 pages:409-422 |
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Antinociceptive Anti-inflammatory Enriched fraction α-Asarone 2,4,5-Trimethoxystyrene |
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Inflammopharmacology |
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Saldanha, Aline Aparecida @@aut@@ Vieira, Letícia @@aut@@ Maia, Débora Soares da Silva @@aut@@ de Oliveira, Flávio Martins @@aut@@ Ribeiro, Rosy Iara Maciel de Azambuja @@aut@@ Thomé, Ralph Gruppi @@aut@@ dos Santos, Hélio Batista @@aut@@ Lopes, Débora de Oliveira @@aut@@ Carollo, Carlos Alexandre @@aut@@ Silva, Denise Brentan @@aut@@ Soares, Adriana Cristina @@aut@@ de Siqueira, João Máximo @@aut@@ |
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2020-11-06T00:00:00Z |
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3610 |
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| author |
Saldanha, Aline Aparecida |
| spellingShingle |
Saldanha, Aline Aparecida ddc 610 bkl 44.38 misc Antinociceptive misc Anti-inflammatory misc Enriched fraction misc α-Asarone misc 2,4,5-Trimethoxystyrene Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea |
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610 ASE 44.38 bkl Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea Antinociceptive (dpeaa)DE-He213 Anti-inflammatory (dpeaa)DE-He213 Enriched fraction (dpeaa)DE-He213 α-Asarone (dpeaa)DE-He213 2,4,5-Trimethoxystyrene (dpeaa)DE-He213 |
| topic |
ddc 610 bkl 44.38 misc Antinociceptive misc Anti-inflammatory misc Enriched fraction misc α-Asarone misc 2,4,5-Trimethoxystyrene |
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ddc 610 bkl 44.38 misc Antinociceptive misc Anti-inflammatory misc Enriched fraction misc α-Asarone misc 2,4,5-Trimethoxystyrene |
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ddc 610 bkl 44.38 misc Antinociceptive misc Anti-inflammatory misc Enriched fraction misc α-Asarone misc 2,4,5-Trimethoxystyrene |
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Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea |
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(DE-627)SPR043624294 (DE-599)SPRs10787-020-00775-7-e (SPR)s10787-020-00775-7-e |
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Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea |
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Saldanha, Aline Aparecida |
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Inflammopharmacology |
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Saldanha, Aline Aparecida Vieira, Letícia Maia, Débora Soares da Silva de Oliveira, Flávio Martins Ribeiro, Rosy Iara Maciel de Azambuja Thomé, Ralph Gruppi dos Santos, Hélio Batista Lopes, Débora de Oliveira Carollo, Carlos Alexandre Silva, Denise Brentan Soares, Adriana Cristina de Siqueira, João Máximo |
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Saldanha, Aline Aparecida |
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10.1007/s10787-020-00775-7 |
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610 |
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verfasserin |
| title_sort |
anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of duguetia furfuracea |
| title_auth |
Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea |
| abstract |
Abstract A previous study reported the in vivo anti-inflammatory and antinociceptive activities of essential oil of the underground stem bark of Duguetia furfuracea, termed EODf. This study aimed to obtain a phenylpropanoid-enriched fraction from the D. furfuracea (EFDf) essential oil and to investigate its anti-inflammatory and antinociceptive effects. The chemical composition of the EFDf was determined by gas chromatography–mass spectrometry (GC–MS). The in vivo anti-inflammatory activity was evaluated with a lipopolysaccharide (LPS)-induced paw oedema model. The effects of the EFDf on the polymorphonuclear leukocyte recruitment and the inducible nitric oxide synthase (iNOS) expression were evaluated in mice footpads. Moreover, the in vivo antinociceptive effect was assayed using the formalin test and the LPS-induced thermal hyperalgesia model. In the EFDf, 8 major compounds were identified, with α-asarone (36.4%) and 2,4,5-trimethoxystyrene (27.8%) the main constituents. A higher concentration of phenylpropanoid derivatives was found in the EFDf, 64.2% compared to the EODf (38%). The oral (p.o.) treatment with the EFDf at a dose of 3 mg/kg significantly attenuated the paw oedema, polymorphonuclear leukocyte migration, iNOS expression, and tumour necrosis factor alpha (TNF-α) production. The EFDf (10 and 30 mg/kg) also inhibited both phases of the formalin test and caused a significant increase in the reaction time in the LPS-induced thermal hyperalgesia model. Finally, EFDf-treated animals did not show any alteration of motor coordination. The results suggest that the enrichment of 2,4,5-trimethoxystyrene and α-asarone enhances the anti-inflammatory activity of the EFDf compared to the EODf. In contrast, the antinociception promoted by the EFDf was similar to the EODf and was mediated via activation of adenosinergic and opioidergic receptors. |
| abstractGer |
Abstract A previous study reported the in vivo anti-inflammatory and antinociceptive activities of essential oil of the underground stem bark of Duguetia furfuracea, termed EODf. This study aimed to obtain a phenylpropanoid-enriched fraction from the D. furfuracea (EFDf) essential oil and to investigate its anti-inflammatory and antinociceptive effects. The chemical composition of the EFDf was determined by gas chromatography–mass spectrometry (GC–MS). The in vivo anti-inflammatory activity was evaluated with a lipopolysaccharide (LPS)-induced paw oedema model. The effects of the EFDf on the polymorphonuclear leukocyte recruitment and the inducible nitric oxide synthase (iNOS) expression were evaluated in mice footpads. Moreover, the in vivo antinociceptive effect was assayed using the formalin test and the LPS-induced thermal hyperalgesia model. In the EFDf, 8 major compounds were identified, with α-asarone (36.4%) and 2,4,5-trimethoxystyrene (27.8%) the main constituents. A higher concentration of phenylpropanoid derivatives was found in the EFDf, 64.2% compared to the EODf (38%). The oral (p.o.) treatment with the EFDf at a dose of 3 mg/kg significantly attenuated the paw oedema, polymorphonuclear leukocyte migration, iNOS expression, and tumour necrosis factor alpha (TNF-α) production. The EFDf (10 and 30 mg/kg) also inhibited both phases of the formalin test and caused a significant increase in the reaction time in the LPS-induced thermal hyperalgesia model. Finally, EFDf-treated animals did not show any alteration of motor coordination. The results suggest that the enrichment of 2,4,5-trimethoxystyrene and α-asarone enhances the anti-inflammatory activity of the EFDf compared to the EODf. In contrast, the antinociception promoted by the EFDf was similar to the EODf and was mediated via activation of adenosinergic and opioidergic receptors. |
| abstract_unstemmed |
Abstract A previous study reported the in vivo anti-inflammatory and antinociceptive activities of essential oil of the underground stem bark of Duguetia furfuracea, termed EODf. This study aimed to obtain a phenylpropanoid-enriched fraction from the D. furfuracea (EFDf) essential oil and to investigate its anti-inflammatory and antinociceptive effects. The chemical composition of the EFDf was determined by gas chromatography–mass spectrometry (GC–MS). The in vivo anti-inflammatory activity was evaluated with a lipopolysaccharide (LPS)-induced paw oedema model. The effects of the EFDf on the polymorphonuclear leukocyte recruitment and the inducible nitric oxide synthase (iNOS) expression were evaluated in mice footpads. Moreover, the in vivo antinociceptive effect was assayed using the formalin test and the LPS-induced thermal hyperalgesia model. In the EFDf, 8 major compounds were identified, with α-asarone (36.4%) and 2,4,5-trimethoxystyrene (27.8%) the main constituents. A higher concentration of phenylpropanoid derivatives was found in the EFDf, 64.2% compared to the EODf (38%). The oral (p.o.) treatment with the EFDf at a dose of 3 mg/kg significantly attenuated the paw oedema, polymorphonuclear leukocyte migration, iNOS expression, and tumour necrosis factor alpha (TNF-α) production. The EFDf (10 and 30 mg/kg) also inhibited both phases of the formalin test and caused a significant increase in the reaction time in the LPS-induced thermal hyperalgesia model. Finally, EFDf-treated animals did not show any alteration of motor coordination. The results suggest that the enrichment of 2,4,5-trimethoxystyrene and α-asarone enhances the anti-inflammatory activity of the EFDf compared to the EODf. In contrast, the antinociception promoted by the EFDf was similar to the EODf and was mediated via activation of adenosinergic and opioidergic receptors. |
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Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea |
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Vieira, Letícia Maia, Débora Soares da Silva de Oliveira, Flávio Martins Ribeiro, Rosy Iara Maciel de Azambuja Thomé, Ralph Gruppi dos Santos, Hélio Batista Lopes, Débora de Oliveira Carollo, Carlos Alexandre Silva, Denise Brentan Soares, Adriana Cristina de Siqueira, João Máximo |
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Vieira, Letícia Maia, Débora Soares da Silva de Oliveira, Flávio Martins Ribeiro, Rosy Iara Maciel de Azambuja Thomé, Ralph Gruppi dos Santos, Hélio Batista Lopes, Débora de Oliveira Carollo, Carlos Alexandre Silva, Denise Brentan Soares, Adriana Cristina de Siqueira, João Máximo |
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10.1007/s10787-020-00775-7 |
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2024-07-03T19:51:33.062Z |
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| score |
7.4000053 |