Difference in Metabolomic Response to Exercise between Patients with and without Hypertrophic Cardiomyopathy
Abstract It is unclear how hypertrophic cardiomyopathy (HCM) affects cardiac metabolic pathways at rest and with exercise. This case–control study compared 15 cases with HCM to 2 control groups without HCM. Metabolomic profiling of 210 metabolites was carried out at rest and at peak exercise. The 50...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Shimada, Yuichi J. [verfasserIn] Batra, Jaya [verfasserIn] Kochav, Stephanie M. [verfasserIn] Patel, Parth [verfasserIn] Jung, Jeeyoun [verfasserIn] Maurer, Mathew S. [verfasserIn] Hasegawa, Kohei [verfasserIn] Reilly, Muredach P. [verfasserIn] Fifer, Michael A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of cardiovascular translational research - New York, NY [u.a.] : Springer, 2008, 14(2020), 2 vom: 27. Juni, Seite 246-255 |
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| Übergeordnetes Werk: |
volume:14 ; year:2020 ; number:2 ; day:27 ; month:06 ; pages:246-255 |
| Links: |
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| DOI / URN: |
10.1007/s12265-020-10051-2 |
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| 520 | |a Abstract It is unclear how hypertrophic cardiomyopathy (HCM) affects cardiac metabolic pathways at rest and with exercise. This case–control study compared 15 cases with HCM to 2 control groups without HCM. Metabolomic profiling of 210 metabolites was carried out at rest and at peak exercise. The 50 most discriminant metabolites differentially regulated during exercise were selected using partial least squares discriminant analysis. Pathway enrichment analysis was also performed. At rest, no significant difference was observed in metabolomic profiling of HCM cases as compared to controls. By contrast, there were significant differences in metabolomic profiling in response to exercise (p < 0.05) in the following metabolic pathways: the aminoacyl-tRNA biosynthesis pathway; the nitrogen metabolism pathway; the glycine, serine, and threonine metabolism pathway; and the arginine and proline metabolism pathway. The present study demonstrates differential regulation of several metabolic pathways in patients with HCM in the setting of exercise stress. | ||
| 650 | 4 | |a Metabolomics |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hypertrophic cardiomyopathy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Exercise |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Batra, Jaya |e verfasserin |4 aut | |
| 700 | 1 | |a Kochav, Stephanie M. |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Parth |e verfasserin |4 aut | |
| 700 | 1 | |a Jung, Jeeyoun |e verfasserin |4 aut | |
| 700 | 1 | |a Maurer, Mathew S. |e verfasserin |4 aut | |
| 700 | 1 | |a Hasegawa, Kohei |e verfasserin |4 aut | |
| 700 | 1 | |a Reilly, Muredach P. |e verfasserin |4 aut | |
| 700 | 1 | |a Fifer, Michael A. |e verfasserin |4 aut | |
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10.1007/s12265-020-10051-2 doi (DE-627)SPR04376715X (DE-599)SPRs12265-020-10051-2-e (SPR)s12265-020-10051-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.85 bkl Shimada, Yuichi J. verfasserin aut Difference in Metabolomic Response to Exercise between Patients with and without Hypertrophic Cardiomyopathy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract It is unclear how hypertrophic cardiomyopathy (HCM) affects cardiac metabolic pathways at rest and with exercise. This case–control study compared 15 cases with HCM to 2 control groups without HCM. Metabolomic profiling of 210 metabolites was carried out at rest and at peak exercise. The 50 most discriminant metabolites differentially regulated during exercise were selected using partial least squares discriminant analysis. Pathway enrichment analysis was also performed. At rest, no significant difference was observed in metabolomic profiling of HCM cases as compared to controls. By contrast, there were significant differences in metabolomic profiling in response to exercise (p < 0.05) in the following metabolic pathways: the aminoacyl-tRNA biosynthesis pathway; the nitrogen metabolism pathway; the glycine, serine, and threonine metabolism pathway; and the arginine and proline metabolism pathway. The present study demonstrates differential regulation of several metabolic pathways in patients with HCM in the setting of exercise stress. Metabolomics (dpeaa)DE-He213 Hypertrophic cardiomyopathy (dpeaa)DE-He213 Exercise (dpeaa)DE-He213 Batra, Jaya verfasserin aut Kochav, Stephanie M. verfasserin aut Patel, Parth verfasserin aut Jung, Jeeyoun verfasserin aut Maurer, Mathew S. verfasserin aut Hasegawa, Kohei verfasserin aut Reilly, Muredach P. verfasserin aut Fifer, Michael A. verfasserin aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 14(2020), 2 vom: 27. Juni, Seite 246-255 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:14 year:2020 number:2 day:27 month:06 pages:246-255 https://dx.doi.org/10.1007/s12265-020-10051-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 14 2020 2 27 06 246-255 |
| spelling |
10.1007/s12265-020-10051-2 doi (DE-627)SPR04376715X (DE-599)SPRs12265-020-10051-2-e (SPR)s12265-020-10051-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.85 bkl Shimada, Yuichi J. verfasserin aut Difference in Metabolomic Response to Exercise between Patients with and without Hypertrophic Cardiomyopathy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract It is unclear how hypertrophic cardiomyopathy (HCM) affects cardiac metabolic pathways at rest and with exercise. This case–control study compared 15 cases with HCM to 2 control groups without HCM. Metabolomic profiling of 210 metabolites was carried out at rest and at peak exercise. The 50 most discriminant metabolites differentially regulated during exercise were selected using partial least squares discriminant analysis. Pathway enrichment analysis was also performed. At rest, no significant difference was observed in metabolomic profiling of HCM cases as compared to controls. By contrast, there were significant differences in metabolomic profiling in response to exercise (p < 0.05) in the following metabolic pathways: the aminoacyl-tRNA biosynthesis pathway; the nitrogen metabolism pathway; the glycine, serine, and threonine metabolism pathway; and the arginine and proline metabolism pathway. The present study demonstrates differential regulation of several metabolic pathways in patients with HCM in the setting of exercise stress. Metabolomics (dpeaa)DE-He213 Hypertrophic cardiomyopathy (dpeaa)DE-He213 Exercise (dpeaa)DE-He213 Batra, Jaya verfasserin aut Kochav, Stephanie M. verfasserin aut Patel, Parth verfasserin aut Jung, Jeeyoun verfasserin aut Maurer, Mathew S. verfasserin aut Hasegawa, Kohei verfasserin aut Reilly, Muredach P. verfasserin aut Fifer, Michael A. verfasserin aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 14(2020), 2 vom: 27. Juni, Seite 246-255 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:14 year:2020 number:2 day:27 month:06 pages:246-255 https://dx.doi.org/10.1007/s12265-020-10051-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 14 2020 2 27 06 246-255 |
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10.1007/s12265-020-10051-2 doi (DE-627)SPR04376715X (DE-599)SPRs12265-020-10051-2-e (SPR)s12265-020-10051-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.85 bkl Shimada, Yuichi J. verfasserin aut Difference in Metabolomic Response to Exercise between Patients with and without Hypertrophic Cardiomyopathy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract It is unclear how hypertrophic cardiomyopathy (HCM) affects cardiac metabolic pathways at rest and with exercise. This case–control study compared 15 cases with HCM to 2 control groups without HCM. Metabolomic profiling of 210 metabolites was carried out at rest and at peak exercise. The 50 most discriminant metabolites differentially regulated during exercise were selected using partial least squares discriminant analysis. Pathway enrichment analysis was also performed. At rest, no significant difference was observed in metabolomic profiling of HCM cases as compared to controls. By contrast, there were significant differences in metabolomic profiling in response to exercise (p < 0.05) in the following metabolic pathways: the aminoacyl-tRNA biosynthesis pathway; the nitrogen metabolism pathway; the glycine, serine, and threonine metabolism pathway; and the arginine and proline metabolism pathway. The present study demonstrates differential regulation of several metabolic pathways in patients with HCM in the setting of exercise stress. Metabolomics (dpeaa)DE-He213 Hypertrophic cardiomyopathy (dpeaa)DE-He213 Exercise (dpeaa)DE-He213 Batra, Jaya verfasserin aut Kochav, Stephanie M. verfasserin aut Patel, Parth verfasserin aut Jung, Jeeyoun verfasserin aut Maurer, Mathew S. verfasserin aut Hasegawa, Kohei verfasserin aut Reilly, Muredach P. verfasserin aut Fifer, Michael A. verfasserin aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 14(2020), 2 vom: 27. Juni, Seite 246-255 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:14 year:2020 number:2 day:27 month:06 pages:246-255 https://dx.doi.org/10.1007/s12265-020-10051-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 14 2020 2 27 06 246-255 |
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10.1007/s12265-020-10051-2 doi (DE-627)SPR04376715X (DE-599)SPRs12265-020-10051-2-e (SPR)s12265-020-10051-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.85 bkl Shimada, Yuichi J. verfasserin aut Difference in Metabolomic Response to Exercise between Patients with and without Hypertrophic Cardiomyopathy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract It is unclear how hypertrophic cardiomyopathy (HCM) affects cardiac metabolic pathways at rest and with exercise. This case–control study compared 15 cases with HCM to 2 control groups without HCM. Metabolomic profiling of 210 metabolites was carried out at rest and at peak exercise. The 50 most discriminant metabolites differentially regulated during exercise were selected using partial least squares discriminant analysis. Pathway enrichment analysis was also performed. At rest, no significant difference was observed in metabolomic profiling of HCM cases as compared to controls. By contrast, there were significant differences in metabolomic profiling in response to exercise (p < 0.05) in the following metabolic pathways: the aminoacyl-tRNA biosynthesis pathway; the nitrogen metabolism pathway; the glycine, serine, and threonine metabolism pathway; and the arginine and proline metabolism pathway. The present study demonstrates differential regulation of several metabolic pathways in patients with HCM in the setting of exercise stress. Metabolomics (dpeaa)DE-He213 Hypertrophic cardiomyopathy (dpeaa)DE-He213 Exercise (dpeaa)DE-He213 Batra, Jaya verfasserin aut Kochav, Stephanie M. verfasserin aut Patel, Parth verfasserin aut Jung, Jeeyoun verfasserin aut Maurer, Mathew S. verfasserin aut Hasegawa, Kohei verfasserin aut Reilly, Muredach P. verfasserin aut Fifer, Michael A. verfasserin aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 14(2020), 2 vom: 27. Juni, Seite 246-255 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:14 year:2020 number:2 day:27 month:06 pages:246-255 https://dx.doi.org/10.1007/s12265-020-10051-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 14 2020 2 27 06 246-255 |
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10.1007/s12265-020-10051-2 doi (DE-627)SPR04376715X (DE-599)SPRs12265-020-10051-2-e (SPR)s12265-020-10051-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.85 bkl Shimada, Yuichi J. verfasserin aut Difference in Metabolomic Response to Exercise between Patients with and without Hypertrophic Cardiomyopathy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract It is unclear how hypertrophic cardiomyopathy (HCM) affects cardiac metabolic pathways at rest and with exercise. This case–control study compared 15 cases with HCM to 2 control groups without HCM. Metabolomic profiling of 210 metabolites was carried out at rest and at peak exercise. The 50 most discriminant metabolites differentially regulated during exercise were selected using partial least squares discriminant analysis. Pathway enrichment analysis was also performed. At rest, no significant difference was observed in metabolomic profiling of HCM cases as compared to controls. By contrast, there were significant differences in metabolomic profiling in response to exercise (p < 0.05) in the following metabolic pathways: the aminoacyl-tRNA biosynthesis pathway; the nitrogen metabolism pathway; the glycine, serine, and threonine metabolism pathway; and the arginine and proline metabolism pathway. The present study demonstrates differential regulation of several metabolic pathways in patients with HCM in the setting of exercise stress. Metabolomics (dpeaa)DE-He213 Hypertrophic cardiomyopathy (dpeaa)DE-He213 Exercise (dpeaa)DE-He213 Batra, Jaya verfasserin aut Kochav, Stephanie M. verfasserin aut Patel, Parth verfasserin aut Jung, Jeeyoun verfasserin aut Maurer, Mathew S. verfasserin aut Hasegawa, Kohei verfasserin aut Reilly, Muredach P. verfasserin aut Fifer, Michael A. verfasserin aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 14(2020), 2 vom: 27. Juni, Seite 246-255 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:14 year:2020 number:2 day:27 month:06 pages:246-255 https://dx.doi.org/10.1007/s12265-020-10051-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 14 2020 2 27 06 246-255 |
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Enthalten in Journal of cardiovascular translational research 14(2020), 2 vom: 27. Juni, Seite 246-255 volume:14 year:2020 number:2 day:27 month:06 pages:246-255 |
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Shimada, Yuichi J. @@aut@@ Batra, Jaya @@aut@@ Kochav, Stephanie M. @@aut@@ Patel, Parth @@aut@@ Jung, Jeeyoun @@aut@@ Maurer, Mathew S. @@aut@@ Hasegawa, Kohei @@aut@@ Reilly, Muredach P. @@aut@@ Fifer, Michael A. @@aut@@ |
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This case–control study compared 15 cases with HCM to 2 control groups without HCM. Metabolomic profiling of 210 metabolites was carried out at rest and at peak exercise. The 50 most discriminant metabolites differentially regulated during exercise were selected using partial least squares discriminant analysis. Pathway enrichment analysis was also performed. At rest, no significant difference was observed in metabolomic profiling of HCM cases as compared to controls. By contrast, there were significant differences in metabolomic profiling in response to exercise (p < 0.05) in the following metabolic pathways: the aminoacyl-tRNA biosynthesis pathway; the nitrogen metabolism pathway; the glycine, serine, and threonine metabolism pathway; and the arginine and proline metabolism pathway. 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Shimada, Yuichi J. |
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Shimada, Yuichi J. ddc 610 bkl 44.85 misc Metabolomics misc Hypertrophic cardiomyopathy misc Exercise Difference in Metabolomic Response to Exercise between Patients with and without Hypertrophic Cardiomyopathy |
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610 ASE 44.85 bkl Difference in Metabolomic Response to Exercise between Patients with and without Hypertrophic Cardiomyopathy Metabolomics (dpeaa)DE-He213 Hypertrophic cardiomyopathy (dpeaa)DE-He213 Exercise (dpeaa)DE-He213 |
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Difference in Metabolomic Response to Exercise between Patients with and without Hypertrophic Cardiomyopathy |
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Shimada, Yuichi J. Batra, Jaya Kochav, Stephanie M. Patel, Parth Jung, Jeeyoun Maurer, Mathew S. Hasegawa, Kohei Reilly, Muredach P. Fifer, Michael A. |
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difference in metabolomic response to exercise between patients with and without hypertrophic cardiomyopathy |
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Difference in Metabolomic Response to Exercise between Patients with and without Hypertrophic Cardiomyopathy |
| abstract |
Abstract It is unclear how hypertrophic cardiomyopathy (HCM) affects cardiac metabolic pathways at rest and with exercise. This case–control study compared 15 cases with HCM to 2 control groups without HCM. Metabolomic profiling of 210 metabolites was carried out at rest and at peak exercise. The 50 most discriminant metabolites differentially regulated during exercise were selected using partial least squares discriminant analysis. Pathway enrichment analysis was also performed. At rest, no significant difference was observed in metabolomic profiling of HCM cases as compared to controls. By contrast, there were significant differences in metabolomic profiling in response to exercise (p < 0.05) in the following metabolic pathways: the aminoacyl-tRNA biosynthesis pathway; the nitrogen metabolism pathway; the glycine, serine, and threonine metabolism pathway; and the arginine and proline metabolism pathway. The present study demonstrates differential regulation of several metabolic pathways in patients with HCM in the setting of exercise stress. |
| abstractGer |
Abstract It is unclear how hypertrophic cardiomyopathy (HCM) affects cardiac metabolic pathways at rest and with exercise. This case–control study compared 15 cases with HCM to 2 control groups without HCM. Metabolomic profiling of 210 metabolites was carried out at rest and at peak exercise. The 50 most discriminant metabolites differentially regulated during exercise were selected using partial least squares discriminant analysis. Pathway enrichment analysis was also performed. At rest, no significant difference was observed in metabolomic profiling of HCM cases as compared to controls. By contrast, there were significant differences in metabolomic profiling in response to exercise (p < 0.05) in the following metabolic pathways: the aminoacyl-tRNA biosynthesis pathway; the nitrogen metabolism pathway; the glycine, serine, and threonine metabolism pathway; and the arginine and proline metabolism pathway. The present study demonstrates differential regulation of several metabolic pathways in patients with HCM in the setting of exercise stress. |
| abstract_unstemmed |
Abstract It is unclear how hypertrophic cardiomyopathy (HCM) affects cardiac metabolic pathways at rest and with exercise. This case–control study compared 15 cases with HCM to 2 control groups without HCM. Metabolomic profiling of 210 metabolites was carried out at rest and at peak exercise. The 50 most discriminant metabolites differentially regulated during exercise were selected using partial least squares discriminant analysis. Pathway enrichment analysis was also performed. At rest, no significant difference was observed in metabolomic profiling of HCM cases as compared to controls. By contrast, there were significant differences in metabolomic profiling in response to exercise (p < 0.05) in the following metabolic pathways: the aminoacyl-tRNA biosynthesis pathway; the nitrogen metabolism pathway; the glycine, serine, and threonine metabolism pathway; and the arginine and proline metabolism pathway. The present study demonstrates differential regulation of several metabolic pathways in patients with HCM in the setting of exercise stress. |
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| container_issue |
2 |
| title_short |
Difference in Metabolomic Response to Exercise between Patients with and without Hypertrophic Cardiomyopathy |
| url |
https://dx.doi.org/10.1007/s12265-020-10051-2 |
| remote_bool |
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| author2 |
Batra, Jaya Kochav, Stephanie M. Patel, Parth Jung, Jeeyoun Maurer, Mathew S. Hasegawa, Kohei Reilly, Muredach P. Fifer, Michael A. |
| author2Str |
Batra, Jaya Kochav, Stephanie M. Patel, Parth Jung, Jeeyoun Maurer, Mathew S. Hasegawa, Kohei Reilly, Muredach P. Fifer, Michael A. |
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| doi_str |
10.1007/s12265-020-10051-2 |
| up_date |
2024-07-03T20:45:31.654Z |
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| score |
7.399168 |