Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults
Abstract Hemophagocytic lymphohistiocytosis (HLH) is an uncontrolled hyperinflammatory disorder driven by an overactive immune system that results in high mortality. Post-transplant-associated hemophagocytic lymphohistiocytosis (PT-HLH) is a type of secondary HLH that occurs following allogeneic hem...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hattori, Norimichi [verfasserIn] Sato, Misuzu [verfasserIn] Uesugi, Yuka [verfasserIn] Nakata, Ayaka [verfasserIn] Sasaki, Yohei [verfasserIn] Shimada, Shotaro [verfasserIn] Watanuki, Megumi [verfasserIn] Fujiwara, Shun [verfasserIn] Kawaguchi, Yukiko [verfasserIn] Arai, Nana [verfasserIn] Uto, Yui [verfasserIn] Matsui, Tomoharu [verfasserIn] Yanagisawa, Kouji [verfasserIn] Tahara, Sachiko [verfasserIn] Koeffler, H Phillip [verfasserIn] Iezumi, Keiichi [verfasserIn] Nakamaki, Tsuyoshi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
Post-transplant-associated hemophagocytic lymphohistiocytosis Hemophagocytic lymphohistiocytosis |
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| Übergeordnetes Werk: |
Enthalten in: International journal of hematology - Tokyo [u.a.] : Springer, 1995, 113(2021), 5 vom: 01. Jan., Seite 693-702 |
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| Übergeordnetes Werk: |
volume:113 ; year:2021 ; number:5 ; day:01 ; month:01 ; pages:693-702 |
| Links: |
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| DOI / URN: |
10.1007/s12185-020-03067-6 |
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| Katalog-ID: |
SPR043862055 |
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| 245 | 1 | 0 | |a Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults |
| 264 | 1 | |c 2021 | |
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| 520 | |a Abstract Hemophagocytic lymphohistiocytosis (HLH) is an uncontrolled hyperinflammatory disorder driven by an overactive immune system that results in high mortality. Post-transplant-associated hemophagocytic lymphohistiocytosis (PT-HLH) is a type of secondary HLH that occurs following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical features of PT-HLH remain unclear and diagnostic and prognostic tools have not yet been established. Here, we retrospectively evaluated the clinical manifestations and outcomes of PT-HLH in 94 patients who underwent allo-HSCT. According to our PT-HLH criteria (hyperferritinemia and increased macrophage count in bone marrow), PT-HLH occurred in 12 patients (12.8%). The PT-HLH patients showed splenomegaly (P = .001), a higher risk of engraftment failure (P = .013), and an increased percentage of macrophages and hemophagocytes in bone marrow aspirates (P = .0009 and P = .0006, respectively). Moreover, univariate and multivariate analyses revealed that the survival rate was lower in PT-HLH patients than non-PT-HLH patients (P = .0017 and P = .034, respectively). This study defines the clinical features of PT-HLH and PT-HLH criteria that could be useful tools for diagnosing PT-HLH. | ||
| 650 | 4 | |a Post-transplant-associated hemophagocytic lymphohistiocytosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hemophagocytic lymphohistiocytosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Allogeneic hematopoietic stem cell transplantation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hyperferritinemia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hemophagocytosis |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Sato, Misuzu |e verfasserin |4 aut | |
| 700 | 1 | |a Uesugi, Yuka |e verfasserin |4 aut | |
| 700 | 1 | |a Nakata, Ayaka |e verfasserin |4 aut | |
| 700 | 1 | |a Sasaki, Yohei |e verfasserin |4 aut | |
| 700 | 1 | |a Shimada, Shotaro |e verfasserin |4 aut | |
| 700 | 1 | |a Watanuki, Megumi |e verfasserin |4 aut | |
| 700 | 1 | |a Fujiwara, Shun |e verfasserin |4 aut | |
| 700 | 1 | |a Kawaguchi, Yukiko |e verfasserin |4 aut | |
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| 700 | 1 | |a Matsui, Tomoharu |e verfasserin |4 aut | |
| 700 | 1 | |a Yanagisawa, Kouji |e verfasserin |4 aut | |
| 700 | 1 | |a Tahara, Sachiko |e verfasserin |4 aut | |
| 700 | 1 | |a Koeffler, H Phillip |e verfasserin |4 aut | |
| 700 | 1 | |a Iezumi, Keiichi |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamaki, Tsuyoshi |e verfasserin |4 aut | |
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10.1007/s12185-020-03067-6 doi (DE-627)SPR043862055 (DE-599)SPRs12185-020-03067-6-e (SPR)s12185-020-03067-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.86 bkl Hattori, Norimichi verfasserin aut Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hemophagocytic lymphohistiocytosis (HLH) is an uncontrolled hyperinflammatory disorder driven by an overactive immune system that results in high mortality. Post-transplant-associated hemophagocytic lymphohistiocytosis (PT-HLH) is a type of secondary HLH that occurs following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical features of PT-HLH remain unclear and diagnostic and prognostic tools have not yet been established. Here, we retrospectively evaluated the clinical manifestations and outcomes of PT-HLH in 94 patients who underwent allo-HSCT. According to our PT-HLH criteria (hyperferritinemia and increased macrophage count in bone marrow), PT-HLH occurred in 12 patients (12.8%). The PT-HLH patients showed splenomegaly (P = .001), a higher risk of engraftment failure (P = .013), and an increased percentage of macrophages and hemophagocytes in bone marrow aspirates (P = .0009 and P = .0006, respectively). Moreover, univariate and multivariate analyses revealed that the survival rate was lower in PT-HLH patients than non-PT-HLH patients (P = .0017 and P = .034, respectively). This study defines the clinical features of PT-HLH and PT-HLH criteria that could be useful tools for diagnosing PT-HLH. Post-transplant-associated hemophagocytic lymphohistiocytosis (dpeaa)DE-He213 Hemophagocytic lymphohistiocytosis (dpeaa)DE-He213 Allogeneic hematopoietic stem cell transplantation (dpeaa)DE-He213 Hyperferritinemia (dpeaa)DE-He213 Hemophagocytosis (dpeaa)DE-He213 Sato, Misuzu verfasserin aut Uesugi, Yuka verfasserin aut Nakata, Ayaka verfasserin aut Sasaki, Yohei verfasserin aut Shimada, Shotaro verfasserin aut Watanuki, Megumi verfasserin aut Fujiwara, Shun verfasserin aut Kawaguchi, Yukiko verfasserin aut Arai, Nana verfasserin aut Uto, Yui verfasserin aut Matsui, Tomoharu verfasserin aut Yanagisawa, Kouji verfasserin aut Tahara, Sachiko verfasserin aut Koeffler, H Phillip verfasserin aut Iezumi, Keiichi verfasserin aut Nakamaki, Tsuyoshi verfasserin aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 113(2021), 5 vom: 01. Jan., Seite 693-702 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:113 year:2021 number:5 day:01 month:01 pages:693-702 https://dx.doi.org/10.1007/s12185-020-03067-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.86 ASE AR 113 2021 5 01 01 693-702 |
| spelling |
10.1007/s12185-020-03067-6 doi (DE-627)SPR043862055 (DE-599)SPRs12185-020-03067-6-e (SPR)s12185-020-03067-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.86 bkl Hattori, Norimichi verfasserin aut Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hemophagocytic lymphohistiocytosis (HLH) is an uncontrolled hyperinflammatory disorder driven by an overactive immune system that results in high mortality. Post-transplant-associated hemophagocytic lymphohistiocytosis (PT-HLH) is a type of secondary HLH that occurs following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical features of PT-HLH remain unclear and diagnostic and prognostic tools have not yet been established. Here, we retrospectively evaluated the clinical manifestations and outcomes of PT-HLH in 94 patients who underwent allo-HSCT. According to our PT-HLH criteria (hyperferritinemia and increased macrophage count in bone marrow), PT-HLH occurred in 12 patients (12.8%). The PT-HLH patients showed splenomegaly (P = .001), a higher risk of engraftment failure (P = .013), and an increased percentage of macrophages and hemophagocytes in bone marrow aspirates (P = .0009 and P = .0006, respectively). Moreover, univariate and multivariate analyses revealed that the survival rate was lower in PT-HLH patients than non-PT-HLH patients (P = .0017 and P = .034, respectively). This study defines the clinical features of PT-HLH and PT-HLH criteria that could be useful tools for diagnosing PT-HLH. Post-transplant-associated hemophagocytic lymphohistiocytosis (dpeaa)DE-He213 Hemophagocytic lymphohistiocytosis (dpeaa)DE-He213 Allogeneic hematopoietic stem cell transplantation (dpeaa)DE-He213 Hyperferritinemia (dpeaa)DE-He213 Hemophagocytosis (dpeaa)DE-He213 Sato, Misuzu verfasserin aut Uesugi, Yuka verfasserin aut Nakata, Ayaka verfasserin aut Sasaki, Yohei verfasserin aut Shimada, Shotaro verfasserin aut Watanuki, Megumi verfasserin aut Fujiwara, Shun verfasserin aut Kawaguchi, Yukiko verfasserin aut Arai, Nana verfasserin aut Uto, Yui verfasserin aut Matsui, Tomoharu verfasserin aut Yanagisawa, Kouji verfasserin aut Tahara, Sachiko verfasserin aut Koeffler, H Phillip verfasserin aut Iezumi, Keiichi verfasserin aut Nakamaki, Tsuyoshi verfasserin aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 113(2021), 5 vom: 01. Jan., Seite 693-702 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:113 year:2021 number:5 day:01 month:01 pages:693-702 https://dx.doi.org/10.1007/s12185-020-03067-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.86 ASE AR 113 2021 5 01 01 693-702 |
| allfields_unstemmed |
10.1007/s12185-020-03067-6 doi (DE-627)SPR043862055 (DE-599)SPRs12185-020-03067-6-e (SPR)s12185-020-03067-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.86 bkl Hattori, Norimichi verfasserin aut Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hemophagocytic lymphohistiocytosis (HLH) is an uncontrolled hyperinflammatory disorder driven by an overactive immune system that results in high mortality. Post-transplant-associated hemophagocytic lymphohistiocytosis (PT-HLH) is a type of secondary HLH that occurs following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical features of PT-HLH remain unclear and diagnostic and prognostic tools have not yet been established. Here, we retrospectively evaluated the clinical manifestations and outcomes of PT-HLH in 94 patients who underwent allo-HSCT. According to our PT-HLH criteria (hyperferritinemia and increased macrophage count in bone marrow), PT-HLH occurred in 12 patients (12.8%). The PT-HLH patients showed splenomegaly (P = .001), a higher risk of engraftment failure (P = .013), and an increased percentage of macrophages and hemophagocytes in bone marrow aspirates (P = .0009 and P = .0006, respectively). Moreover, univariate and multivariate analyses revealed that the survival rate was lower in PT-HLH patients than non-PT-HLH patients (P = .0017 and P = .034, respectively). This study defines the clinical features of PT-HLH and PT-HLH criteria that could be useful tools for diagnosing PT-HLH. Post-transplant-associated hemophagocytic lymphohistiocytosis (dpeaa)DE-He213 Hemophagocytic lymphohistiocytosis (dpeaa)DE-He213 Allogeneic hematopoietic stem cell transplantation (dpeaa)DE-He213 Hyperferritinemia (dpeaa)DE-He213 Hemophagocytosis (dpeaa)DE-He213 Sato, Misuzu verfasserin aut Uesugi, Yuka verfasserin aut Nakata, Ayaka verfasserin aut Sasaki, Yohei verfasserin aut Shimada, Shotaro verfasserin aut Watanuki, Megumi verfasserin aut Fujiwara, Shun verfasserin aut Kawaguchi, Yukiko verfasserin aut Arai, Nana verfasserin aut Uto, Yui verfasserin aut Matsui, Tomoharu verfasserin aut Yanagisawa, Kouji verfasserin aut Tahara, Sachiko verfasserin aut Koeffler, H Phillip verfasserin aut Iezumi, Keiichi verfasserin aut Nakamaki, Tsuyoshi verfasserin aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 113(2021), 5 vom: 01. Jan., Seite 693-702 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:113 year:2021 number:5 day:01 month:01 pages:693-702 https://dx.doi.org/10.1007/s12185-020-03067-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.86 ASE AR 113 2021 5 01 01 693-702 |
| allfieldsGer |
10.1007/s12185-020-03067-6 doi (DE-627)SPR043862055 (DE-599)SPRs12185-020-03067-6-e (SPR)s12185-020-03067-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.86 bkl Hattori, Norimichi verfasserin aut Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hemophagocytic lymphohistiocytosis (HLH) is an uncontrolled hyperinflammatory disorder driven by an overactive immune system that results in high mortality. Post-transplant-associated hemophagocytic lymphohistiocytosis (PT-HLH) is a type of secondary HLH that occurs following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical features of PT-HLH remain unclear and diagnostic and prognostic tools have not yet been established. Here, we retrospectively evaluated the clinical manifestations and outcomes of PT-HLH in 94 patients who underwent allo-HSCT. According to our PT-HLH criteria (hyperferritinemia and increased macrophage count in bone marrow), PT-HLH occurred in 12 patients (12.8%). The PT-HLH patients showed splenomegaly (P = .001), a higher risk of engraftment failure (P = .013), and an increased percentage of macrophages and hemophagocytes in bone marrow aspirates (P = .0009 and P = .0006, respectively). Moreover, univariate and multivariate analyses revealed that the survival rate was lower in PT-HLH patients than non-PT-HLH patients (P = .0017 and P = .034, respectively). This study defines the clinical features of PT-HLH and PT-HLH criteria that could be useful tools for diagnosing PT-HLH. Post-transplant-associated hemophagocytic lymphohistiocytosis (dpeaa)DE-He213 Hemophagocytic lymphohistiocytosis (dpeaa)DE-He213 Allogeneic hematopoietic stem cell transplantation (dpeaa)DE-He213 Hyperferritinemia (dpeaa)DE-He213 Hemophagocytosis (dpeaa)DE-He213 Sato, Misuzu verfasserin aut Uesugi, Yuka verfasserin aut Nakata, Ayaka verfasserin aut Sasaki, Yohei verfasserin aut Shimada, Shotaro verfasserin aut Watanuki, Megumi verfasserin aut Fujiwara, Shun verfasserin aut Kawaguchi, Yukiko verfasserin aut Arai, Nana verfasserin aut Uto, Yui verfasserin aut Matsui, Tomoharu verfasserin aut Yanagisawa, Kouji verfasserin aut Tahara, Sachiko verfasserin aut Koeffler, H Phillip verfasserin aut Iezumi, Keiichi verfasserin aut Nakamaki, Tsuyoshi verfasserin aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 113(2021), 5 vom: 01. Jan., Seite 693-702 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:113 year:2021 number:5 day:01 month:01 pages:693-702 https://dx.doi.org/10.1007/s12185-020-03067-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.86 ASE AR 113 2021 5 01 01 693-702 |
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10.1007/s12185-020-03067-6 doi (DE-627)SPR043862055 (DE-599)SPRs12185-020-03067-6-e (SPR)s12185-020-03067-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.86 bkl Hattori, Norimichi verfasserin aut Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hemophagocytic lymphohistiocytosis (HLH) is an uncontrolled hyperinflammatory disorder driven by an overactive immune system that results in high mortality. Post-transplant-associated hemophagocytic lymphohistiocytosis (PT-HLH) is a type of secondary HLH that occurs following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical features of PT-HLH remain unclear and diagnostic and prognostic tools have not yet been established. Here, we retrospectively evaluated the clinical manifestations and outcomes of PT-HLH in 94 patients who underwent allo-HSCT. According to our PT-HLH criteria (hyperferritinemia and increased macrophage count in bone marrow), PT-HLH occurred in 12 patients (12.8%). The PT-HLH patients showed splenomegaly (P = .001), a higher risk of engraftment failure (P = .013), and an increased percentage of macrophages and hemophagocytes in bone marrow aspirates (P = .0009 and P = .0006, respectively). Moreover, univariate and multivariate analyses revealed that the survival rate was lower in PT-HLH patients than non-PT-HLH patients (P = .0017 and P = .034, respectively). This study defines the clinical features of PT-HLH and PT-HLH criteria that could be useful tools for diagnosing PT-HLH. Post-transplant-associated hemophagocytic lymphohistiocytosis (dpeaa)DE-He213 Hemophagocytic lymphohistiocytosis (dpeaa)DE-He213 Allogeneic hematopoietic stem cell transplantation (dpeaa)DE-He213 Hyperferritinemia (dpeaa)DE-He213 Hemophagocytosis (dpeaa)DE-He213 Sato, Misuzu verfasserin aut Uesugi, Yuka verfasserin aut Nakata, Ayaka verfasserin aut Sasaki, Yohei verfasserin aut Shimada, Shotaro verfasserin aut Watanuki, Megumi verfasserin aut Fujiwara, Shun verfasserin aut Kawaguchi, Yukiko verfasserin aut Arai, Nana verfasserin aut Uto, Yui verfasserin aut Matsui, Tomoharu verfasserin aut Yanagisawa, Kouji verfasserin aut Tahara, Sachiko verfasserin aut Koeffler, H Phillip verfasserin aut Iezumi, Keiichi verfasserin aut Nakamaki, Tsuyoshi verfasserin aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 113(2021), 5 vom: 01. Jan., Seite 693-702 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:113 year:2021 number:5 day:01 month:01 pages:693-702 https://dx.doi.org/10.1007/s12185-020-03067-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.86 ASE AR 113 2021 5 01 01 693-702 |
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Enthalten in International journal of hematology 113(2021), 5 vom: 01. Jan., Seite 693-702 volume:113 year:2021 number:5 day:01 month:01 pages:693-702 |
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Enthalten in International journal of hematology 113(2021), 5 vom: 01. Jan., Seite 693-702 volume:113 year:2021 number:5 day:01 month:01 pages:693-702 |
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Post-transplant-associated hemophagocytic lymphohistiocytosis Hemophagocytic lymphohistiocytosis Allogeneic hematopoietic stem cell transplantation Hyperferritinemia Hemophagocytosis |
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International journal of hematology |
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Hattori, Norimichi @@aut@@ Sato, Misuzu @@aut@@ Uesugi, Yuka @@aut@@ Nakata, Ayaka @@aut@@ Sasaki, Yohei @@aut@@ Shimada, Shotaro @@aut@@ Watanuki, Megumi @@aut@@ Fujiwara, Shun @@aut@@ Kawaguchi, Yukiko @@aut@@ Arai, Nana @@aut@@ Uto, Yui @@aut@@ Matsui, Tomoharu @@aut@@ Yanagisawa, Kouji @@aut@@ Tahara, Sachiko @@aut@@ Koeffler, H Phillip @@aut@@ Iezumi, Keiichi @@aut@@ Nakamaki, Tsuyoshi @@aut@@ |
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2021-01-01T00:00:00Z |
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3610 |
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SPR043862055 |
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englisch |
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Hattori, Norimichi |
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Hattori, Norimichi ddc 610 bkl 44.86 misc Post-transplant-associated hemophagocytic lymphohistiocytosis misc Hemophagocytic lymphohistiocytosis misc Allogeneic hematopoietic stem cell transplantation misc Hyperferritinemia misc Hemophagocytosis Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults |
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610 ASE 44.86 bkl Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults Post-transplant-associated hemophagocytic lymphohistiocytosis (dpeaa)DE-He213 Hemophagocytic lymphohistiocytosis (dpeaa)DE-He213 Allogeneic hematopoietic stem cell transplantation (dpeaa)DE-He213 Hyperferritinemia (dpeaa)DE-He213 Hemophagocytosis (dpeaa)DE-He213 |
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ddc 610 bkl 44.86 misc Post-transplant-associated hemophagocytic lymphohistiocytosis misc Hemophagocytic lymphohistiocytosis misc Allogeneic hematopoietic stem cell transplantation misc Hyperferritinemia misc Hemophagocytosis |
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ddc 610 bkl 44.86 misc Post-transplant-associated hemophagocytic lymphohistiocytosis misc Hemophagocytic lymphohistiocytosis misc Allogeneic hematopoietic stem cell transplantation misc Hyperferritinemia misc Hemophagocytosis |
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ddc 610 bkl 44.86 misc Post-transplant-associated hemophagocytic lymphohistiocytosis misc Hemophagocytic lymphohistiocytosis misc Allogeneic hematopoietic stem cell transplantation misc Hyperferritinemia misc Hemophagocytosis |
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Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults |
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Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults |
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Hattori, Norimichi |
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International journal of hematology |
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Hattori, Norimichi Sato, Misuzu Uesugi, Yuka Nakata, Ayaka Sasaki, Yohei Shimada, Shotaro Watanuki, Megumi Fujiwara, Shun Kawaguchi, Yukiko Arai, Nana Uto, Yui Matsui, Tomoharu Yanagisawa, Kouji Tahara, Sachiko Koeffler, H Phillip Iezumi, Keiichi Nakamaki, Tsuyoshi |
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Hattori, Norimichi |
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characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults |
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Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults |
| abstract |
Abstract Hemophagocytic lymphohistiocytosis (HLH) is an uncontrolled hyperinflammatory disorder driven by an overactive immune system that results in high mortality. Post-transplant-associated hemophagocytic lymphohistiocytosis (PT-HLH) is a type of secondary HLH that occurs following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical features of PT-HLH remain unclear and diagnostic and prognostic tools have not yet been established. Here, we retrospectively evaluated the clinical manifestations and outcomes of PT-HLH in 94 patients who underwent allo-HSCT. According to our PT-HLH criteria (hyperferritinemia and increased macrophage count in bone marrow), PT-HLH occurred in 12 patients (12.8%). The PT-HLH patients showed splenomegaly (P = .001), a higher risk of engraftment failure (P = .013), and an increased percentage of macrophages and hemophagocytes in bone marrow aspirates (P = .0009 and P = .0006, respectively). Moreover, univariate and multivariate analyses revealed that the survival rate was lower in PT-HLH patients than non-PT-HLH patients (P = .0017 and P = .034, respectively). This study defines the clinical features of PT-HLH and PT-HLH criteria that could be useful tools for diagnosing PT-HLH. |
| abstractGer |
Abstract Hemophagocytic lymphohistiocytosis (HLH) is an uncontrolled hyperinflammatory disorder driven by an overactive immune system that results in high mortality. Post-transplant-associated hemophagocytic lymphohistiocytosis (PT-HLH) is a type of secondary HLH that occurs following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical features of PT-HLH remain unclear and diagnostic and prognostic tools have not yet been established. Here, we retrospectively evaluated the clinical manifestations and outcomes of PT-HLH in 94 patients who underwent allo-HSCT. According to our PT-HLH criteria (hyperferritinemia and increased macrophage count in bone marrow), PT-HLH occurred in 12 patients (12.8%). The PT-HLH patients showed splenomegaly (P = .001), a higher risk of engraftment failure (P = .013), and an increased percentage of macrophages and hemophagocytes in bone marrow aspirates (P = .0009 and P = .0006, respectively). Moreover, univariate and multivariate analyses revealed that the survival rate was lower in PT-HLH patients than non-PT-HLH patients (P = .0017 and P = .034, respectively). This study defines the clinical features of PT-HLH and PT-HLH criteria that could be useful tools for diagnosing PT-HLH. |
| abstract_unstemmed |
Abstract Hemophagocytic lymphohistiocytosis (HLH) is an uncontrolled hyperinflammatory disorder driven by an overactive immune system that results in high mortality. Post-transplant-associated hemophagocytic lymphohistiocytosis (PT-HLH) is a type of secondary HLH that occurs following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical features of PT-HLH remain unclear and diagnostic and prognostic tools have not yet been established. Here, we retrospectively evaluated the clinical manifestations and outcomes of PT-HLH in 94 patients who underwent allo-HSCT. According to our PT-HLH criteria (hyperferritinemia and increased macrophage count in bone marrow), PT-HLH occurred in 12 patients (12.8%). The PT-HLH patients showed splenomegaly (P = .001), a higher risk of engraftment failure (P = .013), and an increased percentage of macrophages and hemophagocytes in bone marrow aspirates (P = .0009 and P = .0006, respectively). Moreover, univariate and multivariate analyses revealed that the survival rate was lower in PT-HLH patients than non-PT-HLH patients (P = .0017 and P = .034, respectively). This study defines the clinical features of PT-HLH and PT-HLH criteria that could be useful tools for diagnosing PT-HLH. |
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Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults |
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Sato, Misuzu Uesugi, Yuka Nakata, Ayaka Sasaki, Yohei Shimada, Shotaro Watanuki, Megumi Fujiwara, Shun Kawaguchi, Yukiko Arai, Nana Uto, Yui Matsui, Tomoharu Yanagisawa, Kouji Tahara, Sachiko Koeffler, H Phillip Iezumi, Keiichi Nakamaki, Tsuyoshi |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR043862055</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519232923.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">210425s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s12185-020-03067-6</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR043862055</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)SPRs12185-020-03067-6-e</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12185-020-03067-6-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.86</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Hattori, Norimichi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Hemophagocytic lymphohistiocytosis (HLH) is an uncontrolled hyperinflammatory disorder driven by an overactive immune system that results in high mortality. Post-transplant-associated hemophagocytic lymphohistiocytosis (PT-HLH) is a type of secondary HLH that occurs following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical features of PT-HLH remain unclear and diagnostic and prognostic tools have not yet been established. Here, we retrospectively evaluated the clinical manifestations and outcomes of PT-HLH in 94 patients who underwent allo-HSCT. According to our PT-HLH criteria (hyperferritinemia and increased macrophage count in bone marrow), PT-HLH occurred in 12 patients (12.8%). The PT-HLH patients showed splenomegaly (P = .001), a higher risk of engraftment failure (P = .013), and an increased percentage of macrophages and hemophagocytes in bone marrow aspirates (P = .0009 and P = .0006, respectively). Moreover, univariate and multivariate analyses revealed that the survival rate was lower in PT-HLH patients than non-PT-HLH patients (P = .0017 and P = .034, respectively). 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