Beta-amyloid peptides(1–42) and (1–40) in the cerebrospinal fluid during pregnancy: a prospective observational study
Abstract To evaluate changes in concentrations of selected biomarkers, neurotrophic factors, and growth factors in the cerebrospinal fluid during pregnancy. A prospective observational study was conducted in 32 pregnant women undergoing gynecological and obstetrical surgery under spinal anesthesia i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Alomar-Dominguez, Cristina [verfasserIn] Dostal, L. [verfasserIn] Thaler, J. [verfasserIn] Putz, G. [verfasserIn] Humpel, C. [verfasserIn] Lederer, W. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Archives of Women's Mental Health - Springer-Verlag, 2002, 24(2020), 3 vom: 02. Okt., Seite 455-461 |
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| Übergeordnetes Werk: |
volume:24 ; year:2020 ; number:3 ; day:02 ; month:10 ; pages:455-461 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00737-020-01072-6 |
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SPR044015240 |
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| 520 | |a Abstract To evaluate changes in concentrations of selected biomarkers, neurotrophic factors, and growth factors in the cerebrospinal fluid during pregnancy. A prospective observational study was conducted in 32 pregnant women undergoing gynecological and obstetrical surgery under spinal anesthesia in a university hospital. Beta-amyloid(1–42) and beta-amyloid(1–40) peptides, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, and vascular endothelial growth factor were analyzed in cerebrospinal fluid using an enzyme-linked immunosorbent assay. Eight women in second trimester pregnancy who underwent spinal anesthesia for gynecological or obstetrical surgery were compared with 24 matched women in third trimester pregnancies. CSF concentrations of beta-amyloid(1–42) were significantly higher in third trimester pregnancies (p = 0.025). During third trimester, the beta-amyloid ratio correlated with the vascular endothelial growth factor (rs = 0.657; p = 0.008). Higher concentrations of beta-amyloid(1–42) in cerebrospinal fluid of third trimester pregnancies and correlations between the beta-amyloid ratio and the vascular endothelial growth factor support the hypothesis that beta-amyloid peptides are involved in complex adaptive brain alterations during pregnancy. | ||
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10.1007/s00737-020-01072-6 doi (DE-627)SPR044015240 (DE-599)SPRs00737-020-01072-6-e (SPR)s00737-020-01072-6-e DE-627 ger DE-627 rakwb eng Alomar-Dominguez, Cristina verfasserin aut Beta-amyloid peptides(1–42) and (1–40) in the cerebrospinal fluid during pregnancy: a prospective observational study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To evaluate changes in concentrations of selected biomarkers, neurotrophic factors, and growth factors in the cerebrospinal fluid during pregnancy. A prospective observational study was conducted in 32 pregnant women undergoing gynecological and obstetrical surgery under spinal anesthesia in a university hospital. Beta-amyloid(1–42) and beta-amyloid(1–40) peptides, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, and vascular endothelial growth factor were analyzed in cerebrospinal fluid using an enzyme-linked immunosorbent assay. Eight women in second trimester pregnancy who underwent spinal anesthesia for gynecological or obstetrical surgery were compared with 24 matched women in third trimester pregnancies. CSF concentrations of beta-amyloid(1–42) were significantly higher in third trimester pregnancies (p = 0.025). During third trimester, the beta-amyloid ratio correlated with the vascular endothelial growth factor (rs = 0.657; p = 0.008). Higher concentrations of beta-amyloid(1–42) in cerebrospinal fluid of third trimester pregnancies and correlations between the beta-amyloid ratio and the vascular endothelial growth factor support the hypothesis that beta-amyloid peptides are involved in complex adaptive brain alterations during pregnancy. Beta-amyloid (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Growth factors (dpeaa)DE-He213 Cerebrospinal fluid (dpeaa)DE-He213 Pregnancy (dpeaa)DE-He213 Dostal, L. verfasserin aut Thaler, J. verfasserin aut Putz, G. verfasserin aut Humpel, C. verfasserin aut Lederer, W. verfasserin aut Enthalten in Archives of Women's Mental Health Springer-Verlag, 2002 24(2020), 3 vom: 02. Okt., Seite 455-461 (DE-627)SPR007667299 nnns volume:24 year:2020 number:3 day:02 month:10 pages:455-461 https://dx.doi.org/10.1007/s00737-020-01072-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 24 2020 3 02 10 455-461 |
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10.1007/s00737-020-01072-6 doi (DE-627)SPR044015240 (DE-599)SPRs00737-020-01072-6-e (SPR)s00737-020-01072-6-e DE-627 ger DE-627 rakwb eng Alomar-Dominguez, Cristina verfasserin aut Beta-amyloid peptides(1–42) and (1–40) in the cerebrospinal fluid during pregnancy: a prospective observational study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To evaluate changes in concentrations of selected biomarkers, neurotrophic factors, and growth factors in the cerebrospinal fluid during pregnancy. A prospective observational study was conducted in 32 pregnant women undergoing gynecological and obstetrical surgery under spinal anesthesia in a university hospital. Beta-amyloid(1–42) and beta-amyloid(1–40) peptides, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, and vascular endothelial growth factor were analyzed in cerebrospinal fluid using an enzyme-linked immunosorbent assay. Eight women in second trimester pregnancy who underwent spinal anesthesia for gynecological or obstetrical surgery were compared with 24 matched women in third trimester pregnancies. CSF concentrations of beta-amyloid(1–42) were significantly higher in third trimester pregnancies (p = 0.025). During third trimester, the beta-amyloid ratio correlated with the vascular endothelial growth factor (rs = 0.657; p = 0.008). Higher concentrations of beta-amyloid(1–42) in cerebrospinal fluid of third trimester pregnancies and correlations between the beta-amyloid ratio and the vascular endothelial growth factor support the hypothesis that beta-amyloid peptides are involved in complex adaptive brain alterations during pregnancy. Beta-amyloid (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Growth factors (dpeaa)DE-He213 Cerebrospinal fluid (dpeaa)DE-He213 Pregnancy (dpeaa)DE-He213 Dostal, L. verfasserin aut Thaler, J. verfasserin aut Putz, G. verfasserin aut Humpel, C. verfasserin aut Lederer, W. verfasserin aut Enthalten in Archives of Women's Mental Health Springer-Verlag, 2002 24(2020), 3 vom: 02. Okt., Seite 455-461 (DE-627)SPR007667299 nnns volume:24 year:2020 number:3 day:02 month:10 pages:455-461 https://dx.doi.org/10.1007/s00737-020-01072-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 24 2020 3 02 10 455-461 |
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10.1007/s00737-020-01072-6 doi (DE-627)SPR044015240 (DE-599)SPRs00737-020-01072-6-e (SPR)s00737-020-01072-6-e DE-627 ger DE-627 rakwb eng Alomar-Dominguez, Cristina verfasserin aut Beta-amyloid peptides(1–42) and (1–40) in the cerebrospinal fluid during pregnancy: a prospective observational study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To evaluate changes in concentrations of selected biomarkers, neurotrophic factors, and growth factors in the cerebrospinal fluid during pregnancy. A prospective observational study was conducted in 32 pregnant women undergoing gynecological and obstetrical surgery under spinal anesthesia in a university hospital. Beta-amyloid(1–42) and beta-amyloid(1–40) peptides, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, and vascular endothelial growth factor were analyzed in cerebrospinal fluid using an enzyme-linked immunosorbent assay. Eight women in second trimester pregnancy who underwent spinal anesthesia for gynecological or obstetrical surgery were compared with 24 matched women in third trimester pregnancies. CSF concentrations of beta-amyloid(1–42) were significantly higher in third trimester pregnancies (p = 0.025). During third trimester, the beta-amyloid ratio correlated with the vascular endothelial growth factor (rs = 0.657; p = 0.008). Higher concentrations of beta-amyloid(1–42) in cerebrospinal fluid of third trimester pregnancies and correlations between the beta-amyloid ratio and the vascular endothelial growth factor support the hypothesis that beta-amyloid peptides are involved in complex adaptive brain alterations during pregnancy. Beta-amyloid (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Growth factors (dpeaa)DE-He213 Cerebrospinal fluid (dpeaa)DE-He213 Pregnancy (dpeaa)DE-He213 Dostal, L. verfasserin aut Thaler, J. verfasserin aut Putz, G. verfasserin aut Humpel, C. verfasserin aut Lederer, W. verfasserin aut Enthalten in Archives of Women's Mental Health Springer-Verlag, 2002 24(2020), 3 vom: 02. Okt., Seite 455-461 (DE-627)SPR007667299 nnns volume:24 year:2020 number:3 day:02 month:10 pages:455-461 https://dx.doi.org/10.1007/s00737-020-01072-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 24 2020 3 02 10 455-461 |
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10.1007/s00737-020-01072-6 doi (DE-627)SPR044015240 (DE-599)SPRs00737-020-01072-6-e (SPR)s00737-020-01072-6-e DE-627 ger DE-627 rakwb eng Alomar-Dominguez, Cristina verfasserin aut Beta-amyloid peptides(1–42) and (1–40) in the cerebrospinal fluid during pregnancy: a prospective observational study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To evaluate changes in concentrations of selected biomarkers, neurotrophic factors, and growth factors in the cerebrospinal fluid during pregnancy. A prospective observational study was conducted in 32 pregnant women undergoing gynecological and obstetrical surgery under spinal anesthesia in a university hospital. Beta-amyloid(1–42) and beta-amyloid(1–40) peptides, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, and vascular endothelial growth factor were analyzed in cerebrospinal fluid using an enzyme-linked immunosorbent assay. Eight women in second trimester pregnancy who underwent spinal anesthesia for gynecological or obstetrical surgery were compared with 24 matched women in third trimester pregnancies. CSF concentrations of beta-amyloid(1–42) were significantly higher in third trimester pregnancies (p = 0.025). During third trimester, the beta-amyloid ratio correlated with the vascular endothelial growth factor (rs = 0.657; p = 0.008). Higher concentrations of beta-amyloid(1–42) in cerebrospinal fluid of third trimester pregnancies and correlations between the beta-amyloid ratio and the vascular endothelial growth factor support the hypothesis that beta-amyloid peptides are involved in complex adaptive brain alterations during pregnancy. Beta-amyloid (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Growth factors (dpeaa)DE-He213 Cerebrospinal fluid (dpeaa)DE-He213 Pregnancy (dpeaa)DE-He213 Dostal, L. verfasserin aut Thaler, J. verfasserin aut Putz, G. verfasserin aut Humpel, C. verfasserin aut Lederer, W. verfasserin aut Enthalten in Archives of Women's Mental Health Springer-Verlag, 2002 24(2020), 3 vom: 02. Okt., Seite 455-461 (DE-627)SPR007667299 nnns volume:24 year:2020 number:3 day:02 month:10 pages:455-461 https://dx.doi.org/10.1007/s00737-020-01072-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 24 2020 3 02 10 455-461 |
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Alomar-Dominguez, Cristina |
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beta-amyloid peptides(1–42) and (1–40) in the cerebrospinal fluid during pregnancy: a prospective observational study |
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Beta-amyloid peptides(1–42) and (1–40) in the cerebrospinal fluid during pregnancy: a prospective observational study |
| abstract |
Abstract To evaluate changes in concentrations of selected biomarkers, neurotrophic factors, and growth factors in the cerebrospinal fluid during pregnancy. A prospective observational study was conducted in 32 pregnant women undergoing gynecological and obstetrical surgery under spinal anesthesia in a university hospital. Beta-amyloid(1–42) and beta-amyloid(1–40) peptides, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, and vascular endothelial growth factor were analyzed in cerebrospinal fluid using an enzyme-linked immunosorbent assay. Eight women in second trimester pregnancy who underwent spinal anesthesia for gynecological or obstetrical surgery were compared with 24 matched women in third trimester pregnancies. CSF concentrations of beta-amyloid(1–42) were significantly higher in third trimester pregnancies (p = 0.025). During third trimester, the beta-amyloid ratio correlated with the vascular endothelial growth factor (rs = 0.657; p = 0.008). Higher concentrations of beta-amyloid(1–42) in cerebrospinal fluid of third trimester pregnancies and correlations between the beta-amyloid ratio and the vascular endothelial growth factor support the hypothesis that beta-amyloid peptides are involved in complex adaptive brain alterations during pregnancy. |
| abstractGer |
Abstract To evaluate changes in concentrations of selected biomarkers, neurotrophic factors, and growth factors in the cerebrospinal fluid during pregnancy. A prospective observational study was conducted in 32 pregnant women undergoing gynecological and obstetrical surgery under spinal anesthesia in a university hospital. Beta-amyloid(1–42) and beta-amyloid(1–40) peptides, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, and vascular endothelial growth factor were analyzed in cerebrospinal fluid using an enzyme-linked immunosorbent assay. Eight women in second trimester pregnancy who underwent spinal anesthesia for gynecological or obstetrical surgery were compared with 24 matched women in third trimester pregnancies. CSF concentrations of beta-amyloid(1–42) were significantly higher in third trimester pregnancies (p = 0.025). During third trimester, the beta-amyloid ratio correlated with the vascular endothelial growth factor (rs = 0.657; p = 0.008). Higher concentrations of beta-amyloid(1–42) in cerebrospinal fluid of third trimester pregnancies and correlations between the beta-amyloid ratio and the vascular endothelial growth factor support the hypothesis that beta-amyloid peptides are involved in complex adaptive brain alterations during pregnancy. |
| abstract_unstemmed |
Abstract To evaluate changes in concentrations of selected biomarkers, neurotrophic factors, and growth factors in the cerebrospinal fluid during pregnancy. A prospective observational study was conducted in 32 pregnant women undergoing gynecological and obstetrical surgery under spinal anesthesia in a university hospital. Beta-amyloid(1–42) and beta-amyloid(1–40) peptides, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, and vascular endothelial growth factor were analyzed in cerebrospinal fluid using an enzyme-linked immunosorbent assay. Eight women in second trimester pregnancy who underwent spinal anesthesia for gynecological or obstetrical surgery were compared with 24 matched women in third trimester pregnancies. CSF concentrations of beta-amyloid(1–42) were significantly higher in third trimester pregnancies (p = 0.025). During third trimester, the beta-amyloid ratio correlated with the vascular endothelial growth factor (rs = 0.657; p = 0.008). Higher concentrations of beta-amyloid(1–42) in cerebrospinal fluid of third trimester pregnancies and correlations between the beta-amyloid ratio and the vascular endothelial growth factor support the hypothesis that beta-amyloid peptides are involved in complex adaptive brain alterations during pregnancy. |
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Beta-amyloid peptides(1–42) and (1–40) in the cerebrospinal fluid during pregnancy: a prospective observational study |
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