Clinical implementation of accelerated $ T_{2} $ mapping: Quantitative magnetic resonance imaging as a biomarker for annular tear and lumbar disc herniation

Objectives This study evaluates GRAPPATINI, an accelerated $ T_{2} $ mapping sequence combining undersampling and model-based reconstruction to facilitate the clinical implementation of $ T_{2} $ mapping of the lumbar intervertebral disc. Methods Fifty-eight individuals (26 females, 32 males, age 23...
Ausführliche Beschreibung

Objectives This study evaluates GRAPPATINI, an accelerated $ T_{2} $ mapping sequence combining undersampling and model-based reconstruction to facilitate the clinical implementation of $ T_{2} $ mapping of the lumbar intervertebral disc. Methods Fifty-eight individuals (26 females, 32 males, age 23.3 ± 8.0 years) were prospectively examined at 3 T. This cohort study consisted of 19 patients, 20 rowers, and 19 volunteers. GRAPPATINI was conducted with the same parameters as a conventional 2D multi-echo spin-echo (MESE) sequence in 02:27 min instead of 13:18 min. Additional $ T_{2} $ maps were calculated after discarding the first echo ($ T_{2-WO1ST} $) and only using even echoes ($ T_{2-EVEN} $). Segmentation was done on the four most central slices. The resulting $ T_{2} $ values were compared for all four measurements. Results $ T_{2-GRAPPATINI} $, $ T_{2-MESE} $, $ T_{2-EVEN} $, and $ T_{2-WO1ST} $ of the nucleus pulposus of normal discs differed significantly from those of bulging discs or herniated discs (all p < 0.001). For the posterior annular region, only $ T_{2-GRAPPATINI} $ showed a significant difference (p = 0.011) between normal and herniated discs. There was a significant difference between $ T_{2-GRAPPATINI} $, $ T_{2-MESE} $, $ T_{2-EVEN} $, and $ T_{2-WO1ST} $ of discs with and without an annular tear for the nucleus pulposus (all p < 0.001). The nucleus pulposus’ $ T_{2} $ at different degeneration states showed significant differences between all group comparisons of Pfirrmann grades for $ T_{2-GRAPPATINI} $ (p = 0.000–0.018), $ T_{2-MESE} $ (p = 0.000–0.015), $ T_{2-EVEN} $ (p = 0.000–0.019), and $ T_{2-WO1ST} $ (p = 0.000–0.015). Conclusions GRAPPATINI facilitates the use of $ T_{2} $ values as quantitative imaging biomarkers to detect disc pathologies such as degeneration, lumbar disc herniation, and annular tears while simultaneously shortening the acquisition time from 13:18 to 2:27 min. Key Points • T2-GRAPPATINI, T2-MESE, T2-EVEN, and T2-WO1STof the nucleus pulposus of normal discs differed significantly from those of discs with bulging or herniation (all p < 0.001). • The investigated T2mapping techniques differed significantly in discs with and without annular tearing (all p < 0.001). • The nucleus pulposus’ T2showed significant differences between different stages of degeneration in all group comparisons for T2-GRAPPATINI(p = 0.000–0.018), T2-MESE(p = 0.000–0.015), T2-EVEN(p = 0.000–0.019), and T2-WO1ST(p = 0.000–0.015). Ausführliche Beschreibung

Autor*in:	Raudner, Marcus [verfasserIn] Schreiner, Markus M. [verfasserIn] Hilbert, Tom [verfasserIn] Kober, Tobias [verfasserIn] Weber, Michael [verfasserIn] Szelényi, Anna [verfasserIn] Windhager, Reinhard [verfasserIn] Juras, Vladimir [verfasserIn] Trattnig, Siegfried [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Spine Intervertebral disc Intervertebral disc displacement Intervertebral disc degeneration

Übergeordnetes Werk:	Enthalten in: European radiology - Berlin : Springer, 1991, 31(2020), 6 vom: 03. Dez., Seite 3590-3599
Übergeordnetes Werk:	volume:31 ; year:2020 ; number:6 ; day:03 ; month:12 ; pages:3590-3599

Links:	Volltext

DOI / URN:	10.1007/s00330-020-07538-6

Katalog-ID:	SPR044052758