Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD
Abstract We have recently reported a new method for detecting T-cell-derived extracellular vesicles (EVs), $ CD3^{+} %$ CD4^{+} $EVs,$ CD3^{+} %$ CD8^{+} $EVs, and $ CD3^{+} $HLA-$ DR^{+} $EVs. In our previous study, $ CD3^{+} $HLA-$ DR^{+} $EVs were released profusely by $ CD8^{+} $T cells, only mo...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Nagasawa, Masayuki [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© Japanese Society of Hematology 2021 |
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| Übergeordnetes Werk: |
Enthalten in: International journal of hematology - Tokyo [u.a.] : Springer, 1995, 113(2021), 6 vom: 08. März, Seite 910-920 |
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| Übergeordnetes Werk: |
volume:113 ; year:2021 ; number:6 ; day:08 ; month:03 ; pages:910-920 |
| Links: |
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| DOI / URN: |
10.1007/s12185-021-03113-x |
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| Katalog-ID: |
SPR044093942 |
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| 100 | 1 | |a Nagasawa, Masayuki |e verfasserin |0 (orcid)0000-0002-8085-4940 |4 aut | |
| 245 | 1 | 0 | |a Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD |
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| 520 | |a Abstract We have recently reported a new method for detecting T-cell-derived extracellular vesicles (EVs), $ CD3^{+} %$ CD4^{+} $EVs,$ CD3^{+} %$ CD8^{+} $EVs, and $ CD3^{+} $HLA-$ DR^{+} $EVs. In our previous study, $ CD3^{+} $HLA-$ DR^{+} $EVs were released profusely by $ CD8^{+} $T cells, only moderately by T helper1 (Th1) $ CD4^{+} $T cells, and very little from Th2 $ CD4^{+} $T cells in vitro. EVs were measured sequentially in patients undergoing hematopoietic stem cell transplantation (HSCT), and their relationship to GVHD was investigated in comparison with other conventional biomarkers. We analyzed peripheral blood samples from 20 patients (13 children and 7 adults) who underwent HSCT at Tokyo Medical and Dental University Hospital. $ CD3^{+} %$ CD4^{+} $EV and $ CD3^{+} %$ CD8^{+} $EV levels specifically correlated with the $ CD4^{+} $ and $ CD8^{+} $T lymphocyte counts, respectively. $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs increased in GVHD and reflected the persistence of GVHD more specifically than soluble IL-2 receptor (sIL-2R). In engraftment syndrome, sIL-2R was markedly elevated, but $ CD3^{+} $HLA-$ DR^{+} $EVs were not. Furthermore, ferritin and sIL-2R markedly increased in hemophagocytic syndrome (HPS) that developed before engraftment; however, the change in $ CD3^{+} $HLA-$ DR^{+} $EVs was marginal. $ CD3^{+} %$ CD4^{+} $, $ CD3^{+} %$ CD8^{+} $, and $ CD3^{+} $HLA-$ DR^{+} $EVs efficiently reflect the cell-mediated immune response, and $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs are more useful than other conventional biomarkers, such as sIL-2R, for monitoring and evaluation of acute GVHD. | ||
| 650 | 4 | |a SCT |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Extracellular vesicle |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a GVHD |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hemophagocytic syndrome |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Soluble IL-2 receptor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Engraftment syndrome |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Mitsuiki, Noriko |4 aut | |
| 700 | 1 | |a Yanagimachi, Masakatsu |4 aut | |
| 700 | 1 | |a Yamamoto, Masahide |4 aut | |
| 700 | 1 | |a Fukuda, Tetsuya |4 aut | |
| 700 | 1 | |a Miura, Osamu |4 aut | |
| 700 | 1 | |a Oba, Ryutaro |4 aut | |
| 700 | 1 | |a Igarashi, Akira |4 aut | |
| 700 | 1 | |a Nagata, Kinya |4 aut | |
| 700 | 1 | |a Morio, Tomohiro |4 aut | |
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| 912 | |a GBV_ILN_2034 | ||
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| 912 | |a GBV_ILN_2055 | ||
| 912 | |a GBV_ILN_2056 | ||
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| 912 | |a GBV_ILN_2059 | ||
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| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
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| 912 | |a GBV_ILN_2336 | ||
| 912 | |a GBV_ILN_2446 | ||
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10.1007/s12185-021-03113-x doi (DE-627)SPR044093942 (SPR)s12185-021-03113-x-e DE-627 ger DE-627 rakwb eng Nagasawa, Masayuki verfasserin (orcid)0000-0002-8085-4940 aut Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Society of Hematology 2021 Abstract We have recently reported a new method for detecting T-cell-derived extracellular vesicles (EVs), $ CD3^{+} %$ CD4^{+} $EVs,$ CD3^{+} %$ CD8^{+} $EVs, and $ CD3^{+} $HLA-$ DR^{+} $EVs. In our previous study, $ CD3^{+} $HLA-$ DR^{+} $EVs were released profusely by $ CD8^{+} $T cells, only moderately by T helper1 (Th1) $ CD4^{+} $T cells, and very little from Th2 $ CD4^{+} $T cells in vitro. EVs were measured sequentially in patients undergoing hematopoietic stem cell transplantation (HSCT), and their relationship to GVHD was investigated in comparison with other conventional biomarkers. We analyzed peripheral blood samples from 20 patients (13 children and 7 adults) who underwent HSCT at Tokyo Medical and Dental University Hospital. $ CD3^{+} %$ CD4^{+} $EV and $ CD3^{+} %$ CD8^{+} $EV levels specifically correlated with the $ CD4^{+} $ and $ CD8^{+} $T lymphocyte counts, respectively. $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs increased in GVHD and reflected the persistence of GVHD more specifically than soluble IL-2 receptor (sIL-2R). In engraftment syndrome, sIL-2R was markedly elevated, but $ CD3^{+} $HLA-$ DR^{+} $EVs were not. Furthermore, ferritin and sIL-2R markedly increased in hemophagocytic syndrome (HPS) that developed before engraftment; however, the change in $ CD3^{+} $HLA-$ DR^{+} $EVs was marginal. $ CD3^{+} %$ CD4^{+} $, $ CD3^{+} %$ CD8^{+} $, and $ CD3^{+} $HLA-$ DR^{+} $EVs efficiently reflect the cell-mediated immune response, and $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs are more useful than other conventional biomarkers, such as sIL-2R, for monitoring and evaluation of acute GVHD. SCT (dpeaa)DE-He213 Extracellular vesicle (dpeaa)DE-He213 GVHD (dpeaa)DE-He213 Hemophagocytic syndrome (dpeaa)DE-He213 Soluble IL-2 receptor (dpeaa)DE-He213 Engraftment syndrome (dpeaa)DE-He213 Mitsuiki, Noriko aut Yanagimachi, Masakatsu aut Yamamoto, Masahide aut Fukuda, Tetsuya aut Miura, Osamu aut Oba, Ryutaro aut Igarashi, Akira aut Nagata, Kinya aut Morio, Tomohiro aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 113(2021), 6 vom: 08. März, Seite 910-920 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:113 year:2021 number:6 day:08 month:03 pages:910-920 https://dx.doi.org/10.1007/s12185-021-03113-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 113 2021 6 08 03 910-920 |
| spelling |
10.1007/s12185-021-03113-x doi (DE-627)SPR044093942 (SPR)s12185-021-03113-x-e DE-627 ger DE-627 rakwb eng Nagasawa, Masayuki verfasserin (orcid)0000-0002-8085-4940 aut Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Society of Hematology 2021 Abstract We have recently reported a new method for detecting T-cell-derived extracellular vesicles (EVs), $ CD3^{+} %$ CD4^{+} $EVs,$ CD3^{+} %$ CD8^{+} $EVs, and $ CD3^{+} $HLA-$ DR^{+} $EVs. In our previous study, $ CD3^{+} $HLA-$ DR^{+} $EVs were released profusely by $ CD8^{+} $T cells, only moderately by T helper1 (Th1) $ CD4^{+} $T cells, and very little from Th2 $ CD4^{+} $T cells in vitro. EVs were measured sequentially in patients undergoing hematopoietic stem cell transplantation (HSCT), and their relationship to GVHD was investigated in comparison with other conventional biomarkers. We analyzed peripheral blood samples from 20 patients (13 children and 7 adults) who underwent HSCT at Tokyo Medical and Dental University Hospital. $ CD3^{+} %$ CD4^{+} $EV and $ CD3^{+} %$ CD8^{+} $EV levels specifically correlated with the $ CD4^{+} $ and $ CD8^{+} $T lymphocyte counts, respectively. $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs increased in GVHD and reflected the persistence of GVHD more specifically than soluble IL-2 receptor (sIL-2R). In engraftment syndrome, sIL-2R was markedly elevated, but $ CD3^{+} $HLA-$ DR^{+} $EVs were not. Furthermore, ferritin and sIL-2R markedly increased in hemophagocytic syndrome (HPS) that developed before engraftment; however, the change in $ CD3^{+} $HLA-$ DR^{+} $EVs was marginal. $ CD3^{+} %$ CD4^{+} $, $ CD3^{+} %$ CD8^{+} $, and $ CD3^{+} $HLA-$ DR^{+} $EVs efficiently reflect the cell-mediated immune response, and $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs are more useful than other conventional biomarkers, such as sIL-2R, for monitoring and evaluation of acute GVHD. SCT (dpeaa)DE-He213 Extracellular vesicle (dpeaa)DE-He213 GVHD (dpeaa)DE-He213 Hemophagocytic syndrome (dpeaa)DE-He213 Soluble IL-2 receptor (dpeaa)DE-He213 Engraftment syndrome (dpeaa)DE-He213 Mitsuiki, Noriko aut Yanagimachi, Masakatsu aut Yamamoto, Masahide aut Fukuda, Tetsuya aut Miura, Osamu aut Oba, Ryutaro aut Igarashi, Akira aut Nagata, Kinya aut Morio, Tomohiro aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 113(2021), 6 vom: 08. März, Seite 910-920 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:113 year:2021 number:6 day:08 month:03 pages:910-920 https://dx.doi.org/10.1007/s12185-021-03113-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 113 2021 6 08 03 910-920 |
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10.1007/s12185-021-03113-x doi (DE-627)SPR044093942 (SPR)s12185-021-03113-x-e DE-627 ger DE-627 rakwb eng Nagasawa, Masayuki verfasserin (orcid)0000-0002-8085-4940 aut Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Society of Hematology 2021 Abstract We have recently reported a new method for detecting T-cell-derived extracellular vesicles (EVs), $ CD3^{+} %$ CD4^{+} $EVs,$ CD3^{+} %$ CD8^{+} $EVs, and $ CD3^{+} $HLA-$ DR^{+} $EVs. In our previous study, $ CD3^{+} $HLA-$ DR^{+} $EVs were released profusely by $ CD8^{+} $T cells, only moderately by T helper1 (Th1) $ CD4^{+} $T cells, and very little from Th2 $ CD4^{+} $T cells in vitro. EVs were measured sequentially in patients undergoing hematopoietic stem cell transplantation (HSCT), and their relationship to GVHD was investigated in comparison with other conventional biomarkers. We analyzed peripheral blood samples from 20 patients (13 children and 7 adults) who underwent HSCT at Tokyo Medical and Dental University Hospital. $ CD3^{+} %$ CD4^{+} $EV and $ CD3^{+} %$ CD8^{+} $EV levels specifically correlated with the $ CD4^{+} $ and $ CD8^{+} $T lymphocyte counts, respectively. $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs increased in GVHD and reflected the persistence of GVHD more specifically than soluble IL-2 receptor (sIL-2R). In engraftment syndrome, sIL-2R was markedly elevated, but $ CD3^{+} $HLA-$ DR^{+} $EVs were not. Furthermore, ferritin and sIL-2R markedly increased in hemophagocytic syndrome (HPS) that developed before engraftment; however, the change in $ CD3^{+} $HLA-$ DR^{+} $EVs was marginal. $ CD3^{+} %$ CD4^{+} $, $ CD3^{+} %$ CD8^{+} $, and $ CD3^{+} $HLA-$ DR^{+} $EVs efficiently reflect the cell-mediated immune response, and $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs are more useful than other conventional biomarkers, such as sIL-2R, for monitoring and evaluation of acute GVHD. SCT (dpeaa)DE-He213 Extracellular vesicle (dpeaa)DE-He213 GVHD (dpeaa)DE-He213 Hemophagocytic syndrome (dpeaa)DE-He213 Soluble IL-2 receptor (dpeaa)DE-He213 Engraftment syndrome (dpeaa)DE-He213 Mitsuiki, Noriko aut Yanagimachi, Masakatsu aut Yamamoto, Masahide aut Fukuda, Tetsuya aut Miura, Osamu aut Oba, Ryutaro aut Igarashi, Akira aut Nagata, Kinya aut Morio, Tomohiro aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 113(2021), 6 vom: 08. März, Seite 910-920 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:113 year:2021 number:6 day:08 month:03 pages:910-920 https://dx.doi.org/10.1007/s12185-021-03113-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 113 2021 6 08 03 910-920 |
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10.1007/s12185-021-03113-x doi (DE-627)SPR044093942 (SPR)s12185-021-03113-x-e DE-627 ger DE-627 rakwb eng Nagasawa, Masayuki verfasserin (orcid)0000-0002-8085-4940 aut Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Society of Hematology 2021 Abstract We have recently reported a new method for detecting T-cell-derived extracellular vesicles (EVs), $ CD3^{+} %$ CD4^{+} $EVs,$ CD3^{+} %$ CD8^{+} $EVs, and $ CD3^{+} $HLA-$ DR^{+} $EVs. In our previous study, $ CD3^{+} $HLA-$ DR^{+} $EVs were released profusely by $ CD8^{+} $T cells, only moderately by T helper1 (Th1) $ CD4^{+} $T cells, and very little from Th2 $ CD4^{+} $T cells in vitro. EVs were measured sequentially in patients undergoing hematopoietic stem cell transplantation (HSCT), and their relationship to GVHD was investigated in comparison with other conventional biomarkers. We analyzed peripheral blood samples from 20 patients (13 children and 7 adults) who underwent HSCT at Tokyo Medical and Dental University Hospital. $ CD3^{+} %$ CD4^{+} $EV and $ CD3^{+} %$ CD8^{+} $EV levels specifically correlated with the $ CD4^{+} $ and $ CD8^{+} $T lymphocyte counts, respectively. $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs increased in GVHD and reflected the persistence of GVHD more specifically than soluble IL-2 receptor (sIL-2R). In engraftment syndrome, sIL-2R was markedly elevated, but $ CD3^{+} $HLA-$ DR^{+} $EVs were not. Furthermore, ferritin and sIL-2R markedly increased in hemophagocytic syndrome (HPS) that developed before engraftment; however, the change in $ CD3^{+} $HLA-$ DR^{+} $EVs was marginal. $ CD3^{+} %$ CD4^{+} $, $ CD3^{+} %$ CD8^{+} $, and $ CD3^{+} $HLA-$ DR^{+} $EVs efficiently reflect the cell-mediated immune response, and $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs are more useful than other conventional biomarkers, such as sIL-2R, for monitoring and evaluation of acute GVHD. SCT (dpeaa)DE-He213 Extracellular vesicle (dpeaa)DE-He213 GVHD (dpeaa)DE-He213 Hemophagocytic syndrome (dpeaa)DE-He213 Soluble IL-2 receptor (dpeaa)DE-He213 Engraftment syndrome (dpeaa)DE-He213 Mitsuiki, Noriko aut Yanagimachi, Masakatsu aut Yamamoto, Masahide aut Fukuda, Tetsuya aut Miura, Osamu aut Oba, Ryutaro aut Igarashi, Akira aut Nagata, Kinya aut Morio, Tomohiro aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 113(2021), 6 vom: 08. März, Seite 910-920 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:113 year:2021 number:6 day:08 month:03 pages:910-920 https://dx.doi.org/10.1007/s12185-021-03113-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 113 2021 6 08 03 910-920 |
| allfieldsSound |
10.1007/s12185-021-03113-x doi (DE-627)SPR044093942 (SPR)s12185-021-03113-x-e DE-627 ger DE-627 rakwb eng Nagasawa, Masayuki verfasserin (orcid)0000-0002-8085-4940 aut Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Society of Hematology 2021 Abstract We have recently reported a new method for detecting T-cell-derived extracellular vesicles (EVs), $ CD3^{+} %$ CD4^{+} $EVs,$ CD3^{+} %$ CD8^{+} $EVs, and $ CD3^{+} $HLA-$ DR^{+} $EVs. In our previous study, $ CD3^{+} $HLA-$ DR^{+} $EVs were released profusely by $ CD8^{+} $T cells, only moderately by T helper1 (Th1) $ CD4^{+} $T cells, and very little from Th2 $ CD4^{+} $T cells in vitro. EVs were measured sequentially in patients undergoing hematopoietic stem cell transplantation (HSCT), and their relationship to GVHD was investigated in comparison with other conventional biomarkers. We analyzed peripheral blood samples from 20 patients (13 children and 7 adults) who underwent HSCT at Tokyo Medical and Dental University Hospital. $ CD3^{+} %$ CD4^{+} $EV and $ CD3^{+} %$ CD8^{+} $EV levels specifically correlated with the $ CD4^{+} $ and $ CD8^{+} $T lymphocyte counts, respectively. $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs increased in GVHD and reflected the persistence of GVHD more specifically than soluble IL-2 receptor (sIL-2R). In engraftment syndrome, sIL-2R was markedly elevated, but $ CD3^{+} $HLA-$ DR^{+} $EVs were not. Furthermore, ferritin and sIL-2R markedly increased in hemophagocytic syndrome (HPS) that developed before engraftment; however, the change in $ CD3^{+} $HLA-$ DR^{+} $EVs was marginal. $ CD3^{+} %$ CD4^{+} $, $ CD3^{+} %$ CD8^{+} $, and $ CD3^{+} $HLA-$ DR^{+} $EVs efficiently reflect the cell-mediated immune response, and $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs are more useful than other conventional biomarkers, such as sIL-2R, for monitoring and evaluation of acute GVHD. SCT (dpeaa)DE-He213 Extracellular vesicle (dpeaa)DE-He213 GVHD (dpeaa)DE-He213 Hemophagocytic syndrome (dpeaa)DE-He213 Soluble IL-2 receptor (dpeaa)DE-He213 Engraftment syndrome (dpeaa)DE-He213 Mitsuiki, Noriko aut Yanagimachi, Masakatsu aut Yamamoto, Masahide aut Fukuda, Tetsuya aut Miura, Osamu aut Oba, Ryutaro aut Igarashi, Akira aut Nagata, Kinya aut Morio, Tomohiro aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 113(2021), 6 vom: 08. März, Seite 910-920 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:113 year:2021 number:6 day:08 month:03 pages:910-920 https://dx.doi.org/10.1007/s12185-021-03113-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 113 2021 6 08 03 910-920 |
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English |
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Enthalten in International journal of hematology 113(2021), 6 vom: 08. März, Seite 910-920 volume:113 year:2021 number:6 day:08 month:03 pages:910-920 |
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Enthalten in International journal of hematology 113(2021), 6 vom: 08. März, Seite 910-920 volume:113 year:2021 number:6 day:08 month:03 pages:910-920 |
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SCT Extracellular vesicle GVHD Hemophagocytic syndrome Soluble IL-2 receptor Engraftment syndrome |
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International journal of hematology |
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Nagasawa, Masayuki @@aut@@ Mitsuiki, Noriko @@aut@@ Yanagimachi, Masakatsu @@aut@@ Yamamoto, Masahide @@aut@@ Fukuda, Tetsuya @@aut@@ Miura, Osamu @@aut@@ Oba, Ryutaro @@aut@@ Igarashi, Akira @@aut@@ Nagata, Kinya @@aut@@ Morio, Tomohiro @@aut@@ |
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In our previous study, $ CD3^{+} $HLA-$ DR^{+} $EVs were released profusely by $ CD8^{+} $T cells, only moderately by T helper1 (Th1) $ CD4^{+} $T cells, and very little from Th2 $ CD4^{+} $T cells in vitro. EVs were measured sequentially in patients undergoing hematopoietic stem cell transplantation (HSCT), and their relationship to GVHD was investigated in comparison with other conventional biomarkers. We analyzed peripheral blood samples from 20 patients (13 children and 7 adults) who underwent HSCT at Tokyo Medical and Dental University Hospital. $ CD3^{+} %$ CD4^{+} $EV and $ CD3^{+} %$ CD8^{+} $EV levels specifically correlated with the $ CD4^{+} $ and $ CD8^{+} $T lymphocyte counts, respectively. $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs increased in GVHD and reflected the persistence of GVHD more specifically than soluble IL-2 receptor (sIL-2R). In engraftment syndrome, sIL-2R was markedly elevated, but $ CD3^{+} $HLA-$ DR^{+} $EVs were not. 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Nagasawa, Masayuki |
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Nagasawa, Masayuki misc SCT misc Extracellular vesicle misc GVHD misc Hemophagocytic syndrome misc Soluble IL-2 receptor misc Engraftment syndrome Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD |
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Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD SCT (dpeaa)DE-He213 Extracellular vesicle (dpeaa)DE-He213 GVHD (dpeaa)DE-He213 Hemophagocytic syndrome (dpeaa)DE-He213 Soluble IL-2 receptor (dpeaa)DE-He213 Engraftment syndrome (dpeaa)DE-He213 |
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misc SCT misc Extracellular vesicle misc GVHD misc Hemophagocytic syndrome misc Soluble IL-2 receptor misc Engraftment syndrome |
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Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD |
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Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD |
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Nagasawa, Masayuki |
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International journal of hematology |
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Nagasawa, Masayuki Mitsuiki, Noriko Yanagimachi, Masakatsu Yamamoto, Masahide Fukuda, Tetsuya Miura, Osamu Oba, Ryutaro Igarashi, Akira Nagata, Kinya Morio, Tomohiro |
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Elektronische Aufsätze |
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Nagasawa, Masayuki |
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10.1007/s12185-021-03113-x |
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utility of novel t-cell-specific extracellular vesicles in monitoring and evaluation of acute gvhd |
| title_auth |
Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD |
| abstract |
Abstract We have recently reported a new method for detecting T-cell-derived extracellular vesicles (EVs), $ CD3^{+} %$ CD4^{+} $EVs,$ CD3^{+} %$ CD8^{+} $EVs, and $ CD3^{+} $HLA-$ DR^{+} $EVs. In our previous study, $ CD3^{+} $HLA-$ DR^{+} $EVs were released profusely by $ CD8^{+} $T cells, only moderately by T helper1 (Th1) $ CD4^{+} $T cells, and very little from Th2 $ CD4^{+} $T cells in vitro. EVs were measured sequentially in patients undergoing hematopoietic stem cell transplantation (HSCT), and their relationship to GVHD was investigated in comparison with other conventional biomarkers. We analyzed peripheral blood samples from 20 patients (13 children and 7 adults) who underwent HSCT at Tokyo Medical and Dental University Hospital. $ CD3^{+} %$ CD4^{+} $EV and $ CD3^{+} %$ CD8^{+} $EV levels specifically correlated with the $ CD4^{+} $ and $ CD8^{+} $T lymphocyte counts, respectively. $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs increased in GVHD and reflected the persistence of GVHD more specifically than soluble IL-2 receptor (sIL-2R). In engraftment syndrome, sIL-2R was markedly elevated, but $ CD3^{+} $HLA-$ DR^{+} $EVs were not. Furthermore, ferritin and sIL-2R markedly increased in hemophagocytic syndrome (HPS) that developed before engraftment; however, the change in $ CD3^{+} $HLA-$ DR^{+} $EVs was marginal. $ CD3^{+} %$ CD4^{+} $, $ CD3^{+} %$ CD8^{+} $, and $ CD3^{+} $HLA-$ DR^{+} $EVs efficiently reflect the cell-mediated immune response, and $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs are more useful than other conventional biomarkers, such as sIL-2R, for monitoring and evaluation of acute GVHD. © Japanese Society of Hematology 2021 |
| abstractGer |
Abstract We have recently reported a new method for detecting T-cell-derived extracellular vesicles (EVs), $ CD3^{+} %$ CD4^{+} $EVs,$ CD3^{+} %$ CD8^{+} $EVs, and $ CD3^{+} $HLA-$ DR^{+} $EVs. In our previous study, $ CD3^{+} $HLA-$ DR^{+} $EVs were released profusely by $ CD8^{+} $T cells, only moderately by T helper1 (Th1) $ CD4^{+} $T cells, and very little from Th2 $ CD4^{+} $T cells in vitro. EVs were measured sequentially in patients undergoing hematopoietic stem cell transplantation (HSCT), and their relationship to GVHD was investigated in comparison with other conventional biomarkers. We analyzed peripheral blood samples from 20 patients (13 children and 7 adults) who underwent HSCT at Tokyo Medical and Dental University Hospital. $ CD3^{+} %$ CD4^{+} $EV and $ CD3^{+} %$ CD8^{+} $EV levels specifically correlated with the $ CD4^{+} $ and $ CD8^{+} $T lymphocyte counts, respectively. $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs increased in GVHD and reflected the persistence of GVHD more specifically than soluble IL-2 receptor (sIL-2R). In engraftment syndrome, sIL-2R was markedly elevated, but $ CD3^{+} $HLA-$ DR^{+} $EVs were not. Furthermore, ferritin and sIL-2R markedly increased in hemophagocytic syndrome (HPS) that developed before engraftment; however, the change in $ CD3^{+} $HLA-$ DR^{+} $EVs was marginal. $ CD3^{+} %$ CD4^{+} $, $ CD3^{+} %$ CD8^{+} $, and $ CD3^{+} $HLA-$ DR^{+} $EVs efficiently reflect the cell-mediated immune response, and $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs are more useful than other conventional biomarkers, such as sIL-2R, for monitoring and evaluation of acute GVHD. © Japanese Society of Hematology 2021 |
| abstract_unstemmed |
Abstract We have recently reported a new method for detecting T-cell-derived extracellular vesicles (EVs), $ CD3^{+} %$ CD4^{+} $EVs,$ CD3^{+} %$ CD8^{+} $EVs, and $ CD3^{+} $HLA-$ DR^{+} $EVs. In our previous study, $ CD3^{+} $HLA-$ DR^{+} $EVs were released profusely by $ CD8^{+} $T cells, only moderately by T helper1 (Th1) $ CD4^{+} $T cells, and very little from Th2 $ CD4^{+} $T cells in vitro. EVs were measured sequentially in patients undergoing hematopoietic stem cell transplantation (HSCT), and their relationship to GVHD was investigated in comparison with other conventional biomarkers. We analyzed peripheral blood samples from 20 patients (13 children and 7 adults) who underwent HSCT at Tokyo Medical and Dental University Hospital. $ CD3^{+} %$ CD4^{+} $EV and $ CD3^{+} %$ CD8^{+} $EV levels specifically correlated with the $ CD4^{+} $ and $ CD8^{+} $T lymphocyte counts, respectively. $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs increased in GVHD and reflected the persistence of GVHD more specifically than soluble IL-2 receptor (sIL-2R). In engraftment syndrome, sIL-2R was markedly elevated, but $ CD3^{+} $HLA-$ DR^{+} $EVs were not. Furthermore, ferritin and sIL-2R markedly increased in hemophagocytic syndrome (HPS) that developed before engraftment; however, the change in $ CD3^{+} $HLA-$ DR^{+} $EVs was marginal. $ CD3^{+} %$ CD4^{+} $, $ CD3^{+} %$ CD8^{+} $, and $ CD3^{+} $HLA-$ DR^{+} $EVs efficiently reflect the cell-mediated immune response, and $ CD3^{+} %$ CD8^{+} $EVs and $ CD3^{+} $HLA-$ DR^{+} $EVs are more useful than other conventional biomarkers, such as sIL-2R, for monitoring and evaluation of acute GVHD. © Japanese Society of Hematology 2021 |
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Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD |
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| score |
7.3989916 |