Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma

Purpose To assess arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) in the differentiation of metastatic from reactive lymph nodes (LNs) in head and neck squamous cell carcinoma (HNSCC). Materials and methods Retrospective analysis of 113 LNs in 43 patients with HNSCC underwent ASL a...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Razek, Ahmed Abdel Khalek Abdel [verfasserIn] Helmy, Eman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Diffusion Arterial spin Perfusion MR imaging Cancer Head Neck

Anmerkung:	© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Übergeordnetes Werk:	Enthalten in: European archives of oto-rhino-laryngology and head & neck - Berlin : Springer, 1864, 278(2020), 7 vom: 30. Sept., Seite 2529-2535
Übergeordnetes Werk:	volume:278 ; year:2020 ; number:7 ; day:30 ; month:09 ; pages:2529-2535

Links:	Volltext

DOI / URN:	10.1007/s00405-020-06390-0

Katalog-ID:	SPR04418607X

Internformat


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245	1	0	\|a Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma
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520			\|a Purpose To assess arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) in the differentiation of metastatic from reactive lymph nodes (LNs) in head and neck squamous cell carcinoma (HNSCC). Materials and methods Retrospective analysis of 113 LNs in 43 patients with HNSCC underwent ASL and DWI of the neck. The tumor blood flow (TBF) and apparent diffusion coefficient (ADC) of the cervical LNs were calculated. The final diagnosis of metastatic (n = 82) and reactive (n = 31) was proved with the pathological examination. Results The TBF of metastatic LNs (58.8 ± 10.2, 58.6 ± 8.5 mL/100 g/min) was significantly higher (p = 0.001) than the reactive LNs (23.2 ± 10.3, 28.2 ± 16.7 mL/100 g/min) for both observers, respectively. The ADC of metastatic LN (1.12 ± 0.07, 1.21 ± 0.07 × $ 10^{−3} %$ mm^{2} $/s) was significantly lower (p = 0.001) than reactive LN (1.41 ± 0.09, 1.44 ± 0.14 × $ 10^{−3} %$ mm^{2} $/s) for both observers, respectively. The threshold of TBF (> 39.5, 40.5 mL/100 g/min), ADC (≥ 1.31, 1.30 $ X10^{−3} %$ mm^{2} $/s) and combined parameters for both observers, respectively, used for differentiating metastatic from reactive LNs revealed an area under the curve of (0.94, 0.945), (0.90, 0.931), and (0.98, 0.989), an accuracy of (88.6%, 80.5%), (80.0%, 88.5%), and (94.3%, 98.2), respectively. Conclusion Combined TBF and ADC are non-invasive imaging parameters that can play a role in differentiation metastatic from reactive LNs in patients with HNSCC.
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Indexfelder

author_variant	a a k a r aaka aakar e h eh
matchkey_str	article:14344726:2020----::utprmtiatrasilblnadifsowiheiaignifrnitoomtsaiforatvlmh
hierarchy_sort_str	2020
bklnumber	44.94
publishDate	2020
allfields	10.1007/s00405-020-06390-0 doi (DE-627)SPR04418607X (SPR)s00405-020-06390-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.94 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Purpose To assess arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) in the differentiation of metastatic from reactive lymph nodes (LNs) in head and neck squamous cell carcinoma (HNSCC). Materials and methods Retrospective analysis of 113 LNs in 43 patients with HNSCC underwent ASL and DWI of the neck. The tumor blood flow (TBF) and apparent diffusion coefficient (ADC) of the cervical LNs were calculated. The final diagnosis of metastatic (n = 82) and reactive (n = 31) was proved with the pathological examination. Results The TBF of metastatic LNs (58.8 ± 10.2, 58.6 ± 8.5 mL/100 g/min) was significantly higher (p = 0.001) than the reactive LNs (23.2 ± 10.3, 28.2 ± 16.7 mL/100 g/min) for both observers, respectively. The ADC of metastatic LN (1.12 ± 0.07, 1.21 ± 0.07 × $ 10^{−3} %$ mm^{2} $/s) was significantly lower (p = 0.001) than reactive LN (1.41 ± 0.09, 1.44 ± 0.14 × $ 10^{−3} %$ mm^{2} $/s) for both observers, respectively. The threshold of TBF (> 39.5, 40.5 mL/100 g/min), ADC (≥ 1.31, 1.30 $ X10^{−3} %$ mm^{2} $/s) and combined parameters for both observers, respectively, used for differentiating metastatic from reactive LNs revealed an area under the curve of (0.94, 0.945), (0.90, 0.931), and (0.98, 0.989), an accuracy of (88.6%, 80.5%), (80.0%, 88.5%), and (94.3%, 98.2), respectively. Conclusion Combined TBF and ADC are non-invasive imaging parameters that can play a role in differentiation metastatic from reactive LNs in patients with HNSCC. Diffusion (dpeaa)DE-He213 Arterial spin (dpeaa)DE-He213 Perfusion (dpeaa)DE-He213 MR imaging (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Head (dpeaa)DE-He213 Neck (dpeaa)DE-He213 Helmy, Eman verfasserin aut Enthalten in European archives of oto-rhino-laryngology and head & neck Berlin : Springer, 1864 278(2020), 7 vom: 30. Sept., Seite 2529-2535 (DE-627)253722667 (DE-600)1459042-6 1434-4726 nnns volume:278 year:2020 number:7 day:30 month:09 pages:2529-2535 https://dx.doi.org/10.1007/s00405-020-06390-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.94 ASE AR 278 2020 7 30 09 2529-2535
spelling	10.1007/s00405-020-06390-0 doi (DE-627)SPR04418607X (SPR)s00405-020-06390-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.94 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Purpose To assess arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) in the differentiation of metastatic from reactive lymph nodes (LNs) in head and neck squamous cell carcinoma (HNSCC). Materials and methods Retrospective analysis of 113 LNs in 43 patients with HNSCC underwent ASL and DWI of the neck. The tumor blood flow (TBF) and apparent diffusion coefficient (ADC) of the cervical LNs were calculated. The final diagnosis of metastatic (n = 82) and reactive (n = 31) was proved with the pathological examination. Results The TBF of metastatic LNs (58.8 ± 10.2, 58.6 ± 8.5 mL/100 g/min) was significantly higher (p = 0.001) than the reactive LNs (23.2 ± 10.3, 28.2 ± 16.7 mL/100 g/min) for both observers, respectively. The ADC of metastatic LN (1.12 ± 0.07, 1.21 ± 0.07 × $ 10^{−3} %$ mm^{2} $/s) was significantly lower (p = 0.001) than reactive LN (1.41 ± 0.09, 1.44 ± 0.14 × $ 10^{−3} %$ mm^{2} $/s) for both observers, respectively. The threshold of TBF (> 39.5, 40.5 mL/100 g/min), ADC (≥ 1.31, 1.30 $ X10^{−3} %$ mm^{2} $/s) and combined parameters for both observers, respectively, used for differentiating metastatic from reactive LNs revealed an area under the curve of (0.94, 0.945), (0.90, 0.931), and (0.98, 0.989), an accuracy of (88.6%, 80.5%), (80.0%, 88.5%), and (94.3%, 98.2), respectively. Conclusion Combined TBF and ADC are non-invasive imaging parameters that can play a role in differentiation metastatic from reactive LNs in patients with HNSCC. Diffusion (dpeaa)DE-He213 Arterial spin (dpeaa)DE-He213 Perfusion (dpeaa)DE-He213 MR imaging (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Head (dpeaa)DE-He213 Neck (dpeaa)DE-He213 Helmy, Eman verfasserin aut Enthalten in European archives of oto-rhino-laryngology and head & neck Berlin : Springer, 1864 278(2020), 7 vom: 30. Sept., Seite 2529-2535 (DE-627)253722667 (DE-600)1459042-6 1434-4726 nnns volume:278 year:2020 number:7 day:30 month:09 pages:2529-2535 https://dx.doi.org/10.1007/s00405-020-06390-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.94 ASE AR 278 2020 7 30 09 2529-2535
allfields_unstemmed	10.1007/s00405-020-06390-0 doi (DE-627)SPR04418607X (SPR)s00405-020-06390-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.94 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Purpose To assess arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) in the differentiation of metastatic from reactive lymph nodes (LNs) in head and neck squamous cell carcinoma (HNSCC). Materials and methods Retrospective analysis of 113 LNs in 43 patients with HNSCC underwent ASL and DWI of the neck. The tumor blood flow (TBF) and apparent diffusion coefficient (ADC) of the cervical LNs were calculated. The final diagnosis of metastatic (n = 82) and reactive (n = 31) was proved with the pathological examination. Results The TBF of metastatic LNs (58.8 ± 10.2, 58.6 ± 8.5 mL/100 g/min) was significantly higher (p = 0.001) than the reactive LNs (23.2 ± 10.3, 28.2 ± 16.7 mL/100 g/min) for both observers, respectively. The ADC of metastatic LN (1.12 ± 0.07, 1.21 ± 0.07 × $ 10^{−3} %$ mm^{2} $/s) was significantly lower (p = 0.001) than reactive LN (1.41 ± 0.09, 1.44 ± 0.14 × $ 10^{−3} %$ mm^{2} $/s) for both observers, respectively. The threshold of TBF (> 39.5, 40.5 mL/100 g/min), ADC (≥ 1.31, 1.30 $ X10^{−3} %$ mm^{2} $/s) and combined parameters for both observers, respectively, used for differentiating metastatic from reactive LNs revealed an area under the curve of (0.94, 0.945), (0.90, 0.931), and (0.98, 0.989), an accuracy of (88.6%, 80.5%), (80.0%, 88.5%), and (94.3%, 98.2), respectively. Conclusion Combined TBF and ADC are non-invasive imaging parameters that can play a role in differentiation metastatic from reactive LNs in patients with HNSCC. Diffusion (dpeaa)DE-He213 Arterial spin (dpeaa)DE-He213 Perfusion (dpeaa)DE-He213 MR imaging (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Head (dpeaa)DE-He213 Neck (dpeaa)DE-He213 Helmy, Eman verfasserin aut Enthalten in European archives of oto-rhino-laryngology and head & neck Berlin : Springer, 1864 278(2020), 7 vom: 30. Sept., Seite 2529-2535 (DE-627)253722667 (DE-600)1459042-6 1434-4726 nnns volume:278 year:2020 number:7 day:30 month:09 pages:2529-2535 https://dx.doi.org/10.1007/s00405-020-06390-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.94 ASE AR 278 2020 7 30 09 2529-2535
allfieldsGer	10.1007/s00405-020-06390-0 doi (DE-627)SPR04418607X (SPR)s00405-020-06390-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.94 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Purpose To assess arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) in the differentiation of metastatic from reactive lymph nodes (LNs) in head and neck squamous cell carcinoma (HNSCC). Materials and methods Retrospective analysis of 113 LNs in 43 patients with HNSCC underwent ASL and DWI of the neck. The tumor blood flow (TBF) and apparent diffusion coefficient (ADC) of the cervical LNs were calculated. The final diagnosis of metastatic (n = 82) and reactive (n = 31) was proved with the pathological examination. Results The TBF of metastatic LNs (58.8 ± 10.2, 58.6 ± 8.5 mL/100 g/min) was significantly higher (p = 0.001) than the reactive LNs (23.2 ± 10.3, 28.2 ± 16.7 mL/100 g/min) for both observers, respectively. The ADC of metastatic LN (1.12 ± 0.07, 1.21 ± 0.07 × $ 10^{−3} %$ mm^{2} $/s) was significantly lower (p = 0.001) than reactive LN (1.41 ± 0.09, 1.44 ± 0.14 × $ 10^{−3} %$ mm^{2} $/s) for both observers, respectively. The threshold of TBF (> 39.5, 40.5 mL/100 g/min), ADC (≥ 1.31, 1.30 $ X10^{−3} %$ mm^{2} $/s) and combined parameters for both observers, respectively, used for differentiating metastatic from reactive LNs revealed an area under the curve of (0.94, 0.945), (0.90, 0.931), and (0.98, 0.989), an accuracy of (88.6%, 80.5%), (80.0%, 88.5%), and (94.3%, 98.2), respectively. Conclusion Combined TBF and ADC are non-invasive imaging parameters that can play a role in differentiation metastatic from reactive LNs in patients with HNSCC. Diffusion (dpeaa)DE-He213 Arterial spin (dpeaa)DE-He213 Perfusion (dpeaa)DE-He213 MR imaging (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Head (dpeaa)DE-He213 Neck (dpeaa)DE-He213 Helmy, Eman verfasserin aut Enthalten in European archives of oto-rhino-laryngology and head & neck Berlin : Springer, 1864 278(2020), 7 vom: 30. Sept., Seite 2529-2535 (DE-627)253722667 (DE-600)1459042-6 1434-4726 nnns volume:278 year:2020 number:7 day:30 month:09 pages:2529-2535 https://dx.doi.org/10.1007/s00405-020-06390-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.94 ASE AR 278 2020 7 30 09 2529-2535
allfieldsSound	10.1007/s00405-020-06390-0 doi (DE-627)SPR04418607X (SPR)s00405-020-06390-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.94 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Purpose To assess arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) in the differentiation of metastatic from reactive lymph nodes (LNs) in head and neck squamous cell carcinoma (HNSCC). Materials and methods Retrospective analysis of 113 LNs in 43 patients with HNSCC underwent ASL and DWI of the neck. The tumor blood flow (TBF) and apparent diffusion coefficient (ADC) of the cervical LNs were calculated. The final diagnosis of metastatic (n = 82) and reactive (n = 31) was proved with the pathological examination. Results The TBF of metastatic LNs (58.8 ± 10.2, 58.6 ± 8.5 mL/100 g/min) was significantly higher (p = 0.001) than the reactive LNs (23.2 ± 10.3, 28.2 ± 16.7 mL/100 g/min) for both observers, respectively. The ADC of metastatic LN (1.12 ± 0.07, 1.21 ± 0.07 × $ 10^{−3} %$ mm^{2} $/s) was significantly lower (p = 0.001) than reactive LN (1.41 ± 0.09, 1.44 ± 0.14 × $ 10^{−3} %$ mm^{2} $/s) for both observers, respectively. The threshold of TBF (> 39.5, 40.5 mL/100 g/min), ADC (≥ 1.31, 1.30 $ X10^{−3} %$ mm^{2} $/s) and combined parameters for both observers, respectively, used for differentiating metastatic from reactive LNs revealed an area under the curve of (0.94, 0.945), (0.90, 0.931), and (0.98, 0.989), an accuracy of (88.6%, 80.5%), (80.0%, 88.5%), and (94.3%, 98.2), respectively. Conclusion Combined TBF and ADC are non-invasive imaging parameters that can play a role in differentiation metastatic from reactive LNs in patients with HNSCC. Diffusion (dpeaa)DE-He213 Arterial spin (dpeaa)DE-He213 Perfusion (dpeaa)DE-He213 MR imaging (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Head (dpeaa)DE-He213 Neck (dpeaa)DE-He213 Helmy, Eman verfasserin aut Enthalten in European archives of oto-rhino-laryngology and head & neck Berlin : Springer, 1864 278(2020), 7 vom: 30. Sept., Seite 2529-2535 (DE-627)253722667 (DE-600)1459042-6 1434-4726 nnns volume:278 year:2020 number:7 day:30 month:09 pages:2529-2535 https://dx.doi.org/10.1007/s00405-020-06390-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.94 ASE AR 278 2020 7 30 09 2529-2535
language	English
source	Enthalten in European archives of oto-rhino-laryngology and head & neck 278(2020), 7 vom: 30. Sept., Seite 2529-2535 volume:278 year:2020 number:7 day:30 month:09 pages:2529-2535
sourceStr	Enthalten in European archives of oto-rhino-laryngology and head & neck 278(2020), 7 vom: 30. Sept., Seite 2529-2535 volume:278 year:2020 number:7 day:30 month:09 pages:2529-2535
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Diffusion Arterial spin Perfusion MR imaging Cancer Head Neck
dewey-raw	610
isfreeaccess_bool	false
container_title	European archives of oto-rhino-laryngology and head & neck
authorswithroles_txt_mv	Razek, Ahmed Abdel Khalek Abdel @@aut@@ Helmy, Eman @@aut@@
publishDateDaySort_date	2020-09-30T00:00:00Z
hierarchy_top_id	253722667
dewey-sort	3610
id	SPR04418607X
language_de	englisch
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Materials and methods Retrospective analysis of 113 LNs in 43 patients with HNSCC underwent ASL and DWI of the neck. The tumor blood flow (TBF) and apparent diffusion coefficient (ADC) of the cervical LNs were calculated. The final diagnosis of metastatic (n = 82) and reactive (n = 31) was proved with the pathological examination. Results The TBF of metastatic LNs (58.8 ± 10.2, 58.6 ± 8.5 mL/100 g/min) was significantly higher (p = 0.001) than the reactive LNs (23.2 ± 10.3, 28.2 ± 16.7 mL/100 g/min) for both observers, respectively. The ADC of metastatic LN (1.12 ± 0.07, 1.21 ± 0.07 × $ 10^{−3} %$ mm^{2} $/s) was significantly lower (p = 0.001) than reactive LN (1.41 ± 0.09, 1.44 ± 0.14 × $ 10^{−3} %$ mm^{2} $/s) for both observers, respectively. The threshold of TBF (> 39.5, 40.5 mL/100 g/min), ADC (≥ 1.31, 1.30 $ X10^{−3} %$ mm^{2} $/s) and combined parameters for both observers, respectively, used for differentiating metastatic from reactive LNs revealed an area under the curve of (0.94, 0.945), (0.90, 0.931), and (0.98, 0.989), an accuracy of (88.6%, 80.5%), (80.0%, 88.5%), and (94.3%, 98.2), respectively. 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author	Razek, Ahmed Abdel Khalek Abdel
spellingShingle	Razek, Ahmed Abdel Khalek Abdel ddc 610 bkl 44.94 misc Diffusion misc Arterial spin misc Perfusion misc MR imaging misc Cancer misc Head misc Neck Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma
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topic_title	610 ASE 44.94 bkl Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma Diffusion (dpeaa)DE-He213 Arterial spin (dpeaa)DE-He213 Perfusion (dpeaa)DE-He213 MR imaging (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Head (dpeaa)DE-He213 Neck (dpeaa)DE-He213
topic	ddc 610 bkl 44.94 misc Diffusion misc Arterial spin misc Perfusion misc MR imaging misc Cancer misc Head misc Neck
topic_unstemmed	ddc 610 bkl 44.94 misc Diffusion misc Arterial spin misc Perfusion misc MR imaging misc Cancer misc Head misc Neck
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title	Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma
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title_full	Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma
author_sort	Razek, Ahmed Abdel Khalek Abdel
journal	European archives of oto-rhino-laryngology and head & neck
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author-letter	Razek, Ahmed Abdel Khalek Abdel
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title_sort	multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma
title_auth	Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma
abstract	Purpose To assess arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) in the differentiation of metastatic from reactive lymph nodes (LNs) in head and neck squamous cell carcinoma (HNSCC). Materials and methods Retrospective analysis of 113 LNs in 43 patients with HNSCC underwent ASL and DWI of the neck. The tumor blood flow (TBF) and apparent diffusion coefficient (ADC) of the cervical LNs were calculated. The final diagnosis of metastatic (n = 82) and reactive (n = 31) was proved with the pathological examination. Results The TBF of metastatic LNs (58.8 ± 10.2, 58.6 ± 8.5 mL/100 g/min) was significantly higher (p = 0.001) than the reactive LNs (23.2 ± 10.3, 28.2 ± 16.7 mL/100 g/min) for both observers, respectively. The ADC of metastatic LN (1.12 ± 0.07, 1.21 ± 0.07 × $ 10^{−3} %$ mm^{2} $/s) was significantly lower (p = 0.001) than reactive LN (1.41 ± 0.09, 1.44 ± 0.14 × $ 10^{−3} %$ mm^{2} $/s) for both observers, respectively. The threshold of TBF (> 39.5, 40.5 mL/100 g/min), ADC (≥ 1.31, 1.30 $ X10^{−3} %$ mm^{2} $/s) and combined parameters for both observers, respectively, used for differentiating metastatic from reactive LNs revealed an area under the curve of (0.94, 0.945), (0.90, 0.931), and (0.98, 0.989), an accuracy of (88.6%, 80.5%), (80.0%, 88.5%), and (94.3%, 98.2), respectively. Conclusion Combined TBF and ADC are non-invasive imaging parameters that can play a role in differentiation metastatic from reactive LNs in patients with HNSCC. © Springer-Verlag GmbH Germany, part of Springer Nature 2020
abstractGer	Purpose To assess arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) in the differentiation of metastatic from reactive lymph nodes (LNs) in head and neck squamous cell carcinoma (HNSCC). Materials and methods Retrospective analysis of 113 LNs in 43 patients with HNSCC underwent ASL and DWI of the neck. The tumor blood flow (TBF) and apparent diffusion coefficient (ADC) of the cervical LNs were calculated. The final diagnosis of metastatic (n = 82) and reactive (n = 31) was proved with the pathological examination. Results The TBF of metastatic LNs (58.8 ± 10.2, 58.6 ± 8.5 mL/100 g/min) was significantly higher (p = 0.001) than the reactive LNs (23.2 ± 10.3, 28.2 ± 16.7 mL/100 g/min) for both observers, respectively. The ADC of metastatic LN (1.12 ± 0.07, 1.21 ± 0.07 × $ 10^{−3} %$ mm^{2} $/s) was significantly lower (p = 0.001) than reactive LN (1.41 ± 0.09, 1.44 ± 0.14 × $ 10^{−3} %$ mm^{2} $/s) for both observers, respectively. The threshold of TBF (> 39.5, 40.5 mL/100 g/min), ADC (≥ 1.31, 1.30 $ X10^{−3} %$ mm^{2} $/s) and combined parameters for both observers, respectively, used for differentiating metastatic from reactive LNs revealed an area under the curve of (0.94, 0.945), (0.90, 0.931), and (0.98, 0.989), an accuracy of (88.6%, 80.5%), (80.0%, 88.5%), and (94.3%, 98.2), respectively. Conclusion Combined TBF and ADC are non-invasive imaging parameters that can play a role in differentiation metastatic from reactive LNs in patients with HNSCC. © Springer-Verlag GmbH Germany, part of Springer Nature 2020
abstract_unstemmed	Purpose To assess arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) in the differentiation of metastatic from reactive lymph nodes (LNs) in head and neck squamous cell carcinoma (HNSCC). Materials and methods Retrospective analysis of 113 LNs in 43 patients with HNSCC underwent ASL and DWI of the neck. The tumor blood flow (TBF) and apparent diffusion coefficient (ADC) of the cervical LNs were calculated. The final diagnosis of metastatic (n = 82) and reactive (n = 31) was proved with the pathological examination. Results The TBF of metastatic LNs (58.8 ± 10.2, 58.6 ± 8.5 mL/100 g/min) was significantly higher (p = 0.001) than the reactive LNs (23.2 ± 10.3, 28.2 ± 16.7 mL/100 g/min) for both observers, respectively. The ADC of metastatic LN (1.12 ± 0.07, 1.21 ± 0.07 × $ 10^{−3} %$ mm^{2} $/s) was significantly lower (p = 0.001) than reactive LN (1.41 ± 0.09, 1.44 ± 0.14 × $ 10^{−3} %$ mm^{2} $/s) for both observers, respectively. The threshold of TBF (> 39.5, 40.5 mL/100 g/min), ADC (≥ 1.31, 1.30 $ X10^{−3} %$ mm^{2} $/s) and combined parameters for both observers, respectively, used for differentiating metastatic from reactive LNs revealed an area under the curve of (0.94, 0.945), (0.90, 0.931), and (0.98, 0.989), an accuracy of (88.6%, 80.5%), (80.0%, 88.5%), and (94.3%, 98.2), respectively. Conclusion Combined TBF and ADC are non-invasive imaging parameters that can play a role in differentiation metastatic from reactive LNs in patients with HNSCC. © Springer-Verlag GmbH Germany, part of Springer Nature 2020
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container_issue	7
title_short	Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma
url	https://dx.doi.org/10.1007/s00405-020-06390-0
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author2	Helmy, Eman
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doi_str	10.1007/s00405-020-06390-0
up_date	2024-07-03T23:23:19.465Z
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Materials and methods Retrospective analysis of 113 LNs in 43 patients with HNSCC underwent ASL and DWI of the neck. The tumor blood flow (TBF) and apparent diffusion coefficient (ADC) of the cervical LNs were calculated. The final diagnosis of metastatic (n = 82) and reactive (n = 31) was proved with the pathological examination. Results The TBF of metastatic LNs (58.8 ± 10.2, 58.6 ± 8.5 mL/100 g/min) was significantly higher (p = 0.001) than the reactive LNs (23.2 ± 10.3, 28.2 ± 16.7 mL/100 g/min) for both observers, respectively. The ADC of metastatic LN (1.12 ± 0.07, 1.21 ± 0.07 × $ 10^{−3} %$ mm^{2} $/s) was significantly lower (p = 0.001) than reactive LN (1.41 ± 0.09, 1.44 ± 0.14 × $ 10^{−3} %$ mm^{2} $/s) for both observers, respectively. 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Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma

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