Extracellular Matrix Remodeling and Development of Cancer

Abstract The importance of stem cell growth and its fate is highly essential for the use of stem cells in therapy and regeneration. There are conflicting evidences regarding the actual role of stem cells when injected into a patient towards damage recovery and its lifespan inside the body. Tumor mic...
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Autor*in:	Girigoswami, Koyeli [verfasserIn] Saini, Devender [verfasserIn] Girigoswami, Agnishwar [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Extracellular matrix Stiffness of ECM ECM remodeling Cancer ECM Cancer niche

Anmerkung:	© Springer Science+Business Media, LLC, part of Springer Nature 2020

Übergeordnetes Werk:	Enthalten in: Stem cell reviews - New York, NY : Springer, 2005, 17(2020), 3 vom: 30. Okt., Seite 739-747
Übergeordnetes Werk:	volume:17 ; year:2020 ; number:3 ; day:30 ; month:10 ; pages:739-747

Links:	Volltext

DOI / URN:	10.1007/s12015-020-10070-1

Katalog-ID:	SPR044194781

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allfields	10.1007/s12015-020-10070-1 doi (DE-627)SPR044194781 (SPR)s12015-020-10070-1-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.15 bkl Girigoswami, Koyeli verfasserin aut Extracellular Matrix Remodeling and Development of Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2020 Abstract The importance of stem cell growth and its fate is highly essential for the use of stem cells in therapy and regeneration. There are conflicting evidences regarding the actual role of stem cells when injected into a patient towards damage recovery and its lifespan inside the body. Tumor microenvironment differs from that of normal cells and may have a role in the growth of stem cells when associated with them. In cancer, the uncontrolled growth of cells remodels the extracellular matrix (ECM). The ECM alteration occurs as the mutated fibroblast cells release growth factors into the ECM which further alters the ECM directly or changes the epithelial cells and then alters the ECM. In this review we will discuss about the components and functions of ECM and how does it differ in cancer cells compared to normal cells. Abnormal dynamics of the ECM and its role in cancer progression will also be discussed. Graphical abstract Extracellular matrix (dpeaa)DE-He213 Stiffness of ECM (dpeaa)DE-He213 ECM remodeling (dpeaa)DE-He213 Cancer ECM (dpeaa)DE-He213 Cancer niche (dpeaa)DE-He213 Saini, Devender verfasserin aut Girigoswami, Agnishwar verfasserin aut Enthalten in Stem cell reviews New York, NY : Springer, 2005 17(2020), 3 vom: 30. Okt., Seite 739-747 (DE-627)494833777 (DE-600)2197218-7 1558-6804 nnns volume:17 year:2020 number:3 day:30 month:10 pages:739-747 https://dx.doi.org/10.1007/s12015-020-10070-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 42.15 ASE AR 17 2020 3 30 10 739-747
spelling	10.1007/s12015-020-10070-1 doi (DE-627)SPR044194781 (SPR)s12015-020-10070-1-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.15 bkl Girigoswami, Koyeli verfasserin aut Extracellular Matrix Remodeling and Development of Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2020 Abstract The importance of stem cell growth and its fate is highly essential for the use of stem cells in therapy and regeneration. There are conflicting evidences regarding the actual role of stem cells when injected into a patient towards damage recovery and its lifespan inside the body. Tumor microenvironment differs from that of normal cells and may have a role in the growth of stem cells when associated with them. In cancer, the uncontrolled growth of cells remodels the extracellular matrix (ECM). The ECM alteration occurs as the mutated fibroblast cells release growth factors into the ECM which further alters the ECM directly or changes the epithelial cells and then alters the ECM. In this review we will discuss about the components and functions of ECM and how does it differ in cancer cells compared to normal cells. Abnormal dynamics of the ECM and its role in cancer progression will also be discussed. Graphical abstract Extracellular matrix (dpeaa)DE-He213 Stiffness of ECM (dpeaa)DE-He213 ECM remodeling (dpeaa)DE-He213 Cancer ECM (dpeaa)DE-He213 Cancer niche (dpeaa)DE-He213 Saini, Devender verfasserin aut Girigoswami, Agnishwar verfasserin aut Enthalten in Stem cell reviews New York, NY : Springer, 2005 17(2020), 3 vom: 30. Okt., Seite 739-747 (DE-627)494833777 (DE-600)2197218-7 1558-6804 nnns volume:17 year:2020 number:3 day:30 month:10 pages:739-747 https://dx.doi.org/10.1007/s12015-020-10070-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 42.15 ASE AR 17 2020 3 30 10 739-747
allfields_unstemmed	10.1007/s12015-020-10070-1 doi (DE-627)SPR044194781 (SPR)s12015-020-10070-1-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.15 bkl Girigoswami, Koyeli verfasserin aut Extracellular Matrix Remodeling and Development of Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2020 Abstract The importance of stem cell growth and its fate is highly essential for the use of stem cells in therapy and regeneration. There are conflicting evidences regarding the actual role of stem cells when injected into a patient towards damage recovery and its lifespan inside the body. Tumor microenvironment differs from that of normal cells and may have a role in the growth of stem cells when associated with them. In cancer, the uncontrolled growth of cells remodels the extracellular matrix (ECM). The ECM alteration occurs as the mutated fibroblast cells release growth factors into the ECM which further alters the ECM directly or changes the epithelial cells and then alters the ECM. In this review we will discuss about the components and functions of ECM and how does it differ in cancer cells compared to normal cells. Abnormal dynamics of the ECM and its role in cancer progression will also be discussed. Graphical abstract Extracellular matrix (dpeaa)DE-He213 Stiffness of ECM (dpeaa)DE-He213 ECM remodeling (dpeaa)DE-He213 Cancer ECM (dpeaa)DE-He213 Cancer niche (dpeaa)DE-He213 Saini, Devender verfasserin aut Girigoswami, Agnishwar verfasserin aut Enthalten in Stem cell reviews New York, NY : Springer, 2005 17(2020), 3 vom: 30. Okt., Seite 739-747 (DE-627)494833777 (DE-600)2197218-7 1558-6804 nnns volume:17 year:2020 number:3 day:30 month:10 pages:739-747 https://dx.doi.org/10.1007/s12015-020-10070-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 42.15 ASE AR 17 2020 3 30 10 739-747
allfieldsGer	10.1007/s12015-020-10070-1 doi (DE-627)SPR044194781 (SPR)s12015-020-10070-1-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.15 bkl Girigoswami, Koyeli verfasserin aut Extracellular Matrix Remodeling and Development of Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2020 Abstract The importance of stem cell growth and its fate is highly essential for the use of stem cells in therapy and regeneration. There are conflicting evidences regarding the actual role of stem cells when injected into a patient towards damage recovery and its lifespan inside the body. Tumor microenvironment differs from that of normal cells and may have a role in the growth of stem cells when associated with them. In cancer, the uncontrolled growth of cells remodels the extracellular matrix (ECM). The ECM alteration occurs as the mutated fibroblast cells release growth factors into the ECM which further alters the ECM directly or changes the epithelial cells and then alters the ECM. In this review we will discuss about the components and functions of ECM and how does it differ in cancer cells compared to normal cells. Abnormal dynamics of the ECM and its role in cancer progression will also be discussed. Graphical abstract Extracellular matrix (dpeaa)DE-He213 Stiffness of ECM (dpeaa)DE-He213 ECM remodeling (dpeaa)DE-He213 Cancer ECM (dpeaa)DE-He213 Cancer niche (dpeaa)DE-He213 Saini, Devender verfasserin aut Girigoswami, Agnishwar verfasserin aut Enthalten in Stem cell reviews New York, NY : Springer, 2005 17(2020), 3 vom: 30. Okt., Seite 739-747 (DE-627)494833777 (DE-600)2197218-7 1558-6804 nnns volume:17 year:2020 number:3 day:30 month:10 pages:739-747 https://dx.doi.org/10.1007/s12015-020-10070-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 42.15 ASE AR 17 2020 3 30 10 739-747
allfieldsSound	10.1007/s12015-020-10070-1 doi (DE-627)SPR044194781 (SPR)s12015-020-10070-1-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.15 bkl Girigoswami, Koyeli verfasserin aut Extracellular Matrix Remodeling and Development of Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2020 Abstract The importance of stem cell growth and its fate is highly essential for the use of stem cells in therapy and regeneration. There are conflicting evidences regarding the actual role of stem cells when injected into a patient towards damage recovery and its lifespan inside the body. Tumor microenvironment differs from that of normal cells and may have a role in the growth of stem cells when associated with them. In cancer, the uncontrolled growth of cells remodels the extracellular matrix (ECM). The ECM alteration occurs as the mutated fibroblast cells release growth factors into the ECM which further alters the ECM directly or changes the epithelial cells and then alters the ECM. In this review we will discuss about the components and functions of ECM and how does it differ in cancer cells compared to normal cells. Abnormal dynamics of the ECM and its role in cancer progression will also be discussed. Graphical abstract Extracellular matrix (dpeaa)DE-He213 Stiffness of ECM (dpeaa)DE-He213 ECM remodeling (dpeaa)DE-He213 Cancer ECM (dpeaa)DE-He213 Cancer niche (dpeaa)DE-He213 Saini, Devender verfasserin aut Girigoswami, Agnishwar verfasserin aut Enthalten in Stem cell reviews New York, NY : Springer, 2005 17(2020), 3 vom: 30. Okt., Seite 739-747 (DE-627)494833777 (DE-600)2197218-7 1558-6804 nnns volume:17 year:2020 number:3 day:30 month:10 pages:739-747 https://dx.doi.org/10.1007/s12015-020-10070-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 42.15 ASE AR 17 2020 3 30 10 739-747
language	English
source	Enthalten in Stem cell reviews 17(2020), 3 vom: 30. Okt., Seite 739-747 volume:17 year:2020 number:3 day:30 month:10 pages:739-747
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institution	findex.gbv.de
topic_facet	Extracellular matrix Stiffness of ECM ECM remodeling Cancer ECM Cancer niche
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authorswithroles_txt_mv	Girigoswami, Koyeli @@aut@@ Saini, Devender @@aut@@ Girigoswami, Agnishwar @@aut@@
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author	Girigoswami, Koyeli
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topic	ddc 570 bkl 42.15 misc Extracellular matrix misc Stiffness of ECM misc ECM remodeling misc Cancer ECM misc Cancer niche
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title	Extracellular Matrix Remodeling and Development of Cancer
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title_sort	extracellular matrix remodeling and development of cancer
title_auth	Extracellular Matrix Remodeling and Development of Cancer
abstract	Abstract The importance of stem cell growth and its fate is highly essential for the use of stem cells in therapy and regeneration. There are conflicting evidences regarding the actual role of stem cells when injected into a patient towards damage recovery and its lifespan inside the body. Tumor microenvironment differs from that of normal cells and may have a role in the growth of stem cells when associated with them. In cancer, the uncontrolled growth of cells remodels the extracellular matrix (ECM). The ECM alteration occurs as the mutated fibroblast cells release growth factors into the ECM which further alters the ECM directly or changes the epithelial cells and then alters the ECM. In this review we will discuss about the components and functions of ECM and how does it differ in cancer cells compared to normal cells. Abnormal dynamics of the ECM and its role in cancer progression will also be discussed. Graphical abstract © Springer Science+Business Media, LLC, part of Springer Nature 2020
abstractGer	Abstract The importance of stem cell growth and its fate is highly essential for the use of stem cells in therapy and regeneration. There are conflicting evidences regarding the actual role of stem cells when injected into a patient towards damage recovery and its lifespan inside the body. Tumor microenvironment differs from that of normal cells and may have a role in the growth of stem cells when associated with them. In cancer, the uncontrolled growth of cells remodels the extracellular matrix (ECM). The ECM alteration occurs as the mutated fibroblast cells release growth factors into the ECM which further alters the ECM directly or changes the epithelial cells and then alters the ECM. In this review we will discuss about the components and functions of ECM and how does it differ in cancer cells compared to normal cells. Abnormal dynamics of the ECM and its role in cancer progression will also be discussed. Graphical abstract © Springer Science+Business Media, LLC, part of Springer Nature 2020
abstract_unstemmed	Abstract The importance of stem cell growth and its fate is highly essential for the use of stem cells in therapy and regeneration. There are conflicting evidences regarding the actual role of stem cells when injected into a patient towards damage recovery and its lifespan inside the body. Tumor microenvironment differs from that of normal cells and may have a role in the growth of stem cells when associated with them. In cancer, the uncontrolled growth of cells remodels the extracellular matrix (ECM). The ECM alteration occurs as the mutated fibroblast cells release growth factors into the ECM which further alters the ECM directly or changes the epithelial cells and then alters the ECM. In this review we will discuss about the components and functions of ECM and how does it differ in cancer cells compared to normal cells. Abnormal dynamics of the ECM and its role in cancer progression will also be discussed. Graphical abstract © Springer Science+Business Media, LLC, part of Springer Nature 2020
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title_short	Extracellular Matrix Remodeling and Development of Cancer
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