Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases
Purpose In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer’s disease (AD). Methods Forty-nine participants were scanned with 18F-PI-2620 PET to examine the distribution of this novel PET ligand throu...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mormino, Elizabeth C. [verfasserIn] Toueg, Tyler N. [verfasserIn] Azevedo, Carmen [verfasserIn] Castillo, Jessica B. [verfasserIn] Guo, Wanjia [verfasserIn] Nadiadwala, Ayesha [verfasserIn] Corso, Nicole K. [verfasserIn] Hall, Jacob N. [verfasserIn] Fan, Audrey [verfasserIn] Trelle, Alexandra N. [verfasserIn] Harrison, Marc B. [verfasserIn] Hunt, Madison P. [verfasserIn] Sha, Sharon J. [verfasserIn] Deutsch, Gayle [verfasserIn] James, Michelle [verfasserIn] Fredericks, Carolyn A. [verfasserIn] Koran, Mary Ellen [verfasserIn] Zeineh, Michael [verfasserIn] Poston, Kathleen [verfasserIn] Greicius, Michael D. [verfasserIn] Khalighi, Mehdi [verfasserIn] Davidzon, Guido A. [verfasserIn] Shen, Bin [verfasserIn] Zaharchuk, Greg [verfasserIn] Wagner, Anthony D. [verfasserIn] Chin, Frederick T. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag GmbH Germany, part of Springer Nature 2020 |
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| Übergeordnetes Werk: |
Enthalten in: European journal of nuclear medicine and molecular imaging - Heidelberg [u.a.] : Springer-Verl., 2002, 48(2020), 7 vom: 23. Juni, Seite 2233-2244 |
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| Übergeordnetes Werk: |
volume:48 ; year:2020 ; number:7 ; day:23 ; month:06 ; pages:2233-2244 |
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| DOI / URN: |
10.1007/s00259-020-04923-7 |
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SPR044216394 |
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| 500 | |a © Springer-Verlag GmbH Germany, part of Springer Nature 2020 | ||
| 520 | |a Purpose In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer’s disease (AD). Methods Forty-nine participants were scanned with 18F-PI-2620 PET to examine the distribution of this novel PET ligand throughout the course of AD: 36 older healthy controls (HC) (age range 61 to 86), 11 beta-amyloid+ (Aβ+) participants with cognitive impairment (CI; clinical diagnosis of either mild cognitive impairment or AD dementia, age range 57 to 86), and 2 participants with semantic variant primary progressive aphasia (svPPA, age 66 and 78). Group differences in brain regions relevant in AD (medial temporal lobe, posterior cingulate cortex, and lateral parietal cortex) were examined using standardized uptake value ratios (SUVRs) normalized to the inferior gray matter of the cerebellum. Results SUVRs in target regions were relatively stable 60 to 90 min post-injection, with the exception of very high binders who continued to show increases over time. Robust elevations in 18F-PI-2620 were observed between HC and Aβ+ CI across all AD regions. Within the HC group, older age was associated with subtle elevations in target regions. Mildly elevated focal uptake was observed in the anterior temporal pole in one svPPA patient. Conclusion Preliminary results suggest strong differences in the medial temporal lobe and cortical regions known to be impacted in AD using 18F-PI-2620 in patients along the AD trajectory. This work confirms that 18F-PI-2620 holds promise as a tool to visualize tau aggregations in AD. | ||
| 650 | 4 | |a Alzheimer’s disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Human aging |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Tau PET |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neurofibrillary tangles |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Toueg, Tyler N. |e verfasserin |4 aut | |
| 700 | 1 | |a Azevedo, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Castillo, Jessica B. |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Wanjia |e verfasserin |4 aut | |
| 700 | 1 | |a Nadiadwala, Ayesha |e verfasserin |4 aut | |
| 700 | 1 | |a Corso, Nicole K. |e verfasserin |4 aut | |
| 700 | 1 | |a Hall, Jacob N. |e verfasserin |4 aut | |
| 700 | 1 | |a Fan, Audrey |e verfasserin |4 aut | |
| 700 | 1 | |a Trelle, Alexandra N. |e verfasserin |4 aut | |
| 700 | 1 | |a Harrison, Marc B. |e verfasserin |4 aut | |
| 700 | 1 | |a Hunt, Madison P. |e verfasserin |4 aut | |
| 700 | 1 | |a Sha, Sharon J. |e verfasserin |4 aut | |
| 700 | 1 | |a Deutsch, Gayle |e verfasserin |4 aut | |
| 700 | 1 | |a James, Michelle |e verfasserin |4 aut | |
| 700 | 1 | |a Fredericks, Carolyn A. |e verfasserin |4 aut | |
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| 700 | 1 | |a Zeineh, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Poston, Kathleen |e verfasserin |4 aut | |
| 700 | 1 | |a Greicius, Michael D. |e verfasserin |4 aut | |
| 700 | 1 | |a Khalighi, Mehdi |e verfasserin |4 aut | |
| 700 | 1 | |a Davidzon, Guido A. |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Zaharchuk, Greg |e verfasserin |4 aut | |
| 700 | 1 | |a Wagner, Anthony D. |e verfasserin |4 aut | |
| 700 | 1 | |a Chin, Frederick T. |e verfasserin |4 aut | |
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10.1007/s00259-020-04923-7 doi (DE-627)SPR044216394 (SPR)s00259-020-04923-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Mormino, Elizabeth C. verfasserin aut Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Purpose In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer’s disease (AD). Methods Forty-nine participants were scanned with 18F-PI-2620 PET to examine the distribution of this novel PET ligand throughout the course of AD: 36 older healthy controls (HC) (age range 61 to 86), 11 beta-amyloid+ (Aβ+) participants with cognitive impairment (CI; clinical diagnosis of either mild cognitive impairment or AD dementia, age range 57 to 86), and 2 participants with semantic variant primary progressive aphasia (svPPA, age 66 and 78). Group differences in brain regions relevant in AD (medial temporal lobe, posterior cingulate cortex, and lateral parietal cortex) were examined using standardized uptake value ratios (SUVRs) normalized to the inferior gray matter of the cerebellum. Results SUVRs in target regions were relatively stable 60 to 90 min post-injection, with the exception of very high binders who continued to show increases over time. Robust elevations in 18F-PI-2620 were observed between HC and Aβ+ CI across all AD regions. Within the HC group, older age was associated with subtle elevations in target regions. Mildly elevated focal uptake was observed in the anterior temporal pole in one svPPA patient. Conclusion Preliminary results suggest strong differences in the medial temporal lobe and cortical regions known to be impacted in AD using 18F-PI-2620 in patients along the AD trajectory. This work confirms that 18F-PI-2620 holds promise as a tool to visualize tau aggregations in AD. Alzheimer’s disease (dpeaa)DE-He213 Human aging (dpeaa)DE-He213 Tau PET (dpeaa)DE-He213 Neurofibrillary tangles (dpeaa)DE-He213 Toueg, Tyler N. verfasserin aut Azevedo, Carmen verfasserin aut Castillo, Jessica B. verfasserin aut Guo, Wanjia verfasserin aut Nadiadwala, Ayesha verfasserin aut Corso, Nicole K. verfasserin aut Hall, Jacob N. verfasserin aut Fan, Audrey verfasserin aut Trelle, Alexandra N. verfasserin aut Harrison, Marc B. verfasserin aut Hunt, Madison P. verfasserin aut Sha, Sharon J. verfasserin aut Deutsch, Gayle verfasserin aut James, Michelle verfasserin aut Fredericks, Carolyn A. verfasserin aut Koran, Mary Ellen verfasserin aut Zeineh, Michael verfasserin aut Poston, Kathleen verfasserin aut Greicius, Michael D. verfasserin aut Khalighi, Mehdi verfasserin aut Davidzon, Guido A. verfasserin aut Shen, Bin verfasserin aut Zaharchuk, Greg verfasserin aut Wagner, Anthony D. verfasserin aut Chin, Frederick T. verfasserin aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 48(2020), 7 vom: 23. Juni, Seite 2233-2244 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:48 year:2020 number:7 day:23 month:06 pages:2233-2244 https://dx.doi.org/10.1007/s00259-020-04923-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 48 2020 7 23 06 2233-2244 |
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10.1007/s00259-020-04923-7 doi (DE-627)SPR044216394 (SPR)s00259-020-04923-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Mormino, Elizabeth C. verfasserin aut Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Purpose In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer’s disease (AD). Methods Forty-nine participants were scanned with 18F-PI-2620 PET to examine the distribution of this novel PET ligand throughout the course of AD: 36 older healthy controls (HC) (age range 61 to 86), 11 beta-amyloid+ (Aβ+) participants with cognitive impairment (CI; clinical diagnosis of either mild cognitive impairment or AD dementia, age range 57 to 86), and 2 participants with semantic variant primary progressive aphasia (svPPA, age 66 and 78). Group differences in brain regions relevant in AD (medial temporal lobe, posterior cingulate cortex, and lateral parietal cortex) were examined using standardized uptake value ratios (SUVRs) normalized to the inferior gray matter of the cerebellum. Results SUVRs in target regions were relatively stable 60 to 90 min post-injection, with the exception of very high binders who continued to show increases over time. Robust elevations in 18F-PI-2620 were observed between HC and Aβ+ CI across all AD regions. Within the HC group, older age was associated with subtle elevations in target regions. Mildly elevated focal uptake was observed in the anterior temporal pole in one svPPA patient. Conclusion Preliminary results suggest strong differences in the medial temporal lobe and cortical regions known to be impacted in AD using 18F-PI-2620 in patients along the AD trajectory. This work confirms that 18F-PI-2620 holds promise as a tool to visualize tau aggregations in AD. Alzheimer’s disease (dpeaa)DE-He213 Human aging (dpeaa)DE-He213 Tau PET (dpeaa)DE-He213 Neurofibrillary tangles (dpeaa)DE-He213 Toueg, Tyler N. verfasserin aut Azevedo, Carmen verfasserin aut Castillo, Jessica B. verfasserin aut Guo, Wanjia verfasserin aut Nadiadwala, Ayesha verfasserin aut Corso, Nicole K. verfasserin aut Hall, Jacob N. verfasserin aut Fan, Audrey verfasserin aut Trelle, Alexandra N. verfasserin aut Harrison, Marc B. verfasserin aut Hunt, Madison P. verfasserin aut Sha, Sharon J. verfasserin aut Deutsch, Gayle verfasserin aut James, Michelle verfasserin aut Fredericks, Carolyn A. verfasserin aut Koran, Mary Ellen verfasserin aut Zeineh, Michael verfasserin aut Poston, Kathleen verfasserin aut Greicius, Michael D. verfasserin aut Khalighi, Mehdi verfasserin aut Davidzon, Guido A. verfasserin aut Shen, Bin verfasserin aut Zaharchuk, Greg verfasserin aut Wagner, Anthony D. verfasserin aut Chin, Frederick T. verfasserin aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 48(2020), 7 vom: 23. Juni, Seite 2233-2244 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:48 year:2020 number:7 day:23 month:06 pages:2233-2244 https://dx.doi.org/10.1007/s00259-020-04923-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 48 2020 7 23 06 2233-2244 |
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10.1007/s00259-020-04923-7 doi (DE-627)SPR044216394 (SPR)s00259-020-04923-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Mormino, Elizabeth C. verfasserin aut Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Purpose In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer’s disease (AD). Methods Forty-nine participants were scanned with 18F-PI-2620 PET to examine the distribution of this novel PET ligand throughout the course of AD: 36 older healthy controls (HC) (age range 61 to 86), 11 beta-amyloid+ (Aβ+) participants with cognitive impairment (CI; clinical diagnosis of either mild cognitive impairment or AD dementia, age range 57 to 86), and 2 participants with semantic variant primary progressive aphasia (svPPA, age 66 and 78). Group differences in brain regions relevant in AD (medial temporal lobe, posterior cingulate cortex, and lateral parietal cortex) were examined using standardized uptake value ratios (SUVRs) normalized to the inferior gray matter of the cerebellum. Results SUVRs in target regions were relatively stable 60 to 90 min post-injection, with the exception of very high binders who continued to show increases over time. Robust elevations in 18F-PI-2620 were observed between HC and Aβ+ CI across all AD regions. Within the HC group, older age was associated with subtle elevations in target regions. Mildly elevated focal uptake was observed in the anterior temporal pole in one svPPA patient. Conclusion Preliminary results suggest strong differences in the medial temporal lobe and cortical regions known to be impacted in AD using 18F-PI-2620 in patients along the AD trajectory. This work confirms that 18F-PI-2620 holds promise as a tool to visualize tau aggregations in AD. Alzheimer’s disease (dpeaa)DE-He213 Human aging (dpeaa)DE-He213 Tau PET (dpeaa)DE-He213 Neurofibrillary tangles (dpeaa)DE-He213 Toueg, Tyler N. verfasserin aut Azevedo, Carmen verfasserin aut Castillo, Jessica B. verfasserin aut Guo, Wanjia verfasserin aut Nadiadwala, Ayesha verfasserin aut Corso, Nicole K. verfasserin aut Hall, Jacob N. verfasserin aut Fan, Audrey verfasserin aut Trelle, Alexandra N. verfasserin aut Harrison, Marc B. verfasserin aut Hunt, Madison P. verfasserin aut Sha, Sharon J. verfasserin aut Deutsch, Gayle verfasserin aut James, Michelle verfasserin aut Fredericks, Carolyn A. verfasserin aut Koran, Mary Ellen verfasserin aut Zeineh, Michael verfasserin aut Poston, Kathleen verfasserin aut Greicius, Michael D. verfasserin aut Khalighi, Mehdi verfasserin aut Davidzon, Guido A. verfasserin aut Shen, Bin verfasserin aut Zaharchuk, Greg verfasserin aut Wagner, Anthony D. verfasserin aut Chin, Frederick T. verfasserin aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 48(2020), 7 vom: 23. Juni, Seite 2233-2244 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:48 year:2020 number:7 day:23 month:06 pages:2233-2244 https://dx.doi.org/10.1007/s00259-020-04923-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 48 2020 7 23 06 2233-2244 |
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10.1007/s00259-020-04923-7 doi (DE-627)SPR044216394 (SPR)s00259-020-04923-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Mormino, Elizabeth C. verfasserin aut Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Purpose In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer’s disease (AD). Methods Forty-nine participants were scanned with 18F-PI-2620 PET to examine the distribution of this novel PET ligand throughout the course of AD: 36 older healthy controls (HC) (age range 61 to 86), 11 beta-amyloid+ (Aβ+) participants with cognitive impairment (CI; clinical diagnosis of either mild cognitive impairment or AD dementia, age range 57 to 86), and 2 participants with semantic variant primary progressive aphasia (svPPA, age 66 and 78). Group differences in brain regions relevant in AD (medial temporal lobe, posterior cingulate cortex, and lateral parietal cortex) were examined using standardized uptake value ratios (SUVRs) normalized to the inferior gray matter of the cerebellum. Results SUVRs in target regions were relatively stable 60 to 90 min post-injection, with the exception of very high binders who continued to show increases over time. Robust elevations in 18F-PI-2620 were observed between HC and Aβ+ CI across all AD regions. Within the HC group, older age was associated with subtle elevations in target regions. Mildly elevated focal uptake was observed in the anterior temporal pole in one svPPA patient. Conclusion Preliminary results suggest strong differences in the medial temporal lobe and cortical regions known to be impacted in AD using 18F-PI-2620 in patients along the AD trajectory. This work confirms that 18F-PI-2620 holds promise as a tool to visualize tau aggregations in AD. Alzheimer’s disease (dpeaa)DE-He213 Human aging (dpeaa)DE-He213 Tau PET (dpeaa)DE-He213 Neurofibrillary tangles (dpeaa)DE-He213 Toueg, Tyler N. verfasserin aut Azevedo, Carmen verfasserin aut Castillo, Jessica B. verfasserin aut Guo, Wanjia verfasserin aut Nadiadwala, Ayesha verfasserin aut Corso, Nicole K. verfasserin aut Hall, Jacob N. verfasserin aut Fan, Audrey verfasserin aut Trelle, Alexandra N. verfasserin aut Harrison, Marc B. verfasserin aut Hunt, Madison P. verfasserin aut Sha, Sharon J. verfasserin aut Deutsch, Gayle verfasserin aut James, Michelle verfasserin aut Fredericks, Carolyn A. verfasserin aut Koran, Mary Ellen verfasserin aut Zeineh, Michael verfasserin aut Poston, Kathleen verfasserin aut Greicius, Michael D. verfasserin aut Khalighi, Mehdi verfasserin aut Davidzon, Guido A. verfasserin aut Shen, Bin verfasserin aut Zaharchuk, Greg verfasserin aut Wagner, Anthony D. verfasserin aut Chin, Frederick T. verfasserin aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 48(2020), 7 vom: 23. Juni, Seite 2233-2244 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:48 year:2020 number:7 day:23 month:06 pages:2233-2244 https://dx.doi.org/10.1007/s00259-020-04923-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 48 2020 7 23 06 2233-2244 |
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10.1007/s00259-020-04923-7 doi (DE-627)SPR044216394 (SPR)s00259-020-04923-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Mormino, Elizabeth C. verfasserin aut Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Purpose In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer’s disease (AD). Methods Forty-nine participants were scanned with 18F-PI-2620 PET to examine the distribution of this novel PET ligand throughout the course of AD: 36 older healthy controls (HC) (age range 61 to 86), 11 beta-amyloid+ (Aβ+) participants with cognitive impairment (CI; clinical diagnosis of either mild cognitive impairment or AD dementia, age range 57 to 86), and 2 participants with semantic variant primary progressive aphasia (svPPA, age 66 and 78). Group differences in brain regions relevant in AD (medial temporal lobe, posterior cingulate cortex, and lateral parietal cortex) were examined using standardized uptake value ratios (SUVRs) normalized to the inferior gray matter of the cerebellum. Results SUVRs in target regions were relatively stable 60 to 90 min post-injection, with the exception of very high binders who continued to show increases over time. Robust elevations in 18F-PI-2620 were observed between HC and Aβ+ CI across all AD regions. Within the HC group, older age was associated with subtle elevations in target regions. Mildly elevated focal uptake was observed in the anterior temporal pole in one svPPA patient. Conclusion Preliminary results suggest strong differences in the medial temporal lobe and cortical regions known to be impacted in AD using 18F-PI-2620 in patients along the AD trajectory. This work confirms that 18F-PI-2620 holds promise as a tool to visualize tau aggregations in AD. Alzheimer’s disease (dpeaa)DE-He213 Human aging (dpeaa)DE-He213 Tau PET (dpeaa)DE-He213 Neurofibrillary tangles (dpeaa)DE-He213 Toueg, Tyler N. verfasserin aut Azevedo, Carmen verfasserin aut Castillo, Jessica B. verfasserin aut Guo, Wanjia verfasserin aut Nadiadwala, Ayesha verfasserin aut Corso, Nicole K. verfasserin aut Hall, Jacob N. verfasserin aut Fan, Audrey verfasserin aut Trelle, Alexandra N. verfasserin aut Harrison, Marc B. verfasserin aut Hunt, Madison P. verfasserin aut Sha, Sharon J. verfasserin aut Deutsch, Gayle verfasserin aut James, Michelle verfasserin aut Fredericks, Carolyn A. verfasserin aut Koran, Mary Ellen verfasserin aut Zeineh, Michael verfasserin aut Poston, Kathleen verfasserin aut Greicius, Michael D. verfasserin aut Khalighi, Mehdi verfasserin aut Davidzon, Guido A. verfasserin aut Shen, Bin verfasserin aut Zaharchuk, Greg verfasserin aut Wagner, Anthony D. verfasserin aut Chin, Frederick T. verfasserin aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 48(2020), 7 vom: 23. Juni, Seite 2233-2244 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:48 year:2020 number:7 day:23 month:06 pages:2233-2244 https://dx.doi.org/10.1007/s00259-020-04923-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 48 2020 7 23 06 2233-2244 |
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Enthalten in European journal of nuclear medicine and molecular imaging 48(2020), 7 vom: 23. Juni, Seite 2233-2244 volume:48 year:2020 number:7 day:23 month:06 pages:2233-2244 |
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Alzheimer’s disease Human aging Tau PET Neurofibrillary tangles |
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European journal of nuclear medicine and molecular imaging |
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Mormino, Elizabeth C. @@aut@@ Toueg, Tyler N. @@aut@@ Azevedo, Carmen @@aut@@ Castillo, Jessica B. @@aut@@ Guo, Wanjia @@aut@@ Nadiadwala, Ayesha @@aut@@ Corso, Nicole K. @@aut@@ Hall, Jacob N. @@aut@@ Fan, Audrey @@aut@@ Trelle, Alexandra N. @@aut@@ Harrison, Marc B. @@aut@@ Hunt, Madison P. @@aut@@ Sha, Sharon J. @@aut@@ Deutsch, Gayle @@aut@@ James, Michelle @@aut@@ Fredericks, Carolyn A. @@aut@@ Koran, Mary Ellen @@aut@@ Zeineh, Michael @@aut@@ Poston, Kathleen @@aut@@ Greicius, Michael D. @@aut@@ Khalighi, Mehdi @@aut@@ Davidzon, Guido A. @@aut@@ Shen, Bin @@aut@@ Zaharchuk, Greg @@aut@@ Wagner, Anthony D. @@aut@@ Chin, Frederick T. @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR044216394</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519183629.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">210604s2020 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00259-020-04923-7</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR044216394</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00259-020-04923-7-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.64</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Mormino, Elizabeth C.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Springer-Verlag GmbH Germany, part of Springer Nature 2020</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer’s disease (AD). Methods Forty-nine participants were scanned with 18F-PI-2620 PET to examine the distribution of this novel PET ligand throughout the course of AD: 36 older healthy controls (HC) (age range 61 to 86), 11 beta-amyloid+ (Aβ+) participants with cognitive impairment (CI; clinical diagnosis of either mild cognitive impairment or AD dementia, age range 57 to 86), and 2 participants with semantic variant primary progressive aphasia (svPPA, age 66 and 78). Group differences in brain regions relevant in AD (medial temporal lobe, posterior cingulate cortex, and lateral parietal cortex) were examined using standardized uptake value ratios (SUVRs) normalized to the inferior gray matter of the cerebellum. Results SUVRs in target regions were relatively stable 60 to 90 min post-injection, with the exception of very high binders who continued to show increases over time. Robust elevations in 18F-PI-2620 were observed between HC and Aβ+ CI across all AD regions. Within the HC group, older age was associated with subtle elevations in target regions. Mildly elevated focal uptake was observed in the anterior temporal pole in one svPPA patient. Conclusion Preliminary results suggest strong differences in the medial temporal lobe and cortical regions known to be impacted in AD using 18F-PI-2620 in patients along the AD trajectory. 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Mormino, Elizabeth C. Toueg, Tyler N. Azevedo, Carmen Castillo, Jessica B. Guo, Wanjia Nadiadwala, Ayesha Corso, Nicole K. Hall, Jacob N. Fan, Audrey Trelle, Alexandra N. Harrison, Marc B. Hunt, Madison P. Sha, Sharon J. Deutsch, Gayle James, Michelle Fredericks, Carolyn A. Koran, Mary Ellen Zeineh, Michael Poston, Kathleen Greicius, Michael D. Khalighi, Mehdi Davidzon, Guido A. Shen, Bin Zaharchuk, Greg Wagner, Anthony D. Chin, Frederick T. |
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tau pet imaging with 18f-pi-2620 in aging and neurodegenerative diseases |
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Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases |
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Purpose In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer’s disease (AD). Methods Forty-nine participants were scanned with 18F-PI-2620 PET to examine the distribution of this novel PET ligand throughout the course of AD: 36 older healthy controls (HC) (age range 61 to 86), 11 beta-amyloid+ (Aβ+) participants with cognitive impairment (CI; clinical diagnosis of either mild cognitive impairment or AD dementia, age range 57 to 86), and 2 participants with semantic variant primary progressive aphasia (svPPA, age 66 and 78). Group differences in brain regions relevant in AD (medial temporal lobe, posterior cingulate cortex, and lateral parietal cortex) were examined using standardized uptake value ratios (SUVRs) normalized to the inferior gray matter of the cerebellum. Results SUVRs in target regions were relatively stable 60 to 90 min post-injection, with the exception of very high binders who continued to show increases over time. Robust elevations in 18F-PI-2620 were observed between HC and Aβ+ CI across all AD regions. Within the HC group, older age was associated with subtle elevations in target regions. Mildly elevated focal uptake was observed in the anterior temporal pole in one svPPA patient. Conclusion Preliminary results suggest strong differences in the medial temporal lobe and cortical regions known to be impacted in AD using 18F-PI-2620 in patients along the AD trajectory. This work confirms that 18F-PI-2620 holds promise as a tool to visualize tau aggregations in AD. © Springer-Verlag GmbH Germany, part of Springer Nature 2020 |
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Purpose In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer’s disease (AD). Methods Forty-nine participants were scanned with 18F-PI-2620 PET to examine the distribution of this novel PET ligand throughout the course of AD: 36 older healthy controls (HC) (age range 61 to 86), 11 beta-amyloid+ (Aβ+) participants with cognitive impairment (CI; clinical diagnosis of either mild cognitive impairment or AD dementia, age range 57 to 86), and 2 participants with semantic variant primary progressive aphasia (svPPA, age 66 and 78). Group differences in brain regions relevant in AD (medial temporal lobe, posterior cingulate cortex, and lateral parietal cortex) were examined using standardized uptake value ratios (SUVRs) normalized to the inferior gray matter of the cerebellum. Results SUVRs in target regions were relatively stable 60 to 90 min post-injection, with the exception of very high binders who continued to show increases over time. Robust elevations in 18F-PI-2620 were observed between HC and Aβ+ CI across all AD regions. Within the HC group, older age was associated with subtle elevations in target regions. Mildly elevated focal uptake was observed in the anterior temporal pole in one svPPA patient. Conclusion Preliminary results suggest strong differences in the medial temporal lobe and cortical regions known to be impacted in AD using 18F-PI-2620 in patients along the AD trajectory. This work confirms that 18F-PI-2620 holds promise as a tool to visualize tau aggregations in AD. © Springer-Verlag GmbH Germany, part of Springer Nature 2020 |
| abstract_unstemmed |
Purpose In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer’s disease (AD). Methods Forty-nine participants were scanned with 18F-PI-2620 PET to examine the distribution of this novel PET ligand throughout the course of AD: 36 older healthy controls (HC) (age range 61 to 86), 11 beta-amyloid+ (Aβ+) participants with cognitive impairment (CI; clinical diagnosis of either mild cognitive impairment or AD dementia, age range 57 to 86), and 2 participants with semantic variant primary progressive aphasia (svPPA, age 66 and 78). Group differences in brain regions relevant in AD (medial temporal lobe, posterior cingulate cortex, and lateral parietal cortex) were examined using standardized uptake value ratios (SUVRs) normalized to the inferior gray matter of the cerebellum. Results SUVRs in target regions were relatively stable 60 to 90 min post-injection, with the exception of very high binders who continued to show increases over time. Robust elevations in 18F-PI-2620 were observed between HC and Aβ+ CI across all AD regions. Within the HC group, older age was associated with subtle elevations in target regions. Mildly elevated focal uptake was observed in the anterior temporal pole in one svPPA patient. Conclusion Preliminary results suggest strong differences in the medial temporal lobe and cortical regions known to be impacted in AD using 18F-PI-2620 in patients along the AD trajectory. This work confirms that 18F-PI-2620 holds promise as a tool to visualize tau aggregations in AD. © Springer-Verlag GmbH Germany, part of Springer Nature 2020 |
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