Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications

Abstract Therapy of uveal melanoma aims to preserve the eye and its function and to avoid metastatic dissemination. The treatment choice is difficult and must keep into account several factors; the therapeutic strategy of uveal melanoma should therefore be personalized, sometimes requiring to combin...
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Autor*in:	Foti, Pietro Valerio [verfasserIn] Travali, Mario [verfasserIn] Farina, Renato [verfasserIn] Palmucci, Stefano [verfasserIn] Spatola, Corrado [verfasserIn] Liardo, Rocco Luca Emanuele [verfasserIn] Milazzotto, Roberto [verfasserIn] Raffaele, Luigi [verfasserIn] Salamone, Vincenzo [verfasserIn] Caltabiano, Rosario [verfasserIn] Broggi, Giuseppe [verfasserIn] Puzzo, Lidia [verfasserIn] Russo, Andrea [verfasserIn] Reibaldi, Michele [verfasserIn] Longo, Antonio [verfasserIn] Vigneri, Paolo [verfasserIn] Avitabile, Teresio [verfasserIn] Ettorre, Giovani Carlo [verfasserIn] Basile, Antonio [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Magnetic resonance imaging Melanoma Eye Brachytherapy Proton therapy

Anmerkung:	© The Author(s) 2021

Übergeordnetes Werk:	Enthalten in: Insights into imaging - Berlin : Springer, 2010, 12(2021), 1 vom: 04. Juni
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:1 ; day:04 ; month:06

Links:	Volltext

DOI / URN:	10.1186/s13244-021-01001-w

Katalog-ID:	SPR044223293

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allfields	10.1186/s13244-021-01001-w doi (DE-627)SPR044223293 (SPR)s13244-021-01001-w-e DE-627 ger DE-627 rakwb eng 610 ASE Foti, Pietro Valerio verfasserin aut Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Therapy of uveal melanoma aims to preserve the eye and its function and to avoid metastatic dissemination. The treatment choice is difficult and must keep into account several factors; the therapeutic strategy of uveal melanoma should therefore be personalized, sometimes requiring to combine different treatment techniques. Nowadays globe-sparing radiotherapy techniques are often preferred to enucleation. Plaque brachytherapy, the most commonly used eye-preserving therapy, is suitable for small- and medium-sized uveal melanomas. Proton beam radiotherapy is indicated for tumours with noticeable size, challenging shape and location, but is more expensive and less available than brachytherapy. Enucleation is currently restricted to advanced tumours, uveal melanomas with orbital or optic nerve involvement, blind and painful eyes because of treatment-related complications (neovascular glaucoma, chronic inflammatory processes). The effect of proton beam therapy on neoplastic tissue is related to direct cytotoxic action of the radiations, impairment of neoplastic vascular supply and immunologic response. Complications after radiotherapy are frequent and numerous and mainly related to tumour thickness, radiation dose and distance between the tumour and optic nerve. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present second section, we discuss the therapeutic management of uveal melanoma, describing the main ocular-conserving radiotherapic techniques. We subsequently present an overview of the effects of radiations on neoplastic tissue. Lastly, we review ocular complications following radiotherapy that should be evaluated by radiologists during follow-up MRI examinations. Magnetic resonance imaging (dpeaa)DE-He213 Melanoma (dpeaa)DE-He213 Eye (dpeaa)DE-He213 Brachytherapy (dpeaa)DE-He213 Proton therapy (dpeaa)DE-He213 Travali, Mario verfasserin aut Farina, Renato verfasserin aut Palmucci, Stefano verfasserin aut Spatola, Corrado verfasserin aut Liardo, Rocco Luca Emanuele verfasserin aut Milazzotto, Roberto verfasserin aut Raffaele, Luigi verfasserin aut Salamone, Vincenzo verfasserin aut Caltabiano, Rosario verfasserin aut Broggi, Giuseppe verfasserin aut Puzzo, Lidia verfasserin aut Russo, Andrea verfasserin aut Reibaldi, Michele verfasserin aut Longo, Antonio verfasserin aut Vigneri, Paolo verfasserin aut Avitabile, Teresio verfasserin aut Ettorre, Giovani Carlo verfasserin aut Basile, Antonio verfasserin aut Enthalten in Insights into imaging Berlin : Springer, 2010 12(2021), 1 vom: 04. Juni (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:12 year:2021 number:1 day:04 month:06 https://dx.doi.org/10.1186/s13244-021-01001-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 04 06
spelling	10.1186/s13244-021-01001-w doi (DE-627)SPR044223293 (SPR)s13244-021-01001-w-e DE-627 ger DE-627 rakwb eng 610 ASE Foti, Pietro Valerio verfasserin aut Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Therapy of uveal melanoma aims to preserve the eye and its function and to avoid metastatic dissemination. The treatment choice is difficult and must keep into account several factors; the therapeutic strategy of uveal melanoma should therefore be personalized, sometimes requiring to combine different treatment techniques. Nowadays globe-sparing radiotherapy techniques are often preferred to enucleation. Plaque brachytherapy, the most commonly used eye-preserving therapy, is suitable for small- and medium-sized uveal melanomas. Proton beam radiotherapy is indicated for tumours with noticeable size, challenging shape and location, but is more expensive and less available than brachytherapy. Enucleation is currently restricted to advanced tumours, uveal melanomas with orbital or optic nerve involvement, blind and painful eyes because of treatment-related complications (neovascular glaucoma, chronic inflammatory processes). The effect of proton beam therapy on neoplastic tissue is related to direct cytotoxic action of the radiations, impairment of neoplastic vascular supply and immunologic response. Complications after radiotherapy are frequent and numerous and mainly related to tumour thickness, radiation dose and distance between the tumour and optic nerve. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present second section, we discuss the therapeutic management of uveal melanoma, describing the main ocular-conserving radiotherapic techniques. We subsequently present an overview of the effects of radiations on neoplastic tissue. Lastly, we review ocular complications following radiotherapy that should be evaluated by radiologists during follow-up MRI examinations. Magnetic resonance imaging (dpeaa)DE-He213 Melanoma (dpeaa)DE-He213 Eye (dpeaa)DE-He213 Brachytherapy (dpeaa)DE-He213 Proton therapy (dpeaa)DE-He213 Travali, Mario verfasserin aut Farina, Renato verfasserin aut Palmucci, Stefano verfasserin aut Spatola, Corrado verfasserin aut Liardo, Rocco Luca Emanuele verfasserin aut Milazzotto, Roberto verfasserin aut Raffaele, Luigi verfasserin aut Salamone, Vincenzo verfasserin aut Caltabiano, Rosario verfasserin aut Broggi, Giuseppe verfasserin aut Puzzo, Lidia verfasserin aut Russo, Andrea verfasserin aut Reibaldi, Michele verfasserin aut Longo, Antonio verfasserin aut Vigneri, Paolo verfasserin aut Avitabile, Teresio verfasserin aut Ettorre, Giovani Carlo verfasserin aut Basile, Antonio verfasserin aut Enthalten in Insights into imaging Berlin : Springer, 2010 12(2021), 1 vom: 04. Juni (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:12 year:2021 number:1 day:04 month:06 https://dx.doi.org/10.1186/s13244-021-01001-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 04 06
allfields_unstemmed	10.1186/s13244-021-01001-w doi (DE-627)SPR044223293 (SPR)s13244-021-01001-w-e DE-627 ger DE-627 rakwb eng 610 ASE Foti, Pietro Valerio verfasserin aut Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Therapy of uveal melanoma aims to preserve the eye and its function and to avoid metastatic dissemination. The treatment choice is difficult and must keep into account several factors; the therapeutic strategy of uveal melanoma should therefore be personalized, sometimes requiring to combine different treatment techniques. Nowadays globe-sparing radiotherapy techniques are often preferred to enucleation. Plaque brachytherapy, the most commonly used eye-preserving therapy, is suitable for small- and medium-sized uveal melanomas. Proton beam radiotherapy is indicated for tumours with noticeable size, challenging shape and location, but is more expensive and less available than brachytherapy. Enucleation is currently restricted to advanced tumours, uveal melanomas with orbital or optic nerve involvement, blind and painful eyes because of treatment-related complications (neovascular glaucoma, chronic inflammatory processes). The effect of proton beam therapy on neoplastic tissue is related to direct cytotoxic action of the radiations, impairment of neoplastic vascular supply and immunologic response. Complications after radiotherapy are frequent and numerous and mainly related to tumour thickness, radiation dose and distance between the tumour and optic nerve. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present second section, we discuss the therapeutic management of uveal melanoma, describing the main ocular-conserving radiotherapic techniques. We subsequently present an overview of the effects of radiations on neoplastic tissue. Lastly, we review ocular complications following radiotherapy that should be evaluated by radiologists during follow-up MRI examinations. Magnetic resonance imaging (dpeaa)DE-He213 Melanoma (dpeaa)DE-He213 Eye (dpeaa)DE-He213 Brachytherapy (dpeaa)DE-He213 Proton therapy (dpeaa)DE-He213 Travali, Mario verfasserin aut Farina, Renato verfasserin aut Palmucci, Stefano verfasserin aut Spatola, Corrado verfasserin aut Liardo, Rocco Luca Emanuele verfasserin aut Milazzotto, Roberto verfasserin aut Raffaele, Luigi verfasserin aut Salamone, Vincenzo verfasserin aut Caltabiano, Rosario verfasserin aut Broggi, Giuseppe verfasserin aut Puzzo, Lidia verfasserin aut Russo, Andrea verfasserin aut Reibaldi, Michele verfasserin aut Longo, Antonio verfasserin aut Vigneri, Paolo verfasserin aut Avitabile, Teresio verfasserin aut Ettorre, Giovani Carlo verfasserin aut Basile, Antonio verfasserin aut Enthalten in Insights into imaging Berlin : Springer, 2010 12(2021), 1 vom: 04. Juni (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:12 year:2021 number:1 day:04 month:06 https://dx.doi.org/10.1186/s13244-021-01001-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 04 06
allfieldsGer	10.1186/s13244-021-01001-w doi (DE-627)SPR044223293 (SPR)s13244-021-01001-w-e DE-627 ger DE-627 rakwb eng 610 ASE Foti, Pietro Valerio verfasserin aut Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Therapy of uveal melanoma aims to preserve the eye and its function and to avoid metastatic dissemination. The treatment choice is difficult and must keep into account several factors; the therapeutic strategy of uveal melanoma should therefore be personalized, sometimes requiring to combine different treatment techniques. Nowadays globe-sparing radiotherapy techniques are often preferred to enucleation. Plaque brachytherapy, the most commonly used eye-preserving therapy, is suitable for small- and medium-sized uveal melanomas. Proton beam radiotherapy is indicated for tumours with noticeable size, challenging shape and location, but is more expensive and less available than brachytherapy. Enucleation is currently restricted to advanced tumours, uveal melanomas with orbital or optic nerve involvement, blind and painful eyes because of treatment-related complications (neovascular glaucoma, chronic inflammatory processes). The effect of proton beam therapy on neoplastic tissue is related to direct cytotoxic action of the radiations, impairment of neoplastic vascular supply and immunologic response. Complications after radiotherapy are frequent and numerous and mainly related to tumour thickness, radiation dose and distance between the tumour and optic nerve. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present second section, we discuss the therapeutic management of uveal melanoma, describing the main ocular-conserving radiotherapic techniques. We subsequently present an overview of the effects of radiations on neoplastic tissue. Lastly, we review ocular complications following radiotherapy that should be evaluated by radiologists during follow-up MRI examinations. Magnetic resonance imaging (dpeaa)DE-He213 Melanoma (dpeaa)DE-He213 Eye (dpeaa)DE-He213 Brachytherapy (dpeaa)DE-He213 Proton therapy (dpeaa)DE-He213 Travali, Mario verfasserin aut Farina, Renato verfasserin aut Palmucci, Stefano verfasserin aut Spatola, Corrado verfasserin aut Liardo, Rocco Luca Emanuele verfasserin aut Milazzotto, Roberto verfasserin aut Raffaele, Luigi verfasserin aut Salamone, Vincenzo verfasserin aut Caltabiano, Rosario verfasserin aut Broggi, Giuseppe verfasserin aut Puzzo, Lidia verfasserin aut Russo, Andrea verfasserin aut Reibaldi, Michele verfasserin aut Longo, Antonio verfasserin aut Vigneri, Paolo verfasserin aut Avitabile, Teresio verfasserin aut Ettorre, Giovani Carlo verfasserin aut Basile, Antonio verfasserin aut Enthalten in Insights into imaging Berlin : Springer, 2010 12(2021), 1 vom: 04. Juni (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:12 year:2021 number:1 day:04 month:06 https://dx.doi.org/10.1186/s13244-021-01001-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 04 06
allfieldsSound	10.1186/s13244-021-01001-w doi (DE-627)SPR044223293 (SPR)s13244-021-01001-w-e DE-627 ger DE-627 rakwb eng 610 ASE Foti, Pietro Valerio verfasserin aut Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Therapy of uveal melanoma aims to preserve the eye and its function and to avoid metastatic dissemination. The treatment choice is difficult and must keep into account several factors; the therapeutic strategy of uveal melanoma should therefore be personalized, sometimes requiring to combine different treatment techniques. Nowadays globe-sparing radiotherapy techniques are often preferred to enucleation. Plaque brachytherapy, the most commonly used eye-preserving therapy, is suitable for small- and medium-sized uveal melanomas. Proton beam radiotherapy is indicated for tumours with noticeable size, challenging shape and location, but is more expensive and less available than brachytherapy. Enucleation is currently restricted to advanced tumours, uveal melanomas with orbital or optic nerve involvement, blind and painful eyes because of treatment-related complications (neovascular glaucoma, chronic inflammatory processes). The effect of proton beam therapy on neoplastic tissue is related to direct cytotoxic action of the radiations, impairment of neoplastic vascular supply and immunologic response. Complications after radiotherapy are frequent and numerous and mainly related to tumour thickness, radiation dose and distance between the tumour and optic nerve. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present second section, we discuss the therapeutic management of uveal melanoma, describing the main ocular-conserving radiotherapic techniques. We subsequently present an overview of the effects of radiations on neoplastic tissue. Lastly, we review ocular complications following radiotherapy that should be evaluated by radiologists during follow-up MRI examinations. Magnetic resonance imaging (dpeaa)DE-He213 Melanoma (dpeaa)DE-He213 Eye (dpeaa)DE-He213 Brachytherapy (dpeaa)DE-He213 Proton therapy (dpeaa)DE-He213 Travali, Mario verfasserin aut Farina, Renato verfasserin aut Palmucci, Stefano verfasserin aut Spatola, Corrado verfasserin aut Liardo, Rocco Luca Emanuele verfasserin aut Milazzotto, Roberto verfasserin aut Raffaele, Luigi verfasserin aut Salamone, Vincenzo verfasserin aut Caltabiano, Rosario verfasserin aut Broggi, Giuseppe verfasserin aut Puzzo, Lidia verfasserin aut Russo, Andrea verfasserin aut Reibaldi, Michele verfasserin aut Longo, Antonio verfasserin aut Vigneri, Paolo verfasserin aut Avitabile, Teresio verfasserin aut Ettorre, Giovani Carlo verfasserin aut Basile, Antonio verfasserin aut Enthalten in Insights into imaging Berlin : Springer, 2010 12(2021), 1 vom: 04. Juni (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:12 year:2021 number:1 day:04 month:06 https://dx.doi.org/10.1186/s13244-021-01001-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 04 06
language	English
source	Enthalten in Insights into imaging 12(2021), 1 vom: 04. Juni volume:12 year:2021 number:1 day:04 month:06
sourceStr	Enthalten in Insights into imaging 12(2021), 1 vom: 04. Juni volume:12 year:2021 number:1 day:04 month:06
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Magnetic resonance imaging Melanoma Eye Brachytherapy Proton therapy
dewey-raw	610
isfreeaccess_bool	true
container_title	Insights into imaging
authorswithroles_txt_mv	Foti, Pietro Valerio @@aut@@ Travali, Mario @@aut@@ Farina, Renato @@aut@@ Palmucci, Stefano @@aut@@ Spatola, Corrado @@aut@@ Liardo, Rocco Luca Emanuele @@aut@@ Milazzotto, Roberto @@aut@@ Raffaele, Luigi @@aut@@ Salamone, Vincenzo @@aut@@ Caltabiano, Rosario @@aut@@ Broggi, Giuseppe @@aut@@ Puzzo, Lidia @@aut@@ Russo, Andrea @@aut@@ Reibaldi, Michele @@aut@@ Longo, Antonio @@aut@@ Vigneri, Paolo @@aut@@ Avitabile, Teresio @@aut@@ Ettorre, Giovani Carlo @@aut@@ Basile, Antonio @@aut@@
publishDateDaySort_date	2021-06-04T00:00:00Z
hierarchy_top_id	621547425
dewey-sort	3610
id	SPR044223293
language_de	englisch
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author	Foti, Pietro Valerio
spellingShingle	Foti, Pietro Valerio ddc 610 misc Magnetic resonance imaging misc Melanoma misc Eye misc Brachytherapy misc Proton therapy Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications
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topic_title	610 ASE Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications Magnetic resonance imaging (dpeaa)DE-He213 Melanoma (dpeaa)DE-He213 Eye (dpeaa)DE-He213 Brachytherapy (dpeaa)DE-He213 Proton therapy (dpeaa)DE-He213
topic	ddc 610 misc Magnetic resonance imaging misc Melanoma misc Eye misc Brachytherapy misc Proton therapy
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title	Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications
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title_full	Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications
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author_browse	Foti, Pietro Valerio Travali, Mario Farina, Renato Palmucci, Stefano Spatola, Corrado Liardo, Rocco Luca Emanuele Milazzotto, Roberto Raffaele, Luigi Salamone, Vincenzo Caltabiano, Rosario Broggi, Giuseppe Puzzo, Lidia Russo, Andrea Reibaldi, Michele Longo, Antonio Vigneri, Paolo Avitabile, Teresio Ettorre, Giovani Carlo Basile, Antonio
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title_sort	diagnostic methods and therapeutic options of uveal melanoma with emphasis on mr imaging—part ii: treatment indications and complications
title_auth	Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications
abstract	Abstract Therapy of uveal melanoma aims to preserve the eye and its function and to avoid metastatic dissemination. The treatment choice is difficult and must keep into account several factors; the therapeutic strategy of uveal melanoma should therefore be personalized, sometimes requiring to combine different treatment techniques. Nowadays globe-sparing radiotherapy techniques are often preferred to enucleation. Plaque brachytherapy, the most commonly used eye-preserving therapy, is suitable for small- and medium-sized uveal melanomas. Proton beam radiotherapy is indicated for tumours with noticeable size, challenging shape and location, but is more expensive and less available than brachytherapy. Enucleation is currently restricted to advanced tumours, uveal melanomas with orbital or optic nerve involvement, blind and painful eyes because of treatment-related complications (neovascular glaucoma, chronic inflammatory processes). The effect of proton beam therapy on neoplastic tissue is related to direct cytotoxic action of the radiations, impairment of neoplastic vascular supply and immunologic response. Complications after radiotherapy are frequent and numerous and mainly related to tumour thickness, radiation dose and distance between the tumour and optic nerve. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present second section, we discuss the therapeutic management of uveal melanoma, describing the main ocular-conserving radiotherapic techniques. We subsequently present an overview of the effects of radiations on neoplastic tissue. Lastly, we review ocular complications following radiotherapy that should be evaluated by radiologists during follow-up MRI examinations. © The Author(s) 2021
abstractGer	Abstract Therapy of uveal melanoma aims to preserve the eye and its function and to avoid metastatic dissemination. The treatment choice is difficult and must keep into account several factors; the therapeutic strategy of uveal melanoma should therefore be personalized, sometimes requiring to combine different treatment techniques. Nowadays globe-sparing radiotherapy techniques are often preferred to enucleation. Plaque brachytherapy, the most commonly used eye-preserving therapy, is suitable for small- and medium-sized uveal melanomas. Proton beam radiotherapy is indicated for tumours with noticeable size, challenging shape and location, but is more expensive and less available than brachytherapy. Enucleation is currently restricted to advanced tumours, uveal melanomas with orbital or optic nerve involvement, blind and painful eyes because of treatment-related complications (neovascular glaucoma, chronic inflammatory processes). The effect of proton beam therapy on neoplastic tissue is related to direct cytotoxic action of the radiations, impairment of neoplastic vascular supply and immunologic response. Complications after radiotherapy are frequent and numerous and mainly related to tumour thickness, radiation dose and distance between the tumour and optic nerve. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present second section, we discuss the therapeutic management of uveal melanoma, describing the main ocular-conserving radiotherapic techniques. We subsequently present an overview of the effects of radiations on neoplastic tissue. Lastly, we review ocular complications following radiotherapy that should be evaluated by radiologists during follow-up MRI examinations. © The Author(s) 2021
abstract_unstemmed	Abstract Therapy of uveal melanoma aims to preserve the eye and its function and to avoid metastatic dissemination. The treatment choice is difficult and must keep into account several factors; the therapeutic strategy of uveal melanoma should therefore be personalized, sometimes requiring to combine different treatment techniques. Nowadays globe-sparing radiotherapy techniques are often preferred to enucleation. Plaque brachytherapy, the most commonly used eye-preserving therapy, is suitable for small- and medium-sized uveal melanomas. Proton beam radiotherapy is indicated for tumours with noticeable size, challenging shape and location, but is more expensive and less available than brachytherapy. Enucleation is currently restricted to advanced tumours, uveal melanomas with orbital or optic nerve involvement, blind and painful eyes because of treatment-related complications (neovascular glaucoma, chronic inflammatory processes). The effect of proton beam therapy on neoplastic tissue is related to direct cytotoxic action of the radiations, impairment of neoplastic vascular supply and immunologic response. Complications after radiotherapy are frequent and numerous and mainly related to tumour thickness, radiation dose and distance between the tumour and optic nerve. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present second section, we discuss the therapeutic management of uveal melanoma, describing the main ocular-conserving radiotherapic techniques. We subsequently present an overview of the effects of radiations on neoplastic tissue. Lastly, we review ocular complications following radiotherapy that should be evaluated by radiologists during follow-up MRI examinations. © The Author(s) 2021
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title_short	Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications
url	https://dx.doi.org/10.1186/s13244-021-01001-w
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author2	Travali, Mario Farina, Renato Palmucci, Stefano Spatola, Corrado Liardo, Rocco Luca Emanuele Milazzotto, Roberto Raffaele, Luigi Salamone, Vincenzo Caltabiano, Rosario Broggi, Giuseppe Puzzo, Lidia Russo, Andrea Reibaldi, Michele Longo, Antonio Vigneri, Paolo Avitabile, Teresio Ettorre, Giovani Carlo Basile, Antonio
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Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications

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